Oncotarget, ISSN 1949-2553, 01/2019, Volume 10, Issue 3, p. 257
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Oncotarget, 01/2019, Volume 10, Issue 3, pp. 257 - 258
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Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 8050 - 8050
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Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 3249 - 3249
Abstract Introduction Plasmacytomas comprise approximately 3% of all plasma cell malignancies. There is a paucity of large studies assessing clinical features...
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Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 86, pp. 35607 - 35608
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Journal of Clinical Oncology, ISSN 0732-183X, 03/2016, Volume 34, Issue 7_suppl, pp. 311 - 311
311 Background: Previous population-based studies have shown variations in disease incidence and overall survival (OS) among multiple myeloma (MM) patients...
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3160 - 3160
Background: c-MYC activation is an early event of myeloma pathogenesis. It upregulates the expression of the glutaminase 1 (GLS1) enzyme which converts...
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 2013, Volume 88, Issue 5, pp. 495 - 511
Abstract Vitamin K antagonists were the only class of oral anticoagulants available to clinicians for decades. However, with the US Food and Drug...
Internal Medicine | ENOXAPARIN | MEDICINE, GENERAL & INTERNAL | DIRECT THROMBIN INHIBITOR | KNEE REPLACEMENT | DABIGATRAN ETEXILATE | VENOUS THROMBOEMBOLISM | STROKE PREVENTION | WARFARIN | RIVAROXABAN | DOUBLE-BLIND | NONVALVULAR ATRIAL-FIBRILLATION | Anticoagulants - administration & dosage | Thiophenes - adverse effects | Humans | beta-Alanine - pharmacokinetics | Thiophenes - administration & dosage | Dabigatran | Pyridones - administration & dosage | Rivaroxaban | Benzimidazoles - administration & dosage | Benzimidazoles - adverse effects | Pyrazoles - pharmacokinetics | beta-Alanine - analogs & derivatives | Morpholines - adverse effects | Pyrazoles - adverse effects | beta-Alanine - adverse effects | Pyridones - pharmacokinetics | Administration, Oral | Morpholines - administration & dosage | beta-Alanine - administration & dosage | Benzimidazoles - pharmacokinetics | Treatment Outcome | Anticoagulants - adverse effects | Thiophenes - pharmacokinetics | Pyrazoles - administration & dosage | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Pyridones - adverse effects | Complications and side effects | Usage | Anticoagulants (Medicine) | Research
Internal Medicine | ENOXAPARIN | MEDICINE, GENERAL & INTERNAL | DIRECT THROMBIN INHIBITOR | KNEE REPLACEMENT | DABIGATRAN ETEXILATE | VENOUS THROMBOEMBOLISM | STROKE PREVENTION | WARFARIN | RIVAROXABAN | DOUBLE-BLIND | NONVALVULAR ATRIAL-FIBRILLATION | Anticoagulants - administration & dosage | Thiophenes - adverse effects | Humans | beta-Alanine - pharmacokinetics | Thiophenes - administration & dosage | Dabigatran | Pyridones - administration & dosage | Rivaroxaban | Benzimidazoles - administration & dosage | Benzimidazoles - adverse effects | Pyrazoles - pharmacokinetics | beta-Alanine - analogs & derivatives | Morpholines - adverse effects | Pyrazoles - adverse effects | beta-Alanine - adverse effects | Pyridones - pharmacokinetics | Administration, Oral | Morpholines - administration & dosage | beta-Alanine - administration & dosage | Benzimidazoles - pharmacokinetics | Treatment Outcome | Anticoagulants - adverse effects | Thiophenes - pharmacokinetics | Pyrazoles - administration & dosage | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Pyridones - adverse effects | Complications and side effects | Usage | Anticoagulants (Medicine) | Research
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 10/2018, Volume 93, Issue 10, pp. 1525 - 1529
A 59-year-old man with type 2 diabetes, hypertension, and hyperlipidemia presented to his primary care physician with a 2-year history of fatigue and a 30-kg...
MULTIPLE-MYELOMA | MEDICINE, GENERAL & INTERNAL | LIGHT-CHAIN AMYLOIDOSIS | AL AMYLOIDOSIS | FAILURE | Immunohistochemistry | Cyclophosphamide - administration & dosage | Hepatomegaly - diagnostic imaging | Humans | Image-Guided Biopsy - methods | Middle Aged | Immunoglobulin Light-chain Amyloidosis - diagnosis | Fatigue - etiology | Tomography, X-Ray Computed - methods | Male | Antineoplastic Agents - administration & dosage | Cardiomyopathies - etiology | Splenomegaly - diagnostic imaging | Peritoneal Neoplasms - diagnosis | Amyloid - metabolism | Cardiomyopathies - diagnosis | Peptide Fragments - blood | Splenomegaly - etiology | Natriuretic Peptide, Brain - blood | Peritoneal Neoplasms - pathology | Cardiomyopathies - blood | Dexamethasone - administration & dosage | Treatment Outcome | Fatigue - diagnosis | Bortezomib - administration & dosage | Weight Loss | Immunoglobulin Light-chain Amyloidosis - metabolism | Immunoglobulin Light-chain Amyloidosis - physiopathology | Hepatomegaly - etiology | Type 2 diabetes | Medicine | Complications and side effects | Care and treatment | Hepatomegaly | Practice | Diagnosis | Tests, problems and exercises | Immunoglobulins | Nuclear magnetic resonance--NMR | Medical imaging | Hematology | Mortality | Multiple myeloma | Fatigue | Chromatography | Abdomen | Stains & staining | Proteins | Chemotherapy | Scientific imaging | Diabetes | Blood diseases | Mass spectrometry
MULTIPLE-MYELOMA | MEDICINE, GENERAL & INTERNAL | LIGHT-CHAIN AMYLOIDOSIS | AL AMYLOIDOSIS | FAILURE | Immunohistochemistry | Cyclophosphamide - administration & dosage | Hepatomegaly - diagnostic imaging | Humans | Image-Guided Biopsy - methods | Middle Aged | Immunoglobulin Light-chain Amyloidosis - diagnosis | Fatigue - etiology | Tomography, X-Ray Computed - methods | Male | Antineoplastic Agents - administration & dosage | Cardiomyopathies - etiology | Splenomegaly - diagnostic imaging | Peritoneal Neoplasms - diagnosis | Amyloid - metabolism | Cardiomyopathies - diagnosis | Peptide Fragments - blood | Splenomegaly - etiology | Natriuretic Peptide, Brain - blood | Peritoneal Neoplasms - pathology | Cardiomyopathies - blood | Dexamethasone - administration & dosage | Treatment Outcome | Fatigue - diagnosis | Bortezomib - administration & dosage | Weight Loss | Immunoglobulin Light-chain Amyloidosis - metabolism | Immunoglobulin Light-chain Amyloidosis - physiopathology | Hepatomegaly - etiology | Type 2 diabetes | Medicine | Complications and side effects | Care and treatment | Hepatomegaly | Practice | Diagnosis | Tests, problems and exercises | Immunoglobulins | Nuclear magnetic resonance--NMR | Medical imaging | Hematology | Mortality | Multiple myeloma | Fatigue | Chromatography | Abdomen | Stains & staining | Proteins | Chemotherapy | Scientific imaging | Diabetes | Blood diseases | Mass spectrometry
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Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 1320 - 1320
Abstract Background: There has been major improvement in the survival of patients diagnosed with multiple myeloma (MM) over the past two decades. Such...
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Acta Haematologica, ISSN 0001-5792, 02/2018, Volume 139, Issue 1, pp. 45 - 46
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Journal of Clinical Oncology, ISSN 0732-183X, 01/2014, Volume 32, Issue 3_suppl, pp. 522 - 522
522 Background: Metformin inhibits mTOR and downstream pathways involved in cell proliferation and survival by inducing AMPK activation. Although its use has...
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1697 - 1697
Introduction: Isocitrate dehydrogenase 1 and 2 (IDH1/2) are metabolic enzymes in the citric acid cycle, producing alpha-ketoglutarate (αKG). Mutations in...
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 2013, Volume 88, Issue 9, pp. 1036 - 1037
Journal Article
European Journal of Haematology, ISSN 0902-4441, 02/2018, Volume 100, Issue 2, pp. 215 - 217
Primary plasma cell leukemia (pPCL) is the most aggressive form of the plasma cell (PC) malignancy, multiple myeloma (MM). It has been commonly associated with...
Bcl‐2 inhibition | plasma cell leukemia | Venetoclax | Bcl-2 inhibition | SURVIVAL | HEMATOLOGY | MYELOMA | Care and treatment | Leukemia | Plasma | Immunoglobulins | Bortezomib | Dexamethasone | Bcl-2 protein | Multiple myeloma | Heavy chains | Clinical trials | Plasma cell leukemia | Malignancy | Chromosome 14
Bcl‐2 inhibition | plasma cell leukemia | Venetoclax | Bcl-2 inhibition | SURVIVAL | HEMATOLOGY | MYELOMA | Care and treatment | Leukemia | Plasma | Immunoglobulins | Bortezomib | Dexamethasone | Bcl-2 protein | Multiple myeloma | Heavy chains | Clinical trials | Plasma cell leukemia | Malignancy | Chromosome 14
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 07/2014, Volume 106, Issue 7
Background KRAS and BRAF(V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and...
ISLAND METHYLATOR PHENOTYPE | PATHOGENESIS | DNA MISMATCH REPAIR | CETUXIMAB | CIGARETTE-SMOKING | ONCOLOGY | CARCINOMAS | RANDOMIZED-TRIAL | ASSOCIATION | METASTATIC COLORECTAL-CANCER | CHEMOTHERAPY | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Prospective Studies | Humans | Middle Aged | Logistic Models | Male | Proto-Oncogene Proteins - genetics | Aspartic Acid | Glycine | Glutamic Acid | Clinical Trials, Phase III as Topic | Neoplasm Grading | Molecular Epidemiology | Proto-Oncogene Proteins B-raf - genetics | Valine | Colonic Neoplasms - pathology | DNA Mismatch Repair | Adult | Female | Surveys and Questionnaires | Aged | Mutation | Colon cancer | Gene mutations | Genetic susceptibility | Genetic research | Genetic aspects | Research | Identification and classification | Risk factors
ISLAND METHYLATOR PHENOTYPE | PATHOGENESIS | DNA MISMATCH REPAIR | CETUXIMAB | CIGARETTE-SMOKING | ONCOLOGY | CARCINOMAS | RANDOMIZED-TRIAL | ASSOCIATION | METASTATIC COLORECTAL-CANCER | CHEMOTHERAPY | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Prospective Studies | Humans | Middle Aged | Logistic Models | Male | Proto-Oncogene Proteins - genetics | Aspartic Acid | Glycine | Glutamic Acid | Clinical Trials, Phase III as Topic | Neoplasm Grading | Molecular Epidemiology | Proto-Oncogene Proteins B-raf - genetics | Valine | Colonic Neoplasms - pathology | DNA Mismatch Repair | Adult | Female | Surveys and Questionnaires | Aged | Mutation | Colon cancer | Gene mutations | Genetic susceptibility | Genetic research | Genetic aspects | Research | Identification and classification | Risk factors
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Full Text
Stem Cell Transplantation for Light Chain Amyloidosis: Decreased Early Mortality Over Time
Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 13, pp. 1323 - 1329
PurposeAutologous stem-cell transplantation (ASCT) has been used in patients with immunoglobulin light chain (AL) amyloidosis for more than two decades. Early...
STAGING SYSTEM | MULTIPLE-MYELOMA | IMPROVED OUTCOMES | PLUS DEXAMETHASONE | EARLY DEATH | ONCOLOGY | PRIMARY SYSTEMIC AMYLOIDOSIS | HIGH-DOSE MELPHALAN | AL AMYLOIDOSIS | INTENSIVE MELPHALAN | CARDIAC BIOMARKERS
STAGING SYSTEM | MULTIPLE-MYELOMA | IMPROVED OUTCOMES | PLUS DEXAMETHASONE | EARLY DEATH | ONCOLOGY | PRIMARY SYSTEMIC AMYLOIDOSIS | HIGH-DOSE MELPHALAN | AL AMYLOIDOSIS | INTENSIVE MELPHALAN | CARDIAC BIOMARKERS
Journal Article
Mayo Clinic Proceedings, ISSN 0025-6196, 04/2017, Volume 92, Issue 4, pp. 578 - 598
Life expectancy in patients with multiple myeloma is increasing because of the availability of an increasing number of novel agents with various mechanisms of...
SINGLE-AGENT CARFILZOMIB | MEDICINE, GENERAL & INTERNAL | BORTEZOMIB-THALIDOMIDE-DEXAMETHASONE | RANDOMIZED PHASE-III | COMBINATION THERAPY | CIRCULATING PLASMA-CELLS | LENALIDOMIDE PLUS DEXAMETHASONE | OPEN-LABEL | STEM-CELL TRANSPLANTATION | LOW-DOSE DEXAMETHASONE | ORAL PROTEASOME INHIBITOR | Recurrence | Multiple Myeloma - drug therapy | Long Term Adverse Effects - diagnosis | Multiple Myeloma - diagnosis | Long Term Adverse Effects - therapy | Clinical Decision-Making | Humans | Antineoplastic Agents - pharmacology | Disease Management | Risk Adjustment - methods | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Practice Guidelines as Topic | Practice guidelines (Medicine) | Evaluation | Care and treatment | Diagnosis | Multiple myeloma | Relapse | Health aspects | Diseases | Fees & charges | Transplants & implants | Hematology | Physicians | Research funding | Stem cells | Oncology | Lymphomas | Trends
SINGLE-AGENT CARFILZOMIB | MEDICINE, GENERAL & INTERNAL | BORTEZOMIB-THALIDOMIDE-DEXAMETHASONE | RANDOMIZED PHASE-III | COMBINATION THERAPY | CIRCULATING PLASMA-CELLS | LENALIDOMIDE PLUS DEXAMETHASONE | OPEN-LABEL | STEM-CELL TRANSPLANTATION | LOW-DOSE DEXAMETHASONE | ORAL PROTEASOME INHIBITOR | Recurrence | Multiple Myeloma - drug therapy | Long Term Adverse Effects - diagnosis | Multiple Myeloma - diagnosis | Long Term Adverse Effects - therapy | Clinical Decision-Making | Humans | Antineoplastic Agents - pharmacology | Disease Management | Risk Adjustment - methods | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Practice Guidelines as Topic | Practice guidelines (Medicine) | Evaluation | Care and treatment | Diagnosis | Multiple myeloma | Relapse | Health aspects | Diseases | Fees & charges | Transplants & implants | Hematology | Physicians | Research funding | Stem cells | Oncology | Lymphomas | Trends
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 1573 - 1573
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3436 - 3436
Abstract Introduction: Outcomes in multiple myeloma have significantly improved in recent times owing to the availability of newer more effective therapies....
Journal Article
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