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Methods in molecular biology (Clifton, N.J.), 2019, Volume 1960, pp. 23 - 40
Transgenic mouse models can be subdivided into two main categories based on genomic location: (1) targeted genomic manipulation and (2) random integration into... 
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. AB7 - AB7
  Respiratory parameters and plasma levels of multiple eicosanoids were recorded at baseline and after four weeks of aspirin therapy using the Asthma Control... 
Allergy and Immunology | ALLERGY | IMMUNOLOGY | Medical colleges | Medical research | Prognosis | Lung diseases | Patient outcomes | Environmental health | Medicine, Experimental | Plasma | Aspirin | Respiratory diseases
Journal Article
Circulation Research, ISSN 0009-7330, 03/2017, Volume 120, Issue 11, pp. 1776 - 1788
RATIONALE:20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome P450 (CYP) eicosanoids, is a potent vasoactive lipid whose vascular... 
cytochrome P-450 enzyme system | cardiovascular diseases | receptor, epidermal growth factor | vascular remodeling | hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | ARACHIDONIC-ACID | ANGIOTENSIN-CONVERTING ENZYME | BLOOD-PRESSURE | SALT-SENSITIVE RATS | CHANNEL | URINARY 20-HYDROXYEICOSATETRAENOIC ACID | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | C-SRC | Receptors, G-Protein-Coupled - metabolism | Humans | Cells, Cultured | Hydroxyeicosatetraenoic Acids - toxicity | Rats | Endothelium, Vascular - drug effects | Male | Mice, Transgenic | Endothelium, Vascular - physiology | Hypertension - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Signal Transduction - drug effects | Hydroxyeicosatetraenoic Acids - pharmacology | Hypertension - chemically induced | Signal Transduction - physiology | Vascular Remodeling - physiology | Mice | Vascular Remodeling - drug effects | Protein Binding - physiology | Myocardial infarction | Phosphorylation | Protein kinase C | G protein-coupled receptors | Eicosanoids | Smooth muscle | Antagonists | Inositol phosphate | Kinases | Proteins | Epidermal growth factor | Vascular diseases | Peptidyl-dipeptidase A | Vasoactive agents | Blood pressure | Growth factors | Hypertension | Cerebral infarction | Enzymes | Cytochrome P450 | Contractility | Vasoconstriction | Src protein | Muscle contraction | Endothelial cells | Angiotensin | Cardiovascular diseases | Binding sites | Cell migration | Index Medicus | 20-HETE | Vascular Remodeling | ACE | Signal Transduction | Vascular Biology | GPR75 | cytochrome P450 | Remodeling | EGFR | eicosanoids | Cell Signaling | GIT1
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2015, Volume 230, Issue 9, pp. 2108 - 2119
Macrophages, owning tremendous phenotypic plasticity and diverse functions, were becoming the target cells in various inflammatory, metabolic and immune... 
SOLUBLE EPOXIDE HYDROLASE | M2 MACROPHAGES | PHYSIOLOGY | ACTIVATED RECEPTOR-GAMMA | ANTIINFLAMMATORY PROPERTIES | SPONTANEOUSLY HYPERTENSIVE-RATS | CYP2J2 OVEREXPRESSION | THERAPEUTIC TARGET | ENDOTHELIAL-CELLS | HEME OXYGENASE-1 | LAMINAR-FLOW | CELL BIOLOGY | Inflammation - chemically induced | Cytochrome P-450 Enzyme System - metabolism | NF-kappa B - metabolism | Heme Oxygenase-1 - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Myocardium - metabolism | PPAR gamma - genetics | Lipopolysaccharides - toxicity | Macrophages - pathology | Gene Expression Regulation - genetics | Myocardium - pathology | PPAR alpha - genetics | Signal Transduction - genetics | Cell Polarity - genetics | Inflammation - therapy | Macrophages - metabolism | Animals | NF-kappa B - genetics | 8,11,14-Eicosatrienoic Acid - administration & dosage | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 Enzyme System - therapeutic use | Inflammation - genetics | Mice | PPAR alpha - metabolism | Unsaturated fatty acids | Evaluation | Macrophages | Cytochrome P-450 | Cytochrome | Heart | Post-transcription | Polarization | Transcription | Viruses | Activation | Arachidonic acid | Inflammatory diseases | Lipopolysaccharides | Signal transduction | Receptors | Rodents | Heme | Heart diseases | Recombinant | Cardiovascular system | NF-κB protein | Cytokines | Medical treatment | Cytochrome P450 | Phenotypic plasticity | Oxygenase | Signaling | Acids | Interleukin 10 | Infiltration | Peroxisome proliferator-activated receptors | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2017, Volume 284, Issue 13, pp. 1970 - 1986
Podocytes play a key role in kidney function by participating in glomerular filtration and maintaining the integrity of the glomerular basement membrane.... 
knockout mice | soluble epoxide hydrolase | proteinuria | podocyte | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | DIABETIC-NEPHROPATHY | ENDOPLASMIC-RETICULUM STRESS | LOWERS BLOOD-PRESSURE | NEPHROTIC-SYNDROME | URINE PROTEINS | MESANGIAL CELLS | PHARMACOLOGICAL INHIBITION | ACUTE-PANCREATITIS | RENAL TUBULAR DISORDERS | Kidney - pathology | Blood Urea Nitrogen | Podocytes - enzymology | Immunoblotting | Acute Kidney Injury - genetics | Kidney - metabolism | Piperidines - pharmacology | Cytokines - genetics | Cytokines - blood | Epoxide Hydrolases - deficiency | Kidney - drug effects | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Solubility | Mice, Transgenic | Signal Transduction - genetics | Proteinuria - genetics | Acute Kidney Injury - enzymology | Reverse Transcriptase Polymerase Chain Reaction | Epoxide Hydrolases - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Proteinuria - enzymology | Animals | Lipopolysaccharides - pharmacology | Phenylurea Compounds - pharmacology | Epoxide Hydrolases - antagonists & inhibitors | Microscopy, Fluorescence | Enzymes | Hydrolases | Mitogens | Renal function | Transcription | Pathogenesis | Epoxide hydrolase | Lipopolysaccharides | Interleukin 6 | Rodents | Interleukin 1 | Attenuation | Inhibition | Injuries | Kidneys | Cytokines | MAP kinase | Pharmacology | Inflammation | Nitrogen | Urea | Inhibitors | Tumor necrosis factor | Mice | In vivo methods and tests | Staphylococcal enterotoxin H | Endoplasmic reticulum | Proteinuria | Index Medicus
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2018, Volume 141, Issue 2, pp. AB181 - AB181
Results In AERD patients, 15-HETE levels in nasal polyp supernatant significantly decreased in response to stimulation by aspirin-lysine (from baseline of 18.6... 
ALLERGY | IMMUNOLOGY | Lysine | Aspirin | Respiratory diseases
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e110162 - e110162
Fatty liver disease is an emerging public health problem without effective therapies, and chronic hepatic inflammation is a key pathologic mediator in its... 
SOLUBLE EPOXIDE HYDROLASE | HYDRODYNAMICS-BASED TRANSFECTION | MULTIDISCIPLINARY SCIENCES | MOUSE | ATHEROGENIC DIET | NONALCOHOLIC STEATOHEPATITIS | EICOSANOID METABOLISM | MICE | ARACHIDONIC-ACID | LARGE GENE LISTS | ENDOTHELIAL EXPRESSION | Biomarkers - metabolism | Fatty Liver - genetics | Epoxide Hydrolases - deficiency | Inflammation - pathology | Arachidonic Acid - metabolism | Liver - pathology | Liver - enzymology | Fatty Liver - blood | Fatty Liver - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Cytochrome P-450 Enzyme System - metabolism | Hydrodynamics | Male | Inflammation - blood | Metabolic Networks and Pathways - genetics | Animals | Diet | Eicosanoids - metabolism | Lipids - blood | Atherosclerosis | Fatty Liver - enzymology | Inflammation - genetics | Epoxide Hydrolases - metabolism | Unsaturated fatty acids | Inflammation | Fatty liver | Analysis | Cytochrome P-450 | Cytochrome | Health sciences | Liver | Inflammatory response | Cardiovascular disease | Biosynthesis | Arachidonic acid | Phosphatase | Epoxide hydrolase | Biological effects | Atherogenic diet | Rodents | Hepatology | Drug therapy | Pharmaceutical sciences | Public health | Cardiovascular system | Enzymes | Liver diseases | Cytochrome P450 | Environmental health | Metabolism | Gene expression | Cholesterol | Biological activity | Nutrition research | Acids | Pharmacy | Mice | Laboratory animals | Apoptosis | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 09/2012, Volume 303, Issue 5, pp. E563 - E575
Chen G, Xu R, Wang Y, Wang P, Zhao G, Xu X, Gruzdev A, Zeldin DC, Wang DW. Genetic disruption of soluble epoxide hydrolase is protective against... 
Epoxyeicosatrienoic acids | Diabetic nephropathy | HK-2 cells | Soluble epoxide hydrolase gene disruption | SIGNALING PATHWAYS | PHYSIOLOGY | hk-2 cells | ACTIVATED PROTEIN-KINASE | NITRIC-OXIDE SYNTHASE | NECROSIS-FACTOR-ALPHA | epoxyeicosatrienoic acids | SKELETAL-MUSCLE | AKT PHOSPHORYLATION | INSULIN-RESISTANCE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | TUBULAR EPITHELIAL-CELLS | soluble epoxide hydrolase gene disruption | HUMAN TISSUE KALLIKREIN | diabetic nephropathy | Kidney Cortex - drug effects | Apoptosis - drug effects | Kidney Cortex - metabolism | Streptozocin | Humans | Diabetic Nephropathies - drug therapy | Cytoplasm - metabolism | 8,11,14-Eicosatrienoic Acid - metabolism | Diabetic Nephropathies - blood | Molecular Targeted Therapy | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | 8,11,14-Eicosatrienoic Acid - urine | 8,11,14-Eicosatrienoic Acid - pharmacology | Disease Models, Animal | Diabetic Nephropathies - urine | Cytoplasm - enzymology | Hyperglycemia - prevention & control | Kidney Tubules, Proximal - pathology | Diabetic Nephropathies - metabolism | Gene Silencing | Kidney Cortex - pathology | Albuminuria - prevention & control | Tumor Necrosis Factor-alpha | Apoptosis Regulatory Proteins - metabolism | Epoxide Hydrolases - genetics | Animals | Signal Transduction - drug effects | Kidney Tubules, Proximal - metabolism | Mice | RNA, Small Interfering | Epoxide Hydrolases - metabolism | Cytoplasm - drug effects | Epoxide Hydrolases - antagonists & inhibitors | Cell Line, Transformed | Kidney Tubules, Proximal - drug effects | Enzymes | Diabetic nephropathies | Cytochrome P-450 | Physiological aspects | Development and progression | Hydrolases | Genetic aspects | Health aspects | Molecules | Pathogenesis | Physiology | Diabetes | Metabolism | Pharmaceuticals | Index Medicus | Call for Papers
Journal Article
Transgenic Research, ISSN 0962-8819, 2/2018, Volume 27, Issue 1, pp. 39 - 49
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 2016, Volume 5, Issue 4, pp. 998 - 1007.e2
Journal Article