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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1714 - 1718
This letter describes progress towards an M-4 PAM preclinical candidate that resulted in the discovery of VU6005806/AZN-00016130. While the thieno[2,3-c[... 
CHEMISTRY, MEDICINAL | SERIES | SAR | CHEMISTRY, ORGANIC | RECEPTOR | DISCOVERY | CHALLENGES | Muscarinic acetylcholine receptor | Structure-activity relationship (SAR) | M-4 | Positive allosteric modulator (PAM) | OPTIMIZATION | Pharmacokinetics
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3029 - 3033
This Letter describes the chemical optimization of a novel series of M-4 positive allosteric modulators (PAMs) based on a 5,6-dimethyl-4-(piperidin-1-yl)... 
POSITIVE ALLOSTERIC MODULATOR | CHEMISTRY, MEDICINAL | Schizophrenia | CHEMISTRY, ORGANIC | DISORDERS | OPPORTUNITIES | Structure-Activity Relationship (SAR) | AGONISTS | Muscarinic acetylcholine receptor | MUSCARINIC ACETYLCHOLINE-RECEPTOR | M-4 | Positive allosteric modulator (PAM) | GPCRS | POTENTIATORS
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2009, Volume 328, Issue 1, pp. 131 - 140
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2224 - 2228
This letter describes progress towards an M-4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant... 
Aldehyde oxidase (AO) | CHEMISTRY, MEDICINAL | SERIES | PRECLINICAL CANDIDATE | CHEMISTRY, ORGANIC | RECEPTOR | CHALLENGES | Muscarinic acetylcholine receptor | Structure-activity relationship (SAR) | VIVO TOOL COMPOUND | M-4 | Positive allosteric modulator (PAM) | POSITIVE ALLOSTERIC MODULATORS | OPTIMIZATION | POTENTIATORS
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 01/2019, Volume 29, Issue 2, pp. 342 - 346
This letter describes the first account of the chemical optimization (SAR and DMPK profiling) of a new series of mGlu(4) positive allosteric modulators (PAMs),... 
mGlu | POSITIVE ALLOSTERIC MODULATOR | Structure-activity relationship (SAR) | CHEMISTRY, MEDICINAL | SERIES | MGLUR4 | VU0418506 | Positive allosteric modulator (PAM) | Parkinson's disease (PD) | CHEMISTRY, ORGANIC | Metabotropic glutamate receptor
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 6, pp. 1788 - 1792
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1714 - 1718
This letter describes progress towards an M PAM preclinical candidate that resulted in the discovery of VU6005806/AZN-00016130. While the thieno[2,3-... 
Structure-activity relationship (SAR) | Pharmacokinetics | Positive allosteric modulator (PAM) | Muscarinic acetylcholine receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2224 - 2228
This letter describes progress towards an M PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant... 
Aldehyde oxidase (AO) | Structure-activity relationship (SAR) | Positive allosteric modulator (PAM) | Muscarinic acetylcholine receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3029 - 3033
Journal Article
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