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1. Full Text Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
by Flaherty, Keith T and Puzanov, Igor and Kim, Kevin B and Ribas, Antoni and McArthur, Grant A and Sosman, Jeffrey A and O'Dwyer, Peter J and Lee, Richard J and Grippo, Joseph F and Nolop, Keith and Chapman, Paul B
The New England journal of medicine, ISSN 0028-4793, 08/2010, Volume 363, Issue 9, pp. 809 - 819
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Biological and medical sciences | General aspects | Medical sciences | Dermatology | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - administration & dosage | Indoles - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Antineoplastic Agents - adverse effects | Melanoma - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Drug Resistance | Treatment Outcome | Melanoma - pathology | Melanoma - secondary | Sulfonamides - pharmacokinetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Sulfonamides - adverse effects | Indoles - pharmacokinetics | Aged | Mutation | Sulfonamides - administration & dosage | Care and treatment | Gene mutations | Melanoma | Genetic aspects | Research | Protein kinases | Health aspects | Proteins | Signal transduction | Kinases | Index Medicus | Abridged Index Medicus
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2. Full Text A New SET Piece in Cancer Development
by Grippo, Paul J
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 08/2020, Volume 159, Issue 2, pp. 437 - 439
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Index Medicus | Abridged Index Medicus
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3. Full Text Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
by Marimuthu, Adhirai and D'Andrea, Kurt and Lin, Paul S and Puzanov, Igor and Chapman, Paul B and Zhang, Jiazhong and Tsai, James and Ibrahim, Prabha N and Cho, Hanna and West, Brian L and Nathanson, Katherine L and Zhang, Kam Y. J and Zhang, Ying and Nolop, Keith and Schlessinger, Joseph and Grippo, Joseph and Shellooe, Rafe and Zhang, Chao and Flaherty, Keith T and Tsang, Garson and Powell, Ben and Kim, Kevin B and Wong, Bernice and Stumm, Michael and Ribas, Antoni and Spevak, Wayne and Higgins, Brian and Sosman, Jeffrey A and Artis, Dean R and Habets, Gaston and Hirth, Peter and Burton, Elizabeth A and Iyer, Raman and Su, Fei and Koehler, Astrid and Lee, Richard J and Bollag, Gideon and Nguyen, Hoa and McArthur, Grant A and Xu, Xiaowei
Nature (London), ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
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4. Full Text Pancreatic cancer subtypes: a roadmap for precision medicine
by Torres, Carolina and Grippo, Paul J
Annals of medicine (Helsinki), ISSN 0785-3890, 05/2018, Volume 50, Issue 4, pp. 277 - 287
subtype classification | precision medicine | Pancreatic cancer | liquid biopsy | genomic analysis | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Index Medicus
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5. Full Text Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase
by Lawrence M Knab Paul J Grippo David J Bentrem
World journal of gastroenterology : WJG, ISSN 1007-9327, 2014, Volume 20, Issue 31, pp. 10729 - 10739
acid | Arachidonic | Cyclooxygenase-2 | 5-lip | Eicosanoid | Inflammation | Arachidonic acid | Pancreatic cancer | 5-Lipoxygenase | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Pancreatic Neoplasms - epidemiology | Arachidonate 5-Lipoxygenase - metabolism | Signal Transduction | Humans | Pancreatic Neoplasms - pathology | Risk Factors | Pancreatic Neoplasms - enzymology | Lipoxygenase Inhibitors - therapeutic use | Receptors, Leukotriene B4 - metabolism | Antineoplastic Agents - therapeutic use | Inflammation - epidemiology | Pancreatic Neoplasms - drug therapy | Animals | Inflammation - drug therapy | Eicosanoids - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase 2 Inhibitors - therapeutic use | Receptors, Leukotriene B4 - antagonists & inhibitors | Inflammation - enzymology | Leukotriene Antagonists - therapeutic use | Index Medicus | Topic Highlight | 5-lipoxygenase
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6. Full Text Omega-3 fatty acids prevent early pancreatic carcinogenesis via repression of the AKT pathway
by Ding, Yongzeng and Mullapudi, Bhargava and Torres, Carolina and Mascariñas, Emman and Mancinelli, Georgina and Diaz, Andrew M and McKinney, Ronald and Barron, Morgan and Schultz, Michelle and Heiferman, Michael and Wojtanek, Mireille and Adrian, Kevin and DeCant, Brian and Rao, Sambasiva and Ouellette, Michel and Tsao, Ming-Sound and Bentrem, David J and Grippo, Paul J
Nutrients, ISSN 2072-6643, 09/2018, Volume 10, Issue 9, p. 1289
Neoplastic disease | Proliferation | Polyunsaturated fatty acids | Chemoprevention | Pancreatic cancer | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Phosphorylation | Cell Proliferation | Diet - adverse effects | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Neoplasms, Experimental - enzymology | Pancreatic Ducts - pathology | Neoplasms, Experimental - pathology | Pancreatic Ducts - enzymology | Anticarcinogenic Agents - administration & dosage | Cell Transformation, Neoplastic - genetics | Neoplasms, Experimental - genetics | Pancreatic Neoplasms - prevention & control | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids, Omega-3 - administration & dosage | Proto-Oncogene Proteins p21(ras) - metabolism | Cell Line | Signal Transduction | Cell Survival | Down-Regulation | Pancreatic Neoplasms - pathology | Neoplasms, Experimental - prevention & control | Pancreatic Neoplasms - enzymology | Mice, Transgenic | Pancreatic Neoplasms - genetics | Cell Transformation, Neoplastic - metabolism | Animals | Mutation | Cell Transformation, Neoplastic - pathology | Apoptosis | Disease | Lung cancer | Hydrocarbons | AKT protein | Carcinogenesis | Epidemiology | Carcinogens | Cell cycle | Pancreas | Fish oils | Breast cancer | Environmental factors | Gene expression | Fatty acids | Chemotherapy | Diet | Food intake | Medical prognosis | Diabetes | Cancer | Tumors | Index Medicus | pancreatic cancer | chemoprevention | proliferation | neoplastic disease | polyunsaturated fatty acids
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7. Full Text Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression
by Dangi-Garimella, S and Strouch, M.J and Grippo, P.J and Bentrem, D.J and Munshi, H.G
Oncogene, ISSN 0950-9232, 02/2011, Volume 30, Issue 8, pp. 1002 - 1008
collagen | TGF-β1 | ERK1/2 | MT1-MMP | fibrosis | let-7 | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Medical sciences | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Tumors | Gene Expression | Collagen Type I - metabolism | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - pathology | Transforming Growth Factor beta1 - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Extracellular Matrix - metabolism | Immunoblotting | MicroRNAs - biosynthesis | Pancreatic Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Matrix Metalloproteinase 14 - biosynthesis | Animals | Mice, Nude | Fibrosis | Cell Line, Tumor | Signal Transduction - physiology | Mice | MicroRNAs - genetics | Extracellular Matrix - pathology | Gene Expression Regulation, Neoplastic - genetics | Index Medicus | 2 | ERK1
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8. Full Text Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
by Guerra, Carmen and Schuhmacher, Alberto J and Cañamero, Marta and Grippo, Paul J and Verdaguer, Lena and Pérez-Gallego, Lucía and Dubus, Pierre and Sandgren, Eric P and Barbacid, Mariano
Cancer cell, ISSN 1535-6108, 2007, Volume 11, Issue 3, pp. 291 - 302
CELLCYCLE | Pancreatic Neoplasms - metabolism | Signal Transduction | Carcinoma in Situ - pathology | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | Pancreas - pathology | Pancreatitis, Chronic - chemically induced | Carcinoma, Pancreatic Ductal - pathology | Pancreatitis, Chronic - pathology | Cell Lineage | Animals | Lung Neoplasms - secondary | Cell Transformation, Neoplastic | Mice, Mutant Strains | Doxycycline - pharmacology | Mice | Mutation | Carcinoma in Situ - metabolism | Ceruletide | Genes, ras | Liver Neoplasms - secondary | Adenocarcinoma | Genetic aspects | Pancreatitis | Index Medicus
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9. Full Text Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
by Grippo, Paul J and Fitchev, Philip S and Bentrem, David J and Melstrom, Laleh G and Dangi-Garimella, Surabhi and Krantz, Seth B and Heiferman, Michael J and Chung, Chuhan and Adrian, Kevin and Cornwell, Mona L and Flesche, Jan B and Rao, Sambasiva M and Talamonti, Mark S and Munshi, Hidayatullah G and Crawford, Susan E
Gut, ISSN 0017-5749, 10/2012, Volume 61, Issue 10, pp. 1454 - 1464
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Tumors | Nerve Growth Factors - deficiency | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Stromal Cells - pathology | Biomarkers, Tumor - deficiency | Humans | Carcinoma, Pancreatic Ductal - metabolism | Carcinoma, Pancreatic Ductal - genetics | Matrix Metalloproteinase 9 - metabolism | Adiposity | Biomarkers, Tumor - metabolism | Serpins - deficiency | Real-Time Polymerase Chain Reaction | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Stromal Cells - metabolism | Pancreas - pathology | Pancreatic Neoplasms - genetics | Genetic Markers | Pancreas - metabolism | Carcinoma, Pancreatic Ductal - pathology | Blotting, Western | Mice, Knockout | Adipocytes, White - pathology | Animals | Cell Line, Tumor | Mice | Mutation | Eye Proteins | Adipocytes, White - metabolism | Obesity | Lipids | Metastasis | Adipocytes | Metabolism | Patients | Insulin | Proteins | Rodents | Medical prognosis | Pancreatic cancer | Insulin resistance | Extracellular matrix | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
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10. Full Text Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
by Dangi-Garimella, Surabhi and Krantz, Seth B and Barron, Morgan R and Shields, Mario A and Heiferman, Michael J and Grippo, Paul J and Bentrem, David J and Munshi, Hidayatullah G
Cancer research (Chicago, Ill.), ISSN 0008-5472, 02/2011, Volume 71, Issue 3, pp. 1019 - 1028
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | HMGA2 Protein - biosynthesis | Humans | Carcinoma, Pancreatic Ductal - metabolism | Collagen Type I - chemistry | Extracellular Matrix - metabolism | Cell Growth Processes - physiology | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Extracellular Matrix - chemistry | Carcinoma, Pancreatic Ductal - genetics | Matrix Metalloproteinase 14 - biosynthesis | Pancreatic Neoplasms - drug therapy | HMGA2 Protein - genetics | Antimetabolites, Antineoplastic - pharmacology | Molecular Targeted Therapy - methods | Cell Growth Processes - drug effects | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Drug Synergism | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Mice | RNA, Small Interfering - administration & dosage | Deoxycytidine - analogs & derivatives | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | HMGA2 | MT1-MMP | fibrosis | ERK1
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