Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods...
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7369, pp. 343 - 348
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression...
X-CHROMOSOME | HUMAN GENOME | CONSERVATION | RNA-SEQ | DOSAGE COMPENSATION | MULTIDISCIPLINARY SCIENCES | SEQUENCE | HUMANS | SEX-CHROMOSOMES | PRIMATES | CHIMPANZEES | Animals | Humans | RNA, Messenger - genetics | Gene Expression Profiling | Phylogeny | Principal Component Analysis | X Chromosome - genetics | Evolution, Molecular | Physiological aspects | Genetic aspects | Research | Gene expression | Mammals | Genes | Trees | Brain | Evolution | Genomes
X-CHROMOSOME | HUMAN GENOME | CONSERVATION | RNA-SEQ | DOSAGE COMPENSATION | MULTIDISCIPLINARY SCIENCES | SEQUENCE | HUMANS | SEX-CHROMOSOMES | PRIMATES | CHIMPANZEES | Animals | Humans | RNA, Messenger - genetics | Gene Expression Profiling | Phylogeny | Principal Component Analysis | X Chromosome - genetics | Evolution, Molecular | Physiological aspects | Genetic aspects | Research | Gene expression | Mammals | Genes | Trees | Brain | Evolution | Genomes
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7485, pp. 635 - 640
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their...
SEQ REVEALS | X-CHROMOSOME | HUMAN GENOME | LONG NONCODING RNAS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | NETWORKS | PLURIPOTENCY | DIFFERENTIATION | IDENTIFICATION | VERTEBRATE | Conserved Sequence - genetics | Multigene Family | Genomics | Humans | Transcriptome | Gene Expression Regulation, Developmental - genetics | RNA Precursors - genetics | RNA, Long Noncoding - genetics | Proteins - genetics | Primates - genetics | Animals | Chickens - genetics | Anura - genetics | Mice | MicroRNAs - genetics | Evolution, Molecular | Proteins | Phylogenetics | Genomes | Placenta | Genes | Age
SEQ REVEALS | X-CHROMOSOME | HUMAN GENOME | LONG NONCODING RNAS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | NETWORKS | PLURIPOTENCY | DIFFERENTIATION | IDENTIFICATION | VERTEBRATE | Conserved Sequence - genetics | Multigene Family | Genomics | Humans | Transcriptome | Gene Expression Regulation, Developmental - genetics | RNA Precursors - genetics | RNA, Long Noncoding - genetics | Proteins - genetics | Primates - genetics | Animals | Chickens - genetics | Anura - genetics | Mice | MicroRNAs - genetics | Evolution, Molecular | Proteins | Phylogenetics | Genomes | Placenta | Genes | Age
Journal Article
PLoS Biology, ISSN 1544-9173, 05/2012, Volume 10, Issue 5, p. e1001328
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that...
Y-CHROMOSOMES | RNA-SEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHICKEN | BIOLOGY | SEX-CHROMOSOME INACTIVATION | UP-REGULATION | X-LINKED GENES | Gene Duplication | Mammals - genetics | Testis - cytology | Gene Expression Regulation | Transcriptome | Male | Chromosome Mapping | Sex Chromosomes | Dosage Compensation, Genetic | Animals | Genes, X-Linked | Sequence Analysis, RNA | Base Sequence | Computer Simulation | Female | Birds - genetics | Evolution, Molecular | Birds | Genetics | Gene expression | Marsupials | Chromosomes
Y-CHROMOSOMES | RNA-SEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHICKEN | BIOLOGY | SEX-CHROMOSOME INACTIVATION | UP-REGULATION | X-LINKED GENES | Gene Duplication | Mammals - genetics | Testis - cytology | Gene Expression Regulation | Transcriptome | Male | Chromosome Mapping | Sex Chromosomes | Dosage Compensation, Genetic | Animals | Genes, X-Linked | Sequence Analysis, RNA | Base Sequence | Computer Simulation | Female | Birds - genetics | Evolution, Molecular | Birds | Genetics | Gene expression | Marsupials | Chromosomes
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7497, pp. 488 - 493
Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y...
W-CHROMOSOME | SEX-DETERMINING REGION | ALIGNMENT | DNA-SEQUENCE | MULTIDISCIPLINARY SCIENCES | MOUSE | DETERMINING GENE | IDENTIFICATION | EXPRESSION | LONG ARM | PLATYPUS | Mammals - genetics | Gene Dosage - genetics | Conserved Sequence - genetics | Receptors, Transforming Growth Factor beta - genetics | Testis - metabolism | Marsupialia - genetics | Spermatogenesis - genetics | Genomics | Male | Transcriptome - genetics | Receptors, Peptide - genetics | Selection, Genetic - genetics | Y Chromosome - genetics | Animals | Sex Chromosomes - genetics | Female | Spatio-Temporal Analysis | Genes, sry - genetics | High-Throughput Nucleotide Sequencing | Birds - genetics | Evolution, Molecular | Sex chromosomes | Physiological aspects | Genetic research | Research | Nucleotide sequencing | Genetic transcription | DNA sequencing | Trees | Genes | Genomes | Mammals | Monkeys & apes | Proteins | Marsupials | Phylogenetics | Evolution | Stratigraphy | Females | Chromosomes
W-CHROMOSOME | SEX-DETERMINING REGION | ALIGNMENT | DNA-SEQUENCE | MULTIDISCIPLINARY SCIENCES | MOUSE | DETERMINING GENE | IDENTIFICATION | EXPRESSION | LONG ARM | PLATYPUS | Mammals - genetics | Gene Dosage - genetics | Conserved Sequence - genetics | Receptors, Transforming Growth Factor beta - genetics | Testis - metabolism | Marsupialia - genetics | Spermatogenesis - genetics | Genomics | Male | Transcriptome - genetics | Receptors, Peptide - genetics | Selection, Genetic - genetics | Y Chromosome - genetics | Animals | Sex Chromosomes - genetics | Female | Spatio-Temporal Analysis | Genes, sry - genetics | High-Throughput Nucleotide Sequencing | Birds - genetics | Evolution, Molecular | Sex chromosomes | Physiological aspects | Genetic research | Research | Nucleotide sequencing | Genetic transcription | DNA sequencing | Trees | Genes | Genomes | Mammals | Monkeys & apes | Proteins | Marsupials | Phylogenetics | Evolution | Stratigraphy | Females | Chromosomes
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7192, pp. 175 - 183
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian...
MONOTREME | CATHELICIDINS | ELECTRORECEPTION | ARRANGEMENT | MONODELPHIS-DOMESTICA | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | CHROMOSOMES | EXPRESSION | INSIGHTS | FAMILY | Mammals - genetics | Platypus - immunology | Repetitive Sequences, Nucleic Acid - genetics | Humans | Genome - genetics | Male | Milk Proteins - genetics | Reptiles - genetics | Phylogeny | Platypus - genetics | Platypus - physiology | Spermatozoa - metabolism | Venoms - genetics | Sequence Analysis, DNA | Genomic Imprinting - genetics | Animals | Base Composition | Dentition | Receptors, Odorant - genetics | Zona Pellucida - metabolism | Female | MicroRNAs - genetics | Immunity - genetics | Evolution, Molecular | Temperature | Digestive system | Genomics | Evolution | Reproductive system | Artificial chromosomes | Marine mammals | Index Medicus
MONOTREME | CATHELICIDINS | ELECTRORECEPTION | ARRANGEMENT | MONODELPHIS-DOMESTICA | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | CHROMOSOMES | EXPRESSION | INSIGHTS | FAMILY | Mammals - genetics | Platypus - immunology | Repetitive Sequences, Nucleic Acid - genetics | Humans | Genome - genetics | Male | Milk Proteins - genetics | Reptiles - genetics | Phylogeny | Platypus - genetics | Platypus - physiology | Spermatozoa - metabolism | Venoms - genetics | Sequence Analysis, DNA | Genomic Imprinting - genetics | Animals | Base Composition | Dentition | Receptors, Odorant - genetics | Zona Pellucida - metabolism | Female | MicroRNAs - genetics | Immunity - genetics | Evolution, Molecular | Temperature | Digestive system | Genomics | Evolution | Reproductive system | Artificial chromosomes | Marine mammals | Index Medicus
Journal Article
Genome Biology, ISSN 1474-7596, 03/2013, Volume 14, Issue 3, pp. R26 - R26
Background: Birds have a ZZ male: ZW female sex chromosome system and while the Z-linked DMRT1 gene is necessary for testis development, the exact mechanism of...
Embryonic chicken gonad | Avian sex | RNA-seq | W chromosome | Sex determination | AVIAN SEX-CHROMOSOMES | DMRT1 | DOSAGE COMPENSATION | OVARIAN DEVELOPMENT | LINKED GENES | EARLY FEMALE EMBRYOS | TRANSCRIPTS | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | VERTEBRATES | RNA seq | BIRDS | Gonads - embryology | Reproducibility of Results | Molecular Sequence Annotation | RNA, Messenger - genetics | Sex Differentiation - genetics | Gene Expression Regulation | Male | Gene Expression Profiling | Blastoderm - metabolism | Sex Characteristics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, RNA - methods | Gonads - metabolism | Animals | Sex Chromosomes - genetics | Conserved Sequence | Chickens - genetics | Female | Genetic Linkage | Avian sex, RNA-seq | Research
Embryonic chicken gonad | Avian sex | RNA-seq | W chromosome | Sex determination | AVIAN SEX-CHROMOSOMES | DMRT1 | DOSAGE COMPENSATION | OVARIAN DEVELOPMENT | LINKED GENES | EARLY FEMALE EMBRYOS | TRANSCRIPTS | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | VERTEBRATES | RNA seq | BIRDS | Gonads - embryology | Reproducibility of Results | Molecular Sequence Annotation | RNA, Messenger - genetics | Sex Differentiation - genetics | Gene Expression Regulation | Male | Gene Expression Profiling | Blastoderm - metabolism | Sex Characteristics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, RNA - methods | Gonads - metabolism | Animals | Sex Chromosomes - genetics | Conserved Sequence | Chickens - genetics | Female | Genetic Linkage | Avian sex, RNA-seq | Research
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99687
The importance of the Piwi-interacting RNA (piRNA) pathway for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control raises...
HUMAN COLON | NOVO DNA METHYLATION | LINE-1 | PROTEIN | RETROTRANSPOSABLE ELEMENTS | MULTIDISCIPLINARY SCIENCES | HIWI GENE | EXPRESSION | MAELSTROM | PIWI | HYPOMETHYLATION | RNA, Small Interfering - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Molecular Sequence Data | RNA, Messenger - metabolism | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | In Situ Hybridization | Transfection | Base Sequence | Aged, 80 and over | Adult | Female | Ovary - metabolism | Neoplasms, Glandular and Epithelial - pathology | Argonaute Proteins - metabolism | Ovary - pathology | Argonaute Proteins - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | Signal Transduction - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Aged | Neoplasm Staging | RNA, Small Interfering - metabolism | RNA | Genes | Genomics | Genetic research | Genomes | Genetic aspects | Comparative analysis | Methylation | Ovarian cancer | Ovarian carcinoma | Transcription | Nonsense mutation | Epithelial cells | Spermatogenesis | Brain cancer | Metastasis | Tissues | Clonal deletion | DNA methylation | Deletion | Discipline | Deoxyribonucleic acid--DNA | Splicing | Invasiveness | Tumor cells | Gynecology | Benign | Stop codon | Tumor cell lines | Mammals | Gene expression | Ribonucleic acid--RNA | Obstetrics | Studies | Insects | Stromal cells | Medical prognosis | Cell lines | Stem cells | Epigenetics | Mutation | Aberration | Tumors | Cancer | Deoxyribonucleic acid | Ribonucleic acid | DNA
HUMAN COLON | NOVO DNA METHYLATION | LINE-1 | PROTEIN | RETROTRANSPOSABLE ELEMENTS | MULTIDISCIPLINARY SCIENCES | HIWI GENE | EXPRESSION | MAELSTROM | PIWI | HYPOMETHYLATION | RNA, Small Interfering - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Molecular Sequence Data | RNA, Messenger - metabolism | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | In Situ Hybridization | Transfection | Base Sequence | Aged, 80 and over | Adult | Female | Ovary - metabolism | Neoplasms, Glandular and Epithelial - pathology | Argonaute Proteins - metabolism | Ovary - pathology | Argonaute Proteins - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | Signal Transduction - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | Aged | Neoplasm Staging | RNA, Small Interfering - metabolism | RNA | Genes | Genomics | Genetic research | Genomes | Genetic aspects | Comparative analysis | Methylation | Ovarian cancer | Ovarian carcinoma | Transcription | Nonsense mutation | Epithelial cells | Spermatogenesis | Brain cancer | Metastasis | Tissues | Clonal deletion | DNA methylation | Deletion | Discipline | Deoxyribonucleic acid--DNA | Splicing | Invasiveness | Tumor cells | Gynecology | Benign | Stop codon | Tumor cell lines | Mammals | Gene expression | Ribonucleic acid--RNA | Obstetrics | Studies | Insects | Stromal cells | Medical prognosis | Cell lines | Stem cells | Epigenetics | Mutation | Aberration | Tumors | Cancer | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2018, Volume 13, Issue 3, p. e0191904
Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian...
RODENT | EVOLUTION | MT2 RECEPTORS | CLONING | MULTIDISCIPLINARY SCIENCES | XENOPUS MELANOPHORES | SEX-CHROMOSOMES | ANTAGONISTS | ORPHAN GPR50 RECEPTOR | AGONISTS | MOLECULAR PHARMACOLOGY | Melatonin | Cell receptors | Platypus | Models | Genetic aspects | Properties | Protein binding | Binding | Melatonin receptors | Brain | Neurosciences | Divergence | G protein-coupled receptors | Genes | Pharmacology | Phylogeny | Mammals | Aquatic mammals | Proteins | Receptors | Evolution | Ligands | Life Sciences
RODENT | EVOLUTION | MT2 RECEPTORS | CLONING | MULTIDISCIPLINARY SCIENCES | XENOPUS MELANOPHORES | SEX-CHROMOSOMES | ANTAGONISTS | ORPHAN GPR50 RECEPTOR | AGONISTS | MOLECULAR PHARMACOLOGY | Melatonin | Cell receptors | Platypus | Models | Genetic aspects | Properties | Protein binding | Binding | Melatonin receptors | Brain | Neurosciences | Divergence | G protein-coupled receptors | Genes | Pharmacology | Phylogeny | Mammals | Aquatic mammals | Proteins | Receptors | Evolution | Ligands | Life Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2004, Volume 101, Issue 46, pp. 16257 - 16261
The platypus (2 n = 52) has a complex karyotype that has been controversial over the last three decades. The presence of unpaired chromosomes and an unknown...
multivalent chain | X-inactivation | X-CHROMOSOMES | COMPLEX | GENE | MULTIDISCIPLINARY SCIENCES | monotremes | HIGHLY CONSERVED REGION | sex determination | TRANSLOCATION HETEROZYGOSITY | TERMITE | Chromosome Painting | Male | Platypus - genetics | Y Chromosome - genetics | Biological Evolution | Dosage Compensation, Genetic | Animals | Sex Determination Processes | Karyotyping | Female | Models, Genetic | Chromosome Pairing | X Chromosome - genetics | Monotremes | Biological Sciences
multivalent chain | X-inactivation | X-CHROMOSOMES | COMPLEX | GENE | MULTIDISCIPLINARY SCIENCES | monotremes | HIGHLY CONSERVED REGION | sex determination | TRANSLOCATION HETEROZYGOSITY | TERMITE | Chromosome Painting | Male | Platypus - genetics | Y Chromosome - genetics | Biological Evolution | Dosage Compensation, Genetic | Animals | Sex Determination Processes | Karyotyping | Female | Models, Genetic | Chromosome Pairing | X Chromosome - genetics | Monotremes | Biological Sciences
Journal Article