Cellular Physiology and Biochemistry, ISSN 1015-8987, 01/2018, Volume 44, Issue 1, pp. 172 - 184
Background/Aims: The human-voltage gated Kv1.3 channel (hKv1.3) is expressed in T- and B lymphocytes. Verapamil is able to block hKv1.3 channels. We...
Lymphocytes | Science | Amino acids | Mutation | Potassium | Experiments | Binding sites
Lymphocytes | Science | Amino acids | Mutation | Potassium | Experiments | Binding sites
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 04/2018, Volume 46, Issue 3, pp. 1112 - 1121
Background/Aims: The replacement of the amino acid valine at position 388 (Shaker position 438) in hKv1.3 channels or at the homologue position 370 in hKv1.2...
Neurosciences | Mutagenesis | Genomics | Cloning | Amino acids | Mutation | Potassium
Neurosciences | Mutagenesis | Genomics | Cloning | Amino acids | Mutation | Potassium
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0176078
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0176078
Current through the σ-pore was first detected in hKv1.3_V388C channels, where the V388C mutation in hKv1.3 channels opened a new pathway (σ-pore) behind the...
Valine - chemistry | Kv1.2 Potassium Channel - genetics | Animals | Cercopithecus aethiops | Cysteine - chemistry | Mutation | COS Cells | Amino Acid Substitution | Kv1.2 Potassium Channel - chemistry | Kv1.2 Potassium Channel - physiology | Protons | Neurosciences | Medical treatment | Homology | Tetraethylammonium | Chloride | Mutagenesis | Charybdotoxin | Physiology | Toxins | Potassium channels (voltage-gated) | Ion channels | Potassium
Valine - chemistry | Kv1.2 Potassium Channel - genetics | Animals | Cercopithecus aethiops | Cysteine - chemistry | Mutation | COS Cells | Amino Acid Substitution | Kv1.2 Potassium Channel - chemistry | Kv1.2 Potassium Channel - physiology | Protons | Neurosciences | Medical treatment | Homology | Tetraethylammonium | Chloride | Mutagenesis | Charybdotoxin | Physiology | Toxins | Potassium channels (voltage-gated) | Ion channels | Potassium
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 04/2018, Volume 46, Issue 3, pp. 1112 - 1121
Background/Aims: The replacement of the amino acid valine at position 388 (Shaker position 438) in hKv1.3 channels or at the homologue position 370 in hKv1.2...
Original Paper | Electrophysiology | Patch-clamp | σ-pore | Potassium channel | 1.3 channl | Membrane Potentials - drug effects | Mutagenesis, Site-Directed | Humans | Cercopithecus aethiops | Kv1.3 Potassium Channel - genetics | Charybdotoxin - toxicity | Molecular Dynamics Simulation | Patch-Clamp Techniques | Animals | Cloning, Molecular | Protein Structure, Quaternary | Kv1.3 Potassium Channel - metabolism | COS Cells | Potassium Channel Blockers - pharmacology | Kv1.3 channel
Original Paper | Electrophysiology | Patch-clamp | σ-pore | Potassium channel | 1.3 channl | Membrane Potentials - drug effects | Mutagenesis, Site-Directed | Humans | Cercopithecus aethiops | Kv1.3 Potassium Channel - genetics | Charybdotoxin - toxicity | Molecular Dynamics Simulation | Patch-Clamp Techniques | Animals | Cloning, Molecular | Protein Structure, Quaternary | Kv1.3 Potassium Channel - metabolism | COS Cells | Potassium Channel Blockers - pharmacology | Kv1.3 channel
Journal Article
6.
Full Text
Kinetic Aspects of Verapamil Binding (On-Rate) on Wild-Type and Six hKv1.3 Mutant Channels
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, ISSN 1015-8987, 2017, Volume 44, Issue 1, pp. 172 - 184
The human-voltage gated Kv1.3 channel (hKv1.3) is expressed in T- and B lymphocytes. Verapamil is able to block hKv1.3 channels. We characterized the effect of...
Membrane Potentials - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Humans | Cercopithecus aethiops | Kv1.3 Potassium Channel - genetics | Potassium Channel Blockers - metabolism | Verapamil - pharmacology | Verapamil - chemistry | Patch-Clamp Techniques | Animals | Protein Binding | Kv1.3 Potassium Channel - metabolism | Molecular Docking Simulation | Kinetics | Binding Sites | COS Cells | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology | Verapamil - metabolism | Open channel block | Electrophysiology | Verapamil | Patch-clamp | Potassium channel | Kv1.3 channel
Membrane Potentials - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Humans | Cercopithecus aethiops | Kv1.3 Potassium Channel - genetics | Potassium Channel Blockers - metabolism | Verapamil - pharmacology | Verapamil - chemistry | Patch-Clamp Techniques | Animals | Protein Binding | Kv1.3 Potassium Channel - metabolism | Molecular Docking Simulation | Kinetics | Binding Sites | COS Cells | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology | Verapamil - metabolism | Open channel block | Electrophysiology | Verapamil | Patch-clamp | Potassium channel | Kv1.3 channel
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2014, Volume 106, Issue 2, pp. 748a - 749a
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, p. 277
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 278a - 278a
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Biophysical Journal, ISSN 0006-3495, 02/2016, Volume 110, Issue 3, pp. 277a - 277a
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2017, Volume 44, Issue 1, pp. 172 - 184
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2010, Volume 98, Issue 3, p. 117
Journal Article
2002, ISBN 9780815714019, xii, 236
Book
Molecular Pharmacology, ISSN 0026-895X, 03/2004, Volume 65, Issue 3, pp. 630 - 638
Ion channels are important in controlling cell cycle progression and proliferation in a variety of cell types. Using the whole-cell recording mode of the...
CA CHANNEL | RAS | CALCIUM | PATCH-CLAMP | PHARMACOLOGY & PHARMACY | ACTIVATED POTASSIUM CHANNELS | PROLIFERATION | HUMAN T-LYMPHOCYTES | DEPENDENT ACTIVATION | CHLORIDE SECRETION | UP-REGULATION | Up-Regulation | Gene Expression | Potassium Channels, Calcium-Activated - physiology | Cell Count | Humans | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Cell Division - drug effects | Potassium Channels, Calcium-Activated - genetics | Cell Division - physiology | Potassium Channels, Calcium-Activated - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Tumor Cells, Cultured | Potassium Channel Blockers - pharmacology
CA CHANNEL | RAS | CALCIUM | PATCH-CLAMP | PHARMACOLOGY & PHARMACY | ACTIVATED POTASSIUM CHANNELS | PROLIFERATION | HUMAN T-LYMPHOCYTES | DEPENDENT ACTIVATION | CHLORIDE SECRETION | UP-REGULATION | Up-Regulation | Gene Expression | Potassium Channels, Calcium-Activated - physiology | Cell Count | Humans | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Cell Division - drug effects | Potassium Channels, Calcium-Activated - genetics | Cell Division - physiology | Potassium Channels, Calcium-Activated - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Tumor Cells, Cultured | Potassium Channel Blockers - pharmacology
Journal Article
Biophysical Journal, ISSN 0006-3495, 2011, Volume 100, Issue 3, pp. 566a - 566a
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2012, Volume 167, Issue 6, pp. 1378 - 1388
BACKGROUND AND PURPOSE T‐cells usually express voltage‐gated Kv1.3 channels. These channels are distinguished by their typical C‐type inactivation. Therefore,...
MTSEA reagent | C‐type inactivation | electrophysiology | voltage‐gated potassium channels | verapamil | voltage-gated potassium channels | C-type inactivation | ACTIVATION | ALVEOLAR EPITHELIAL-CELLS | CORREOLIDE | SELECTIVITY FILTER | STRUCTURAL BASIS | FORCE-FIELD | PHARMACOLOGY & PHARMACY | K+ CHANNEL | POTASSIUM-CHANNEL | BINDING | T cells | Amino acids | Verapamil | Binding sites | Research Papers
MTSEA reagent | C‐type inactivation | electrophysiology | voltage‐gated potassium channels | verapamil | voltage-gated potassium channels | C-type inactivation | ACTIVATION | ALVEOLAR EPITHELIAL-CELLS | CORREOLIDE | SELECTIVITY FILTER | STRUCTURAL BASIS | FORCE-FIELD | PHARMACOLOGY & PHARMACY | K+ CHANNEL | POTASSIUM-CHANNEL | BINDING | T cells | Amino acids | Verapamil | Binding sites | Research Papers
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2000, Volume 97, Issue 14, pp. 8151 - 8156
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated k channel, IKCa1, is in clinical trials for the treatment of...
T lymphocytes | COS cells | Enzymes | Biological Sciences | Imidazoles | Calcium | Pyrazoles | Lymphocytes | Cyclosporins | Cytochromes | Tetrazoles | CYP3A | CELLS | CA CHANNEL | EFFICACY | MULTIDISCIPLINARY SCIENCES | DEPEND | ACTIVATED POTASSIUM CHANNELS | PROLIFERATION | AGENTS | HUMAN T-LYMPHOCYTES | CLOTRIMAZOLE
T lymphocytes | COS cells | Enzymes | Biological Sciences | Imidazoles | Calcium | Pyrazoles | Lymphocytes | Cyclosporins | Cytochromes | Tetrazoles | CYP3A | CELLS | CA CHANNEL | EFFICACY | MULTIDISCIPLINARY SCIENCES | DEPEND | ACTIVATED POTASSIUM CHANNELS | PROLIFERATION | AGENTS | HUMAN T-LYMPHOCYTES | CLOTRIMAZOLE
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2012, Volume 167, Issue 6, pp. 1378 - 1388
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 12/2005, Volume 57, Issue 4, pp. 473 - 508
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2010, Volume 98, Issue 3, p. 115
Journal Article
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