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Journal of NeuroInterventional Surgery, ISSN 1759-8478, 07/2019, p. neurintsurg-2019-015179
INTRODUCTIONThe neuroprotective benefit of therapeutic hypothermia (TH) has been demonstrated, but systemic side effects and time required to achieve effective... 
Index Medicus
Journal Article
Journal Article
Human Gene Therapy, ISSN 1043-0342, 03/2018, Volume 29, Issue 3, pp. 312 - 326
Journal Article
Journal Article
Nature Biotechnology, ISSN 1087-0156, 08/2019, Volume 37, Issue 8, pp. 884 - 894
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA... 
Physiological aspects | Genetic aspects | Gene expression | Central nervous system | Brain | Spinal cord | Drug delivery systems | Huntingtin | Toxicity | RNA-mediated interference | Nervous system | mRNA | siRNA | Cerebrospinal fluid | Injection | Ribonucleic acid--RNA | Neurological diseases | Gene silencing | Organic chemistry | Bioaccumulation | Primates | Mice | Phosphorothioate | Index Medicus
Journal Article
Molecular Therapy, ISSN 1525-0016, 04/2017, Volume 25, Issue 4, pp. 892 - 903
Journal Article
Journal of Neuroscience Methods, ISSN 0165-0270, 04/2014, Volume 227, pp. 10 - 17
Feline models of neurologic diseases, such as lysosomal storage diseases, leukodystrophies, Parkinson's disease, stroke and NeuroAIDS, accurately recreate many... 
Brain | Animal model | Translational | MRI | Cat | Central nervous system | Magnetic resonance imaging | Cats | Analysis
Journal Article
Experimental Neurology, ISSN 0014-4886, 01/2015, Volume 263, pp. 102 - 112
Journal Article
Molecular Genetics and Metabolism, ISSN 1096-7192, 09/2015, Volume 116, Issue 1-2, pp. 80 - 87
Journal Article
Molecular Therapy - Methods & Clinical Development, ISSN 2329-0501, 09/2017, Volume 6, Issue C, pp. 135 - 142
GM1 gangliosidosis is a fatal lysosomal disorder, for which there is no effective treatment. Adeno-associated virus (AAV) gene therapy in GM1 cats has resulted... 
feline | neurologic disease | AAV | biomarkers | gene therapy | adeno-associated virus | GM1 gangliosidosis | lipidomics | BIOMARKERS | MEDICINE, RESEARCH & EXPERIMENTAL | PLASMA | GM1 GANGLIOSIDOSIS | CSF | MOUSE | SCLEROSIS | LYSOSOMAL STORAGE | CEREBROSPINAL-FLUID | METABOLITE | DEFICIENCY
Journal Article