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Frontiers in oncology, ISSN 2234-943X, 2018, Volume 8, p. 75
Metabolic reprogramming confers cancer cells the ability to grow and survive under nutrient-depleted or stressful microenvironments. The amplification of... 
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1458, pp. 273 - 290
The tumor microenvironment is a complex and heterogeneous milieu in which cancer cells undergo metabolic reprogramming to fuel their growth. Cancer cell lines... 
GC-MS | Metabolomics | Stable isotope | Silylation | Methoximation | Hypoxia | Nutrients | Microenvironment | Neoplasms - metabolism | Gas Chromatography-Mass Spectrometry | Humans | Cells, Cultured | Cell Line, Tumor | Metabolome | Tumor Microenvironment | Workflow | Neoplasms - pathology | Metabolomics - methods | Hypoxia - metabolism | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 698 - 711
mRNA translation is thought to be the most energy-consuming process in the cell. Translation and energy metabolism are dysregulated in a variety of diseases... 
MAMMALIAN TARGET | RAPAMYCIN | BINDING PARTNER | SKELETAL-MUSCLE | DIFFERENTIAL TRANSLATION | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | GENOME-WIDE | MOTIF PHOSPHORYLATION | CELL-GROWTH | COMPLEX 2 | CELL BIOLOGY | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Mitochondrial Turnover | Adenosine Triphosphate - biosynthesis | Mechanistic Target of Rapamycin Complex 2 | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Cell Nucleus - metabolism | Cell Respiration | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Autophagy - genetics | DNA, Mitochondrial - biosynthesis | Eukaryotic Initiation Factors - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Mitochondria - metabolism | Genome, Human - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Mice | Adaptor Proteins, Signal Transducing - metabolism | RNA | Physiological aspects | Biosynthesis | Mitochondrial DNA | Diabetes | Binding proteins | Heart diseases | Genetic translation | Protein binding | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 1 - 9
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of... 
senescence | mitochondria | ROS | AMPK | PGC-1α | ULK1 | LKB1 | oxidative stress | nutrient signaling energy stress | CANCER-CELLS | SURVIVAL | COMPLEX-III | ENERGY STRESS | ACTIVATED PROTEIN-KINASE | GROWTH | NEURODEGENERATION | HYDROGEN-PEROXIDE | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Uncoupling Protein 3 - genetics | Humans | Autophagy-Related Protein-1 Homolog - metabolism | AMP-Activated Protein Kinases - deficiency | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - deficiency | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Superoxide Dismutase-1 - metabolism | HEK293 Cells | Protein Stability | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Cellular Senescence - genetics | Glutathione Peroxidase - metabolism | Uncoupling Protein 3 - metabolism | Signal Transduction | Uncoupling Protein 2 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | Mice, Transgenic | Mitochondria - metabolism | Glutathione Peroxidase - genetics | Uncoupling Protein 2 - genetics | Metabolic Networks and Pathways - genetics | Animals | Superoxide Dismutase-1 - genetics | Fibroblasts - cytology | Mice | Primary Cell Culture | Autophagy-Related Protein-1 Homolog - genetics | AMP-Activated Protein Kinases - genetics | Homeostasis - genetics | Index Medicus
Journal Article
Canadian Journal of Cardiology, ISSN 0828-282X, 04/2018, Volume 34, Issue 4, pp. 347 - 348
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 4826 - 4838
The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to... 
CELLS | METFORMIN | REDUCTIVE GLUTAMINE-METABOLISM | MAMMARY-TUMORS | ONCOLOGY | PHOSPHORYLATION | AEROBIC GLYCOLYSIS | GROWTH | MITOCHONDRIA | EXPRESSION | TUMORIGENESIS | Index Medicus
Journal Article