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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2009, Volume 106, Issue 15, pp. 6250 - 6255
Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models... 
Biological Sciences
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | LYTIC FUNCTION | IMMUNOTHERAPY | ACTIN POLYMERIZATION | GENE-EXPRESSION | LENALIDOMIDE | MALIGNANCIES | CANCER | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0143847
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5772 - 5781
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress, which is adaptively managed by... 
SURVIVAL | CELLS | IN-VITRO | UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | BONE-MARROW | ENDOPLASMIC-RETICULUM STRESS | IDENTIFICATION | HEMATOLOGY | TRANSCRIPTION FACTOR | eIF-2 Kinase - metabolism | Humans | Pyrazines - therapeutic use | Endoribonucleases - antagonists & inhibitors | Boronic Acids - therapeutic use | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Multiple Myeloma - drug therapy | Enzyme Inhibitors - chemistry | RNA Splicing - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Death - drug effects | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Unfolded Protein Response - drug effects | Bortezomib | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Bone Marrow Cells - cytology | RNA, Messenger - genetics | Stromal Cells - metabolism | Enzyme Inhibitors - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Lactams, Macrocyclic - pharmacology | Enzyme Inhibitors - therapeutic use | Regulatory Factor X Transcription Factors | Benzoquinones - pharmacology | Multiple Myeloma - pathology | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pyrazines - pharmacology | Bone Marrow Cells - metabolism | Multiple Myeloma - genetics | Stromal Cells - cytology | Boronic Acids - pharmacology | Lymphoid Neoplasia
Journal Article
Blood, ISSN 0006-4971, 09/2010, Volume 116, Issue 9, pp. 1460 - 1468
In this study, we demonstrate expression and examined the biologic sequelae of PI3K/p110 delta signaling in multiple myeloma (MM). Knockdown of p110 delta by... 
APOPTOSIS | IN-VITRO | CANCER CELLS | PATHWAY | BONE-MARROW | SYNERGISTIC CYTOTOXICITY | BORTEZOMIB | AUTOPHAGY | HEMATOLOGY | PHOSPHATIDYLINOSITOL 3'-KINASE/AKT | P70 S6 KINASE | Lymphoid Neoplasia
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 04/2010, Volume 9, Issue 4, pp. 963 - 975
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2009, Volume 106, Issue 15, pp. 6250 - 6255
Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models... 
DRUG | CD4 | PEPTIDES | THERAPY | MULTIDISCIPLINARY SCIENCES | MOUSE | LENALIDOMIDE | CD28 | IMMUNOLOGICAL SYNAPSE | EXPRESSION
Journal Article
Journal Article