2008, Kaleĭdoskop istoriĭ, ISBN 9785955511184, 333
Book
Methods in Molecular Biology, ISSN 1064-3745, 09/2016, Volume 1459, pp. 231 - 247
Tumor interstitial fluid (TIF) surrounds and perfuses bodily tumorigenic tissues and cells, and can accumulate by-products of tumors and stromal cells in a...
Tissue secretome | Tissue section | Tumor interstitial fluid | 2D-PAGE | Tumor microenvironment | Proteomic profiling | Immunohistochemistry | Neoplasms - metabolism | Extracellular Fluid - metabolism | Breast Neoplasms - pathology | Humans | Tumor Microenvironment | Proteome | Proteomics - methods | Neoplasms - pathology | Biomarkers, Tumor | Breast Neoplasms - metabolism
Tissue secretome | Tissue section | Tumor interstitial fluid | 2D-PAGE | Tumor microenvironment | Proteomic profiling | Immunohistochemistry | Neoplasms - metabolism | Extracellular Fluid - metabolism | Breast Neoplasms - pathology | Humans | Tumor Microenvironment | Proteome | Proteomics - methods | Neoplasms - pathology | Biomarkers, Tumor | Breast Neoplasms - metabolism
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2010, Volume 12, Issue 1, pp. 80 - 86
Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage. However, the spectrum of known...
ORGANIZATION | RECOVERY | UBC13 | LARGE PROTEIN | DEFICIENT | RNF8 | MICE | STRAND BREAKS | ATR | CELL BIOLOGY | Guanine Nucleotide Exchange Factors - physiology | Phosphorylation | Humans | Ubiquitin - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Kidney - metabolism | Ubiquitination | Chromosomes, Human - radiation effects | Ultraviolet Rays | DNA Damage - physiology | BRCA1 Protein - metabolism | Bone Neoplasms - genetics | Lysine - metabolism | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Osteosarcoma - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Kidney - cytology | Mutation - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | Lysine - genetics | Carrier Proteins - metabolism | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | DNA Repair | Osteosarcoma - genetics | Tumor Suppressor p53-Binding Protein 1 | DNA damage | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Ubiquitin-proteasome system | DNA repair
ORGANIZATION | RECOVERY | UBC13 | LARGE PROTEIN | DEFICIENT | RNF8 | MICE | STRAND BREAKS | ATR | CELL BIOLOGY | Guanine Nucleotide Exchange Factors - physiology | Phosphorylation | Humans | Ubiquitin - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Kidney - metabolism | Ubiquitination | Chromosomes, Human - radiation effects | Ultraviolet Rays | DNA Damage - physiology | BRCA1 Protein - metabolism | Bone Neoplasms - genetics | Lysine - metabolism | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Osteosarcoma - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Kidney - cytology | Mutation - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | Lysine - genetics | Carrier Proteins - metabolism | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | DNA Repair | Osteosarcoma - genetics | Tumor Suppressor p53-Binding Protein 1 | DNA damage | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Ubiquitin-proteasome system | DNA repair
Journal Article
Montenegrin Journal of Economics, ISSN 1800-5845, 09/2018, Volume 14, Issue 3, pp. 177 - 188
Small and medium entrepreneurship is an important factor in the development and transformation of the Russian economy. Taking this into account, the study of...
Share of SMEs employees in total employment | Regions | Small and medium enterprises | Type of economic activity | Entrepreneurs | Employees | Statistics | Gross Domestic Product--GDP | Hypotheses | Economic growth | Employment | Entrepreneurship | Economic activity | Small & medium sized enterprises-SME | Methods | Aquaculture | Economic crisis | type of economic activity | regions | small and medium enterprises | share of SMEs employees in total employment
Share of SMEs employees in total employment | Regions | Small and medium enterprises | Type of economic activity | Entrepreneurs | Employees | Statistics | Gross Domestic Product--GDP | Hypotheses | Economic growth | Employment | Entrepreneurship | Economic activity | Small & medium sized enterprises-SME | Methods | Aquaculture | Economic crisis | type of economic activity | regions | small and medium enterprises | share of SMEs employees in total employment
Journal Article
ChemistryOpen, ISSN 2191-1363, 11/2018, Volume 7, Issue 11, pp. 890 - 901
The N‐(2,3‐butadienyl)carboxamide of isopimaric acid, that is, compound 3, was prepared through a two‐step synthetic procedure starting from the natural...
cross-coupling | chromenes | terpenoids | heterocycles | cyclization | ASYMMETRIC-SYNTHESIS | CATALYZED REACTIONS | PALLADACYCLES | CRYSTAL-STRUCTURE | NATURAL-PRODUCTS | CHEMISTRY, MULTIDISCIPLINARY | N-PROPARGYL AMIDES | CYCLOADDITION | BENZOFURANS | TRANSFORMATIONS | Heterocyclic compounds | Coupling (molecular) | Synthesis | Iodides | Allene | Aromatic compounds | Optical activity | Bromides | Derivatives | Functional groups | Substrates | Acids | Chromatography
cross-coupling | chromenes | terpenoids | heterocycles | cyclization | ASYMMETRIC-SYNTHESIS | CATALYZED REACTIONS | PALLADACYCLES | CRYSTAL-STRUCTURE | NATURAL-PRODUCTS | CHEMISTRY, MULTIDISCIPLINARY | N-PROPARGYL AMIDES | CYCLOADDITION | BENZOFURANS | TRANSFORMATIONS | Heterocyclic compounds | Coupling (molecular) | Synthesis | Iodides | Allene | Aromatic compounds | Optical activity | Bromides | Derivatives | Functional groups | Substrates | Acids | Chromatography
Journal Article
Genome Biology, ISSN 1474-7596, 09/2016, Volume 17, Issue 1, p. 185
Background: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream...
Somatic mutation | Replication stress | APOBEC | Genomic instability | MUTATIONAL PROCESSES | ACTIVATION | BARRIER | PATTERNS | CYTIDINE DEAMINASE | CHK1 INHIBITOR | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MYC | GENETICS & HEREDITY | EXPRESSION | Multigene Family | Ataxia Telangiectasia Mutated Proteins - metabolism | Signal Transduction | DNA Replication - drug effects | Humans | Biomarkers, Tumor | Cell Transformation, Neoplastic - metabolism | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Breast Neoplasms - genetics | Gene Amplification | Cytosine Deaminase - metabolism | Mutagenesis | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Stress, Physiological - drug effects | DNA Damage | Enzyme Activation | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Cytosine Deaminase - genetics | Oncogenes | Antibody diversity | Nucleosides | Breast cancer | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | Cancer | Camptothecin | Gemcitabine | Transcription | DNA damage | Cytotoxicity | Hydroxyurea | Genomes | DNA repair | Breast carcinoma | Signal transduction | Next-generation sequencing | Cell cycle | Protein-tyrosine kinase receptors | Tumorigenesis | Supplementation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | CHK1 protein | ErbB-2 protein | Aphidicolin | DNA biosynthesis | Replication | Lymphomas | PTEN protein | Cytidine deaminase | Tumors
Somatic mutation | Replication stress | APOBEC | Genomic instability | MUTATIONAL PROCESSES | ACTIVATION | BARRIER | PATTERNS | CYTIDINE DEAMINASE | CHK1 INHIBITOR | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MYC | GENETICS & HEREDITY | EXPRESSION | Multigene Family | Ataxia Telangiectasia Mutated Proteins - metabolism | Signal Transduction | DNA Replication - drug effects | Humans | Biomarkers, Tumor | Cell Transformation, Neoplastic - metabolism | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Breast Neoplasms - genetics | Gene Amplification | Cytosine Deaminase - metabolism | Mutagenesis | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Stress, Physiological - drug effects | DNA Damage | Enzyme Activation | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Cytosine Deaminase - genetics | Oncogenes | Antibody diversity | Nucleosides | Breast cancer | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | Cancer | Camptothecin | Gemcitabine | Transcription | DNA damage | Cytotoxicity | Hydroxyurea | Genomes | DNA repair | Breast carcinoma | Signal transduction | Next-generation sequencing | Cell cycle | Protein-tyrosine kinase receptors | Tumorigenesis | Supplementation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | CHK1 protein | ErbB-2 protein | Aphidicolin | DNA biosynthesis | Replication | Lymphomas | PTEN protein | Cytidine deaminase | Tumors
Journal Article
Molecular & Cellular Proteomics, ISSN 1535-9476, 04/2004, Volume 3, Issue 4, pp. 327 - 344
Clinical cancer proteomics aims at the identification of markers for early detection and predictive purposes, as well as to provide novel targets for drug...
Journal Article
Toxicology Letters, ISSN 0378-4274, 10/2017, Volume 280, pp. S203 - S203
Journal Article
Oncogene, ISSN 0950-9232, 2019, Volume 38, Issue 17, pp. 3170 - 3184
HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed...
PROTEIN | HUMAN-BREAST-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | IDENTIFICATION | CELL BIOLOGY | ONCOLOGY | ERBB2 | GENETICS & HEREDITY | INHIBITORS | HER2 | EXPRESSION | PROGRESSION | CANCER CELL INVASION | Phosphorylation | Research | Genetic transcription | Serine | Transcription factors | Invasiveness | Breast cancer | Gene expression | Kinases | ErbB-2 protein | Spheroids | Metastases | SUMO protein | Gene silencing | Repressors | Transcription activation | Zinc finger proteins | Tumors | transcription factor | ErbB2 | breast cancer | PRKCA | CTCF | invasion | MYC | lysosomes | breast cancer cell spheroid | SUMOylation | MZF1 | phosphorylation | PAK4 | CTSB | Clinical Medicine | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Cancer and Oncology | Cancer och onkologi
PROTEIN | HUMAN-BREAST-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | IDENTIFICATION | CELL BIOLOGY | ONCOLOGY | ERBB2 | GENETICS & HEREDITY | INHIBITORS | HER2 | EXPRESSION | PROGRESSION | CANCER CELL INVASION | Phosphorylation | Research | Genetic transcription | Serine | Transcription factors | Invasiveness | Breast cancer | Gene expression | Kinases | ErbB-2 protein | Spheroids | Metastases | SUMO protein | Gene silencing | Repressors | Transcription activation | Zinc finger proteins | Tumors | transcription factor | ErbB2 | breast cancer | PRKCA | CTCF | invasion | MYC | lysosomes | breast cancer cell spheroid | SUMOylation | MZF1 | phosphorylation | PAK4 | CTSB | Clinical Medicine | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Cancer and Oncology | Cancer och onkologi
Journal Article
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 10/2019, Volume 91, Issue 20, pp. 12661 - 12669
The efficient and sensitive detection of pathogenic microorganisms in aqueous environments, such as water used in medical applications, drinking water, and...
AGINS2 NANOCRYSTALS | CHEMISTRY, ANALYTICAL | LEGIONELLA-PNEUMOPHILA | PHOTOLUMINESCENCE | PARTICLES | CALCIUM-CARBONATE MICROSPHERES | POLYMER | ENHANCEMENT | FABRICATION | HIGHLY EFFICIENT | WATER | Drinking water | Flow cytometry | Cultivation | Quantum dots | Antibodies | Fluorescence | Emissions | Nanoparticles | Cooling water | Microspheres | Microorganisms | Magnetic separation | Calcium carbonate | Aqueous environments | Bacteria | Conjugation | Industrial plants | Iron oxides | Beads | Industrial plant emissions | Legionnaires' disease bacterium | Fluorescence microscopy
AGINS2 NANOCRYSTALS | CHEMISTRY, ANALYTICAL | LEGIONELLA-PNEUMOPHILA | PHOTOLUMINESCENCE | PARTICLES | CALCIUM-CARBONATE MICROSPHERES | POLYMER | ENHANCEMENT | FABRICATION | HIGHLY EFFICIENT | WATER | Drinking water | Flow cytometry | Cultivation | Quantum dots | Antibodies | Fluorescence | Emissions | Nanoparticles | Cooling water | Microspheres | Microorganisms | Magnetic separation | Calcium carbonate | Aqueous environments | Bacteria | Conjugation | Industrial plants | Iron oxides | Beads | Industrial plant emissions | Legionnaires' disease bacterium | Fluorescence microscopy
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0188827
Bladder cancer associated protein (Blcap) expression is commonly down-regulated in invasive bladder cancer, and may have prognostic value given that its...
CELLS | APOPTOSIS | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | CERVICAL-CANCER | YXXQ MOTIF | CARCINOMA | EXPRESSION | IN-SITU | PROXIMITY LIGATION | Genetic aspects | Cellular signal transduction | Prognosis | Research | Gene expression | Bladder cancer
CELLS | APOPTOSIS | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | CERVICAL-CANCER | YXXQ MOTIF | CARCINOMA | EXPRESSION | IN-SITU | PROXIMITY LIGATION | Genetic aspects | Cellular signal transduction | Prognosis | Research | Gene expression | Bladder cancer
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 12/2019, Volume 20, Issue 23, p. 6082
The burden of colorectal cancer (CRC) is considerable—approximately 1.8 million people are diagnosed each year with CRC and of these about half will succumb to...
Journal Article
BMC Cancer, ISSN 1471-2407, 11/2019, Volume 19, Issue 1, pp. 1158 - 1158
We evaluated the levels and possible associations of seven parameters including the status of the TOP1 gene (i.e. amplification), TOP1 protein expression...
Enzymes | Care and treatment | Cell death | Oncology, Experimental | DNA topoisomerase I | Breast cancer | Research | Comparative analysis | Cancer | Index Medicus | Topoisomerase I | Camptothecin sensivity | Breast cancer cell lines | Breast tumor subtypes
Enzymes | Care and treatment | Cell death | Oncology, Experimental | DNA topoisomerase I | Breast cancer | Research | Comparative analysis | Cancer | Index Medicus | Topoisomerase I | Camptothecin sensivity | Breast cancer cell lines | Breast tumor subtypes
Journal Article
Journal of History Culture and Art Research, ISSN 2147-0626, 09/2018, Volume 7, Issue 3, p. 493
Journal Article
E3S Web of Conferences, ISSN 2267-1242, 2019, Volume 127, p. 1010
We analyzed the appearance of two supersubstorms observed during storm on September 07, 2017. Supersubstorms (SSS) are called substorms with SML index < - 2500...
Journal Article
Cell Reports, ISSN 2211-1247, 05/2018, Volume 23, Issue 9, pp. 2705 - 2717
Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA)....
neurobeachin | endosomal recycling | dynein | Rab GTPase | retromer | social behavior | synapse | KIF21B | autism spectrum disorder | NMDA receptor | ENDOSOMES | GLUTAMATE RECEPTORS | TRANSPORT | AMPA RECEPTORS | AUTISM | POTENTIATION | SYNAPSES | TRAFFICKING | SYNAPTIC PLASTICITY | SUBUNIT | CELL BIOLOGY
neurobeachin | endosomal recycling | dynein | Rab GTPase | retromer | social behavior | synapse | KIF21B | autism spectrum disorder | NMDA receptor | ENDOSOMES | GLUTAMATE RECEPTORS | TRANSPORT | AMPA RECEPTORS | AUTISM | POTENTIATION | SYNAPSES | TRAFFICKING | SYNAPTIC PLASTICITY | SUBUNIT | CELL BIOLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99628
The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug...
LUNG-CANCER | PROTEIN-KINASE-C | LYMPHOMA-CELLS | DNA | MULTIDISCIPLINARY SCIENCES | SODIUM-BUTYRATE | LINE | RESISTANCE | IDENTIFICATION | METASTATIC COLORECTAL-CANCER | TUMOR-INITIATING CELLS | Caco-2 Cells | DNA Topoisomerases, Type I - metabolism | Neoplastic Stem Cells - drug effects | Humans | Hyaluronan Receptors - metabolism | Drug Resistance, Neoplasm | Phosphorylation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Camptothecin | Phosphorylation | Protein kinase C | Laboratories | Colorectal carcinoma | Colorectal cancer | Biochemistry | Genomes | Dephosphorylation | Kinases | Casein kinase II | Mimicry | Proteins | CD44 antigen | Deoxyribonucleic acid--DNA | Medical research | Subpopulations | Enzymes | Sensitivity analysis | DNA topoisomerase | Chromatography | Sensitivity | Chemotherapy | Stem cells | Lymphomas | Molecular biology | Cancer | Tumors | Deoxyribonucleic acid
LUNG-CANCER | PROTEIN-KINASE-C | LYMPHOMA-CELLS | DNA | MULTIDISCIPLINARY SCIENCES | SODIUM-BUTYRATE | LINE | RESISTANCE | IDENTIFICATION | METASTATIC COLORECTAL-CANCER | TUMOR-INITIATING CELLS | Caco-2 Cells | DNA Topoisomerases, Type I - metabolism | Neoplastic Stem Cells - drug effects | Humans | Hyaluronan Receptors - metabolism | Drug Resistance, Neoplasm | Phosphorylation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Camptothecin | Phosphorylation | Protein kinase C | Laboratories | Colorectal carcinoma | Colorectal cancer | Biochemistry | Genomes | Dephosphorylation | Kinases | Casein kinase II | Mimicry | Proteins | CD44 antigen | Deoxyribonucleic acid--DNA | Medical research | Subpopulations | Enzymes | Sensitivity analysis | DNA topoisomerase | Chromatography | Sensitivity | Chemotherapy | Stem cells | Lymphomas | Molecular biology | Cancer | Tumors | Deoxyribonucleic acid
Journal Article
Expert Review of Proteomics, ISSN 1478-9450, 11/2017, Volume 14, Issue 11, pp. 1021 - 1035
Introduction: Tumor-associated proteins released by cancer cells and by tumor stroma cells, referred as 'cancer secretome', represent a valuable resource for...
conditioned media | proteomics | biomarker | cancer secretome | Bioinformatics | tumor interstitial fluid | Tumor interstitial fluid | Biomarker | Conditioned media | Cancer secretome | Proteomics | TUMOR-STROMA | BIOCHEMICAL RESEARCH METHODS | MULTI-OMICS | CELL-LINES | BREAST-CANCER | LC-MS/MS | INTEGRATIVE ANALYSIS | CANDIDATE BIOMARKERS | PROXIMAL FLUID PROTEOMICS | TISSUE INTERSTITIAL FLUID | Neoplasms - metabolism | Biomarkers, Tumor - secretion | Computational Biology - methods | Neoplasms - secretion | Animals | Neoplasm Proteins - secretion | Humans | Cell Line, Tumor | Proteomics - methods
conditioned media | proteomics | biomarker | cancer secretome | Bioinformatics | tumor interstitial fluid | Tumor interstitial fluid | Biomarker | Conditioned media | Cancer secretome | Proteomics | TUMOR-STROMA | BIOCHEMICAL RESEARCH METHODS | MULTI-OMICS | CELL-LINES | BREAST-CANCER | LC-MS/MS | INTEGRATIVE ANALYSIS | CANDIDATE BIOMARKERS | PROXIMAL FLUID PROTEOMICS | TISSUE INTERSTITIAL FLUID | Neoplasms - metabolism | Biomarkers, Tumor - secretion | Computational Biology - methods | Neoplasms - secretion | Animals | Neoplasm Proteins - secretion | Humans | Cell Line, Tumor | Proteomics - methods
Journal Article