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1. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided,... 
CRISPR-CAS SYSTEMS | AMPLIFICATION | CIRCULATING TUMOR DNA | PROTEINS | MULTIDISCIPLINARY SCIENCES | ZIKA VIRUS | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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2. Full Text Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a and Csm6
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Kellner, Max J and Joung, Julia and Collins, James J and Zhang, Feng
Science, ISSN 0036-8075, 04/2018, Volume 360, Issue 6387, pp. 439 - 444
Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological applications. We recently developed a platform termed SHERLOCK... 
IMMUNITY | SYSTEMS | CRISPR-CAS13 | THERMOPHILUS | CLEAVAGE | MULTIDISCIPLINARY SCIENCES | CRISPR-Associated Proteins - chemistry | RNA - analysis | DNA - analysis | Humans | Sensitivity and Specificity | Bacterial Proteins - chemistry | RNA, Viral - analysis | Dengue Virus - isolation & purification | Enzyme Assays | Zika Virus - isolation & purification | Endonucleases - chemistry | Multiplexing | Vector-borne diseases | CRISPR | Enzymes | RNA viruses | Single-stranded DNA | Dengue | Viral diseases | Viruses | Genomes | Nucleic acids | Ribonucleic acid--RNA | Sensitivity | Sample preparation | Acids | Biopsy | Technology | Diagnostic systems | Mutation | Enzymology | Deoxyribonucleic acid--DNA
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3. Full Text Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
by Zetsche, Bernd and Gootenberg, Jonathan S and Abudayyeh, Omar O and Slaymaker, Ian M and Makarova, Kira S and Essletzbichler, Patrick and Volz, Sara E and Joung, Julia and van der Oost, John and Regev, Aviv and Koonin, Eugene V and Zhang, Feng
Cell, ISSN 0092-8674, 10/2015, Volume 163, Issue 3, pp. 759 - 771
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1... 
ADAPTIVE IMMUNITY | STREPTOCOCCUS-THERMOPHILUS | BACTERIA | SPECIFICITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TARGET DNA | SURVEILLANCE COMPLEX | CLEAVAGE | PROKARYOTES | CELL BIOLOGY | Genetic Engineering - methods | Amino Acid Sequence | Endonucleases - genetics | RNA, Guide - genetics | Humans | Molecular Sequence Data | Endonucleases - chemistry | Sequence Alignment | Francisella - enzymology | CRISPR-Cas Systems | HEK293 Cells | Nucleic Acid Conformation | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | Cells | Research institutes | Microbiological Laboratory | Microbiologie | Microbiology | VLAG | Laboratorium voor Microbiologie
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4. Full Text RNA editing with CRISPR-Cas13
by Cox, David B. T and Gootenberg, Jonathan S and Abudayyeh, Omar O and Franklin, Brian and Kellner, Max J and Joung, Julia and Zhang, Feng
Science, ISSN 0036-8075, 11/2017, Volume 358, Issue 6366, pp. 1019 - 1027
Nucleic acid editing holds promise for treating genetic disease, particularly at the RNA level, where disease-relevant sequences can be rescued to yield... 
IFIH1 | GUIDE | MULTIDISCIPLINARY SCIENCES | GENOME | ADAR1 | BASE | Biotechnology | Genetic Therapy | Endonucleases - genetics | Protein Engineering - methods | Adenosine Deaminase - genetics | Adenosine Deaminase - metabolism | RNA Editing | Humans | Bacterial Proteins - genetics | Endonucleases - metabolism | Recombinant Fusion Proteins - metabolism | Gene Knockdown Techniques | Endonucleases - classification | Diabetes Insipidus, Nephrogenic - therapy | Mutagenesis | Diabetes Insipidus, Nephrogenic - genetics | CRISPR-Cas Systems | HEK293 Cells | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Bacterial Proteins - classification | Fanconi Anemia - genetics | Fanconi Anemia - therapy | RNA | CRISPR | Protein engineering | Adenosine | RNA editing | Genetic disorders | Editing | Adenosine deaminase | Ribonuclease | Nucleic acids | Mammals | Gene expression | Ribonucleic acid--RNA | Gene sequencing | Mammalian cells | Engineering | Mutation | Repair
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5. Full Text Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
by Shmakov, Sergey and Abudayyeh, Omar O and Makarova, Kira S and Wolf, Yuri I and Gootenberg, Jonathan S and Semenova, Ekaterina and Minakhin, Leonid and Joung, Julia and Konermann, Silvana and Severinov, Konstantin and Zhang, Feng and Koonin, Eugene V
Molecular Cell, ISSN 1097-2765, 11/2015, Volume 60, Issue 3, pp. 385 - 397
Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, only two... 
computational discovery pipeline | CRISPR-Cas adaptive immunity | RuvC-like endonuclease | RNA-seq | Cpf1 | Cas9 | PAM | crRNA | HEPN domain | tracrRNA | CrRNA | TracrRNA | Computational discovery pipeline | ADAPTIVE IMMUNITY | EVOLUTION | ENDONUCLEASE | DATABASE | DUAL-RNA | FAMILIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASSIFICATION | IDENTIFICATION | CLEAVAGE | MULTIPLE SEQUENCE ALIGNMENT | CELL BIOLOGY | Protein Structure, Tertiary | Bacteria - metabolism | Recombination, Genetic - physiology | Ribonucleases - genetics | CRISPR-Cas Systems - physiology | Bacterial Proteins - genetics | RNA, Bacterial - genetics | Bacterial Proteins - metabolism | Bacteria - genetics | RNA, Bacterial - metabolism | Ribonucleases - metabolism | Evolution, Molecular | RNA | Analysis | Ribonuclease
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6. Full Text Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
by Konermann, Silvana and Brigham, Mark D and Trevino, Alexandro E and Joung, Julia and Abudayyeh, Omar O and Barcena, Clea and Hsu, Patrick D and Habib, Naomi and Gootenberg, Jonathan S and Nishimasu, Hiroshi and Nureki, Osamu and Zhang, Feng
Nature, ISSN 0028-0836, 01/2015, Volume 517, Issue 7536, pp. 583 - 588
Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe... 
RAF INHIBITION | MELANOMA | RNA | PATHWAY | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PROTEIN-COUPLED RECEPTORS | TARGET DNA | CAS9 | CANCER | Transcriptional Activation - genetics | Genetic Testing | RNA, Untranslated - metabolism | Humans | DNA, Complementary - genetics | Genetic Loci - genetics | RNA, Untranslated - genetics | Melanoma - genetics | DNA, Complementary - biosynthesis | Indoles - pharmacology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Expression Regulation, Neoplastic - genetics | Genetic Engineering - methods | Reproducibility of Results | Gene Library | CRISPR-Associated Proteins - genetics | Up-Regulation - genetics | Sulfonamides - pharmacology | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | RNA, Untranslated - biosynthesis | CRISPR-Associated Proteins - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Drug Resistance, Neoplasm - drug effects | Enzymes | Nucleotide sequence | Genetic research | Genomes | Genetic aspects | Genetic engineering | Genetic transcription | Research | Proteins | Transcription factors | Genomics | Melanoma | Epigenetics | Drug resistance | Gene expression | Crystal structure
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7. Full Text Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
by Ran, F. Ann and Hsu, Patrick D and Lin, Chie-Yu and Gootenberg, Jonathan S and Konermann, Silvana and Trevino, Alexandro E and Scott, David A and Inoue, Azusa and Matoba, Shogo and Zhang, Feng and Zhang, Yi
Cell, ISSN 0092-8674, 09/2013, Volume 154, Issue 6, pp. 1380 - 1389
Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is... 
SYSTEM | CELLS | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | KNOCKOUT | NUCLEASE | CELL BIOLOGY | Streptococcus pyogenes - genetics | Gene Targeting - methods | Animals | RNA, Guide - genetics | Base Sequence | Streptococcus pyogenes - enzymology | Zygote - metabolism | Molecular Sequence Data | Mice | Genome | DNA Breaks, Double-Stranded | RNA | Genomics | Index Medicus
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8. Full Text In vivo genome editing using Staphylococcus aureus Cas9
by Ran, F. Ann and Cong, Le and Yan, Winston X and Scott, David A and Gootenberg, Jonathan S and Kriz, Andrea J and Zetsche, Bernd and Shalem, Ophir and Wu, Xuebing and Makarova, Kira S and Koonin, Eugene V and Sharp, Phillip A and Zhang, Feng
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 186 - 191
The RNA-guided endonuclease Cas9 has emerged as a versatile genom-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes... 
NUCLEASE SPECIFICITY | IMMUNITY | OFF-TARGET SITES | DNA CLEAVAGE | ENDONUCLEASE | GENE | CRISPR RNA | MULTIDISCIPLINARY SCIENCES | SEQUENCE | SYSTEMS | GUIDE RNA | Staphylococcus aureus - enzymology | Cholesterol - blood | Genome - genetics | Substrate Specificity | Male | Proprotein Convertases - genetics | Proprotein Convertases - biosynthesis | Base Sequence | Serine Endopeptidases - genetics | Proprotein Convertases - blood | Genetic Engineering - methods | Staphylococcus aureus - genetics | Gene Targeting | Serine Endopeptidases - deficiency | Serine Endopeptidases - biosynthesis | CRISPR-Associated Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Cholesterol - metabolism | Proprotein Convertases - deficiency | Animals | CRISPR-Associated Proteins - metabolism | Serine Endopeptidases - blood | Liver - physiology | Mice | Proprotein Convertase 9 | Enzymes | Usage | Genetic engineering | Genetic aspects | Methods | Staphylococcus aureus | Bacteria | Genomes | Biomedical research | Molecular weight
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9. Full Text Diversity and evolution of class 2 CRISPR-Cas systems
by Shmakov, Sergey and Smargon, Aaron and Scott, David and Cox, David and Pyzocha, Neena and Yan, Winston and Abudayyeh, Omar O and Gootenberg, Jonathan S and Makarova, Kira S and Wolf, Yuri I and Severinov, Konstantin and Zhang, Feng and Koonin, Eugene V
Nature Reviews Microbiology, ISSN 1740-1526, 02/2017, Volume 15, Issue 3, pp. 169 - 182
Class 2 CRISPR-Cas systems are characterized by effector modules that consist of a single multidomain protein, such as Cas9 or Cpf1. We designed a... 
ADAPTIVE IMMUNITY | COMPLEX | DEFENSE SYSTEMS | RNA | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | HUMAN-CELLS | DNA RECOGNITION | ESCHERICHIA-COLI | PROKARYOTIC DIVERSITY | MICROBIOLOGY | Genome, Bacterial - genetics | CRISPR-Associated Proteins - genetics | Genome, Archaeal - genetics | Archaea - genetics | Gene Editing - methods | Bacteria - genetics | CRISPR-Cas Systems - genetics | Protein Domains - genetics | Transposons | Research | Genetic regulation | Genomics | Analysis | Biological diversity
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10. Full Text C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
by Abudayyeh, Omar O and Gootenberg, Jonathan S and Konermann, Silvana and Joung, Julia and Slaymaker, Ian M and Cox, David B. T and Shmakov, Sergey and Makarova, Kira S and Semenova, Ekaterina and Minakhin, Leonid and Severinov, Konstantin and Regev, Aviv and Lander, Eric S and Koonin, Eugene V and Zhang, Feng
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6299, pp. aaf5573 - aaf5573
The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign... 
STREPTOCOCCUS-THERMOPHILUS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | BINDING PROTEINS | SURVEILLANCE COMPLEX | CAS IMMUNITY | THERMUS-THERMOPHILUS | PYROCOCCUS-FURIOSUS | ADAPTIVE BACTERIAL IMMUNITY | SPACER ACQUISITION | Bacteria | Ribonucleic acid--RNA | Genes | Immune system | Adaptive systems | Ribonucleic acids | Prokaryotes | Effectors | Interference | In vitro testing | Catalysis
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