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1. Full Text Primary ‘dehydration’ and acute stroke: a systematic research review
by Bahouth, Mona N and Gottesman, R F and Szanton, S L
Journal of Neurology, ISSN 0340-5354, 10/2018, Volume 265, Issue 10, pp. 2167 - 2181
Hydration status at the time of stroke has been acknowledged as an important determinant in early stroke recovery. However, the diagnosis of dehydration, or... 
Neurology | Neurosciences | Medicine & Public Health | Early recovery | Acute stroke | Rehydration | Dehydration | Neuroradiology | URINE SPECIFIC-GRAVITY | HYDRATION THERAPY | BLOOD-VISCOSITY | BARTHEL INDEX | CLINICAL NEUROLOGY | EARLY NEUROLOGICAL DETERIORATION | UREA NITROGEN/CREATININE RATIO | PREDICTORS | ACUTE ISCHEMIC-STROKE | REHABILITATION | FLUID INTAKE | Brain Ischemia - complications | Dehydration - diagnosis | Brain Ischemia - therapy | Humans | Dehydration - therapy | Stroke - complications | Stroke - therapy | Dehydration - etiology | Stroke (Disease) | Drinking (Physiology) | Research | Patient outcomes | Viscosity | Studies | Stroke | Animal models | Hydration | Ischemia | Standardization | Diagnosis | Thirst
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2. Full Text Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
by Davies, Gail and Armstrong, Nicola and Bis, Joshua and Bressler, Jan and Chouraki, Vincent and Giddaluru, Sudheer and Hofer, E and Ibrahim-Verbaas, Carla and Kirin, Mirna and Lahti, J and Lee, Sven and Le Hellard, Stephanie and Liu, T and Marioni, Riccardo and Oldmeadow, Christopher and Postmus, Douwe and Smith, Davey and Smith, Jennifer A and Thalamuthu, Anbupalam and Thomson, Russell and Vitart, Veronique and Wang, J and Yu, L and Zgaga, Lina and Zhao, Wei and Boxall, Ruth and Harris, Sarah and Hill, W. David and Liewald, David C and Luciano, Michelle and Adams, Hieab and Ames, David and Amin, Najaf and Amouyel, Philippe and Assareh, A.A and Au, R and Becker, James and Beiser, A and Berr, Claudine and Bertram, Lars and Boerwinkle, Eric and Buckley, Brendan M and Campbell, Harry and Corley, J and De Jager, P.L and Dufouil, Carole and Eriksson, Johan G and Espeseth, Thomas and Faul, J.D and Ford, I and Scotland, Generation and Gottesman, Rebecca and Griswold, Michael and Gudnason, Vilmundur and Harris, T.B and Heiss, Gerardo and Hofman, Albert and Holliday, Elizabeth and Huffman, Jennifer and Kardia, Sharon and Kochan, Nicole A and Knopman, David and Kwok, J.B and Lambert, J.-C and Lee, T and Li, G and Li, S.-C and Loitfelder, Marisa and Lopez, Oscar and Lundervold, A.J and Lundqvist, A and Mather, R and Mirza, Saira and Nyberg, L and Oostra, Ben and Palotie, Aarno and Papenberg, G and Pattie, Alison and Petrovic, Katja and Polasek, Ozren and Psaty, Bruce and Redmond, Paul and Reppermund, S and Rotter, J.I and Schmidt, Reinhold and Schuur, Maaike and Schofield, P.W and Scott, R.J and Steen, Vidar and Stott, David J and Swieten, John and Taylor, Kent and Trollor, J and Trompet, Stella and Uitterlinden, Ané and Weinstein, G and Widen, Elisabeth and Windham, B Gwen and Jukema, Jan Wouter and Wright, Alan and ... and Generation Scotland and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Molecular Psychiatry, ISSN 1359-4184, 01/2015, Volume 20, Issue 2, pp. 183 - 192
textabstractGeneral cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic... 
MORTALITY | PSYCHIATRY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY LOCI | NEUROSCIENCES | APOLIPOPROTEIN-E | DECLINE | TYPE-4 ALLELE | IDENTIFIES VARIANTS | HUMAN INTELLIGENCE | COMMON SNPS | AGE | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | HMGN1 Protein - genetics | Humans | Middle Aged | Atherosclerosis - complications | Male | Scotland | Cognition Disorders - genetics | Neuropsychological Tests | Phenotype | Cognition Disorders - etiology | Aged, 80 and over | Cognition - physiology | Polymorphism, Single Nucleotide - genetics | Female | Aged | Cohort Studies | Cognition | Genetic aspects | Research | Single nucleotide polymorphisms | Immediate Communication | Biological Sciences | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | Naturvetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Psykiatri | Natural Sciences | Psychiatry | Neurovetenskaper
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3. Full Text Delirium after coronary artery bypass graft surgery and late mortality
by Gottesman, Rebecca F and Grega, Maura A and Bailey, Maryanne M and Pham, Luu D and Zeger, Scott L and Baumgartner, William A and Selnes, Ola A and McKhann, Guy M
Annals of Neurology, ISSN 0364-5134, 03/2010, Volume 67, Issue 3, pp. 338 - 344
Objective Delirium is common after cardiac surgery, although under‐recognized, and its long‐term consequences are likely underestimated. The primary goal of... 
POSTOPERATIVE DELIRIUM | RISK-FACTORS | OUTCOMES | NEUROSCIENCES | CARDIAC-SURGERY | CLINICAL NEUROLOGY | Delirium - etiology | Prospective Studies | Brain - physiopathology | Risk Factors | Survival Rate | Time | Postoperative Complications - mortality | Hypoxia-Ischemia, Brain - etiology | Brain - blood supply | Coronary Artery Bypass - adverse effects | Time Factors | Hypoxia-Ischemia, Brain - mortality | Survival Analysis | Coronary Artery Bypass - statistics & numerical data | Delirium - mortality | Cohort Studies | Hypoxia-Ischemia, Brain - physiopathology
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4. Full Text Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study
by Alonso, A and Mosley, T H and Gottesman, R F and Catellier, D and Sharrett, A R and Coresh, J
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 11/2009, Volume 80, Issue 11, pp. 1194 - 1201
Background:Cardiovascular risk factors are associated with a higher risk of developing dementia. Studies in older populations, however, have often failed to... 
DIABETES-MELLITUS | SURGERY | WHITE-MATTER LESIONS | ALZHEIMER-DISEASE | POPULATION | COGNITIVE DECLINE | PSYCHIATRY | NATIONAL-HEALTH | SMOKING | PREVALENCE | BLOOD-PRESSURE | CLINICAL NEUROLOGY | Smoking - adverse effects | Prospective Studies | Age Factors | Cardiovascular Diseases - ethnology | Dementia - therapy | Humans | Middle Aged | Risk Factors | European Continental Ancestry Group | Male | Hospitalization | Dementia - epidemiology | Dementia - ethnology | African Americans - statistics & numerical data | Cardiovascular Diseases - complications | Dementia - complications | Cardiovascular Diseases - epidemiology | Diabetes Complications - epidemiology | Hypertension - complications | Female | Aged | Hypertension | Demographic aspects | Age factors in disease | Patient outcomes | Hospital care | Research | Diabetes | Cardiovascular diseases | Health aspects | Risk factors | Dementia | Smoking | Cognitive ability | African Americans | Cardiovascular disease | Studies | Disease prevention | Older people | Atherosclerosis | Population | Blood pressure | Health risk assessment | Age | dementia | incidence | cardiovascular risk factors
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5. Full Text Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) study
by Bezerra, D.C and Sharrett, A.R and Matsushita, K and Gottesman, R.F and Shibata, D and Mosley Jr, T.H and Coresh, J and Szklo, M and Carvalho, M.S and Selvin, E
Neurology, ISSN 0028-3878, 01/2012, Volume 78, Issue 2, pp. 102 - 108
Objective: Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences... 
STROKE | SMALL VESSEL DISEASE | SILENT BRAIN INFARCTS | HEMORRHAGE | SPACES | PREVALENCE | CORONARY-HEART-DISEASE | SEVERITY | LESIONS | CLINICAL NEUROLOGY | Stroke, Lacunar - classification | Ethnic Groups - statistics & numerical data | Prevalence | Cross-Sectional Studies | Follow-Up Studies | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Risk Factors | Male | Models, Statistical | Atherosclerosis - epidemiology | Magnetic Resonance Imaging | Residence Characteristics - statistics & numerical data | Diabetes Mellitus - epidemiology | Brain - pathology | Cholesterol, HDL - blood | Stroke, Lacunar - epidemiology | Female | Hypertension - epidemiology
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6. Full Text Novel genetic loci underlying human intracranial volume identified through genome-wide association
by Adams, H.H and Hibar, D.P and Chouraki, V and Stein, J.L and Nyquist, P.A and Renteria, M.E and Trompet, S and Arias-Vasquez, A and Seshai, S and Desrivieres, S and Beecham, A.H and Jahanshad, N and Wittfeld, K and Lee, S.J. van der and Abramovic, L and Alhusaini, S and Amin, N and Andersson, M and Arfanakis, K and Aribisala, B.S and Armstrong, N.J and Athanasiu, L and Axelsson, T and Beiser, A and Bernard, M and Bis, J.C and Blanken, L.M and Blanton, S.H and Bohlken, M.M and Boks, M.P and Bralten, J and Brickman, A.M and Carmichael, O and Chakravarty, M.M and Chauhan, G and Chen, Q and Ching, C.R and Cuellar-Partida, G and Braber, A.D and Doan, N.T and Ehrlich, S and Filippi, I and Ge, T and Giddaluru, S and Goldman, A.L and Gottesman, R.F and Greven, C.U and Grimm, O and Griswold, M.E and Guadalupe, T.M and Hass, J and Haukvik, U.K and Hilal, S and Hofer, E and Hoehn, D and Holmes, A.J and Hoogman, M and Janowitz, D and Jia, T and Kasperaviciute, D and Kim, S and Klein, M and Kraemer, B and Lee, P.H and Liao, J and Liewald, D.C and Lopez, L.M and Luciano, M and Macare, C and Marquand, A and Matarin, M and Mather, K.A and Mattheisen, M and Mazoyer, B and McKay, D.R and McWhirter, R and Milaneschi, Y and Mirza-Schreiber, N and Muetzel, R.L and Maniega, S.M and Nho, K and Nugent, A.C and Loohuis, L.M and Oosterlaan, J and Papmeyer, M and Pappa, I and Pirpamer, L and Pudas, S and Putz, B and Rajan, K.B and Ramasamy, A and Richards, J.S and Risacher, S.L and Roiz-Santianez, R and Rommelse, N and Rose, E.J and Royle, N.A and Rundek, T and Samann, P.G and Satizabal, C.L and ... and EPIGEN and SYS and Alzheimer's Dis Neuroimaging Initi and IMAGEN and Mind Research Network, Albuquerque, NM (United States) and Medicinska fakulteten and Institutionen för integrativ medicinsk biologi (IMB) and Umeå centrum för funktionell hjärnavbildning (UFBI) and Umeå universitet
Nature Neuroscience, ISSN 1097-6256, 2016, Volume 19, Issue 12, pp. 1569 - 1582
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable,... 
CONSORTIUM | COMMON VARIANTS | IGF-I | METAANALYSIS | ALZHEIMERS-DISEASE | 17Q21.31 MICRODELETION | BRAIN SIZE | HEIGHT | NEUROSCIENCES | HEAD CIRCUMFERENCE | PARKINSONS-DISEASE | Genetic Predisposition to Disease | Humans | Genetic Loci - genetics | European Continental Ancestry Group | Brain - growth & development | Parkinson Disease - genetics | Phosphatidylinositol 3-Kinases - genetics | Phenotype | Oncogene Protein v-akt - genetics | Brain - pathology | Cognition - physiology | Polymorphism, Single Nucleotide - genetics | Genome-Wide Association Study - methods | Research | Genetic variation | Genomics | Analysis | Neurophysiology | Neuroscience | Cognitive science | Neurosciences & Neurology | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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7. Full Text Cognitive Decline and Oral Health in Middle-aged Adults in the ARIC Study
by Naorungroj, S and Slade, G.D and Beck, J.D and Mosley, T.H and Gottesman, R.F and Alonso, A and Heiss, G
Journal of Dental Research, ISSN 0022-0345, 9/2013, Volume 92, Issue 9, pp. 795 - 801
Even before dementia becomes apparent, cognitive decline may contribute to deterioration in oral health. This cohort study of middle-aged adults evaluated... 
oral hygiene | memory | cognition | tooth loss | periodontitis | executive function | MORTALITY | POPULATION | DEMENTIA | OLDER-ADULTS | NHANES-III | DENTAL-HEALTH | PERIODONTAL-DISEASE | ATHEROSCLEROSIS RISK | DENTISTRY, ORAL SURGERY & MEDICINE | ASSOCIATION | Dental Plaque - classification | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | African Americans | Male | Educational Status | Language | Time Factors | Cognition - physiology | Female | Cognition Disorders - physiopathology | Periodontitis - classification | Dental Devices, Home Care | Tooth Loss - classification | European Continental Ancestry Group | Verbal Learning - physiology | Executive Function - physiology | Health Behavior | Social Class | Gingivitis - classification | Mental Recall - physiology | Mouth, Edentulous - classification | Toothbrushing | Oral Health | Health Status | Cohort Studies | Dental Care - utilization | Research Reports
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8. Full Text GWAS for executive function and processing speed suggests involvement of the CADM2 gene
by Ibrahim-Verbaas, Carla and Bressler, Jan and Debette, Stéphanie and Schuur, Maaike and Smith, Albert and Bis, Joshua and Davies, Gail and Trompet, Stella and Smith, J.A and Björnsson, Asgeir and Chibnik, Lori and Liu, Y and Vitart, Veronique and Kirin, Mirna and Petrovic, Katja and Polasek, Ozren and Zgaga, Lina and Fawns-Ritchie, C and Hoffmann, Per and Karjalainen, Juha and Lahti, J and Llewellyn, D.J and Schmidt, Carsten O and Mather, R and Chouraki, Vincent and Sun, Q and Resnick, Susan and Rose, Lynda and Oldmeadow, Christopher and Stewart, M and Smith, B.H and Gudnason, Vilmundur and Yang, Qiong and Mirza, Saira and Jukema, J.W and DeJager, Philip L and Harris, Tamara and Liewald, David C and Amin, Najaf and Coker, Laura and Stegle, Oliver and Lopez, O.L and Schmidt, R and Teumer, Alexander and Ford, I and Karbalai, Nazanin and Becker, James and Jonsdottir, Maria K and Au, Rhoda and Fehrmann, Rudolf and Herms, Stefan and Nalls, Michael and Zhao, W and Turner, Stephen and Yaffe, K and Lohman, Kurt and Swieten, John and Kardia, Sharon L.r and Knopman, David and Meeks, William and Heiss, Gerardo and Holliday, Elizabeth and Schofield, P.W and Tanaka, Toshiko and Stott, David J and Wang, Jing and Ridker, Paul and Gow, A.J and Pattie, Alison and Starr, John and Hocking, L.J and Armstrong, Nicola and McLachlan, Stela and Shulman, J.M and Pilling, Luke and Eiriksdottir, Gudny and Scott, Rodney and Kochan, Nicole A and Palotie, Aarno and Hsieh, Yi-Chen and Eriksson, Johan G and Penman, Alan and Gottesman, Rebecca and Oostra, Ben and Yu, Lei and DeStefano, Anita and Beiser, Alexa and Garcia, M and Rotter, Jerome I and Nöthen, Markus M and Hofman, Albert and Slagboom, Eline and Westendorp, R.G.J and Buckley, Brendan M and Wolf, P.A and Uitterlinden, Ané and Psaty, Bruce and Grabe, Hans Jörgen and Bandinelli, Stefania and Chasman, Daniel and ... and Generation Scotland and on behalf of Generation Scotland
Molecular Psychiatry, ISSN 1359-4184, 02/2016, Volume 21, Issue 2, pp. 189 - 197
textabstractTo identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide... 
COMMON VARIANTS | METAANALYSIS | PSYCHIATRY | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCE | SCHIZOPHRENIA | LOCI | NEUROSCIENCES | COGNITIVE FUNCTION | LINKAGE ANALYSIS | EXPRESSION | GENOME-WIDE ASSOCIATION | gamma-Aminobutyric Acid | Cell Adhesion Molecules - genetics | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Cell Adhesion Molecules - physiology | Genetic Association Studies | Introns | Genomics | Humans | Middle Aged | Male | Executive Function - physiology | Neuropsychological Tests | Aged, 80 and over | Cognition - physiology | Female | Aged | Genetic Variation - genetics | Polymorphism, Single Nucleotide | Cohort Studies | GABA | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Research | Diagnosis | Dementia
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9. Full Text Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) study
by Christman, A L and Matsushita, K and Gottesman, R F and Mosley, T and Alonso, A and Coresh, J and Hill-Briggs, F and Sharrett, A R and Selvin, E
Diabetologia, ISSN 0012-186X, 7/2011, Volume 54, Issue 7, pp. 1645 - 1652
This study aimed to examine the association between diabetes and hyperglycaemia—assessed by HbA1c—and change in cognitive function in persons with and without... 
Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Cognition | Diabetes | Haemoglobin A 1c | Epidemiology | Haemoglobin A | DIABETES-MELLITUS | DEMENTIA | ENDOCRINOLOGY & METABOLISM | Haemoglobin A(1c) | CARDIOVASCULAR RISK | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Risk Factors | Diabetes Mellitus - metabolism | Dementia - physiopathology | Male | Dementia - epidemiology | Atherosclerosis - epidemiology | Atherosclerosis - etiology | Dementia - metabolism | Diabetes Mellitus - physiopathology | Diabetes Mellitus - epidemiology | Cognition - physiology | Female | Medical colleges | Glycosylated hemoglobin | Risk factors | Public health | Cholesterol | Hyperglycemia | Haemoglobin A1c
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10. Full Text Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study
by Schneider, A. L. C and Lutsey, P. L and Selvin, E and Mosley, T. H and Sharrett, A. R and Carson, K. A and Post, W. S and Pankow, J. S and Folsom, A. R and Gottesman, R. F and Michos, E. D
European Journal of Neurology, ISSN 1351-5101, 08/2015, Volume 22, Issue 8, pp. 1220 - 1227
Background and purpose Low vitamin D levels, measured by serum 25‐hydroxyvitamin D [25(OH)D], are associated with increased stroke risk. Less is known about... 
race | stroke | vitamin D | Vitamin D | Stroke | Race | DENSITY | DESIGN | METAANALYSIS | DISEASE | 25-HYDROXYVITAMIN D | D DEFICIENCY | ASSOCIATION | NEUROSCIENCES | CLINICAL NEUROLOGY | Follow-Up Studies | United States - ethnology | African Continental Ancestry Group - ethnology | Atherosclerosis - genetics | Humans | Middle Aged | Risk Factors | Male | Atherosclerosis - ethnology | European Continental Ancestry Group - ethnology | Stroke - genetics | Incidence | Vitamin D - blood | Atherosclerosis - blood | Stroke - blood | Vitamin D-Binding Protein - genetics | Stroke - ethnology | Female | Vitamin D - analogs & derivatives | Polymorphism, Single Nucleotide | Stroke (Disease) | Diet therapy | Atherosclerosis | Genetic research | Calcifediol | Genetic aspects | Alfacalcidol | Single nucleotide polymorphisms | Mass spectrometry | Risk factors | Protein binding
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