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PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89292
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13779
The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies implicate microRNAs (miRNAs) as important agents in melanoma... 
CUTANEOUS MALIGNANT-MELANOMA | METHYLATION | GENE | MULTIDISCIPLINARY SCIENCES | UV DAMAGE | MICRORNAS | DNA-REPAIR | TRANSCRIPTION FACTOR | TUMOR SUPPRESSORS | SKIN-CANCER | PROGRESSION | Cell Line | Cell Proliferation | Introns - genetics | Oligonucleotide Array Sequence Analysis | Neoplasm Invasiveness | Humans | Cells, Cultured | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism | MicroRNAs - metabolism | Gene Expression Profiling | Binding Sites - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics | RNA Interference | Melanoma - genetics | Cell Line, Tumor | TRPM Cation Channels - genetics | MicroRNAs - genetics | Mutation | MicroRNA | Metastasis | Comparative analysis | Prostate cancer | Melanoma | Post-transcription | Biotechnology | Transcription factors | Brain tumors | Melanocytes | Genomes | Kinases | Cancer therapies | Gene sequencing | Metastases | Skin cancer | Proteins | Transient receptor potential proteins | Signal transduction | Cell growth | Coding | Cell cycle | DNA methylation | Cleavage | miRNA | Deoxyribonucleic acid--DNA | Microphthalmia-associated transcription factor | Medical research | Invasiveness | Breast cancer | Gene expression | Molecular modelling | Glioma | 3' Untranslated regions | MicroRNAs | Stem cells | Epigenetics | Prostate | Binding sites | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Nature Medicine, ISSN 1078-8956, 2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e41845
Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer... 
BREAST-CANCER | IN-VITRO | PA2.26 ANTIGEN | PLATELET-AGGREGATION | LYMPHATIC MARKER PODOPLANIN | MULTIDISCIPLINARY SCIENCES | ORAL-CANCER | TUMOR | MAACKIA-AMURENSIS HEMAGGLUTININ | MALIGNANT-MELANOMA | EXPRESSION | Melanoma - metabolism | Amino Acid Sequence | Melanoma - blood supply | Membrane Glycoproteins - metabolism | Humans | Maackia - chemistry | Molecular Sequence Data | Neovascularization, Pathologic - diet therapy | Plant Lectins - pharmacology | Melanoma - diet therapy | Melanoma - pathology | N-Acetylneuraminic Acid - metabolism | Necrosis - chemically induced | Dose-Response Relationship, Drug | Cell Movement - drug effects | Animals | Cell Transformation, Neoplastic | src-Family Kinases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Plant Lectins - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Plant Lectins - metabolism | Chemotherapy | Growth | Proteolysis | Amino acids | Plant lectins | Metastasis | Galactose | Health aspects | Cancer | Motility | Seeds | Leukocyte migration | Cell adhesion & migration | Metastases | Skin cancer | Proteins | Receptors | Cell growth | Aging | Tumorigenesis | Osteopathic medicine | Cardiovascular system | Carbohydrates | Melanoma | Dentistry | Gene expression | Sialic acids | Biological activity | Medicine | Mucin | Acids | Diet | Proteomics | Lectins | Molecular biology | Cell migration | Tumors
Journal Article
Journal Article
Cancer Treatment and Research, ISSN 0927-3042, 2016, Volume 167, pp. 321 - 329
Acral lentiginous melanoma (ALM) is a rare subtype of melanoma mainly arising on the palms, soles, and nail beds. ALM is the most common subtype of melanoma... 
Reconstruction | Acral | C-Kit | Subungual | Delayed diagnosis | Skin Neoplasms - pathology | Prognosis | Skin Neoplasms - therapy | Humans | Nail Diseases - therapy | Foot Diseases - therapy | Melanoma - pathology | Melanoma - therapy | Hand | Nail Diseases - pathology | Foot Diseases - pathology
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e81126
TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human... 
SIGNAL-TRANSDUCTION | MOLECULAR PORTRAITS | MELANOMA | RAS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PROTEIN-COUPLED RECEPTORS | KINASE-C | AMYOTROPHIC-LATERAL-SCLEROSIS | CELL-LINES | XENOGRAFT MODEL | Gene Expression | Cell Proliferation | Signal Transduction | Humans | Gene Silencing | Receptors, Metabotropic Glutamate - metabolism | Cell Transformation, Neoplastic - metabolism | Cell Movement - genetics | Disease Progression | Animals | Heterografts | Triple Negative Breast Neoplasms - genetics | Receptors, Metabotropic Glutamate - genetics | Cell Transformation, Neoplastic - genetics | Triple Negative Breast Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Cell Transformation, Neoplastic - pathology | Disease Models, Animal | Development and progression | Amino acids | Breast cancer | Epidermal growth factor | Progesterone | Glutamate | Cell proliferation | Transformation | Estrogens | Hyperplasia | Estrogen receptors | Oncology | Glutamic acid receptors | Metastasis | Kinases | Carcinogenesis | Medical schools | Signal transduction | Receptors | Carcinogens | Rodents | Surgery | Xenografts | Growth factors | Invasiveness | Melanoma | Pharmacology | FDA approval | Gene expression | Epithelium | ErbB-2 protein | Progesterone receptors | Medicine | Signaling | Breast | In vivo methods and tests | Glutamatergic transmission | Glutamic acid receptors (metabotropic) | Cancer
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 04/2019, Volume 103, Issue 5, pp. E47 - E48
Journal Article
International Journal of Radiation OncologyBiologyPhysics, ISSN 0360-3016, 04/2019, Volume 103, Issue 5, pp. E47 - E48
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 5172 - 5172
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47312
Riluzole, an inhibitor of glutamate release, has shown the ability to inhibit melanoma cell xenograft growth. A phase 0 clinical trial of riluzole as a single... 
CYCLIN-DEPENDENT KINASES | ESOPHAGEAL-CARCINOMA | GROWTH-FACTOR-BETA | ACTIVIN-A | LINKER PHOSPHORYLATION | TGF-BETA | PLASMINOGEN-ACTIVATOR | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | IN-VIVO | MALIGNANT-MELANOMA | Melanoma - metabolism | Up-Regulation | Glutamic Acid - genetics | Humans | Smad2 Protein - metabolism | Glycogen Synthase Kinase 3 beta | Transplantation, Heterologous | Smad3 Protein - metabolism | Melanoma - pathology | Glycogen Synthase Kinase 3 - metabolism | Smad3 Protein - genetics | Animals | Signal Transduction - drug effects | Melanoma - genetics | Smad2 Protein - genetics | Cell Line, Tumor | Glutamic Acid - metabolism | Mice | Riluzole - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Transforming Growth Factor beta - metabolism | Dosage and administration | Drug therapy | Riluzole | Melanoma | Phosphorylation | Smad protein | Serine | Transforming growth factor-b | Colorectal cancer | Oncology | AKT protein | Smad3 protein | Glutamic acid receptors | Kinases | Medical schools | Skin cancer | Signal transduction | Receptors | Smad2 protein | Surgery | Xenografts | Growth factors | Medical research | Glycogen | Glycogen synthase kinase 3 | MAP kinase | siRNA | Dentistry | Gene expression | Patients | 1-Phosphatidylinositol 3-kinase | Medicine | Studies | Signaling | Inhibitors | Protein kinase | Pharmacy | Glutamic acid receptors (metabotropic) | Esophageal cancer | Tumors
Journal Article
Oncogenesis, ISSN 2157-9024, 11/2018, Volume 7, Issue 11, pp. 86 - 12
Our research group demonstrated that riluzole, an inhibitor of glutamatergic signaling reduced melanoma cell proliferation in vitro and tumor progression in... 
RILUZOLE | INVASION | METABOTROPIC GLUTAMATE-RECEPTOR-1 | ONCOLOGY | GLUTAMATE | RESISTANCE | MUTATIONS | ANTIPORTER | RECEPTORS | EXPRESSION | GRM1 | Cell proliferation | Cloning | Melanoma | Amino acids | Patients | Lysates | Cell growth | Transfection | Biopsy | Xenografts | Tumorigenesis | Glutamatergic transmission | Cancer
Journal Article