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by Brat, Daniel J and Verhaak, Roel G. W and Aldape, Kenneth D and Yung, W. K. Alfred and Salama, Sofie R and Cooper, Lee A. D and Rheinbay, Esther and Miller, C. Ryan and Vitucci, Mark and Morozova, Olena and Robertson, A. Gordon and Noushmehr, Houtan and Laird, Peter W and Cherniack, Andrew D and Akbani, Rehan and Huse, Jason T and Ciriello, Giovanni and Poisson, Laila M and Barnholtz-Sloan, Jill S and Berger, Mitchel S and Brennan, Cameron and Colen, Rivka R and Colman, Howard and Flanders, Adam E and Giannini, Caterina and Grifford, Mia and Iavarone, Antonio and Jain, Rajan and Joseph, Isaac and Kim, Jaegil and Kasaian, Katayoon and Mikkelsen, Tom and Murray, Bradley A and O'Neill, Brian Patrick and Pachter, Lior and Parsons, Donald W and Sougnez, Carrie and Sulman, Erik P and Vandenberg, Scott R and Van Meir, Erwin G and Von Deimling, Andreas and Zhang, Hailei and Crain, Daniel and Lau, Kevin and Mallery, David and Morris, Scott and Paulauskis, Joseph and Penny, Robert and Shelton, Troy and Sherman, Mark and Yena, Peggy and Black, Aaron and Bowen, Jay and Dicostanzo, Katie and Gastier-Foster, Julie and Leraas, Kristen M and Lichtenberg, Tara M and Pierson, Christopher R and Ramirez, Nilsa C and Taylor, Cynthia and Weaver, Stephanie and Wise, Lisa and Zmuda, Erik and Davidsen, Tanja and Demchok, John A and Eley, Greg and Ferguson, Martin L and Hutter, Carolyn M and Shaw, Kenna R. Mills and Ozenberger, Bradley A and Sheth, Margi and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean Claude and Ayala, Brenda and Baboud, Julien and Chudamani, Sudha and Jensen, Mark A and Liu, Jia and Pihl, Todd and Raman, Rohini and Wan, Yunhu and Wu, Ye and Ally, Adrian and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Baylin, Stephen B and Beroukhim, Rameen and Bootwalla, Moiz S and Bowlby, Reanne and Bristow, Christopher A and Brooks, Denise and Butterfield, Yaron and Carlsen, Rebecca and Carter, Scott and Chin, Lynda and Chu, Andy and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 26, pp. 2481 - 2498
Journal Article
by Shungin, Dmitry and Winkler, Thomas W and Croteau-Chonka, Damien C and Ferreira, Teresa and Locke, Adam E and Mägi, Reedik and Strawbridge, Rona J and Pers, Tune H and Fischer, Krista and Justice, Anne E and Workalemahu, Tsegaselassie and Wu, Joseph M. W and Buchkovich, Martin L and Heard-Costa, Nancy L and Roman, Tamara S and ng, Alexander W and Song, Ci and Gustafsson, Stefan and Day, Felix R and Esko, Tonu and Fall, Tove and Kutalik, Zoltán and Luan, Jian'an and Randall, Joshua C and Scherag, Ané and Vedantam, Sailaja and Wood, Anew R and Chen, Jin and Fehrmann, Rudolf and Karjalainen, Juha and Kahali, Bratati and Liu, Ching-Ti and Schmidt, Ellen M and Absher, Devin and Amin, Najaf and Anderson, Denise and Beekman, Marian and Bragg-Gresham, Jennifer L and Buyske, Steven and Demirkan, Ayse and Ehret, Georg B and Feitosa, Mary F and Goel, Anuj and Jackson, Anne U and Johnson, Toby and Kleber, Marcus E and Kristiansson, Kati and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Peters, Marjolein J and Prokopenko, Inga and Stančáková, Alena and Ju Sung, Yun and Tanaka, Toshiko and Teumer, Alexander and van Vliet-Ostaptchouk, Jana V and Yengo, Loïc and Zhang, Weihua and Albrecht, Eva and Ärnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Böhringer, Stefan and Bonnet, Fabrice and Böttcher, Yvonne and Bruinenberg, Marcel and Carba, Delia B and Caspersen, Ida H and Clarke, Robert and Daw, E. Warwick and Deelen, Joris and Deelman, Ewa and Delgado, Graciela and Doney, Alex S. F and Eklund, Niina and Erdos, Michael R and Estrada, Karol and Eury, Elodie and Frieich, Nele and Garcia, Melissa E and Gieaitis, Vilmantas and Gigante, Bruna and Go, Alan S and Golay, Alain and Grallert, Harald and Grammer, Tanja B and Gräßler, Jürgen and Grewal, Jagvir and Groves, Christopher J and Haller, Toomas and Hallmans, Goran and ... and PAGE Consortium and LifeLines Cohort Study and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and ADIPOGEN Consortium and CKDGen Consortium and GEFOS Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and GLGC and ADIPOGen Consortium and International Endogene Consortium and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GENIE Consortium and The GLGC and The GEFOS Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 187 - U378
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our... 
HUMAN HEIGHT | ABDOMINAL ADIPOSITY | MULTIDISCIPLINARY SCIENCES | COMMON SNPS | SUSCEPTIBILITY LOCI | GLYCEMIC TRAITS | FALSE DISCOVERY | MESENCHYMAL STEM-CELLS | GENOME-WIDE ASSOCIATION | ADIPOGENIC DIFFERENTIATION | SEXUAL-DIMORPHISM | Body Mass Index | Genome-Wide Association Study | Age Factors | Neovascularization, Physiologic - genetics | Epigenesis, Genetic | Humans | Male | Continental Population Groups - genetics | Sex Characteristics | Obesity - genetics | Europe - ethnology | Genome, Human - genetics | Adipose Tissue - metabolism | Insulin - metabolism | Models, Biological | Adipocytes - metabolism | Insulin Resistance - genetics | Polymorphism, Single Nucleotide - genetics | Female | Body Fat Distribution | Transcription, Genetic - genetics | Adipogenesis - genetics | Waist-Hip Ratio | Quantitative Trait Loci - genetics | Adipose tissues | Quantitative trait loci | Genetic research | Genetic aspects | Research | Metabolism | Health aspects | Studies | Body mass index | Genealogy | Body fat | Insulin resistance | Genetics | Genomes | Abdomen | Meta-analysis | Index Medicus | Life Sciences | Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism Age Factors Body Fat Distribution Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study Humans Insulin/metabolism Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio | Clinical Medicine | Hälsa och välfärd | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Health and Welfare
Journal Article
Science, ISSN 0036-8075, 7/2003, Volume 301, Issue 5631, pp. 370 - 373
Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as... 
Circles | Blood glucose | Enzymes | Hepatocytes | Homeostasis | Reports | Glucose tolerance test | Type 2 diabetes mellitus | Diabetes | Insulin | Vehicles | GLUCOSE-HOMEOSTASIS | MUTANTS | MODY-2 | MULTIDISCIPLINARY SCIENCES | LIVER | BETA-CELL | MICE | MUTATIONS | MELLITUS | Enzyme Activators - pharmacology | Islets of Langerhans - drug effects | Rats, Wistar | Stereoisomerism | Allosteric Regulation | Humans | Liver Glycogen - biosynthesis | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Keto Acids - metabolism | Dose-Response Relationship, Drug | Liver - drug effects | Islets of Langerhans - metabolism | Enzyme Activators - chemistry | Drug Evaluation, Preclinical | Insulin Secretion | Carrier Proteins | Recombinant Proteins - metabolism | Glucose Tolerance Test | Liver - metabolism | Mice, Inbred C57BL | Rats | Hypoglycemic Agents - chemistry | Glucokinase - metabolism | Hypoglycemic Agents - pharmacology | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Proteins - metabolism | Glucose - metabolism | Mice, Obese | Thiazoles - chemistry | Mice | Proteins - pharmacology | Thiazoles - pharmacology | Enzyme Activation | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Care and treatment | Research | Glucose | Drug therapy | Metabolism | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 05/2015, Volume 64, Issue 5, pp. 1670 - 1681
Journal Article
by Manning, Alisa K and Hivert, Marie-France and Scott, Robert A and Grimsby, Jonna L and Bouatia-Naji, Nabila and Chen, Han and Rybin, Denis and Liu, Ching-Ti and Bielak, Lawrence F and Prokopenko, Inga and Amin, Najaf and Barnes, Daniel and Cadby, Gemma and Hottenga, Jouke-Jan and Ingelsson, Erik and Jackson, Anne U and Johnson, Toby and Kanoni, Stavroula and Ladenvall, Claes and Lagou, Vasiliki and Lahti, Jari and Lecoeur, Cecile and Liu, Yongmei and Martinez-Larrad, Maria Teresa and Montasser, May E and Navarro, Pau and Perry, John R. B and Rasmussen-Torvik, Laura J and Salo, Perttu and Sattar, Naveed and Shungin, Dmitry and Strawbridge, Rona J and Tanaka, Toshiko and van Duijn, Cornelia M and An, Ping and de Anade, Mariza and Anews, Jeanette S and Aspelund, Thor and Atalay, Mustafa and Aulchenko, Yurii and Balkau, Beverley and Bandinelli, Stefania and Beckmann, Jacques S and Beilby, John P and Bellis, Claire and Bergman, Richard N and Blangero, John and Boban, Mladen and Boehnke, Michael and Boerwinkle, Eric and Bonnycastle, Lori L and Boomsma, Dorret I and Borecki, Ingrid B and Boettcher, Yvonne and Bouchard, Claude and Brunner, Eric and Budimir, Danijela and Campbell, Harry and Carlson, Olga and Chines, Peter S and Clarke, Robert and Collins, Francis S and Corbaton-Anchuelo, Arturo and Couper, David and de Faire, Ulf and Dedoussis, George V and Deloukas, Panos and Dimitriou, Maria and Egan, Josephine M and Eiriksdottir, Gudny and Erdos, Michael R and Eriksson, Johan G and Eury, Elodie and Ferrucci, Luigi and Ford, Ian and Forouhi, Nita G and Fox, Caroline S and Franzosi, Maria Grazia and Franks, Paul W and Frayling, Timothy M and Froguel, Philippe and Galan, Pilar and de Geus, Eco and Gigante, Bruna and Glazer, Nicole L and Goel, Anuj and Groop, Leif and Gudnason, Vilmundur and Hallmans, Goeran and Hamsten, Anders and Hansson, Ola and Harris, Tamara B and Hayward, Caroline and Heath, Simon and Hercberg, Serge and Hicks, Anew A and Hingorani, Aroon and Hofman, Albert and Hui, Jennie and Hung, Joseph and ... and DIAGRAM Consortium and MUTHER Consortium and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Multiple Tissue Human Expression Resource (MUTHER) Consortium and The Multiple Tissue Human Expression Resource (MUTHER) Consortium and Medicinska fakulteten and Institutionen för odontologi and Institutionen för folkhälsa och klinisk medicin and Näringsforskning and Umeå universitet and Medicin
Nature Genetics, ISSN 1061-4036, 06/2012, Volume 44, Issue 6, pp. 659 - 669
Journal Article