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Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 6177 - 11
Proteasomes are responsible for protein turnover in eukaryotic cells, degrading short-lived species but also removing improperly folded or oxidatively damaged... 
COMPLEX | CHANNEL | MULTIDISCIPLINARY SCIENCES | RESOLUTION | OPENS | TERMINI | GATE | INHIBITORS | PROTEINS | BINDING | X-ray crystallography | Neurodegenerative diseases | Proteasomes | Gating | Crystallography | Molecular weight | Protein turnover | Crystal structure
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 10/2019, Volume 20, Issue 19, p. 4821
Glucose phosphorylating enzymes are crucial in the regulation of basic cellular processes, including metabolism and gene expression. Glucokinases and... 
COMPLEX | ADP-DEPENDENT GLUCOKINASE | PROTEIN | sugar metabolism | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | HEXOKINASE PII | CHEMISTRY, MULTIDISCIPLINARY | YEAST | ENZYME | REPRESSION | GLUCOSE | Kluyveromyces lactis | OPTIMIZATION | glucokinase | kluyveromyces lactis
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5857 - 5867
Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based... 
unclassified drug | protein interaction | 4 [[[4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2methylphenyl]methoxy] 2,5 difluorophenyl]methyl]amino] 3 hydroxybutanoic acid hydrochloride | drug synthesis | 3 [4 chloro 5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formylphenoxymethyl]benzonitrile | 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2,5 difluorobenzaldehyde | drug structure | protein function | 2 [[[2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]amino] 3 methylbutan 1 ol hydrochloride | X ray analysis | 2 [[[2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 5 methylphenyl] methyl]amino] 3 hydroxypropanoic acid hydrochloride | 1 [[3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]phenyl]methyl]piperidine 2 carboxylic acid | protein structure | oligomerization | 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxy 5 methylbenzaldehyde | drug determination | 3 [5 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 formyl 4 methylphenoxymethyl]benzonitrile | IC50 | immunomodulating agent | 2,6 dimethoxy 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde | 5 chloro 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy] 2 hydroxybenzaldehyde | human | protein expression | [3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methanol | n [2 [[[2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridin 3 yl]methyl]amino]ethyl]acetamide hydrochloride | 3 bromo 4 [(2 methyl 3 phenylphenyl)methoxy]benzaldehyde | dimerization | nuclear magnetic resonance spectroscopy | programmed death 1 ligand 1 | heteronuclear multiple quantum coherence | 1 [[5 chloro 2 [(3 cyanophenyl)methoxy] 4 [[3 (2,3 dihydro 1,4 benzodioxin 6 yl) 2 methylphenyl]methoxy]phenyl] methyl] 4 hydroxypyrrolidine 2 carboxylic acid hydrochloride | protein inhibitor | (2 methyl 3 biphenylyl)methanol | article | To be checked by Faculty | hydrophobicity | 2 methoxy 6 [(2 methyl 3 phenylphenyl)methoxy]pyridine 3 carbaldehyde | cancer immunotherapy | crystallization | COMPLEX | CHEMISTRY, MEDICINAL | THERAPY | CANCER-IMMUNOTHERAPY | MONOCLONAL-ANTIBODIES | DERIVATIVES | CHECKPOINT BLOCKADE | Small Molecule Libraries - pharmacology | Programmed Cell Death 1 Receptor - chemistry | Protein Interaction Maps - drug effects | Humans | Programmed Cell Death 1 Receptor - metabolism | Crystallography, X-Ray | Programmed Cell Death 1 Receptor - antagonists & inhibitors | B7-H1 Antigen - chemistry | Small Molecule Libraries - chemistry | B7-H1 Antigen - metabolism | B7-H1 Antigen - antagonists & inhibitors | Molecular Docking Simulation | Protein Multimerization - drug effects
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 08/2019, Volume 671, pp. 130 - 142
Heme oxygenase-1 (HO-1, ) degrades pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe ) and biliverdin. The enzyme exerts multiple cytoprotective... 
Angiogenesis | HO-1 | Tumorigenesis | Prostate cancer | Pancreatic cancer | Migration | Care and treatment | Heme | Drug therapy | Cells | Cancer
Journal Article
Polish Journal of Environmental Studies, ISSN 1230-1485, 2014, Volume 23, Issue 3, pp. 949 - 954
Thallium is a metal with a high rate of accumulation in the environment and at the same time there is a very large dispersion of it. Heavy metal studies and... 
Thallium | Intoxication | Laying hens | Blood | ENVIRONMENTAL SCIENCES | laying hens | CHINA | TOXICITY | ACCUMULATION | blood | intoxication | thallium
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 13399 - 10
PIM1 is an oncogenic kinase overexpressed in a number of cancers where it correlates with poor prognosis. Several studies demonstrated that inhibition of PIM1... 
REFINEMENT | TARGET | POTENT | DESIGN | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL EVALUATION | CRYSTAL-STRUCTURES | PROTEIN-KINASES | DISCOVERY | Cyclin-dependent kinase | Fighting | Casein | Kinases | Casein kinase II | Cyclin-dependent kinases
Journal Article
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 03/2015, Volume 83, Issue 3, pp. 582 - 589
Journal Article