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science & technology (12) 12
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abstracts from the 3rd biennial conference on pediatric neuro-oncology basic and translational research (1) 1
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1. Full Text The landscape of genomic alterations across childhood cancers
by Gröbner, Susanne N and Worst, Barbara C and Weischenfeldt, Joachim and Buchhalter, Ivo and Kleinheinz, Kortine and Rudneva, Vasilisa A and Johann, Pascal D and Balasubramanian, Gnana Prakash and Segura-Wang, Maia and Brabetz, Sebastian and Bender, Sebastian and Hutter, Barbara and Sturm, Dominik and Pfaff, Elke and Hübschmann, Daniel and Zipprich, Gideon and Heinold, Michael and Eils, Jürgen and Lawerenz, Christian and Erkek, Serap and Lambo, Sander and Waszak, Sebastian and Blattmann, Claudia and Borkhardt, Arndt and Kuhlen, Michaela and Eggert, Angelika and Fulda, Simone and Gessler, Manfred and Wegert, Jenny and Kappler, Roland and Baumhoer, Daniel and Burdach, Stefan and Kirschner-Schwabe, Renate and Kontny, Udo and Kulozik, Aneas E and Lohmann, Dietmar and Hettmer, Simone and Eckert, Cornelia and Bielack, Stefan and Nathrath, Michaela and Niemeyer, Charlotte and Richter, Günther H and Schulte, Johannes and Siebert, Reiner and Westermann, Frank and Molenaar, Jan J and Vassal, Gilles and Koster, Jan and Zwijnenburg, Danny A and Kool, Marcel and ICGC PedBrain-Seq Project ICGC and ICGC MMML-Seq Project and ICGC PedBrain-Seq Project
Nature (London), ISSN 0028-0836, 2018, Volume 555, Issue 7696, pp. 321 - 327
no | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic Predisposition to Disease - genetics | Genomics | Humans | Mutation Rate | Neoplasms - classification | DNA Copy Number Variations - genetics | Germ-Line Mutation - genetics | Molecular Targeted Therapy | Mutation - genetics | Chromothripsis | Genome, Human - genetics | Tumor Suppressor Protein p53 - genetics | Neoplasms - drug therapy | Young Adult | Diploidy | Neoplasms - genetics | Adolescent | Adult | Child | Cohort Studies | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Health aspects | Cancer in children | Cancer | Medical research | Young adults | p53 Protein | Genes | Clinical trials | Workflow | Genomes | Neoplasms | Studies | Alterations | Genetic analysis | Adults | Mutation | Children | Adolescents | Signatures | Bioinformatics | Tumors | Index Medicus
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2. Full Text Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
by Mack, Stephen C and Pajtler, Kristian W and Chavez, Lukas and Okonechnikov, Konstantin and Bertrand, Kelsey C and Wang, Xiuxing and Erkek, Serap and Federation, Alexander and Song, Anne and Lee, Christine and Wang, Xin and McDonald, Laura and Morrow, James J and Saiakhova, Alina and Sin-Chan, Patrick and Wu, Qiulian and Michaelraj, Kulandaimanuvel Antony and Miller, Tyler E and Hubert, Christopher G and Ryzhova, Marina and Garzia, Livia and Donovan, Laura and Dombrowski, Stephen and Factor, Daniel C and Luu, Betty and Valentim, Claudia L.L and Gimple, Ryan C and Morton, Andrew and Kim, Leo and Prager, Briana C and Lee, John J.Y and Wu, Xiaochong and Zuccaro, Jennifer and Thompson, Yuan and Holgado, Borja L and Reimand, Jüri and Ke, Susan Q and Tropper, Adam and Lai, Sisi and Vijayarajah, Senthuran and Doan, Sylvia and Mahadev, Vaidehi and Miñan, Ana Fernandez and Gröbner, Susanne N and Lienhard, Matthias and Zapatka, Marc and Huang, Zhiqin and Aldape, Kenneth D and Carcaboso, Angel M and Houghton, Peter J and Keir, Stephen T and Milde, Till and Witt, Hendrik and Li, Yan and Li, Chao-Jun and Bian, Xiu-Wu and Jones, David T.W and Scott, Ian and Singh, Sheila K and Huang, Annie and Dirks, Peter B and Bouffet, Eric and Bradner, James E and Ramaswamy, Vijay and Jabado, Nada and Rutka, James T and Northcott, Paul A and Lupien, Mathieu and Lichter, Peter and Korshunov, Andrey and Scacheri, Peter C and Pfister, Stefan M and Kool, Marcel and Taylor, Michael D and Rich, Jeremy N
Nature (London), ISSN 0028-0836, 01/2018, Volume 553, Issue 7686, pp. 101 - 105
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oncogenes - genetics | Gene Regulatory Networks - genetics | Humans | Gene Expression Regulation, Neoplastic | Ependymoma - classification | Ependymoma - genetics | Molecular Targeted Therapy | Ependymoma - drug therapy | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | RNA Interference | Base Sequence | Ependymoma - pathology | Female | Enhancer Elements, Genetic - genetics | Mice | Precision Medicine | Brain | NF-κB protein | Medical research | Chromatin | Animal models | Transcription | Brain tumors | Brain cancer | Genomics | Gene expression | Ribonucleic acid--RNA | Cancer therapies | Gene fusion | Gene sequencing | Yes-associated protein | Enhancers | Chemotherapy | Neurospheres | DNA methylation | Drug discovery | RelA protein | Gene mapping | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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3. Full Text The whole-genome landscape of medulloblastoma subtypes
by Northcott, Paul A and Buchhalter, Ivo and Morrissy, A. Sorana and Hovestadt, Volker and Weischenfeldt, Joachim and Ehrenberger, Tobias and Gröbner, Susanne and Segura-Wang, Maia and Zichner, Thomas and Rudneva, Vasilisa A and Warnatz, Hans-Jörg and Sidiropoulos, Nikos and Phillips, Aaron H and Schumacher, Steven and Kleinheinz, Kortine and Waszak, Sebastian M and Erkek, Serap and Jones, David T. W and Worst, Barbara C and Kool, Marcel and Zapatka, Marc and Jäger, Natalie and Chavez, Lukas and Hutter, Barbara and Bieg, Matthias and Paramasivam, Nagarajan and Heinold, Michael and Gu, Zuguang and Ishaque, Naveed and Jäger-Schmidt, Christina and Imbusch, Charles D and Jugold, Alke and Hübschmann, Daniel and Risch, Thomas and Amstislavskiy, Vyacheslav and Gonzalez, Francisco German Roiguez and Weber, Ursula D and Wolf, Stephan and Robinson, Giles W and Zhou, Xin and Wu, Gang and Finkelstein, David and Liu, Yanling and Cavalli, Florence M. G and Luu, Betty and Ramaswamy, Vijay and Wu, Xiaochong and Koster, Jan and Ryzhova, Marina and Cho, Yoon-Jae and Pomeroy, Scott L and Herold-Mende, Christel and Schuhmann, Martin and Ebinger, Martin and Liau, Linda M and Mora, Jaume and McLendon, Roger E and Jabado, Nada and Kumabe, Toshihiro and Chuah, Eric and Ma, Yussanne and Moore, Richard A and Mungall, Anew J and Mungall, Karen L and Thiessen, Nina and Tse, Kane and Wong, Tina and Jones, Steven J. M and Witt, Olaf and Milde, Till and von Deimling, Aneas and Capper, David and Korshunov, Aney and Yaspo, Marie-Laure and Kriwacki, Richard and Gajjar, Amar and Zhang, Jinghui and Beroukhim, Rameen and Fraenkel, Ernest and Korbel, Jan O and Brors, Benedikt and Schlesner, Matthias and Eils, Roland and Marra, Marco A and Pfister, Stefan M and Taylor, Michael D and Lichter, Peter
Nature (London), ISSN 0028-0836, 2017, Volume 547, Issue 7663, pp. 311 - 317
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oncogenes - genetics | Datasets as Topic | Genomics | Humans | Carcinogenesis - genetics | Transcription Factors - genetics | Molecular Targeted Therapy | Genome, Human - genetics | Whole Genome Sequencing | Muscle Proteins - genetics | Carrier Proteins - genetics | DNA Methylation | Wnt Proteins - genetics | DNA Mutational Analysis | Epistasis, Genetic | Mutation | Medulloblastoma - genetics | Medulloblastoma - classification | Cohort Studies | Medical research | Medulloblastoma | Medicine, Experimental | Genomes | Genetic aspects | Research | Nucleotide sequencing | Varieties | DNA sequencing | Medical colleges | Care and treatment | Analysis | Methylation | Genetic research | Tumors in children | Gene mutations | Brain | Toxicity | Brain tumors | Brain cancer | Genes | Biodiversity | Patients | Heterogeneity | DNA methylation | Children | Index Medicus
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4. Full Text The molecular landscape of ETMR at diagnosis and relapse
by Lambo, Sander and Gröbner, Susanne N and Rausch, Tobias and Waszak, Sebastian M and Schmidt, Christin and Gorthi, Aparna and Romero, July Carolina and Mauermann, Monika and Brabetz, Sebastian and Krausert, Sonja and Buchhalter, Ivo and Koster, Jan and Zwijnenburg, Danny A and Sill, Martin and Hübner, Jens-Martin and Mack, Norman and Schwalm, Benjamin and Ryzhova, Marina and Hovestadt, Volker and Papillon-Cavanagh, Simon and Chan, Jennifer A and Landgraf, Pablo and Ho, Ben and Milde, Till and Witt, Olaf and Ecker, Jonas and Sahm, Felix and Sumerauer, David and Ellison, David W and Orr, Brent A and Darabi, Anna and Haberler, Christine and Figarella-Branger, Dominique and Wesseling, Pieter and Schittenhelm, Jens and Remke, Marc and Taylor, Michael D and Gil-da-Costa, Maria J and Łastowska, Maria and Grajkowska, Wiesława and Hasselblatt, Martin and Hauser, Peter and Pietsch, Torsten and Uro-Coste, Emmanuelle and Bourdeaut, Franck and Masliah-Planchon, Julien and Rigau, Valérie and Alexanescu, Sanda and Wolf, Stephan and Li, Xiao-Nan and Schüller, Ulrich and Snuderl, Matija and Karajannis, Matthias A and Giangaspero, Felice and Jabado, Nada and von Deimling, Aneas and Jones, David T. W and Korbel, Jan O and von Hoff, Katja and Lichter, Peter and Huang, Annie and Bishop, Alexander J. R and Pfister, Stefan M and Korshunov, Aney and Kool, Marcel and et al
Nature (London), ISSN 0028-0836, 12/2019, Volume 576, Issue 7786, pp. 274 - 280
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | DEAD-box RNA Helicases - genetics | Recurrence | Poly(ADP-ribose) Polymerases - genetics | Ribonuclease III - genetics | Humans | DNA Topoisomerases, Type I - genetics | MicroRNAs - genetics | Neoplasms, Germ Cell and Embryonal - genetics | Polymorphism, Single Nucleotide | Mutation | Poly(ADP-ribose) Polymerase Inhibitors | Neoplasms, Germ Cell and Embryonal - diagnosis | Brain tumors | Medical treatment | Conservation | Poly(ADP-ribose) polymerase | Genomes | Nucleotides | Ribonucleic acid--RNA | Cisplatin | Gene sequencing | Genomic instability | Amplification | MicroRNAs | DNA methylation | miRNA | R-loops | Chromosomes | Tumors | Index Medicus | Life Sciences | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Cancer and Oncology | Cancer och onkologi
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5. Full Text A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
by Alioto, Tyler S and Buchhalter, Ivo and Derdak, Sophia and Hutter, Barbara and Eldridge, Matthew D and Hovig, Eivind and Heisler, Lawrence E and Beck, Timothy A and Simpson, Jared T and Tonon, Laurie and Sertier, Anne-Sophie and Patch, Ann-Marie and Jäger, Natalie and Ginsbach, Philip and Drews, Ruben and Paramasivam, Nagarajan and Kabbe, Rolf and Chotewutmontri, Sasithorn and Diessl, Nicolle and Previti, Christopher and Schmidt, Sabine and Brors, Benedikt and Feuerbach, Lars and Heinold, Michael and Gröbner, Susanne and Korshunov, Andrey and Tarpey, Patrick S and Butler, Adam P and Hinton, Jonathan and Jones, David and Menzies, Andrew and Raine, Keiran and Shepherd, Rebecca and Stebbings, Lucy and Teague, Jon W and Ribeca, Paolo and Giner, Francesc Castro and Beltran, Sergi and Raineri, Emanuele and Dabad, Marc and Heath, Simon C and Gut, Marta and Denroche, Robert E and Harding, Nicholas J and Yamaguchi, Takafumi N and Fujimoto, Akihiro and Nakagawa, Hidewaki and Quesada, Víctor and Valdés-Mas, Rafael and Nakken, Sigve and Vodák, Daniel and Bower, Lawrence and Lynch, Andrew G and Anderson, Charlotte L and Waddell, Nicola and Pearson, John V and Grimmond, Sean M and Peto, Myron and Spellman, Paul and He, Minghui and Kandoth, Cyriac and Lee, Semin and Zhang, John and Létourneau, Louis and Ma, Singer and Seth, Sahil and Torrents, David and Xi, Liu and Wheeler, David A and López-Otín, Carlos and Campo, Elías and Campbell, Peter J and Boutros, Paul C and Puente, Xose S and Gerhard, Daniela S and Pfister, Stefan M and McPherson, John D and Hudson, Thomas J and Schlesner, Matthias and Lichter, Peter and Eils, Roland and Jones, David T.W and Gut, Ivo G
Nature communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, pp. 10001 - 10001
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Mutation | Genome, Human | High-Throughput Nucleotide Sequencing - methods | Medulloblastoma - genetics | Humans | Leukemia, Lymphoid - genetics | Index Medicus | Càncer | Medical genetics | Mutació (Biologia) | Genètica mèdica | Genètica humana | Human genetics | Mutation (Biology) | Cancer
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6. Full Text A biobank of patient-derived pediatric brain tumor models
by Brabetz, Sebastian and Leary, Sarah E. S and Gröbner, Susanne N and Nakamoto, Madison W and Şeker-Cin, Huriye and Girard, Emily J and Cole, Bonnie and Strand, Anew D and Bloom, Karina L and Hovestadt, Volker and Mack, Norman L and Pakiam, Fiona and Schwalm, Benjamin and Korshunov, Aney and Balasubramanian, Gnana Prakash and Northcott, Paul A and Peo, Kyle D and Dey, Joyoti and Hansen, Stacey and Ditzler, Sally and Lichter, Peter and Chavez, Lukas and Jones, David T. W and Koster, Jan and Pfister, Stefan M and Kool, Marcel and Olson, James M
Nature medicine, ISSN 1078-8956, 2018, Volume 24, Issue 11, pp. 1752 - 1761
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunohistochemistry | Pediatrics | Genomics | Humans | Brain Neoplasms - pathology | Child, Preschool | Male | DNA Methylation - genetics | Xenograft Model Antitumor Assays - methods | Animals | Biological Specimen Banks | Cell Line, Tumor | Female | Mice | Mutation | Child | Cell culture | Brain | Copy number | Brain tumors | Brain cancer | Xenotransplantation | Histology | Gene expression | Patients | Subgroups | Heterogeneity | Molecular modelling | Xenografts | DNA methylation | Children | Methylation | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus
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7. Full Text Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
by Bugaytsova, Jeanna A and Björnham, Oscar and Chernov, Yevgen A and Gideonsson, Pär and Henriksson, Sara and Mendez, Melissa and Sjöström, Rolf and Mahdavi, Jafar and Shevtsova, Anna and Ilver, Dag and Moonens, Kristof and Quintana-Hayashi, Macarena P and Moskalenko, Roman and Aisenbrey, Christopher and Bylund, Göran and Schmidt, Alexej and Åberg, Anna and Brännström, Kristoffer and Königer, Verena and Vikström, Susanne and Rakhimova, Lena and Hofer, Anders and Ögren, Johan and Liu, Hui and Goldman, Matthew D and Whitmire, Jeannette M and Ådén, Jörgen and Younson, Justine and Kelly, Charles G and Gilman, Robert H and Chowdhury, Abhijit and Mukhopadhyay, Asish K and Nair, G. Balakrish and Papadakos, Konstantinos S and Martinez-Gonzalez, Beatriz and Sgouras, Dionyssios N and Engstrand, Lars and Unemo, Magnus and Danielsson, Dan and Suerbaum, Sebastian and Oscarson, Stefan and Morozova-Roche, Ludmilla A and Olofsson, Anders and Gröbner, Gerhard and Holgersson, Jan and Esberg, Anders and Strömberg, Nicklas and Landström, Maréne and Eldridge, Angela M and Chromy, Brett A and Hansen, Lori M and Solnick, Jay V and Lindén, Sara K and Haas, Rainer and Dubois, Andre and Merrell, D. Scott and Schedin, Staffan and Remaut, Han and Arnqvist, Anna and Berg, Douglas E and Borén, Thomas and Göteborgs universitet and Gothenburg University and Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin and Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi and Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Cell host & microbe, ISSN 1931-3128, 03/2017, Volume 21, Issue 3, pp. 376 - 389
gastric acidity | multimerization | diversity | Helicobacter pylori | gastric cancer | subpopulations |