Gene Therapy, ISSN 0969-7128, 01/2003, Volume 10, Issue 1, p. 4
Journal Article
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 874 - 879
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes,...
POLY(ADP-RIBOSE) POLYMERASE | CELLS | MULTIPLE LOCI | GENE | VARIANTS | GENETICS & HEREDITY | Chromosomes, Human, Pair 8 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Humans | Proto-Oncogene Proteins c-myb - genetics | Genotype | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 2 - genetics | Polymorphism, Single Nucleotide - genetics | Female | Biomarkers, Tumor - genetics | Genome, Human | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Ovary - metabolism | Prevention | Evaluation | Genetic susceptibility | Genomics | Oncology, Experimental | Genetic aspects | Genomes | Research | Risk factors | Cancer | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Family medical history | Public health
POLY(ADP-RIBOSE) POLYMERASE | CELLS | MULTIPLE LOCI | GENE | VARIANTS | GENETICS & HEREDITY | Chromosomes, Human, Pair 8 - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Humans | Proto-Oncogene Proteins c-myb - genetics | Genotype | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 2 - genetics | Polymorphism, Single Nucleotide - genetics | Female | Biomarkers, Tumor - genetics | Genome, Human | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Ovary - metabolism | Prevention | Evaluation | Genetic susceptibility | Genomics | Oncology, Experimental | Genetic aspects | Genomes | Research | Risk factors | Cancer | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Family medical history | Public health
Journal Article
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 880 - 884
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer...
COMPLEX | BRCA1 | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Oligonucleotide Array Sequence Analysis | Adenocarcinoma, Mucinous - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Case-Control Studies | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 19 - genetics | Endometrial Neoplasms - genetics | Female | Tumor Cells, Cultured | Ovary - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Genotype | Adaptor Proteins, Signal Transducing - genetics | Polymorphism, Single Nucleotide - genetics | Endometrial Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Biomarkers, Tumor - genetics | Adenocarcinoma, Mucinous - genetics | Genome, Human | Adenocarcinoma, Clear Cell - genetics | Prevention | Evaluation | Genetic susceptibility | Genetic variation | Identification and classification | Risk factors | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Histology | Cancer
COMPLEX | BRCA1 | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Oligonucleotide Array Sequence Analysis | Adenocarcinoma, Mucinous - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Gene Expression Profiling | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Case-Control Studies | Ovarian Neoplasms - genetics | Chromosomes, Human, Pair 19 - genetics | Endometrial Neoplasms - genetics | Female | Tumor Cells, Cultured | Ovary - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Ovary - pathology | Genotype | Adaptor Proteins, Signal Transducing - genetics | Polymorphism, Single Nucleotide - genetics | Endometrial Neoplasms - pathology | Adenocarcinoma, Clear Cell - pathology | Biomarkers, Tumor - genetics | Adenocarcinoma, Mucinous - genetics | Genome, Human | Adenocarcinoma, Clear Cell - genetics | Prevention | Evaluation | Genetic susceptibility | Genetic variation | Identification and classification | Risk factors | Ovarian cancer | Studies | Medical research | Hospitals | Biomedical research | Councils | Health services | Histology | Cancer
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 11/2012, Volume 167, Issue 5, pp. 987 - 994
Summary Until recently, no effective treatment was available for patients with metastatic malignant melanoma, and median overall survival was little more than...
PATHWAY | RAS MUTATIONS | PHASE-III | KIT | BRAF INHIBITORS | IMPROVED SURVIVAL | DACARBAZINE | SORAFENIB | IPILIMUMAB | LESIONS | DERMATOLOGY | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Eruptions - etiology | Indoles - adverse effects | Skin Neoplasms - drug therapy | Drug Eruptions - diagnosis | Humans | Melanoma - drug therapy | Sulfonamides - adverse effects | Clinical Trials as Topic | Drug Eruptions - prevention & control | Protein Kinase Inhibitors - adverse effects | Prevention | Complications and side effects | Care and treatment | Algorithms | Gene mutations | Melanoma | Skin | Metastasis | Index Medicus
PATHWAY | RAS MUTATIONS | PHASE-III | KIT | BRAF INHIBITORS | IMPROVED SURVIVAL | DACARBAZINE | SORAFENIB | IPILIMUMAB | LESIONS | DERMATOLOGY | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Eruptions - etiology | Indoles - adverse effects | Skin Neoplasms - drug therapy | Drug Eruptions - diagnosis | Humans | Melanoma - drug therapy | Sulfonamides - adverse effects | Clinical Trials as Topic | Drug Eruptions - prevention & control | Protein Kinase Inhibitors - adverse effects | Prevention | Complications and side effects | Care and treatment | Algorithms | Gene mutations | Melanoma | Skin | Metastasis | Index Medicus
Journal Article
Journal of Heart and Lung Transplantation, ISSN 1053-2498, 04/2018, Volume 37, Issue 4, pp. S356 - S357
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 08/2010, Volume 163, Issue 2, pp. 238 - 256
Journal Article
International Journal of Hydrogen Energy, ISSN 0360-3199, 09/2019, Volume 44, Issue 42, pp. 23793 - 23806
Hot-jet ignition is usually designed to reduce emissions in lean-burn combustion engines, and has potential in enabling novel pressure-gain combustion....
Transient jet | Large eddy simulation | Hot jet ignition | ELECTROCHEMISTRY | COMBUSTION | DISSIPATION RATE | ENERGY & FUELS | ENGINE | CHEMISTRY, PHYSICAL | TURBULENT | METHANE/AIR MIXTURES | FLAME | ENTRAINMENT | LARGE-EDDY SIMULATION | INJECTION | AUTO-IGNITION
Transient jet | Large eddy simulation | Hot jet ignition | ELECTROCHEMISTRY | COMBUSTION | DISSIPATION RATE | ENERGY & FUELS | ENGINE | CHEMISTRY, PHYSICAL | TURBULENT | METHANE/AIR MIXTURES | FLAME | ENTRAINMENT | LARGE-EDDY SIMULATION | INJECTION | AUTO-IGNITION
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 08/2010, Volume 163, Issue 2, pp. 238 - 256
treatment | investigation | melanoma | evidence | guideline | SURGICAL-MANAGEMENT | MALIGNANT-MELANOMA | SENTINEL-NODE | ISOLATED LIMB PERFUSION | LENTIGO MALIGNA | DERMATOLOGY | LYMPH-NODE METASTASES | POSITRON-EMISSION-TOMOGRAPHY | RANDOMIZED PHASE-III | EXCISION MARGINS | NEEDLE-ASPIRATION-CYTOLOGY | Skin Neoplasms - pathology | Melanoma - diagnosis | Lymph Nodes - pathology | Skin Neoplasms - therapy | Humans | Male | United Kingdom | Antineoplastic Agents - therapeutic use | Interferons - therapeutic use | Melanoma - secondary | Pregnancy | Skin Neoplasms - diagnosis | Female | Referral and Consultation | Sentinel Lymph Node Biopsy | Chemotherapy, Adjuvant | Melanoma - therapy | Melanoma
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2015, Volume 93, Issue 3, pp. S191 - S191
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2013, Volume 108, Issue 12, pp. 2470 - 2477
Background: Prognostic factors for progression-free survival (PFS), overall survival (OS), and long-term OS (>= 30 months) were investigated in...
sunitinib | metastatic | EFFICACY | survival | prognostic factors | CYTOKINE | renal cell carcinoma | PHASE-II TRIAL | INTERFERON-ALPHA | ONCOLOGY | JAPANESE PATIENTS | 1ST-LINE THERAPY | PROGRESSION | Multivariate Analysis | Prognosis | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Young Adult | Neoplasm Metastasis | Antineoplastic Agents - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Retrospective Studies | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Carcinoma, Renal Cell - pathology | Survival Rate | Kidney Neoplasms - mortality | Carcinoma, Renal Cell - mortality | Indoles - adverse effects | Survival Analysis | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Clinical Study
sunitinib | metastatic | EFFICACY | survival | prognostic factors | CYTOKINE | renal cell carcinoma | PHASE-II TRIAL | INTERFERON-ALPHA | ONCOLOGY | JAPANESE PATIENTS | 1ST-LINE THERAPY | PROGRESSION | Multivariate Analysis | Prognosis | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Young Adult | Neoplasm Metastasis | Antineoplastic Agents - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Retrospective Studies | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Carcinoma, Renal Cell - pathology | Survival Rate | Kidney Neoplasms - mortality | Carcinoma, Renal Cell - mortality | Indoles - adverse effects | Survival Analysis | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Clinical Study
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2015, Volume 113, Issue 1, pp. 12 - 19
Background: We report final results with extended follow-up from a global, expanded-access trial that pre-regulatory approval provided sunitinib to metastatic...
sunitinib | tyrosine kinase inhibitor | Renal cell carcinoma | prognosis | expanded-access trial | SURVIVAL | CYTOREDUCTIVE NEPHRECTOMY | EFFICACY | SAFETY | SORAFENIB | FACTOR RECEPTOR | SU11248 | renal cell carcinoma | INTERFERON-ALPHA | ONCOLOGY | ENDOTHELIAL GROWTH-FACTOR | Carcinoma, Renal Cell - pathology | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Young Adult | Neoplasm Metastasis | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Pyrroles - therapeutic use | Clinical Studies
sunitinib | tyrosine kinase inhibitor | Renal cell carcinoma | prognosis | expanded-access trial | SURVIVAL | CYTOREDUCTIVE NEPHRECTOMY | EFFICACY | SAFETY | SORAFENIB | FACTOR RECEPTOR | SU11248 | renal cell carcinoma | INTERFERON-ALPHA | ONCOLOGY | ENDOTHELIAL GROWTH-FACTOR | Carcinoma, Renal Cell - pathology | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Young Adult | Neoplasm Metastasis | Indoles - adverse effects | Antineoplastic Agents - adverse effects | Aged, 80 and over | Pyrroles - adverse effects | Adult | Female | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Pyrroles - therapeutic use | Clinical Studies
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2011, Volume 104, Issue 3, pp. 399 - 406
Optimum efficacy is the primary goal for any cancer therapy, and entails controlling tumour growth and prolonging survival as far as possible. The prognosis...
sequential therapy | targeted agents | combinatorial therapy | renal cell carcinoma | sunitinib malate | chronic disease | 1ST-LINE TREATMENT | EVEROLIMUS | BEVACIZUMAB | SORAFENIB | CANCER | PHASE-II TRIAL | INTERFERON-ALPHA | ONCOLOGY | TEMSIROLIMUS | DOUBLE-BLIND | SUNITINIB | Carcinoma, Renal Cell - mortality | Prognosis | Carcinoma, Renal Cell - secondary | Humans | Survival Analysis | Kidney Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Kidney Neoplasms - mortality | Chronic Disease | Reviews | Clinical trials | Drug development | Drug resistance | Metastases | Minireview
sequential therapy | targeted agents | combinatorial therapy | renal cell carcinoma | sunitinib malate | chronic disease | 1ST-LINE TREATMENT | EVEROLIMUS | BEVACIZUMAB | SORAFENIB | CANCER | PHASE-II TRIAL | INTERFERON-ALPHA | ONCOLOGY | TEMSIROLIMUS | DOUBLE-BLIND | SUNITINIB | Carcinoma, Renal Cell - mortality | Prognosis | Carcinoma, Renal Cell - secondary | Humans | Survival Analysis | Kidney Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Kidney Neoplasms - mortality | Chronic Disease | Reviews | Clinical trials | Drug development | Drug resistance | Metastases | Minireview
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 12/2009, Volume 161, Issue 6, p. 1424
Journal Article
Computers and Fluids, ISSN 0045-7930, 04/2019, Volume 183, pp. 28 - 37
Hot jet ignition technology is a promising improvement to conventional spark ignition for reducing emissions in premixed combustion engines as it can extend...
Auto-ignition | LES | Hot jet ignition | COMBUSTION | MECHANISM | VALIDATION | SCALAR DISSIPATION RATE | FLAME | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MECHANICS | METHANE | TEMPERATURE | DYNAMICS | Combustion | Air quality management | Hydrogen | Analysis | Formaldehyde | Reactive environments | Spark ignition | Turbulent flow | Computer simulation |
Auto-ignition | LES | Hot jet ignition | COMBUSTION | MECHANISM | VALIDATION | SCALAR DISSIPATION RATE | FLAME | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MECHANICS | METHANE | TEMPERATURE | DYNAMICS | Combustion | Air quality management | Hydrogen | Analysis | Formaldehyde | Reactive environments | Spark ignition | Turbulent flow | Computer simulation |