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Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 8, pp. 829 - 840
Summary Background We aimed to assess the efficacy and safety of sequential or simultaneous telomerase vaccination (GV1001) in combination with chemotherapy in... 
Hematology, Oncology and Palliative Medicine | COLONY-STIMULATING FACTOR | ONCOLOGY | DUCTAL ADENOCARCINOMA | IMMUNOTHERAPY | METAANALYSES | SUPPRESSOR-CELLS | RESISTANT PROSTATE-CANCER | T-CELLS | CHEMOTHERAPY | IPILIMUMAB | TUMOR-ANTIGEN | Cell Proliferation | Capecitabine | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fatigue - chemically induced | Pain - chemically induced | Pancreatic Neoplasms - drug therapy | Fluorouracil - administration & dosage | Female | Neutropenia - chemically induced | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Fluorouracil - analogs & derivatives | Cancer Vaccines - administration & dosage | Deoxycytidine - administration & dosage | Pancreatic Ducts | Pancreatic Neoplasms - pathology | Peptide Fragments - administration & dosage | Immunologic Factors - administration & dosage | Kaplan-Meier Estimate | Cancer Vaccines - adverse effects | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Telomerase - administration & dosage | Disease-Free Survival | Telomerase - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | T-Lymphocytes - immunology | Aged | Peptide Fragments - adverse effects | Deoxycytidine - analogs & derivatives | Care and treatment | Chemotherapy | Hospitals | Gemcitabine | Peptides | Pancreatic cancer | Vaccination | Product development | Vaccines | Metastasis | Telomerase | Cancer
Journal Article
Nature Reviews Gastroenterology and Hepatology, ISSN 1759-5045, 08/2012, Volume 9, Issue 8, pp. 435 - 444
Late diagnosis of pancreatic ductal adenocarcinoma ( pancreatic cancer) and the limited response to current treatments results in an exceptionally poor... 
PHASE-III TRIAL | ADJUVANT CHEMOTHERAPY | STEM-CELLS | DUCTAL ADENOCARCINOMA | MOUSE MODEL | TUMOR-CELLS | RANDOMIZED CONTROLLED-TRIAL | FOLINIC ACID | NUCLEOSIDE TRANSPORTER 1 | GASTROENTEROLOGY & HEPATOLOGY | GEMCITABINE | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prognosis | Humans | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Fluorouracil - therapeutic use | Poly(ADP-ribose) Polymerases - drug effects | Deoxycytidine - therapeutic use | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Equilibrative Nucleoside Transport Proteins - blood | CD40 Antigens - physiology | Biomarkers, Tumor - analysis | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Computational Biology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Treatment Outcome | Receptor Protein-Tyrosine Kinases - drug effects | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Gene Rearrangement | Signal Transduction - physiology | Deoxycytidine - analogs & derivatives | Physiological aspects | Care and treatment | Research | Diagnosis | Biological markers | Pancreatic cancer
Journal Article
Nature Reviews Gastroenterology and Hepatology, ISSN 1759-5045, 06/2018, Volume 15, Issue 6, pp. 333 - 348
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 4, pp. 486 - 499
Journal Article
by Whitcomb, David C and LaRusch, Jessica and Krasinskas, Alyssa M and Klei, Lambertus and Smith, Jill P and Brand, Randall E and Neoptolemos, John P and Lerch, Markus M and Tector, Matt and Sandhu, Bimaljit S and Guda, Nalini M and Orlichenko, Lidiya and Alkaade, Samer and Amann, Stephen T and Anderson, Michelle A and Baillie, John and Banks, Peter A and Conwell, Darwin and Coté, Gregory A and Cotton, Peter B and DiSario, James and Farrer, Lindsay A and Forsmark, Chris E and Johnstone, Marianne and Gardner, Timothy B and Gelrud, Andres and Greenhalf, William and Haines, Jonathan L and Hartman, Douglas J and Hawes, Robert A and Lawrence, Christopher and Lewis, Michele and Mayerle, Julia and Mayeux, Richard and Melhem, Nadine M and Money, Mary E and Muniraj, Thiruvengadam and Papachristou, Georgios I and Pericak-Vance, Margaret A and Romagnuolo, Joseph and Schellenberg, Gerard D and Sherman, Stuart and Simon, Peter and Singh, Vijay P and Slivka, Adam and Stolz, Donna and Sutton, Robert and Weiss, Frank Ulrich and Wilcox, C. Mel and Zarnescu, Narcis Octavian and Wisniewski, Stephen R and O'Connell, Michael R and Kienholz, Michelle L and Roeder, Kathryn and Barmada, M Michael and Yadav, Dhiraj and Devlin, Bernie and Albert, Marilyn S and Albin, Roger L and Apostolova, Liana G and Arnold, Steven E and Baldwin, Clinton T and Barber, Robert and Barnes, Lisa L and Beach, Thomas G and Beecham, Gary W and Beekly, Duane and Bennett, David A and Bigio, Eileen H and Bird, Thomas D and Blacker, Deborah and Boxer, Adam and Burke, James R and Buxbaum, Joseph D and Cairns, Nigel J and Cantwell, Laura B and Cao, Chuanhai and Carney, Regina M and Carroll, Steven L and Chui, Helena C and Clark, David G and Cribbs, David H and Crocco, Elizabeth A and Cruchaga, Carlos and DeCarli, Charles and Demirci, F Yesim and Dick, Malcolm and Dickson, Dennis W and Duara, Ranjan and Ertekin-Taner, Nilufer and Faber, Kelley M and Fallon, Kenneth B and Farlow, Martin R and Ferris, Steven and Foroud, Tatiana M and Frosch, Matthew P and Galasko, Douglas R and Ganguli, Mary and Gearing, Marla and Geschwind, Daniel H and ... and Alzheimer's Dis Genetics Consortiu and Alzheimer's Disease Genetics Consortium
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1349 - 1354
Journal Article
Gut, ISSN 0017-5749, 09/2017, Volume 66, Issue 9, pp. 1665 - 1676
Background and aimsThe role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma... 
Gene Regulation | Pancreatic Cancer | Cancer Genetics | Epithelial Differentiation | Adjuvant Treatment | EPITHELIAL-MESENCHYMAL TRANSITION | TRANSCRIPTION FACTORS | BLADDER-CANCER | GENOMIC ANALYSES | DUCTAL ADENOCARCINOMA | SUBTYPES | GENE-EXPRESSION | RANDOMIZED CONTROLLED-TRIAL | FOLINIC ACID | E-CADHERIN | GASTROENTEROLOGY & HEPATOLOGY | Humans | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Pancreatic Neoplasms - genetics | Statistics as Topic | Epithelial-Mesenchymal Transition - genetics | Carcinoma, Pancreatic Ductal - pathology | Cell Movement - genetics | GATA6 Transcription Factor - metabolism | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Chemotherapy, Adjuvant - methods | Cell Line, Tumor | Antimetabolites, Antineoplastic - pharmacology | Fluorouracil - pharmacology | Mice | GATA6 Transcription Factor - genetics | Usage | Pancreatic cancer | Patient outcomes | Adjuvant treatment | Genetic aspects | Research | Drug therapy | Cell differentiation | Cancer | Adenocarcinoma | Transcription factors | Phenotypes | Animal models | Mesenchyme | 5-Fluorouracil | Taxonomy | Gene regulation | Metastasis | Gene expression | Ribonucleic acid--RNA | Patients | Bladder cancer | Cancer therapies | Genotype & phenotype | Chemotherapy | Medical prognosis | Rodents | Cell lines | Tumors | Index Medicus | Abridged Index Medicus | Cancer genetics | Epithelial differentiation | Life Sciences | Genetics | CANCER GENETICS | PANCREATIC CANCER | ADJUVANT TREATMENT | GENE REGULATION | Pancreas | 1506 | EPITHELIAL DIFFERENTIATION
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1381, pp. 93 - 110
Genetic heterogeneity explains variation in predisposition for cancer. Whole-genome analysis allows risk to be quantified, giving better targeted screening and... 
Single-nucleotide polymorphism (SNP) | Next Generation Sequencing (NGS) | Neoplasms - genetics | Single-Cell Analysis - methods | Humans | Polymorphism, Single Nucleotide | Genome, Human | Genotyping Techniques - methods | High-Throughput Nucleotide Sequencing - methods | Polymerase Chain Reaction - methods
Journal Article
Gut, ISSN 0017-5749, 08/2014, Volume 63, Issue 8, pp. 1313 - 1324
Journal Article