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1. Full Text Inflammation and colorectal cancer: colitis-associated neoplasia
by Grivennikov, Sergei I and Grivennikov, Sergei I
Seminars in Immunopathology, ISSN 1863-2297, 3/2013, Volume 35, Issue 2, pp. 229 - 244
Connection between inflammation and cancer is a rapidly developing field. Epidemiological data suggests that inflammation along with distinct arms of host... 
Inflammatory bowel disease | Biomedicine | Immunology | Colon cancer | Cytokines | Internal Medicine | Bacteria | Inflammation | INDUCED CYTIDINE DEAMINASE | SPONTANEOUS INTESTINAL TUMORIGENESIS | IMMUNOLOGY | PATHOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | DEXTRAN SODIUM-SULFATE | TUMOR-NECROSIS-FACTOR | MURINE ULCERATIVE-COLITIS | BETA-CATENIN ACTIVATION | PROMOTES COLON TUMORIGENESIS | NF-KAPPA-B | GENOME-WIDE ASSOCIATION | Colonic Neoplasms - prevention & control | Humans | Risk Factors | Colitis - complications | Colitis - pathology | Inflammatory Bowel Diseases - metabolism | Colonic Neoplasms - metabolism | Rectal Neoplasms - prevention & control | Rectal Neoplasms - microbiology | Animals | Colitis - microbiology | Colitis - therapy | Colonic Neoplasms - pathology | Inflammatory Bowel Diseases - pathology | Colitis - metabolism | Inflammatory Bowel Diseases - microbiology | Rectal Neoplasms - metabolism | Rectal Neoplasms - pathology | Inflammatory Bowel Diseases - complications | Rectal Neoplasms - etiology | Colonic Neoplasms - etiology | Inflammatory Bowel Diseases - therapy | Colonic Neoplasms - microbiology | Prevention | Gastrointestinal diseases | Colorectal cancer | Development and progression | Colitis | Risk factors | Tumors | Inflammatory bowel diseases | Molecular modelling | Intestine | Data processing | Tumorigenesis | Neoplasia | Immune system | Metastases | cytokines | bacteria | inflammation | colon cancer | inflammatory bowel disease
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2. Full Text B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
by Ammirante, Massimo and Luo, Jun-Li and Grivennikov, Sergei and Nedospasov, Sergei and Karin, Michael
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7286, pp. 302 - 305
Prostate cancer (CaP) progresses from prostatic intraepithelial neoplasia through locally invasive adenocarcinoma to castration-resistant metastatic... 
ACTIVATION | METASTASIS | PATHWAY | TRANSGENIC MOUSE | MULTIDISCIPLINARY SCIENCES | INDUCED ARTHRITIS | FACTOR-KAPPA-B | IKK-ALPHA | CHRONIC INFLAMMATION | T-CELLS | PROGRESSION | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Humans | Male | Lymphotoxin-alpha - metabolism | Prostatic Neoplasms - physiopathology | I-kappa B Kinase - genetics | Prostate - metabolism | Orchiectomy | Prostate - pathology | Animals | I-kappa B Kinase - metabolism | Survival Analysis | Mice | Androgens - metabolism | B-Lymphocytes - metabolism | Lymphocytes | Physiological aspects | Development and progression | Hormones, Sex | Metastasis | Prostate cancer | Health aspects | Bone marrow | Gene expression | Rodents | Apoptosis | Tumors
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3. Full Text Tumor Promotion via Injury- and Death-Induced Inflammation
by Kuraishy, Ali and Karin, Michael and Grivennikov, Sergei I
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 4, pp. 467 - 477
Inhibition of programmed cell death is considered to be a major aspect of tumorigenesis. Indeed, several key oncogenic transcription factors, such as NF-κB and... 
STAT3 ACTIVATION | HEPATOCELLULAR-CARCINOMA | STEM-CELLS | COLORECTAL-CANCER | SQUAMOUS-CELL CARCINOMA | COLITIS-ASSOCIATED CANCER | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Animals | Cell Survival | Humans | Cell Death | Inflammation - immunology | Neoplasms - pathology | Cytokines - immunology | Medical research | Wound healing | Cytokines | Melanoma | Homeostasis | Recruitment | Inflammatory bowel disease | Cell growth | Hypotheses | Rodents | Stem cells | Skin | Tumorigenesis | Chemokines | Tumors | Cancer | Apoptosis | cytokines | immunity | cell death | tissue injury | inflammation
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4. Full Text Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
by Grivennikov, Sergei I and Karin, Michael
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2009, Volume 21, Issue 1, pp. 11 - 19
Abstract Transcriptional factors of the NF-κB family and STAT3 are ubiquitously expressed and control numerous physiological processes including development,... 
Advanced Basic Science | Inflammation | Immunity | Cytokine | Cancer | TRANSCRIPTION FACTORS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTESTINAL EPITHELIAL-CELLS | UNPHOSPHORYLATED STAT3 | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | PROMOTION STAGES | REGULATORY T-CELLS | TNF-ALPHA | SIGNAL TRANSDUCERS | INNATE IMMUNITY
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5. Full Text Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
by Grivennikov, Sergei I and Karin, Michael
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2011, Volume 70, Issue Suppl 1, pp. i104 - i108
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all, solid tumours contain inflammatory infiltrates. Immune cells have... 
COLON-CANCER | STAT3 ACTIVATION | HEPATOCELLULAR-CARCINOMA | MOUSE MODEL | IN-VIVO | COMPENSATORY PROLIFERATION | COLITIS-ASSOCIATED CANCER | RHEUMATOLOGY | NF-KAPPA-B | INTESTINAL EPITHELIAL-CELLS | BOWEL-DISEASE | Colonic Neoplasms - physiopathology | Animals | Humans | Interleukin-6 - physiology | Liver Neoplasms - physiopathology | Tumor Necrosis Factor-alpha - physiology | Mice | Neoplasms - physiopathology | Cell Transformation, Neoplastic - metabolism | Inflammation Mediators - physiology | Disease Models, Animal | Tumor necrosis factor-TNF | Cell growth | Kinases | Colorectal cancer
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6. Full Text The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment
by Li, Ning and Grivennikov, Sergei I and Karin, Michael
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 4, pp. 429 - 431
Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of demonstrate the importance of tumor-elicited... 
ONCOLOGY | IMMUNITY | CELL BIOLOGY | Development and progression | Inflammation | Cytokines | Cancer | cytokines | cancer | immunity | tumor microenvironment | inflammation | STAT3
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7. Full Text Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis
by Wang, Kepeng and Kim, Min Kyoung and Di Caro, Giuseppe and Wong, Jerry and Shalapour, Shabnam and Wan, Jun and Zhang, Wei and Zhong, Zhenyu and Sanchez-Lopez, Elsa and Wu, Li-Wha and Taniguchi, Koji and Feng, Ying and Fearon, Eric and Grivennikov, Sergei I and Karin, Michael
Immunity, ISSN 1074-7613, 12/2014, Volume 41, Issue 6, pp. 1052 - 1063
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine linked to rapid malignant progression of colorectal cancer (CRC) and therapy resistance. IL-17A exerts... 
COLON-CANCER | APC INACTIVATION | GASTRIC-CANCER | IFN-GAMMA | MOUSE MODEL | COLITIS-ASSOCIATED CANCER | SUPPRESSOR-CELLS | IMMUNOLOGY | TUMOR-GROWTH | INTESTINAL EPITHELIAL-CELLS | T-CELLS | Colonic Neoplasms - drug therapy | Humans | Receptors, Interleukin-17 - immunology | Colonic Neoplasms - chemically induced | NF-kappa B - metabolism | Receptors, Interleukin-17 - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Tamoxifen - administration & dosage | Antibodies, Blocking - administration & dosage | Aberrant Crypt Foci - genetics | Fluorouracil - administration & dosage | Colonic Neoplasms - immunology | Colorectal Neoplasms - drug therapy | p38 Mitogen-Activated Protein Kinases - metabolism | Receptors, Interleukin-17 - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Carcinogenesis - genetics | Mice, Transgenic | Signal Transduction - genetics | Colorectal Neoplasms - chemically induced | Mice, Knockout | Carcinogenesis - drug effects | Interleukin-17 - metabolism | Animals | Colorectal Neoplasms - immunology | Enterocytes - drug effects | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice | Cell Line, Transformed | Drug Resistance, Neoplasm - drug effects | Enterocytes - physiology | Chemotherapy | Colon cancer | Interleukins | Gastrointestinal diseases | Development and progression | Cellular signal transduction | Tumors | Cancer | Science | Medical research | Rodents | Metabolic disorders | Colorectal cancer
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8. Full Text Tumour-infiltrating regulatory T cells stimulate mammary cancermetastasis through RANKL-RANK signalling
by Tan, Wei and Zhang, Weizhou and Strasner, Amy and Grivennikov, Sergei and Cheng, Jin Q and Hoffman, Robert M and Karin, Michael
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7335, pp. 548 - 553
  Inflammatory mechanisms influence tumorigenesis and metastatic progression even in cancers whose aetiology does not involve pre-existing inflammation or... 
Proteins | Breast cancer | Lymphocytes | Rodents | Apoptosis
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9. Full Text Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation
by Reis, Bernardo S and Hoytema van Konijnenburg, David P and Grivennikov, Sergei I and Mucida, Daniel
Immunity, ISSN 1074-7613, 08/2014, Volume 41, Issue 2, pp. 244 - 256
The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state.... 
RESPONSES | HOMEOSTASIS | ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | RETINOIC ACID | TGF-BETA | DIFFERENTIATION | IMMUNOLOGY | CELL FATE | CELIAC-DISEASE | CD8-ALPHA-ALPHA | Up-Regulation | Colitis - genetics | T-Box Domain Proteins - biosynthesis | T-Box Domain Proteins - immunology | Intestinal Mucosa - cytology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Intestinal Mucosa - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | Receptors, Antigen, T-Cell, alpha-beta - biosynthesis | Colitis - immunology | Transcription Factors - immunology | Receptors, Cytokine - genetics | Receptors, Interferon - genetics | Core Binding Factor Alpha 3 Subunit - immunology | Tretinoin | DNA-Binding Proteins - immunology | Mice, Inbred C57BL | Cells, Cultured | CD8 Antigens - biosynthesis | T-Box Domain Proteins - genetics | Mice, Knockout | Cell Differentiation - immunology | Animals | Interferon-gamma - immunology | Mice | Biological response modifiers | T cells | Cell differentiation | Inflammatory bowel disease | Transcription factors | Lymphocytes | Laboratories | Rodents | Cytotoxicity | T cell receptors | Gene expression | Small intestine | Experiments | Acquisitions & mergers
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10. Full Text Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection
by Allie, Nasiema and Grivennikov, Sergei I and Keeton, Roanne and Hsu, Nai-Jen and Bourigault, Marie-Laure and Court, Nathalie and Fremond, Cecile and Yeremeev, Vladimir and Shebzukhov, Yuriy and Ryffel, Bernhard and Nedospasov, Sergei A and Quesniaux, Valerie F. J and Jacobs, Muazzam
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1809
Tumour Necrosis Factor (TNF) is critical for host control of M. tuberculosis, but the relative contribution of TNF from innate and adaptive immune responses... 
GROWTH-INHIBITION | BCG INFECTION | GRANULOMA-FORMATION | INTERFERON-GAMMA | BOVIS BCG | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | HUMAN ALVEOLAR MACROPHAGES | PROTECTIVE IMMUNE-RESPONSE | MURINE PERITONEAL-MACROPHAGES | FACTOR-ALPHA | Myeloid Cells - cytology | Lung - microbiology | Neutrophils - cytology | Cell Proliferation | Mycobacterium tuberculosis - immunology | Pneumonia - pathology | Tuberculosis - microbiology | Lung - cytology | Flow Cytometry | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | Integrases - metabolism | Cell Differentiation | Neutrophils - microbiology | Real-Time Polymerase Chain Reaction | Macrophages - immunology | Macrophages - microbiology | Pneumonia - etiology | Signal Transduction | RNA, Messenger - genetics | Cells, Cultured | Neutrophils - immunology | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Tuberculosis - immunology | Animals | Tuberculosis - prevention & control | Tumor Necrosis Factor-alpha - physiology | Mice | CD8-Positive T-Lymphocytes - immunology | Pneumonia - metabolism | Lung - immunology | Myeloid Cells - microbiology | Tuberculosis | Immunology | Immune response | Gangrene | Tumor necrosis factor-TNF | Infections | Lymphocytes T
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11. Full Text Inflammation and Cancer: Triggers, Mechanisms, and Consequences
by Greten, Florian R and Grivennikov, Sergei I
Immunity, ISSN 1074-7613, 07/2019, Volume 51, Issue 1, pp. 27 - 41
Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory... 
cytokine | tumor progression | inflammation | metastasis | cancer | tumor microenvironment | cell plasticity | mechanisms | BREAST-CANCER | ADAPTIVE IMMUNITY | COLORECTAL-CANCER | TUMOR-ASSOCIATED MACROPHAGES | DELTA T-CELLS | IKK-BETA | INTESTINAL TUMORIGENESIS | IMMUNOLOGY | PANCREATIC ONCOGENESIS | NF-KAPPA-B | MAMMARY CARCINOMAS | Autoimmunity | Animals | Neoplasms - immunology | Humans | Neovascularization, Pathologic | Homeostasis | Tumor Microenvironment | Inflammation | Wound Healing | Carcinogenesis | Chronic Disease | Infections - immunology | Prevention | Development and progression | Metastasis | Analysis | Cancer | Tissue engineering | Phenotypic plasticity | Biology | Roles | Vaccines | Gene expression | Cancer therapies | Immunity | Metastases | Signal transduction | Immunology | Higher education | Lymphocytes | Immunotherapy | Medical prognosis | Tumorigenesis | Tumors | Immune system
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