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chitosan (48) 48
polymer science (36) 36
index medicus (34) 34
nanoparticles (34) 34
biochemistry & molecular biology (25) 25
chitosan - chemistry (20) 20
chemistry, applied (18) 18
drug delivery systems (16) 16
chitin (15) 15
humans (15) 15
chemistry, organic (14) 14
animals (13) 13
polysaccharides (13) 13
acetylation (12) 12
materials science, biomaterials (11) 11
chemistry, physical (10) 10
drugs (10) 10
in-vitro (10) 10
pharmacology & pharmacy (10) 10
plant physiology (10) 10
alginate (9) 9
analysis (9) 9
drug delivery (9) 9
gelation (9) 9
nanocapsules (9) 9
particle size (9) 9
temperature (9) 9
delivery (8) 8
drug-delivery (8) 8
hydrogen-ion concentration (8) 8
molecular-weight (8) 8
nanoparticles - chemistry (8) 8
proteins (8) 8
carriers (7) 7
chemistry, multidisciplinary (7) 7
cytotoxicity (7) 7
hydrogels (7) 7
solubility (7) 7
vehicles (7) 7
binding (6) 6
biosensors (6) 6
capsaicin (6) 6
cell survival - drug effects (6) 6
chemistry (6) 6
derivatives (6) 6
drug carriers - chemistry (6) 6
drug compounding (6) 6
encapsulation (6) 6
food science & technology (6) 6
materials science, multidisciplinary (6) 6
microparticles (6) 6
molecular weight (6) 6
pectin (6) 6
polyelectrolytes (6) 6
polymers (6) 6
polysaccharide (6) 6
release (6) 6
toxicity (6) 6
acid (5) 5
adsorption (5) 5
bacteria (5) 5
behavior (5) 5
biophysics (5) 5
biopolymers (5) 5
chemical properties (5) 5
fluorescence (5) 5
gene delivery (5) 5
kinetics (5) 5
mechanisms (5) 5
medicine (5) 5
multidisciplinary sciences (5) 5
nanopartikel (5) 5
organic chemistry (5) 5
permeability (5) 5
polyelectrolyte complexes (5) 5
science (5) 5
water (5) 5
aggregation (4) 4
article (4) 4
biomedical applications (4) 4
chromatography (4) 4
colloidal stability (4) 4
cross-linking (4) 4
dogs (4) 4
drug liberation (4) 4
female (4) 4
food science (4) 4
formulations (4) 4
gels (4) 4
insulin (4) 4
madin darby canine kidney cells (4) 4
model (4) 4
molekulargewicht (4) 4
mucoadhesion (4) 4
nanoemulsions (4) 4
nanoscience & nanotechnology (4) 4
polyelectrolyte complex (4) 4
polymers - chemistry (4) 4
protein (4) 4
quorum sensing (4) 4
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1. Full Text Advances in Chitin/Chitosan Characterization and Applications
by Rinaudo, Marguerite and Goycoolea, Francisco M
2019, ISBN 9783038978022
Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most... 
chitosan | cyclodextrin | graft copolymer | polyelectrolyte complex | polymer carrier | iron(III) hydroxide | marine resources | over-the counter-drug | chitooligosaccharides | papermaking | methylene blue | nanoparticles | biosynthesis | sorption competition | zinc | self-masking nanosphere lithography | Citrobacter | wet-end | skin care | cicada | chitosan derivative | nanoparticle | swelling | bio-sorbent | gene delivery | metabolic pathway | TEOS | hydrogel | dendrimer | binary | aerogels | ionic liquids | drug delivery systems | sorption | fruits | FTIR | hear care | mechanism | plant growth | chitosan structure | strontium | click chemistry | nanostructured biomaterial | lead | non-viral vectors | thermal transition sol-gel | single | medical applications | salt effects | neodymium | chitin derivative | characterization | easily recyclable | bioflocculant | deacetylation pattern | chitosan complexes | drug delivery | XRD | heterogeneous catalyst | Boron | controlled functionalization | DSC | eco-friendly formulations | adsorption | wastewater | chitosan supported copper | derivatization | modelling | mechanical properties | chitin | wet and dried states | pDNA | PEO/chitosan blend | thermodynamic | PCL | craniofacial engineering | desorption | polymer | biological activity | mercury | self-assembled | oral care | ionic cross-linking | scaffolds | cross-linking | pesticides | chitin deacetylases | substrate specificity | phase transition | interpenetrating | coating | phosphate | MTDSC | siRNA | structure | defense responses | organosilicon compound | iron | ionogels | gelation mechanism | carbohydrate esterases
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2. Full Text Extraction and physicochemical characterization of galactomannans from Dichrostachys cinerea seeds
by Lavudi, Harikrishna Naik and Kottapalli, Seshagirirao and Goycoolea, Francisco M
Food Hydrocolloids, ISSN 0268-005X, 09/2018, Volume 82, pp. 451 - 456
Water soluble seed polysaccharide from Dichrostachys cinerea seeds were extracted and characterized by several techniques such as SEM, GC-MS, attenuated total... 
Polysaccharides | Seeds | Analysis | Polyethylene terephthalate | Polymerization | Methylation | Sugars | Monosaccharides
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3. Full Text 12th International Conference of the European Chitin Society and 13th International Conference on Chitin and Chitosan (EUCHIS/ICCC 2015)
by Moerschbacher, Bruno M and Goycoolea, Francisco M
Pure and Applied Chemistry, ISSN 0033-4545, 09/2016, Volume 88, Issue 9, pp. 841 - 842
chitosan | chitin and chitosan chemistry | chitin and chitosan biomaterials | chitin and chitosan analysis | chitin and chitosan applications | chitin and chitosan production | chitin and chitosan biology | chitin | EUCHIS-12 | chitin and chitosan nanomaterials | chitin and chitosan modifying enzymes | chito-oligosaccharides | ICCC-13 | CHEMISTRY, MULTIDISCIPLINARY | Conferences, meetings and seminars | Chitin | Chitosan
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4. Full Text Production and characterization of supercritical CO.sub.2 dried chitosan nanoparticles as novel carrier device
by Caro-Leon, Francisco J and Arguelles-Monal, Waldo and Carvajal-Millan, Elizabeth and Lopez-Franco, Yolanda L and Goycoolea-Valencia, Francisco M and San Roman del Barrio, Julio and Lizardi-Mendoza, Jaime
Carbohydrate Polymers, ISSN 0144-8617, 10/2018, Volume 198, p. 556
Nanoparticles | Cysteine | Milk proteins | Analysis | Sodium tripolyphosphate
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5. Polysaccharides as Bacterial Antiadhesive Agents and "Smart" Constituents for Improved Drug Delivery Systems Against Helicobacter pylori Infection
by Menchicchi, Bianca and Hensel, Andreas and Goycoolea, Francisco M
Current Pharmaceutical Design, ISSN 1381-6128, 10/2015, Volume 21, Issue 33, pp. 4888 - 4906
The standard eradication treatment of the hostile Helicobacter pylori (H. pylori) stomach infection is facing increasing alarming antibiotic resistance... 
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6. Full Text Assessment of the Quorum Sensing Inhibition Activity of a Non-Toxic Chitosan in an N-Acyl Homoserine Lactone (AHL)-Based Escherichia coli Biosensor
by Qin, Xiaofei and Qin, Xiaofei and Emich, Jana and Emich, Jana and Goycoolea, Francisco M and Goycoolea, Francisco M
Biomolecules, ISSN 2218-273X, 09/2018, Volume 8, Issue 3, p. 87
New approaches to deal with drug-resistant pathogenic bacteria are urgent. We studied the antibacterial effect of chitosans against an Escherichia coli quorum... 
antibacterial activity | chitosan | quorum sensing | quorum sensing inhibition | NANOPARTICLES | BACTERIA | TO-CELL COMMUNICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODE | ANTIMICROBIAL ACTIVITY | DELIVERY | N-Acyl homoserine lactone | Pathogens | Scanning electron microscopy | Nuclear magnetic resonance--NMR | Bacterial infections | Laboratories | Polymerization | Gram-positive bacteria | Antimicrobial agents | Drug resistance | Gene expression | Molecular weight | Lactones | Nanoparticles | Biofilms | E coli | Antibiotics | Bacteria | Acetylation | Chitosan | Biosensors | Homoserine lactones
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7. Full Text Physicochemical characterization of FRET-labelled chitosan nanocapsules and model degradation studies
by Hoffmann, Stefan and Gorzelanny, Christian and Moerschbacher, Bruno and Goycoolea, Francisco M
Nanomaterials, ISSN 2079-4991, 10/2018, Volume 8, Issue 10, p. 846
Sub-micron o/w emulsions coated with chitosan have been used for drug delivery, quorum sensing inhibition, and vaccine development. To study interactions with... 
Degradation | Bioimaging | FRET | Chitosan | Protein corona | Nanocapsules | chitosan | CANCER-CHEMOTHERAPY | MATERIALS SCIENCE, MULTIDISCIPLINARY | protein corona | nanocapsules | NANOSCIENCE & NANOTECHNOLOGY | degradation | COPOLYMERS | DELIVERY | PEPTIDES | bioimaging | DRUGS | NANOPARTICLE INTERACTION | CAPSAICIN | Drugs | Drug delivery systems | Emulsions | Dyes | Disintegration | Fluorescent dyes | Fluorescence | Labelling | Drug delivery | Fluorescent indicators | Photon correlation spectroscopy | Nanoparticles | Proteins | Turbidity | Surface properties | Fluorescence resonance energy transfer | Labeling | Pancreatin | Biological products | Ethanol | Light scattering | Nanoemulsions | Bioavailability | Surfactants | Dissolution | Studies | Absorbance | In vitro methods and tests | Energy transfer
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8. Full Text Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity
by Pistone, Sara and Goycoolea, Francisco M and Young, Alix and Smistad, Gro and Hiorth, Marianne
ISSN 0928-0987, 2017
The efficacy of treatments for oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity.... 
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9. Full Text Physico-chemical characteristics and primary structure of an affinity-purified [alpha]-D-galactose-specific, jacalin-related lectin from the latex of mulberry
by Datta, Debparna and Pohlentz, Gottfried and Schulte, Mona and Kaiser, Mathias and Goycoolea, Francisco M and MAaAaAeA thing, Johann and Mormann, Michael and Swamy, Musti J
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 11/2016, Volume 609, p. 59
An [alpha]-D-galactose specific lectin belonging to the family of jacalin-related lectins (JRL) has been purified by affinity chromatography on cross-linked... 
Proteins | Lectins | Amino acids | Galactose | Mass spectrometry | Denaturation | Antigens | Peptides | Chromatography
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10. Polysaccharides as bacterial antiadhesive agents and “smart” constituents for improved drug delivery systems against Helicobacter pylori infection
by Menchicchi, Bianca and Hensel, Andreas and Goycoolea, Francisco M
Current Pharmaceutical Design, ISSN 1381-6128, 10/2015, Volume 21, Issue 33, pp. 4888 - 4906
Antiadhesion | Polysaccharides | Antiadhesive therapy | Helicobacter pylori
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11. Full Text Parameters influencing the size of chitosan-TPP nano- and microparticles
by Sreekumar, Sruthi and Goycoolea, Francisco M and Moerschbacher, Bruno M and Rivera-Rodriguez, Gustavo R
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4695 - 11
Chitosan nanoparticles, produced by ionic gelation, are among the most intensely studied nanosystems for drug delivery. However, a lack of inter-laboratory... 
IONOTROPIC GELATION | NANOPARTICLES | DESIGN | MOLECULAR-WEIGHT | MULTIDISCIPLINARY SCIENCES | CHITIN | COLLOIDAL STABILITY | IONIC GELATION TECHNIQUE | Nanoparticles | Salts | Gelation | Drug delivery | Acetylation | Chitosan | Design of experiments | Microparticles
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12. Full Text Chitosan/Cyclodextrin/TPP nanoparticles loaded with quercetin as novel bacterial quorum sensing inhibitors
by Nguyen, Hao Thanh and Goycoolea, Francisco M
Molecules, ISSN 1420-3049, 11/2017, Volume 22, Issue 11, p. 1975
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health.... 
Nanoparticles | Cyclodextrin | E. coli Top 10 | Captisol | Quercetin | Chitosan | Quorum sensing inhibitors | chitosan | ANTIBACTERIAL ACTION | quorum sensing inhibitors | BIOCHEMISTRY & MOLECULAR BIOLOGY | cyclodextrin | SUSCEPTIBILITY | PREVENTION | CYCLODEXTRINS | CARRIERS | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | IN-VITRO | nanoparticles | Captisol (R) | VIRULENCE FACTORS | quercetin | BIOFILM FORMATION | Microbial Sensitivity Tests | Particle Size | Chitosan - chemistry | Quercetin - chemistry | Quercetin - pharmacology | Quorum Sensing - drug effects | Anti-Bacterial Agents - chemistry | Escherichia coli - drug effects | Cyclodextrins - chemistry | Drug Compounding | Anti-Bacterial Agents - pharmacology | Gelation | Bioassays | Virulence | Tripolyphosphate | Hydrophobicity | Antibiotics | E coli | Virulence factors | Zeta potential | Animal health | Antibiotic resistance | Polydispersity | Bacteria | Biosensors | Physicochemical properties
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13. Full Text Electrostatic self-assembled chitosan-pectin nano- and microparticles for insulin delivery
by Maciel, Vinicius B. V and Yoshida, Cristiana M. P and Pereira, Susana M. S. S and Goycoolea, Francisco M and Franco, Telma T
Molecules, ISSN 1420-3049, 10/2017, Volume 22, Issue 10, p. 1707
A polyelectrolyte complex system of chitosan-pectin nano-and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to... 
Nanoparticles | Pectin | Caco-2 cells | Chitosan | Insulin | Microparticles | SYSTEM | chitosan | CORE-SHELL NANOPARTICLES | POLYMERS | insulin | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | microparticles | IN-VITRO CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | nanoparticles | POLYELECTROLYTE COMPLEX NANOPARTICLES | pectin | ORAL-DRUG DELIVERY | IONIC-STRENGTH | ENZYMATIC DEGRADATION | Caco-2 Cells | Cell Survival - drug effects | Nanoparticles - chemistry | Drug Stability | Humans | Nanoparticles - ultrastructure | Insulin - administration & dosage | Static Electricity | Drug Carriers - chemistry | Pectins - chemistry | Drug Delivery Systems | Particle Size | Chitosan - chemistry | Drug Compounding | Drug Liberation | Encapsulation | Drug delivery systems | Peptides | Biodegradability | Toxicity | Polyelectrolytes | Cytotoxicity | Drug delivery | pH effects | Polysaccharides | Intestine | Biocompatibility | Acetylation | Saccharides | Biodegradation | Oral administration | Particulates | Crosslinking | Electron microscopy | Transmission electron microscopy | Simulation | Zeta potential | In vitro methods and tests
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14. Full Text Production and characterization of supercritical CO 2 dried chitosan nanoparticles as novel carrier device
by Caro-León, Francisco J and Argüelles-Monal, Waldo and Carvajal-Millán, Elizabeth and López-Franco, Yolanda L and Goycoolea-Valencia, Francisco M and San Román Del Barrio, Julio and Lizardi-Mendoza, Jaime
Carbohydrate polymers, 10/2018, Volume 198, p. 556
The materials produced by the supercritical CO drying have outstanding properties that allow the incorporation of molecules in their porous structure. In this... 
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15. Full Text In vitro and sensory evaluation of capsaicin-loaded nanoformulations
by Kaiser, Mathias and Kirsch, Benedikt and Hauser, Hannah and Schneider, Désirée and Seub-Baum, Ingrid and Goycoolea, Francisco M
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0141017
Capsaicin has known health beneficial and therapeutic properties. It is also able to enhance the permeability of drugs across epithelial tissues.... 
MECHANISMS | MULTIDISCIPLINARY SCIENCES | CHITOSAN | ALPHA-AMYLASE | Cell Line | Cell Survival - drug effects | Chitosan - chemistry | Administration, Oral | Capsaicin - pharmacology | Humans | Nanocapsules | Mouth Mucosa | Permeability | Chemistry, Pharmaceutical | Drug Carriers - pharmacology | Phenols | Lipids | Capsaicin | Health aspects | Encapsulation | Senses | Formulations | Drug delivery systems | Oral administration | Plant biology | Cytotoxicity | Life assessment | Nanoemulsions | Pungent principles | Phospholipids | Food science | Coatings | Studies | Coating effects | Sensory evaluation | Occupational health | Chitosan | Saliva | Viability | Pharmaceutical sciences
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16. Full Text Electrokinetic behavoir of chitosan adsorbed on o/w nanoemulsion droplets
by Goycoolea, Francisco M and Milkova, Viktoria
Colloids and Surfaces A: Physicochemical and Engineering Aspects, ISSN 0927-7757, 04/2017, Volume 519, pp. 205 - 211
Chitosans with different molecular weight and degree of acetylation (DA) were adsorbed onto lecithin stabilized nanoemulsion droplets at pH ∼4.7. The... 
Chitosan | Counterion condensation | Nanoemulsion | Electrokinetics | CHARGE INVERSION | ACETYLATION | CHEMISTRY, PHYSICAL | NANOCAPSULES | MODEL | ADSORPTION | POLYELECTROLYTE COMPLEXES | FILMS | COUNTERION RELEASE | IN-WATER EMULSIONS | Polyelectrolytes | Lecithin | Adsorption | Electric properties
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17. Full Text Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations
by Real, Daniel and Hoffmann, Stefan and Leonardi, Darío and Salomon, Claudio and Goycoolea, Francisco M
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, p. e0207625
Triclabendazole is a poorly-water soluble (0.24 mu g/mL) compound classified into the Class I I/IV of the Biopharmaceutical Classification System. It is the... 
PRAZIQUANTEL | NANOPARTICLES | HUMAN FASCIOLIASIS | MULTIDISCIPLINARY SCIENCES | SPONTANEOUS EMULSIFICATION | ORAL BIOAVAILABILITY | ALBENDAZOLE | NANOCAPSULES | MICROPARTICLES | SOLUBILITY | DELIVERY | Caco-2 Cells | Cell Survival - drug effects | Temperature | Drug Stability | Humans | Triclabendazole - chemistry | Nanocapsules - chemistry | Drug Carriers - chemistry | Chitosan - chemistry | Triclabendazole - pharmacology | Drug Compounding | Drug Liberation | Hydrogen-Ion Concentration | Pediatrics | Drug delivery systems | Size distribution | Tablets | Toxicity | Plant biology | Cytotoxicity | Confocal microscopy | Drug delivery | Parasites | Drug development | Veterinary medicine | Nanoparticles | Parasitic diseases | Pharmaceutical industry | Drug dosages | Formulations | Oral administration | Nanoemulsions | Stability analysis | Saline solutions | Bioavailability | Particle size distribution | Nanocrystals | Microscopy | Zeta potential | Polydispersity | Chitosan | Biosensors | Scanning microscopy | Nanotechnology | Pharmaceuticals
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18. Full Text Chitosan in non-viral gene delivery: Role of structure, characterization methods, and insights in cancer and rare diseases therapies
by Santos-Carballal, Beatriz and Fernández, Elena Fernández and Goycoolea, Francisco M
Polymers, ISSN 2073-4360, 04/2018, Volume 10, Issue 4, p. 444
Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of clinical trials of gene therapy nanomedicines. Even when non-viral... 
Gene delivery | Chitosan structure | Non-viral vectors | PDNA | SiRNA | MUCOCILIARY CLEARANCE DISORDER | AIRWAY EPITHELIAL-CELLS | DYNAMIC LIGHT-SCATTERING | POLYMER SCIENCE | GIANT AXONAL NEUROPATHY | chitosan structure | siRNA | CELL-PENETRATING PEPTIDES | RECOMBINANT SENDAI-VIRUS | non-viral vectors | gene delivery | DIGITAL HOLOGRAPHIC MICROSCOPY | pDNA | WISKOTT-ALDRICH SYNDROME | SURFACE-PLASMON RESONANCE | CYSTIC-FIBROSIS GENE | Medical research | Physiological effects | Transgenic | Viruses | Nuclei (nuclear physics) | Nucleic acids | Gene expression | Biopolymers | Complexity | Proteins | Ribonucleic acids | Chitosan | Acetylation | Gene therapy | Structural analysis
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19. Full Text Chitosan-alginate blended nanoparticles as carriers for the transmucosal delivery of macromolecules
by Goycoolea, Francisco M and Lollo, Giovanna and Remuñán-López, Carmen and Quaglia, Fabiana and Alonso, María J
Biomacromolecules, ISSN 1525-7797, 07/2009, Volume 10, Issue 7, pp. 1736 - 1743
Nanoparticles intended for use in the transmucosal delivery of macromolecules were prepared by the ionic gelation of chitosan (CS) hydrochloride with... 
SYSTEM | POLYMER SCIENCE | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ALGINATE/CHITOSAN NANOPARTICLES | POLYELECTROLYTE COMPLEXES | INSULIN-LOADED NANOPARTICLES | POLYSACCHARIDES | ENHANCEMENT | ABSORPTION | EPITHELIAL-CELLS CACO-2 | PROTEIN DELIVERY | Particle Size | Insulin - pharmacology | Rabbits | Animals | Nanoparticles - chemistry | Colloids | Macromolecular Substances - administration & dosage | Insulin - administration & dosage | Administration, Mucosal | Alginates | Chitosan | Drug Carriers - chemistry
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20. Full Text Nanoencapsulated capsaicin changes migration behavior and morphology of madin darby canine kidney cell monolayers
by Kaiser, Mathias and Pohl, Luisa and Ketelhut, Steffi and Kastl, Lena and Gorzelanny, Christian and Götte, Martin and Schnekenburger, Jürgen and Goycoolea, Francisco M and Kemper, Björn
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0187497
We have developed a drug delivery nanosystem based on chitosan and capsaicin. Both substances have a wide range of biological activities. We investigated the... 
NANOPARTICLES | IN-VITRO | ABSORPTION ENHANCERS | DIGITAL HOLOGRAPHIC MICROSCOPY | MOLECULAR-WEIGHT | MULTIDISCIPLINARY SCIENCES | TRANSMUCOSAL DELIVERY | TUMOR-CELLS | CHITOSAN NANOCAPSULES | ION CHANNELS | POORLY ABSORBABLE DRUGS | Cell Movement - drug effects | Animals | Calcium - metabolism | Capsaicin - pharmacology | Dogs | Madin Darby Canine Kidney Cells | Nanocapsules | Microscopy, Fluorescence | Influence | Research | Capsaicin | Epithelial cells | Morphology | Cell migration | Drug delivery systems | Calcium | Leukocyte migration | Cytology | Plant biology | Fluorescence | Drug delivery | Cell surface | Calcium influx | Cell adhesion & migration | Nanoparticles | Biological effects | Alterations | Biomedical materials | Biocompatibility | Ion channels | Stains | Dermatology | Body temperature | Surface roughness | Permeability | Studies | Digital imaging | Microscopy | Cytoskeleton | Chitosan | Fluorescence microscopy
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