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1. Full Text Rare variants are common in schizophrenia
by Gratten, Jacob
Nature Neuroscience, ISSN 1097-6256, 10/2016, Volume 19, Issue 11, pp. 1426 - 1428
A large DNA sequencing study of schizophrenia finds more evidence that rare inherited coding mutations across many genes contribute to risk of the disorder.... 
RISK | LOCI | MUTATIONS | NEUROSCIENCES | GENOME-WIDE ASSOCIATION | Schizophrenia | Genetic Predisposition to Disease | Polymorphism, Single Nucleotide | Humans | Physiological aspects | Genetic aspects | Research | Genetic variation | Risk factors | Index Medicus
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2. Full Text Sizing up whole-genome sequencing studies of common diseases news-and-views
by Wray, Naomi R and Gratten, Jacob
Nature Genetics, ISSN 1061-4036, 05/2018, Volume 50, Issue 5, pp. 635 - 637
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3. Full Text Sizing up whole-genome sequencing studies of common diseases
by Wray, NR and Gratten, J
NATURE GENETICS, ISSN 1061-4036, 05/2018, Volume 50, Issue 5, pp. 635 - 637
Werling et al.3 analyzed WGS data from 519 autism spectrum disorder (ASD) quartet families (child, unaffected sibling and two parents) from the Simons Simplex... 
GENETIC ARCHITECTURE | DE-NOVO MUTATIONS | ASSOCIATION | GENETICS & HEREDITY | Medical research | Genomics | Genetic research | Medicine, Experimental | Genomes | Genetic aspects | Nucleotide sequencing | DNA sequencing | Studies | Hypotheses | Annotations | Disease | Families & family life | Mutation | Gene sequencing
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4. Full Text Genetic pleiotropy in complex traits and diseases: Implications for genomic medicine
by Gratten, Jacob and Visscher, Peter M
Genome Medicine, ISSN 1756-994X, 07/2016, Volume 8, Issue 1, pp. 78 - 78
  A form of pleiotropy commonly encountered in GWAS is that trait- or disease-associated single nucleotide polymorphisms (SNPs) are frequently also associated... 
GWAS | GENETICS & HEREDITY | Psychotic Disorders - diagnosis | Genome-Wide Association Study | Quantitative Trait, Heritable | Rett Syndrome - diagnosis | Humans | Genotype | Genetic Pleiotropy | Arthritis, Rheumatoid - pathology | Genetic Variation | Arthritis, Rheumatoid - genetics | Phenotype | Psychotic Disorders - genetics | Animals | Epistasis, Genetic | Rett Syndrome - pathology | Psychotic Disorders - pathology | Models, Genetic | Quantitative Trait Loci | Rett Syndrome - genetics | Arthritis, Rheumatoid - diagnosis | Type 2 diabetes | Pleiotropy | Care and treatment | Genomics | Genetic aspects | Research | Risk factors | Editing | Cardiovascular disease | Genomes | Gene expression | Medicine | Studies | Genotype & phenotype | Body mass index | Coronary vessels | Rheumatoid arthritis | DNA methylation | Mutation | Diabetes | Deoxyribonucleic acid--DNA | Index Medicus
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5. Full Text Life history trade-offs at a single locus maintain sexually selected genetic variation
by Johnston, Susan E and Gratten, Jacob and Berenos, Camillo and Pilkington, Jill G and Clutton-Brock, Tim H and Pemberton, Josephine M and Slate, Jon
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7469, pp. 93 - 95
Sexual selection, through intra-male competition or female choice, is assumed to be a source of strong and sustained directional selection in the wild(1,2). In... 
FITNESS | NATURAL-POPULATIONS | MULTIDISCIPLINARY SCIENCES | SHEEP | WEAPONRY | RESISTANCE | FRAMEWORK | POLYMORPHISM | ANTAGONISTIC SELECTION | LEK PARADOX | ASSOCIATION | Selection, Genetic | Reproduction - genetics | Genotype | Male | Mating Preference, Animal - physiology | Polymorphism, Genetic | Genetic Variation | Phenotype | Animals | Survival Analysis | Female | Horns | Receptors, G-Protein-Coupled - genetics | Confidence intervals | Genotype & phenotype | Animal reproduction | Population | Sheep | Gene loci | Males | Success | Index Medicus
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6. Full Text Biological insights from 108 schizophrenia-associated genetic loci
by Ripke, Stephan and Neale, Benjamin M and Corvin, Aiden and Walters, James T. R and Farh, Kai-How and Holmans, Peter A and Lee, Phil and Bulik-Sullivan, Brendan and Collier, David A and Huang, Hailiang and Pers, Tune H and Agartz, Ingrid and Agerbo, Esben and Albus, Margot and Alexander, Madeline and Amin, Farooq and Bacanu, Silviu A and Begemann, Martin and Belliveau, Richard A and Bene, Judit and Bergen, Sarah E and Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W and Bruggeman, Richard and Buccola, Nancy G and Buckner, Randy L and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Campion, Dominique and Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and Catts, Stanley V and Chambert, Kimberly D and Chan, Raymond C. K and Chen, Ronald Y. L and Chen, Eric Y. H and Cheng, Wei and Cheung, Eric F. C and Chong, Siow Ann and Cloninger, C. Robert and Cohen, David and Cohen, Nadine and Cormican, Paul and Craddock, Nick and Crowley, James J and Curtis, David and Davidson, Michael and Davis, Kenneth L and Degenhardt, Franziska and del Favero, Jurgen and Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and peau, Elodie and Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and Eichhammer, Peter and Eriksson, Johan and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farrell, Martilias S and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B and Friedl, Marion and Friedman, Joseph I and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Giegling, Ina and Giusti-Roíguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I and Golimbet, Vera and Gopal, Srihari and Gratten, Jacob and de Haan, Lieuwe and Hammer, Christian and Hamshere, Marian L and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette M and Henskens, Frans A and Herms, Stefan and Hirschhorn, Joel N and Hoffmann, Per and Hofman, Anea and Hollegaard, Mads V and Hougaard, David M and Ikeda, Masashi and Joa, Inge and ... and Psychiat Genomics Consortium and Wellcome Trust Case-Control Consor and Psychosis Endophenotypes Int Conso and Schizophrenia Working Group of the Psychiatric Genomics Consortium and Medicinska fakulteten and Institutionen för klinisk vetenskap and Psykiatri and Umeå universitet
Nature, ISSN 0028-0836, 2014, Volume 511, Issue 7510, pp. 421 - 427
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be... 
COMMON VARIANTS | MUTATIONS | MULTIDISCIPLINARY SCIENCES | CONFERRING RISK | GENOME-WIDE ASSOCIATION | Schizophrenia | Genetic research | Research | Health aspects | Analysis | Studies | Confidence intervals | Hypotheses | Genealogy | Sample size | Genomics | Genetics | Trends | Index Medicus | Clinical Medicine | Psykiatri | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Psychiatry
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7. Full Text Genome-wide association study identifies 74 loci associated with educational attainment
by Okbay, Aysu and Beauchamp, Jonathan and Fontana, M.A and Lee, James J and Pers, Tune and Rietveld, C.A and Turley, Patrick and Chen, G.-B and Emilsson, Valur and Meddens, S.F.W and Oskarsson, S and Pickrell, J.K and Thom, K and Timshel, P and Vlaming, Ronald and Abdellaoui, Abdel and Ahluwalia, Tarunveer Singh and Bacelis, Jonas and Baumbach, Clemens and Bjornsdottir, G and Brandsma, Johan and Pina Concas, M and Derringer, J and Furlotte, N.A and Galesloot, Tessel and Girotto, S and Gupta, R and Hall, Leanne M and Harris, Sarah and Hofer, E and Horikoshi, M and Huffman, Jennifer E and Kaasik, K and Kalafati, Ioanna-Panagiota and Karlsson, Robert and Kong, Augustine and Lahti, Jari and Lee, Sven and Deleeuw, C and Lind, Penelope and Lindgren, K.-O and Liu, T and Mangino, Massimo and Marten, Jonathan and Mihailov, Evelin and Miller, Mike and Most, Peter and Oldmeadow, Christopher and Payton, Antony and Pervjakova, Natalia and Peyrot, Wouter and Qian, Y and Raitakari, Olli and Rueedi, R and Salvi, E and Schmidt, B and Schraut, K.E and Shi, J and Smith, Albert Vernon and Poot, Raymond and St Pourcain, Beate and Teumer, Alexander and Thorleifsson, Gudmar and Verweij, Niek and Vuckovic, gana and Wellmann, J and Westra, Harm-Jan and Yang, J and Zhao, W and Zhu, Z and Alizadeh, Behrooz and Amin, Najaf and Bakshi, A and Baumeister, Sebastian and Biino, G and Bønnelykke, Klaus and Boyle, Patricia and Campbell, Harry and Cappuccio, F.P and Davies, Gail and Neve, Jan-Emmanuel and Deloukas, Panagiotis and Demuth, Ilja and Ding, J and Eibich, P and Eisele, L and Eklund, Niina and Evans, David and Faul, Jessica D and Feitosa, Mary Furlan and Forstner, Aneas and Gandin, Ilaria and Gunnarsson, B and Halldorsson, Bjarni and Harris, Tamara and Holliday, Elizabeth and Heath, Anew C and Hocking, L.J and Homuth, Georg and Horan, Mike and ... and LifeLines Cohort Study and Humanistisk-samhällsvetenskapliga vetenskapsområdet and Uppsala universitet and Statsvetenskapliga institutionen and Samhällsvetenskapliga fakulteten
Nature: international weekly journal of science, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 539 - 542
textabstractEducational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least... 
ACHIEVEMENT | TRAITS | MULTIDISCIPLINARY SCIENCES | HERITABILITY | Genome-Wide Association Study | Gene Expression Regulation - genetics | Humans | Molecular Sequence Annotation | Computational Biology | Fetus - metabolism | United Kingdom | Cognition | Educational Status | Bipolar Disorder - genetics | Gene-Environment Interaction | Brain - metabolism | Schizophrenia - genetics | Polymorphism, Single Nucleotide - genetics | Alzheimer Disease - genetics | Quantitative trait loci | Academic achievement | Genome-wide association studies | Genetic aspects | Observations | Studies | Genomes | Gene expression | Genes | Educational attainment | Meta-analysis | Index Medicus | Quantitative Finance | Samhällsvetenskap | Biological Sciences | Social Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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8. Full Text Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease
by Gratten, Jacob and Visscher, Peter M and Mowry, Bryan J and Wray, Naomi R
Nature Genetics, ISSN 1061-4036, 03/2013, Volume 45, Issue 3, pp. 234 - 238
Pedigree, linkage and association studies are consistent with heritable variation for complex disease due to the segregation of genetic factors in families and... 
HUMAN GENOME | MENTAL-RETARDATION | FUNCTIONAL IMPACT | GENES | GENETICS & HEREDITY | HUMAN EXOMES | SCHIZOPHRENIA | RISK | AUTISM SPECTRUM DISORDERS | COPY NUMBER VARIANTS | REVEALS | Autistic Disorder - genetics | Genetic Predisposition to Disease | Schizophrenia - genetics | Genetic Association Studies | Pedigree | Humans | Exons - genetics | Mutation | Open Reading Frames - genetics | Genetic Linkage | Quantitative genetics | Gene mutations | Genetic variation | Neuropsychiatry | Nucleotide sequencing | Research | Methods | DNA sequencing | Proteins | Studies | Genetics | Genes | Index Medicus
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9. Full Text Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
by Okbay, Aysu and Baselmans, B.M.L and Neve, Jan-Emmanuel and Turley, Patrick and Nivard, Michel and Fontana, M.A and Meddens, S.F.W and Linnér, R.K and Rietveld, C.A and Derringer, J and Gratten, Jacob and Lee, James J and Liu, J.Z and Vlaming, Ronald and SAhluwalia, T and Buchwald, J and Cavadino, Alana and Frazier-Wood, Alexis C and Furlotte, N.A and Garfield, V and Geisel, M.H and Gonzalez, Juan R and Haitjema, S and Karlsson, Robert and Der Laan, S.W and Ladwig, Karl-Heinz and Lahti, Jari and Lee, Sven and Lind, Penelope and Liu, T and Matteson, L and Mihailov, Evelin and Miller, Mike and CMinica, C and MNolte, I and Mook-Kanamori, Dennis and Most, Peter and Oldmeadow, Christopher and Qian, Yong and Raitakari, Olli and Rawal, R and Realo, A and Rueedi, R and Schmidt, B and Smith, Albert Vernon and Stergiakouli, Evangelia and Tanaka, Toshiko and Taylor, Kent and Wedenoja, J and Wellmann, J and Westra, Harm-Jan and MWillems, S and Zhao, W and Study, LifeLines Cohort and Amin, Najaf and Bakshi, A and Boyle, Patricia and Cherney, S and Cox, S.R and Davies, Gail and Davis, Oliver S and Ding, Jun and Direk, Nese and Eibich, P and Emeny, Rebecca and Fatemifar, G and Faul, J.D and Ferrucci, Luigi and Forstner, Aneas and Gieger, Christian and Gupta, R and Harris, Tamara B and Harris, Juliette and Holliday, Elizabeth and Hottenga, Jouke Jan and Jager, Philip and Kaakinen, Marika and Kajantie, Eero and Karhunen, V and Kolcic, Ivana and Kumari, Meena and Launer, Lenore and Franke, Lude and Li-Gao, R and Koini, M and Loukola, Anu and Marques-Vidal, P and Montgomery, Grant and Mosing, Miriam and Paternoster, Lavinia and Pattie, Alison and Petrovic, Katja and Pulkki-R'back, L and Quaye, Lydia and R'ikkönen, K and Rudan, Igor and Scott, Rodney and Smith, Jennifer A and Sutin, A.R and Trzaskowski, M and ... and LifeLines Cohort Study
Nature Genetics, ISSN 1061-4036, 06/2016, Volume 48, Issue 6, pp. 624 - 633
textabstractVery few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies.... 
PERSONALITY | COMMON VARIANTS | HUMAN HEIGHT | METAANALYSIS | DISEASE | GENETICS & HEREDITY | RISK | MAJOR DEPRESSION | HAPPINESS | HERITABILITY | RESOURCE | Neuroticism | Genome-Wide Association Study | Phenotype | Humans | Bayes Theorem | Anxiety Disorders - genetics | Polymorphism, Single Nucleotide | Depression - genetics | Genome-wide association studies | Genetic variation | Depression, Mental | Genetic aspects | Identification and classification | Methods | Risk factors | Studies | Psychological aspects | Consortia | Social sciences | Quality control | Personality | Genomes | Behavior | Mental depression | Statistics | Epidemiology | Meta-analysis | Index Medicus | Quantitative Finance
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10. Full Text Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
by Marshall, Christian R and Howrigan, Daniel P and Merico, Daniele and Thiruvahinapuram, Bhooma and Wu, Wenting and Greer, Douglas S and Antaki, Danny and Shetty, Aniket and Holmans, Peter A and Pinto, Dalila and Gujral, Madhusudan and Brandler, William M and Malhotra, Dheeraj and Wang, Zhouzhi and Fajarado, Karin V Fuentes and Maile, Michelle S and Ripke, Stephan and Agartz, Ingrid and Albus, Margot and Alexander, Madeline and Amin, Farooq and Atkins, Joshua and Bacanu, Silviu A and Belliveau, Richard A and Bergen, Sarah E and Bertalan, Marcelo and Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W and Bruggeman, Richard and Buccola, Nancy G and Buckner, Randy L and Bulik-Sullivan, Brendan and Byerley, William and Cahn, Wiepke and Cai, Guiqing and Cairns, Murray J and Campion, Dominique and Cantor, Rita M and Carr, Vaughan J and Carrera, Noa and Catts, Stanley V and Chambert, Kimberley D and Cheng, Wei and Cloninger, C Robert and Cohen, David and Cormican, Paul and Craddock, Nick and Crespo-Facorro, Benedicto and Crowley, James J and Curtis, David and Davidson, Michael and Davis, Kenneth L and Degenhardt, Franziska and Del Favero, Jurgen and DeLisi, Lynn E and Dikeos, Dimitris and Dinan, Timothy and Djurovic, Srdjan and Donohoe, Gary and peau, Elodie and Duan, Jubao and Dudbridge, Frank and Eichhammer, Peter and Eriksson, Johan and Escott-Price, Valentina and Essioux, Laurent and Fanous, Ayman H and Farh, Kai-How and Farrell, Martilias S and Frank, Josef and Franke, Lude and Freedman, Robert and Freimer, Nelson B and Friedman, Joseph I and Forstner, Aneas J and Fromer, Menachem and Genovese, Giulio and Georgieva, Lyudmila and Gershon, Elliot S and Giegling, Ina and Giusti-Roíguez, Paola and Godard, Stephanie and Goldstein, Jacqueline I and Gratten, Jacob and de Haan, Lieuwe and Hamshere, Marian L and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette M and Henskens, Frans A and Herms, Stefan and Hirschhorn, Joel N and Hoffmann, Per and Hofman, Anea and Huang, Hailiang and Ikeda, Masashi and Joa, Inge and Kähler, Anna K and ... and Schizophrenia Working Grp and Psychosis Endophenotypes and CNV and Psychosis Endophenotypes International Consortium and CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium and Medicinska fakulteten and Institutionen för klinisk vetenskap and Psykiatri and Umeå universitet
Nature Genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 1, pp. 27 - 35
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the... 
DUPLICATIONS | AUTISM | GENE | CNVS | GENETICS & HEREDITY | RISK | DISORDERS | 16P11.2 | PHENOTYPES | MUTATIONS | REARRANGEMENTS | Genetic Predisposition to Disease | Genome-Wide Association Study | Schizophrenia - genetics | Genetic Markers - genetics | Humans | Risk Factors | Genetic Loci - genetics | Female | Genotype | Male | DNA Copy Number Variations - genetics | Case-Control Studies | Schizophrenia | Genome-wide association studies | Genetic aspects | Copy number variations | Analysis | Studies | Consortia | Datasets | Working groups | Pipelines | Genomics | Quality control | Data processing | Genomes | Meta-analysis | Index Medicus | Clinical Medicine | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Psykiatri | Klinisk medicin | Psychiatry | Cell- och molekylärbiologi
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11. Full Text Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations
by Gratten, Jacob and Wray, Naomi R and Peyrot, Wouter J and McGrath, John J and Visscher, Peter M and Goddard, Michael E
Nature Genetics, ISSN 1061-4036, 07/2016, Volume 48, Issue 7, pp. 718 - 724
The offspring of older fathers have higher risk of psychiatric disorders such as schizophrenia and autism. Paternal-agerelated de novo mutations are widely... 
POPULATION | RATES | GERMLINE MUTATION | DETERMINANTS | GENETICS & HEREDITY | ARCHITECTURE | SCHIZOPHRENIA | COMMON VARIATION | AUTISM SPECTRUM DISORDERS | BIPOLAR DISORDER | FAMILIAL RISK | Age Factors | Paternal Age | Genetic Markers - genetics | Humans | Risk Factors | Male | Mutation - genetics | Child | Autistic Disorder - etiology | Schizophrenia - etiology | Gene mutations | Father and child | Aging | Development and progression | Genetic aspects | Mental illness | Population genetics | Identification and classification | Health aspects | Methods | Mental disorders | Schizophrenia | Genomes | Studies | Autism | Hypotheses | Liability | Fathers | Mutation | Behavior | Health risk assessment | Public health | Age | Index Medicus
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