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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12649 - 12654
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However, clinical development of these... 
Adenocarcinoma | Acinar cells | Cell growth | Cell lines | Pancreatic cells | Small interfering RNA | Genetic mutation | Pancreatic neoplasms | Tumors | Cancer | INHIBITION | PATHWAY | STABILIZATION | REGENERATION | MULTIDISCIPLINARY SCIENCES | DISEASE | GROWTH | ACINAR-CELLS | BETA-CATENIN | INTRAEPITHELIAL NEOPLASIA | CANCER | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Wnt Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Wnt Proteins - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Wnt Signaling Pathway | Acyltransferases | beta Catenin | Membrane Proteins - genetics | Oncogene Proteins - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | Frizzled Receptors - genetics | Membrane Proteins - antagonists & inhibitors | Cell Line, Tumor | Mutation | Clinical Trials, Phase I as Topic | Gene mutations | Pancreatic cancer | Physiological aspects | Genetic aspects | Research | Gene expression | Molecules | Biomarkers | Cancer therapies | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2019, Volume 25, Issue 1, pp. 95 - 102
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 05/2011, Volume 25, Issue 10, pp. 1041 - 1051
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138486 - e0138486
Journal Article
PLoS ONE, 09/2015, Volume 10, Issue 9
Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5560 - 5560
Journal Article
Journal Article
Genome Research, ISSN 1088-9051, 2000, Volume 10, Issue 8, pp. 1158 - 1171
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1116 - 1121
Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Are). Having identified an... 
Mutant IDH1 | clinical candidate | inhibition of 2-HG production | in vivo anticancer activity | brain penetration | ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | ACUTE MYELOID-LEUKEMIA | OPPORTUNITIES | HYPOXIA | Mutant IDHI | METABOLISM | MUTATIONS
Journal Article
mAbs, ISSN 1942-0862, 11/2014, Volume 6, Issue 6, pp. 1560 - 1570
Journal Article