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Science, ISSN 0036-8075, 12/2014, Volume 346, Issue 6216, pp. 1480 - 1486
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic... 
CELL LUNG-CANCER | ALK | KINASE INHIBITION | GEFITINIB | ACTIVATION | CERITINIB | MULTIDISCIPLINARY SCIENCES | CRIZOTINIB | MUTATIONS | CHEMOTHERAPY | BYPASS MECHANISMS | Lung Neoplasms - drug therapy | Sulfones - therapeutic use | Humans | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | MAP Kinase Kinase 1 - genetics | DNA Mutational Analysis | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Cells, Cultured | Molecular Targeted Therapy - methods | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Patient-Specific Modeling | Drug Resistance, Neoplasm - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Enzyme Activation - genetics | Drug Screening Assays, Antitumor | Antimitotic agents | Cancer patients | Care and treatment | Lung cancer | Dosage and administration | Genetic aspects | Antineoplastic agents | Drug therapy | Drug resistance | Methods | Cancer | Cell culture | Oncology | Pharmaceutical sciences | Drugs | Mutations | Therapy | Genetics | Kinases | Patients | Tumors
Journal Article
Cell, ISSN 0092-8674, 07/2016, Volume 166, Issue 3, pp. 740 - 754
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 570 - 575
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 50, pp. 19936 - 19941
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2013, Volume 41, Issue 1, pp. D955 - D961
Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The... 
IDENTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Computer Graphics | Neoplasms - genetics | Genes, Neoplasm | Genomics | Humans | Cell Line, Tumor | Databases, Genetic | Antineoplastic Agents - pharmacology | Genetic Markers | Internet | Mutation | Neoplasms - drug therapy
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2017, Volume 16, Issue 6, pp. 1054 - 1067
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2013, Volume 3, Issue 3, pp. 309 - 323
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to... 
ANAPLASTIC LYMPHOMA KINASE | CELL LUNG-CANCER | DRUG-SENSITIVITY | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | THERAPEUTIC TARGET | N-MYC | C-MYC | ALK KINASE | ACUTE MYELOID-LEUKEMIA | ACTIVATING MUTATIONS | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Transcription Factors - deficiency | Apoptosis - genetics | Molecular Targeted Therapy | Transfection | Nuclear Proteins - deficiency | Cell Cycle Checkpoints - genetics | Female | N-Myc Proto-Oncogene Protein | Cell Growth Processes - genetics | Nuclear Proteins - genetics | Child | Neuroblastoma - pathology | Protein Structure, Tertiary | Promoter Regions, Genetic | Neuroblastoma - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Down-Regulation - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Gene Amplification | Cell Cycle Checkpoints - drug effects | Neuroblastoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | RNA, Small Interfering - administration & dosage | neuroblastoma | BET bromodomain inhibitor | MYCN | JQ1 | BRD4
Journal Article
PLoS Biology, ISSN 1544-9173, 08/2018, Volume 16, Issue 8, p. e2005756
Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/ threonine-protein kinase 3... 
DRUG-SENSITIVITY | APOPTOSIS | RECEPTOR TYROSINE KINASES | MLKL | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | WEB TOOL | TAM RECEPTORS | NECROPTOTIC CELL-DEATH | Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - physiology | Humans | Receptor Protein-Tyrosine Kinases - physiology | Apoptosis - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - physiology | Xenograft Model Antitumor Assays | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Mice | Necrosis - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins B-raf - metabolism | Cell culture | Biotechnology | Xenotransplantation | Oncology | Biology | Genomes | Kinases | Medical schools | Axl protein | Ovarian cancer | Proteins | Xenografts | DNA methylation | Tumor necrosis factor-TNF | Tumorigenesis | Bioinformatics | Supervision | Sensitivity analysis | Threonine | Principal components analysis | Tumor cell lines | Gene expression | Resistance factors | Sensitivity | Protein kinase | Cell death | Biopsy | Cell lines | Epigenetics | Software | Mutation | Prostate | Apoptosis | Tumors | Cancer
Journal Article