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Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2013, Volume 23, Issue 3, pp. 816 - 820
Triaylsulfonamides were identified as novel anti-inflammatory agents, acting by inhibition of RANKL and TNF[alpha] signaling. Structure-activity studies led to... 
Antiinflammatory agents | Inflammation | Models | TRANCE protein
Journal Article
ISSN 1477-0520, 3/2013, Volume 11, Issue 14, pp. 2273 - 2287
Tubulysins are cytotoxic natural products with promising anti-cancer properties, originally isolated from myxobacterial cultures. Structurally, tubulysins are... 
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 12/2015, Volume 40, Issue 13, pp. 2948 - 2959
Journal Article
Calcified Tissue International, ISSN 0171-967X, 3/2008, Volume 82, Issue 3, pp. 191 - 201
Journal Article
Biology of Reproduction, ISSN 0006-3363, 11/2018, Volume 99, Issue 5, pp. 1082 - 1090
Abstract Low molecular weight heparin (LMWH) is being investigated as a potential preventative therapy against preeclampsia. There is evidence suggesting that... 
molecular biology | placenta | preeclampsia | immunology | angiogenesis | MEDIATED PREGNANCY COMPLICATIONS | COMPLEMENT ACTIVATION | PREVENTION | WOMEN | REPRODUCTIVE BIOLOGY | TYROSINE KINASE-1 | HIGH-RISK | IN-VIVO | THROMBOPHILIA | GROWTH-FACTOR | HYPERTENSION | Reproductive health | Preeclampsia | Molecular weight
Journal Article
Synthesis, ISSN 0039-7881, 01/2016, Volume 48, Issue 1, pp. 73 - 78
Abstract Racemic perhexiline has been used (or is currently undergoing clinical trials) for the treatment of a variety of cardiovascular disorders. Increasing... 
paper | crystal structure | stereochemistry | asymmetric synthesis | medicinal chemistry | perhexiline | HEART | HYDROGENATION | INHIBITION | ACID | CHEMISTRY, ORGANIC | TARGETS
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 1, pp. 91 - 104
GPR55 is activated by L-alpha-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various... 
PLANT CANNABINOIDS | NEUROPATHIC PAIN | L-ALPHA-LYSOPHOSPHATIDYLINOSITOL | B-RAF INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CB1 RECEPTOR ANTAGONIST | ENDOTHELIAL-CELLS | GPR55 | CANCER-CELL PROLIFERATION | ALLOSTERIC MODULATION | IDENTIFICATION | Analgesics - pharmacology | Plant Extracts - chemistry | Receptor, Cannabinoid, CB2 - agonists | Receptors, G-Protein-Coupled - metabolism | Plant Extracts - pharmacology | Humans | Neuralgia - metabolism | Phosphoproteins - metabolism | Cannabis - chemistry | Pyrazoles - chemistry | Piperidines - pharmacology | Dronabinol - analogs & derivatives | HEK293 Cells | Lysophospholipids - pharmacology | Phosphorylation - drug effects | Dronabinol - pharmacology | Pyrazoles - pharmacology | Allosteric Regulation - drug effects | Piperidines - chemistry | Cannabinoids - chemistry | Cannabinoids - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Analgesics - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Ligands | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Cannabinoids | G Protein-coupled Receptors (GPCR) | Signal Transduction | AlphaScreen | Allosteric Regulation | Acomplia | PLX-4720 BRAF Inhibitor | Cannabinoid Receptors | Pharmacology | Bitopic Ligand
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2016, Volume 26, Issue 18, pp. 4403 - 4407
Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs,... 
Negative allosteric modulator | Cannabinoid | Indole sulfonamide | CB1 NAM | SYSTEM | OBESITY | CHEMISTRY, MEDICINAL | ANTAGONIST | INDOLE-2-CARBOXAMIDES | CHEMISTRY, ORGANIC | CB1 RECEPTOR | Cannabinoid Receptor Modulators - pharmacology | Indoles - pharmacology | Sulfonamides - pharmacology | Allosteric Regulation | Humans | Sulfonamides | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 5049 - 5062
The first generation of CB1 positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs... 
MILD | ROUTE | CHEMISTRY, MEDICINAL | PAIN | CATALYST | INDOLES | DISCOVERY
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 01/2015, Volume 74, Issue 1, pp. 220 - 226
Journal Article