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Circulation, ISSN 0009-7322, 04/2019, Volume 139, Issue 15, pp. 1813 - 1827
BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been... 
models, animal | muscles | myocardial contraction | hypertrophy | cardiomyopathies | heart diseases | Proteins | Cardiomyopathy | Physiological aspects | Cellular signal transduction | Research | Cardiovascular research | Muscle proteins | Structure | Health aspects | Heart diseases | Risk factors | Heart muscle
Journal Article
Journal Article
by Liu, Jimmy Z and Hov, Johannes Roksund and Folseraas, Trine and Ellinghaus, Eva and Rushbrook, Simon M and Doncheva, Nadezhda T and Aneassen, Ole A and Weersma, Rinse K and Weismüller, Tobias J and Eksteen, Bertus and Invernizzi, Pietro and Hirschfield, Gideon M and Gotthardt, Daniel Nils and Pares, Albert and Ellinghaus, David and Shah, Tejas and Juran, Brian D and Milkiewicz, Piotr and Rust, Christian and Schramm, Christoph and Müller, Tobias and Srivastava, Brijesh and Dalekos, Georgios and Nöthen, Markus M and Herms, Stefan and Winkelmann, Juliane and Mitrovic, Mitja and Braun, Felix and Ponsioen, Cyriel Y and Croucher, Peter J. P and Sterneck, Martina and Teufel, Aneas and Mason, Anew L and Saarela, Janna and Leppa, Virpi and Dorfman, Ruslan and Alvaro, Domenico and Floreani, Annarosa and Onengut-Gumuscu, Suna and Rich, Stephen S and Thompson, Wesley K and Schork, Anew J and Næss, Sigrid and Thomsen, Ingo and Mayr, Gabriele and König, Inke R and Hveem, Kristian and Cleynen, Isabelle and Gutierrez-Achury, Javier and Ricaño-Ponce, Isis and van Heel, David and Björnsson, Einar and Sandford, Richard N and Durie, Peter R and Melum, Espen and Vatn, Morten H and Silverberg, Mark S and Duerr, Richard H and Padyukov, Leonid and Brand, Stephan and Sans, Miquel and Annese, Vito and Achkar, Jean-Paul and Boberg, Kirsten Muri and Marschall, Hanns-Ulrich and Chazouillères, Olivier and Bowlus, Christopher L and Wijmenga, Cisca and Schrumpf, Erik and Vermeire, Severine and Albrecht, Mario and Rioux, John D and Alexander, Graeme and Bergquist, Annika and Cho, Judy and Schreiber, Stefan and Manns, Michael P and Färkkilä, Martti and Dale, Anders M and Chapman, Roger W and Lazaridis, Konstantinos N and Franke, Ane and Anderson, Carl A and Karlsen, Tom H and Int PSCSC Study Grp and UK-PSCSC Consortium and Int IBD Genetics Consortium and International PSC Study Group and International IBD Genetics Consortium and The UK-PSCSC Consortium and The International IBD Genetics Consortium and The International PSC Study Group and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 6, pp. 670 - 675
Journal Article
by Ji, Sun-Gou and Juran, Brian D and Mucha, Soeren and Folseraas, Trine and Jostins, Luke and Melum, Espen and Kumasaka, Natsuhiko and Atkinson, Elizabeth J and Schlicht, Erik M and Liu, Jimmy Z and Shah, Tejas and Gutierrez-Achury, Javier and Boberg, Kirsten M and Bergquist, Annika and Vermeire, Severine and Eksteen, Bertus and Durie, Peter R and Farkkila, Martti and Mueller, Tobias and Schramm, Christoph and Sterneck, Martina and Weismueller, Tobias J and Gotthardt, Daniel Nils and Ellinghaus, David and Braun, Felix and Teufel, Aneas and Laudes, Mattias and Lieb, Wolfgang and Jacobs, Gunnar and Beuers, Ulrich and Weersma, Rinse K and Wijmenga, Cisca and Marschall, Hanns-Ulrich and Milkiewicz, Piotr and Pares, Albert and Kontula, Kimmo and Chazouilleres, Olivier and Invernizzi, Pietro and Goode, Elizabeth and Spiess, Kelly and Moore, Carmel and Sambrook, Jennifer and Ouwehand, Willem H and Roberts, David J and Danesh, John and Floreani, Annarosa and Gulamhusein, Aliya F and Eaton, John E and Schreiber, Stefan and Coltescu, Catalina and Int PSC Study Grp and UK-PSC Consortium and Int IBD Genetics Consortium and International PSC Study Group and International IBD Genetics Consortium and The International IBD Genetics Consortium and The International PSC Study Group and The UK-PSC Consortium and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Nature Genetics, ISSN 1061-4036, 02/2017, Volume 49, Issue 2, pp. 269 - 273
Journal Article
Journal Article
by Alberts, Rudi and de Vries, Elisabeth M G and Goode, Elizabeth C and Jiang, Xiaojun and Sampaziotis, Fotis and Rombouts, Krista and Böttcher, Katrin and Folseraas, Trine and Weismüller, Tobias J and Mason, Andrew L and Wang, Weiwei and Alexander, Graeme and Alvaro, Domenico and Bergquist, Annika and Björkström, Niklas K and Beuers, Ulrich and Björnsson, Einar and Boberg, Kirsten Muri and Bowlus, Christopher L and Bragazzi, Maria C and Carbone, Marco and Chazouillères, Olivier and Cheung, Angela and Dalekos, Georgios and Eaton, John and Eksteen, Bertus and Ellinghaus, David and Färkkilä, Martti and Festen, Eleonora A M and Floreani, Annarosa and Franceschet, Irene and Gotthardt, Daniel Nils and Hirschfield, Gideon M and Hoek, Bart van and Holm, Kristian and Hohenester, Simon and Hov, Johannes Roksund and Imhann, Floris and Invernizzi, Pietro and Juran, Brian D and Lenzen, Henrike and Lieb, Wolfgang and Liu, Jimmy Z and Marschall, Hanns-Ulrich and Marzioni, Marco and Melum, Espen and Milkiewicz, Piotr and Müller, Tobias and Pares, Albert and Rupp, Christian and Rust, Christian and Sandford, Richard N and Schramm, Christoph and Schreiber, Stefan and Schrumpf, Erik and Silverberg, Mark S and Srivastava, Brijesh and Sterneck, Martina and Teufel, Andreas and Vallier, Ludovic and Verheij, Joanne and Vila, Arnau Vich and Vries, Boudewijn de and Zachou, Kalliopi and Chapman, Roger W and Manns, Michael P and Pinzani, Massimo and Rushbrook, Simon M and Lazaridis, Konstantinos N and Franke, Andre and Anderson, Carl A and Karlsen, Tom H and Ponsioen, Cyriel Y and Weersma, Rinse K and PSC Study Grp and UK PSC Consortium and International PSC Study Group, The UK PSC Consortium and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Gut, ISSN 0017-5749, 08/2018, Volume 67, Issue 8, pp. 1517 - 1524
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 63, Issue 6, pp. 549 - 559
Journal Article
by Weismüller, Tobias J and Trivedi, Palak J and Bergquist, Annika and Imam, Mohamad and Lenzen, Henrike and Ponsioen, Cyriel Y and Holm, Kristian and Gotthardt, Daniel and Färkkilä, Martti A and Marschall, Hanns-Ulrich and Thorburn, Douglas and Weersma, Rinse K and Fevery, Johan and Mueller, Tobias and Chaouillères, Olivier and Schulze, Kornelius and Lazaridis, Konstantinos N and Almer, Sven and Pereira, Stephen P and Levy, Cynthia and Mason, Andrew and Naess, Sigrid and Bowlus, Christopher L and Floreani, Annarosa and Halilbasic, Emina and Yimam, Kidist K and Milkiewicz, Piotr and Beuers, Ulrich and Huynh, Dep K and Pares, Albert and Manser, Christine N and Dalekos, George N and Eksteen, Bertus and Invernizzi, Pietro and Berg, Christoph P and Kirchner, Gabi I and Sarrazin, Christoph and Zimmer, Vincent and Fabris, Luca and Braun, Felix and Marzioni, Marco and Juran, Brian D and Said, Karouk and Rupp, Christian and Jokelainen, Kalle and Benito de Valle, Maria and Saffioti, Francesca and Cheung, Angela and Trauner, Michael and Schramm, Christoph and Chapman, Roger W and Karlsen, Tom H and Schrumpf, Erik and Strassburg, Christian P and Manns, Michael P and Lindor, Keith D and Hirschfield, Gideon M and Hansen, Bettina E and Boberg, Kirsten M and Int PSC Study Grp and International PSC Study Group and Region Östergötland and Avdelningen för inflammationsmedicin and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Magtarmmedicinska kliniken and Hjärt- och Medicincentrum and Hälsouniversitetet
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 8, pp. 1975 - 1984.e8
Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to... 
Gastroenterology and Hepatology | Risk Stratification | Immune-Mediated Liver Disease | Autoimmune Liver Disease | Cholestasis | DOSE URSODEOXYCHOLIC ACID | RISK-FACTORS | LIVER-TRANSPLANTATION | ALKALINE-PHOSPHATASE | ULCERATIVE-COLITIS | NATURAL-HISTORY | CLINICAL PRESENTATION | PRIMARY BILIARY-CIRRHOSIS | PROGNOSTIC VARIABLES | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION | Crohn Disease - epidemiology | Multivariate Analysis | Liver Transplantation | Age Distribution | Prognosis | Humans | Middle Aged | Crohn Disease - surgery | Crohn Disease - mortality | Male | Colitis, Ulcerative - epidemiology | Incidence | Young Adult | Time Factors | Crohn Disease - diagnosis | Adult | Colitis, Ulcerative - surgery | Female | Retrospective Studies | Cholangitis, Sclerosing - surgery | Risk Assessment | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Europe - epidemiology | Chi-Square Distribution | Australia - epidemiology | Disease Progression | Phenotype | Cholangitis, Sclerosing - epidemiology | Colitis, Ulcerative - diagnosis | Colitis, Ulcerative - mortality | Sex Distribution | Cholangitis, Sclerosing - diagnosis | North America - epidemiology | Cholangitis, Sclerosing - mortality | Gastrointestinal diseases | Genetic aspects | Analysis | Colitis ulcerosa | Inflammation | Inflamació | Ulcerative colitis | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Gastroenterologi | Risk Stratification; Immune-Mediated Liver Disease; Autoimmune Liver Disease; Cholestasis | Klinisk medicin
Journal Article
Journal of Muscle Research and Cell Motility, ISSN 0142-4319, 12/2005, Volume 26, Issue 6, pp. 381 - 388
We investigated the response to deletion of the titin M-line region in striated muscle, using a titin knockout model and a range of techniques that include... 
Life Sciences | Animal Anatomy / Morphology / Histology | Biomedicine general | Proteomics | Cell Biology | RAT SKELETAL-MUSCLE | LIGHT-CHAIN KINASE | EXPRESSION PATTERNS | SARCOMERIC M-BAND | PASSIVE STIFFNESS | MOLECULAR-STRUCTURE | FIBER-TYPE | MUSCULAR-DYSTROPHY | DILATED CARDIOMYOPATHY | ONLY PROTEIN FHL2 | CELL BIOLOGY | Protein Kinases - genetics | Connectin | Gene Expression - genetics | Muscle Fibers, Fast-Twitch - metabolism | Electrophoresis, Gel, Two-Dimensional | Muscle Proteins - deficiency | Muscle, Skeletal - metabolism | Muscle Fibers, Slow-Twitch - metabolism | Muscle Fibers, Skeletal - metabolism | Sarcomeres - pathology | In Situ Hybridization | Protein Isoforms - metabolism | Protein Kinases - deficiency | Muscular Atrophy - metabolism | Sarcomeres - metabolism | Heat-Shock Proteins - metabolism | Muscular Atrophy - pathology | Muscle, Skeletal - ultrastructure | Exons - genetics | Muscular Atrophy - genetics | Mice, Inbred Strains | Microscopy, Electron | Mice, Knockout | Muscle Proteins - genetics | Sarcomeres - ultrastructure | Animals | Muscle Fibers, Slow-Twitch - pathology | Muscle Fibers, Fast-Twitch - pathology | Muscle Fibers, Skeletal - pathology | Mice | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Protein Isoforms - genetics | Proteins | Muscular system | Kinases | Binding sites
Journal Article