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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Index Medicus | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 11, pp. 905 - 912
Journal Article
CELL, ISSN 0092-8674, 01/2017, Volume 168, Issue 1-2, pp. 86 - 86
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77155 - e77155
Journal Article
Chemical Science, ISSN 2041-6520, 04/2015, Volume 6, Issue 4, pp. 2449 - 2456
The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an... 
ORGANOMETALLIC RUTHENIUM(II) | IN-VITRO | DRUG DISCOVERY | COMPOUND | ANTICANCER METALLODRUGS | REACTIVITY | ICP-MS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | MIDKINE | PROTEIN ADDUCTS | Proteins | Antiproliferatives | Proteomics | Histones | Fibroblasts | Guanines | Ruthenium organometallic complexes | Cancer
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 6/2009, Volume 18, Issue 11, pp. 1990 - 2000
The effects of heat shock (HS; 42°C) on the cell cycle and underlying molecular mechanisms are astonishingly unexplored. Here, we show that HS caused rapid... 
Journal Article
EuPA Open Proteomics, ISSN 2212-9685, 12/2015, Volume 9, Issue C, pp. 43 - 53
Gel-free liquid chromatography mass spectrometry coupled to chemical proteomics is a powerful approach for characterizing cellular target profiles of small... 
Dasatinib | Sunitinib | Double elution | Mass spectrometry gel-free | Chemical proteomics
Journal Article
Journal Article