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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5233 - 11
Clostridium difficile is the leading cause of nosocomial diarrhea and colitis in the industrialized world. Disruption of the protective gut microbiota by... 
TOXIN-B | CANCER CELLS | PROTECTION | SMALL-MOLECULE INHIBITORS | BEZLOTOXUMAB | MULTIDISCIPLINARY SCIENCES | POSITIVE CLOSTRIDIUM-DIFFICILE | INFECTION | IDENTIFICATION | EPIDEMIC | STRAIN | Epidemics | Nosocomial infection | Disease | Complications | Pathogenesis | Digestive system | Virulence | Niclosamide | Diarrhea | Drug resistance | Proteins | Microbiota | Hospitals | Antibiotics | Toxins | Mice | Disruption | Colitis | Digestive tract | Colonization
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2016, Volume 8, Issue 370, pp. 370tc2 - 370tc2
New insights into the mechanism of action of ebselen, a small-molecule antivirulence agent that reduces disease pathology in a mouse model of Clostridium... 
MEDICINE, RESEARCH & EXPERIMENTAL | TOXIN-B | CYTOTOXICITY | CELL BIOLOGY
Journal Article
Journal Article
Trends in Microbiology, ISSN 0966-842X, 2015, Volume 23, Issue 12, pp. 746 - 748
Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al. , using... 
Internal Medicine | small molecule | ebselen | TcdB | inhibitor | Clostridium difficile | MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOXIN-B | Virulence - drug effects | Anti-Bacterial Agents - therapeutic use | Clostridium Infections - drug therapy | Animals | Clostridium difficile - isolation & purification
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 11/2018, Volume 15, Issue 11, pp. 5217 - 5226
Despite a wealth of potential applications inside target cells, protein-based therapeutics are largely limited to extracellular targets due to the inability of... 
toxin delivery | enzyme replacement | translocation | intracellular delivery | MEDICINE, RESEARCH & EXPERIMENTAL | DOMAIN | MEDIATED DELIVERY | MEMBRANES | RECEPTOR | DEVELOPMENTAL DELAY | MAMMALIAN-CELLS | DEFICIENCY | PHARMACOLOGY & PHARMACY | CYTOSOL | FUSION PROTEINS
Journal Article
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2020, Volume 117, Issue 11, pp. 5791 - 5800
Journal Article
Journal Article
Experimental Cell Research, ISSN 0014-4827, 04/2010, Volume 316, Issue 7
1,25 Dihydroxyvitamin D{sub 3} (1,25D{sub 3}) primes NB4 promyelocytic leukemia cells to differentiate along the monocyte/macrophage lineage through a... 
ANTIBODIES | TRANSCRIPTION FACTORS | TRANSLOCATION | FRACTIONATION | STEROIDS | MACROPHAGES | MONOCYTES | PHENOTYPE | MICROSCOPY | 60 APPLIED LIFE SCIENCES | GENES | LEUKEMIA | RECEPTORS | PHORBOL ESTERS | VITAMIN D | HORMONES
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 8/2008, Volume 283, Issue 32, pp. 22222 - 22232
Thymidine analogue-associated mutations (TAMs) in reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) cause resistance to... 
Enzyme Catalysis and Regulation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2008, Volume 283, Issue 32, p. 22222
Thymidine analogue-associated mutations (TAMs) in reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) cause resistance to... 
Journal Article