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1. Full Text Abstract CN08-02: Metabolic adaptations and liabilities of TCA cycle-truncated tumors
by Gottlieb, Eyal
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. CN08-02 - CN08-02
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2. Full Text Abstract IA06: De novo purine biosynthesis dictates glutamine dependency of glioblastoma cells
by Gottlieb, Eyal
Molecular Cancer Research, ISSN 1541-7786, 01/2016, Volume 14, Issue 1 Supplement, pp. IA06 - IA06
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3. Full Text Abstract SY03-01: Revealing new metabolic networks in cancer
by Gottlieb, Eyal
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. SY03-01 - SY03-01
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4. Full Text Predicting selective drug targets in cancer through metabolic networks
by Folger, Ori and Jerby, Livnat and Frezza, Christian and Gottlieb, Eyal and Ruppin, Eytan and Shlomi, Tomer
Molecular Systems Biology, ISSN 1744-4292, 2011, Volume 7, Issue 1, pp. 501 - n/a
The interest in studying metabolic alterations in cancer and their potential role as novel targets for therapy has been rejuvenated in recent years. Here, we... 
selectivity | cancer | metabolism | modeling | metabolic | RECONSTRUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | DISCOVERY | ATLAS | MODELS | GENES | GROWTH | CONSTRAINTS | CELL | PLASTICITY | Neoplasms - metabolism | RNA, Small Interfering - genetics | Cytostatic Agents - chemistry | Cell Proliferation | Down-Regulation | Humans | Computational Biology | Drug Delivery Systems | Neoplasms - drug therapy | Metabolic Networks and Pathways - genetics | Neoplasms - genetics | Models, Biological | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | RNA, Small Interfering - metabolism | Cell proliferation | Drugs | Biotechnology | Metabolomics | Yeast | Target recognition | Growth rate | Genes | Metabolic networks | Performance prediction | Lipids | Genomes | Drug delivery | Biosynthesis | Biomass | Inactivation | Cancer therapies | Glucose metabolism | Alterations | Antitumor agents | Nutrients | Constraint modelling | Reconstruction | Construction | Effectiveness | Deactivation | Tumor cells | Tumor cell lines | Metabolism | Gene expression | Gene silencing | Side effects | Computation | Scale (ratio) | Proteomics | Cell lines | Computer applications | Collection | Mutation | Cost analysis | Tumors | Cancer | Index Medicus
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5. Full Text Anti-cancer effects of vitamin C revisited
by Jiska van der Reest Eyal Gottlieb
细胞研究：英文版, ISSN 1001-0602, 2016, Volume 26, Issue 3, pp. 269 - 270
Vitamin C was first suggested to have cancer-fighting properties in the 1930s and has been the subject of controversy ever since. Despite re- peated reports of... 
小鼠模型 | 维生素C | 抗肿瘤作用 | 细胞毒性 | 大剂量 | CELLS | DEHYDROASCORBIC ACID | TRANSPORTERS | CANCER | CELL BIOLOGY | ras Proteins - genetics | Animals | Ascorbic Acid - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Female | Proto-Oncogene Proteins - genetics | Index Medicus | Research Highlight
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6. Full Text p53 guards the metabolic pathway less travelled
by Gottlieb, Eyal
Nature Cell Biology, ISSN 1465-7392, 03/2011, Volume 13, Issue 3, pp. 195 - 197
Glucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer... 
TRANSFORMATION | CANCER | ANTIOXIDANT | CELL BIOLOGY | Neoplasms - metabolism | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Disease Progression | Oxygen - metabolism | Animals | Models, Biological | Alleles | Cell Line, Tumor | Glucose - metabolism | Mice | Pentose Phosphate Pathway | Apoptosis | Physiological aspects | Glucose metabolism | Tumor suppressor genes | Research | Cancer cells
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7. Full Text Friendly neighbours feed tumour cells
by Kamphorst, Jurre J and Gottlieb, Eyal
Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 401 - 402
The cancer pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and is an area of intense biomedical research. Previous studies1,2 have shown that... 
Cell growth | Mitochondria | Biomedical research | Medical prognosis | Pancreatic cancer | Amino acids | Biosynthesis | Metabolism | Autophagy | Tumors
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8. Full Text The fat and the furious
by Gottlieb, Eyal
Nature, ISSN 0028-0836, 09/2009, Volume 461, Issue 7260, pp. 44 - 45
In an interesting twist, Schafer et al. note that anoikis can be prevented in normal, detached, glucose-starved cells if they are given antioxidants, showing... 
Fat metabolism | Cancer cells | Physiological aspects | Development and progression | Genetic aspects | Breast cancer | Research | Rodents | Cells | Apoptosis | Cancer
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9. Full Text Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
by Maddocks, Oliver D. K and Berkers, Celia R and Mason, Susan M and Zheng, Liang and Blyth, Karen and Gottlieb, Eyal and Vousden, Karen H
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7433, pp. 542 - 546
Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The... 
APOPTOSIS | GLYCINE | RETINOBLASTOMA PROTEIN | P53-INDUCIBLE REGULATOR | MULTIDISCIPLINARY SCIENCES | PYRUVATE-KINASE M2 | DNA-DAMAGE | CYCLE ARREST | MICE | TUMORS | P53 | Neoplasms - metabolism | Neoplasm Transplantation | Cell Proliferation | Oxidative Stress | Antioxidants - metabolism | Humans | Serine - biosynthesis | Glycolysis - drug effects | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | Glutathione - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Disease Models, Animal | Starvation | Aerobiosis | Cell Survival | HCT116 Cells | Cells, Cultured | Serine - deficiency | Tumor Suppressor Protein p53 - metabolism | Nucleotides - metabolism | Tumor Suppressor Protein p53 - deficiency | Serine - metabolism | Citric Acid Cycle | Cell Cycle Checkpoints | G1 Phase | Animals | Energy Metabolism | Serine - pharmacology | Cell Line, Tumor | Mice | Neoplasms - pathology | Physiological aspects | Oxidative stress | Tumor suppressor genes | Health aspects | Serine | Cancer cells | Proteins | Phosphorylation | Metabolites | Amino acids | Labeling | Cancer | Index Medicus
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10. Full Text A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
by Kaplon, Joanna and Zheng, Liang and Meissl, Katrin and Chaneton, Barbara and Selivanov, Vitaly A and MacKay, Gillian and Van Der Burg, Sjoerd H and Verdegaal, Elizabeth M. E and Cascante, Marta and Shlomi, Tomer and Gottlieb, Eyal and Peeper, Daniel S
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7452, pp. 109 - 112
In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor networks to avert the hazard of... 
COMPLEX | MELANOMA | THERAPY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | CELL SENESCENCE | MICE | CANCER | TUMORS | Mitochondria - enzymology | Protein-Serine-Threonine Kinases - deficiency | Humans | Melanoma - enzymology | Molecular Targeted Therapy | Melanoma - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Pyruvate Dehydrogenase Complex - metabolism | Cell Line | Cellular Senescence - genetics | Oncogenes - genetics | Signal Transduction | Oxidative Phosphorylation | Mitochondria - metabolism | Melanoma - pathology | Mice, SCID | Citric Acid Cycle | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Glycolysis | Mice, Inbred NOD | Mice | Enzyme Activation | Physiological aspects | Aging | Tumor suppressor genes | Research | Pyruvate dehydrogenase complex | Oncogenes | Proteins | Metabolites | Kinases | Rodents | Index Medicus
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11. Full Text Abstract IA-17: The roles of prolyl hydroxylases in metabolism and cancer
by Gottlieb, Eyal
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23 Supplement, pp. IA-17 - IA-17
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12. Full Text Obstructive sleep apnea-hypopnea and incident stroke: The sleep heart health study
by Redline, Susan and Yenokyan, Gayane and Gottlieb, Daniel J and Shahar, Eyal and O'Connor, George T and Resnick, Helaine E and Diener-West, Marie and Sanders, Mark H and Wolf, Philip A and Geraghty, Estella M and Ali, Tauqeer and Lebowitz, Michael and Punjabi, Naresh M
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2010, Volume 182, Issue 2, pp. 269 - 277
Rationale Although obstructive sleep apnea is associated with physiological perturbations that increase risk of hypertension and are proatherogenic, it is... 
Epidemiology | Stroke | Sleep apnea | RISK-FACTORS | NOCTURNAL ARRHYTHMIAS | ATHEROSCLEROSIS | COMMUNITIES | stroke | HEMODYNAMICS | epidemiology | INTERMITTENT HYPOXIA | RESPIRATORY SYSTEM | CARDIOVASCULAR-DISEASE | POSITIVE AIRWAY PRESSURE | sleep apnea | ISCHEMIC-STROKE | ASSOCIATION | CRITICAL CARE MEDICINE | Severity of Illness Index | Prospective Studies | Humans | Middle Aged | Proportional Hazards Models | Male | Polysomnography | Sex Factors | Female | Stroke - epidemiology | Aged | Sleep Apnea, Obstructive - epidemiology | Longitudinal Studies | Index Medicus | Abridged Index Medicus | J. Sleep and Control of Ventilation
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13. Full Text P53 status determines the role of autophagy in pancreatic tumour development
by Rosenfeldt, Mathias T and O'Prey, Jim and Morton, Jennifer P and Nixon, Colin and Mackay, Gillian and Mrowinska, Agata and Au, Amy and Rai, Taranjit Singh and Zheng, Liang and Ridgway, Rachel and Adams, Peter D and Anderson, Kurt I and Gottlieb, Eyal and Sansom, Owen J and Ryan, Kevin M
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 296 - 300
Macroautophagy (hereafter referred to as autophagy) is a process in which organelles termed autophagosomes deliver cytoplasmic constituents to lysosomes for... 
SUPPRESSOR | MULTIDISCIPLINARY SCIENCES | DISEASE | GROWTH | MOUSE | MAMMARY TUMORIGENESIS | MICE | METABOLIC STRESS | CANCER | PROGRESSION | CELL-DEATH | Metabolomics | Pancreatic Neoplasms - metabolism | Microtubule-Associated Proteins - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Precancerous Conditions - metabolism | Mice, 129 Strain | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | Glycolysis - genetics | Precancerous Conditions - pathology | Autophagy - genetics | Disease Models, Animal | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Tumor Suppressor Protein p53 - metabolism | Pancreatic Neoplasms - genetics | Genes, p53 - genetics | Tumor Suppressor Protein p53 - deficiency | Carcinoma, Pancreatic Ductal - pathology | Precancerous Conditions - genetics | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Alleles | Survival Analysis | Cell Line, Tumor | Glucose - metabolism | Hydroxychloroquine - pharmacology | Mice | Pentose Phosphate Pathway - genetics | Oncogene Protein p21(ras) - genetics | Diabetes | Autophagy | Rodents | Mortality | Cancer | Index Medicus
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14. Full Text One carbon, many roads
by Gottlieb, Eyal and Vousden, Karen H
Cell Death and Differentiation, ISSN 1350-9047, 02/2017, Volume 24, Issue 2, pp. 193 - 194
SERINE BIOSYNTHESIS | ACTIVATION | INHIBITOR | CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | and
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15. Full Text Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the warburg effect
by Shlomi, Tomer and Benyamini, Tomer and Gottlieb, Eyal and Sharan, Roded and Ruppin, Eytan
PLoS Computational Biology, ISSN 1553-734X, 03/2011, Volume 7, Issue 3, pp. e1002018 - e1002018
The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to... 
CANCER-CELLS | TRANSFORMATION | NETWORK | EVOLUTION | RECONSTRUCTION | AEROBIC GLYCOLYSIS | GROWTH | SEQUENCE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | COOPERATION | OXIDATIVE-METABOLISM | Glycolysis - genetics | Neoplasms - metabolism | Glycolysis - physiology | Gene Expression | Cell Proliferation | Energy Metabolism | Metabolic Networks and Pathways | Neoplasms - genetics | Humans | Glutamine - metabolism | Biomass | Genome, Human | Physiological aspects | Research | Metabolism | Adenosine triphosphate | Cancer cells | Adaptations | Cell proliferation | Enzymes | Solvents | Oxygen | metabolic networks | Secretion | Amino acids | Genomes | Mitochondria | Energy | Computer applications | Glycolysis | Lactic acid | Electron transport | ATP | Cancer | Glutamine | Index Medicus | Medical research | Phosphorylation | DNA damage | Glucose | Carbon | Molecular weight | Studies | Hypotheses | Hypoxia
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16. Full Text Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
by Kuntz, Elodie M and Baquero, Pablo and Michie, Alison M and Dunn, Karen and Tardito, Saverio and Holyoake, Tessa L and Helgason, G Vignir and Gottlieb, Eyal
Nature Medicine, ISSN 1078-8956, 10/2017, Volume 23, Issue 10, pp. 1234 - 1240
Treatment of chronic myeloid leukemia (CML) with imatinib mesylate and other second-and/or third-generation c-Abl-specific tyrosine kinase inhibitors (TKIs)... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | KINASE-ACTIVITY | COMPLETE MOLECULAR REMISSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISCONTINUATION | CELL BIOLOGY | BCR | METABOLISM | FATTY-ACID OXIDATION | IMATINIB | SUPPORTING ASPARTATE BIOSYNTHESIS | DIFFERENTIATION | Metabolomics | Up-Regulation | Minocycline - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Minocycline - analogs & derivatives | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Oxidative Phosphorylation - drug effects | Imatinib Mesylate - therapeutic use | Neoplastic Stem Cells - metabolism | Mass Spectrometry | Chromatography, Liquid | Female | Tumor Cells, Cultured | Drug Therapy, Combination | Cell Survival - drug effects | Tumor Stem Cell Assay | Imatinib Mesylate - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Phenformin - pharmacology | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Animals | Protein Kinase Inhibitors - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice, Inbred NOD | Anti-Bacterial Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | In Vitro Techniques | Drug Resistance, Neoplasm - drug effects | Oxidative stress | Care and treatment | Genotype | Development and progression | Genetic aspects | Chronic myeloid leukemia | Health aspects | Phosphorylation | Transformation | Target recognition | Oxidative metabolism | Leukemia | Xenotransplantation | Disease resistance | Oxidation resistance | Mitochondria | Transformed cells | CD38 antigen | Xenografts | Drug therapy | Protein-tyrosine kinase | Chronic illnesses | Tyrosine | CD34 antigen | Imatinib | Cell survival | Myeloid leukemia | Minimal residual disease | Metabolism | Survival | Oxidative phosphorylation | Antibiotics | Stem cells | Tigecycline | Index Medicus
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17. Full Text Nonlinear damping in a micromechanical oscillator
by Zaitsev, Stav and Shtempluck, Oleg and Buks, Eyal and Gottlieb, Oded
Nonlinear Dynamics, ISSN 0924-090X, 1/2012, Volume 67, Issue 1, pp. 859 - 883
Nonlinear elastic effects play an important role in the dynamics of microelectromechanical systems (MEMS). A Duffing oscillator is widely used as an... 
Engineering | Vibration, Dynamical Systems, Control | Forced vibration | Nonlinear damping | Mechanics | Automotive Engineering | MEMS | Duffing oscillator | Mechanical Engineering | Parameter identification | Saddle-node bifurcation | BROWNIAN-MOTION | PARAMETRIC RESONANCE | RESONANCE FORCE MICROSCOPY | NANOELECTROMECHANICAL SYSTEMS | QUANTUM | EXACTLY SOLVABLE MODEL | INTERNAL RESONANCES | ENGINEERING, MECHANICAL | MECHANICS | ENERGY-DISSIPATION | NANOMECHANICAL RESONATORS | Electrical engineering | Vibration | Mechanical engineering | Analysis | Microelectromechanical systems | Viscoelasticity | Domains | Damping | Duffing oscillators | Energy dissipation | Elasticity | Nonlinearity | Bifurcations | Elastic properties | Nonlinear dynamics | Dissipation | Mathematical models | Dynamical systems | Oscillators
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