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Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2018, Volume 142, Issue 10, pp. 2139 - 2152
Increased CDK4 activity occurs in the majority of melanomas and CDK4/6 inhibitors in combination with BRAF and MEK inhibitors are currently in clinical trials... 
melanoma | BRAF | drug resistance | drug tolerance | CDK4 | DABRAFENIB | SAFETY | RAS | IMPROVED SURVIVAL | PHASE-3 | BRAF(V600E) | METASTATIC MELANOMA | ONCOLOGY | PLUS TRAMETINIB | SENESCENCE | VEMURAFENIB | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Humans | Melanoma - enzymology | Drug Resistance, Neoplasm | Indoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Female | Indoles - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Pyridines - administration & dosage | Mice, SCID | Sulfonamides - pharmacology | Piperazines - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Sulfonamides - administration & dosage | Medical research | Senescence | Effectiveness | Tumor cells | Xenotransplantation | MEK inhibitors | Melanoma | Clinical trials | Immunological tolerance | Cyclin-dependent kinase 4 | Signaling | Inhibitors | Robustness (mathematics) | Cell death | Cell lines | Xenografts | In vivo methods and tests | Inhibition | Tumors
Journal Article
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 03/2017, Volume 11, Issue 3, p. e0005432
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an... 
NUCLEOLUS | TREATMENT OPTIONS | VSG EXPRESSION SITES | ANTIGENIC VARIATION | G-QUADRUPLEXES | DNA-DAMAGE | BRUCEI | DRUG-RESISTANCE | IDENTIFICATION | CANCER | PARASITOLOGY | TROPICAL MEDICINE | Transcription, Genetic - drug effects | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - pharmacology | Enzyme Inhibitors - pharmacology | Inhibitory Concentration 50 | Trypanosoma brucei brucei - enzymology | Trypanosoma brucei brucei - drug effects | RNA Polymerase I - antagonists & inhibitors | Care and treatment | Genetic aspects | Genetic transcription | Properties | Health aspects | RNA polymerases | African trypanosomiasis | RNA | Biochemistry | Vaccines | Cancer therapies | Blood | Eukaryotes | Alterations | Escape systems | Biocompatibility | Life sciences | Inhibition | Temporal variations | Chemical synthesis | Public health | Medical research | Antigens | Splicing | Data acquisition | Glycoproteins | RNA polymerase | Nucleic acids | Gene expression | Mammals | Chemotherapy | Infectious diseases | Inhibitors | Ribonucleic acids | Information processing | Cell proliferation | Chromatin | Toxicity | Disintegration | DNA damage | Clinical trials | Risk | Homology | Biology | DNA-directed RNA polymerase | Immunosuppressive agents | Nucleoli | Biological effects | ESB | RNA processing | Immune system | Protozoa | Buildings | rRNA | Data processing | Diphtheria | Cell death | Polyadenylation | Tetanus | Cancer
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 09/2019, Volume 116, Issue 36, pp. 17990 - 18000
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2004, Volume 23, Issue 16, pp. 3325 - 3335
Journal Article
Cancer Discovery, ISSN 2159-8274, 01/2016, Volume 6, Issue 1, pp. 59 - 70
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 31, pp. 49800 - 49818
Journal Article