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acute lymphoblastic leukemia; checkpoint kinase; dna damage; drug-sensitivity; new targets; animals; apoptosis; benzodiazepinones; blotting, western; cell cycle; cell line, tumor; cell survival; dose-response relationship, drug; gene expression profiling; gene expression regulation, leukemic; humans; leukemia, experimental; mice, inbred c57bl; microscopy, fluorescence; neoplastic stem cells; precursor b-cell lymphoblastic leukemia-lymphoma; precursor t-cell lymphoblastic leukemia-lymphoma; protein kinase inhibitors; protein kinases; pyrazoles; survival analysis; hematology; oncology; cancer research; molecular biology (1) 1
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Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40934
Journal Article
Cancer, ISSN 0008-543X, 03/2019, Volume 125, Issue 5, pp. 712 - 725
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3372 - 3372
There has been a fast progress in clinical use of antibody-based immunotherapy, given the superior efficacy commonly achieved in clinic and the limited... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1675 - 1675
Abstract Background: Patient stratification to match individual patients with the most effective drug treatment is still a major open challenge in cancer care.... 
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 07/2015, Volume 13, Issue 1, p. 229
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14_Supplement, pp. 2723 - 2723
Different Checkpoint kinase inhibitors (Chk-i) have been developed to increase the cytotoxic effect of genotoxic agents inhibiting the key elements of the DNA... 
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 11/2015, Volume 8, Issue 1, p. 125
Background: Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736... 
Checkpoint kinase | Acute lymphoblastic leukemia | Drug-sensitivity | DNA damage | New targets | PHOSPHORYLATION | PF-00477736 | G CHECKPOINT | CHEMOTHERAPY-INDUCED APOPTOSIS | CANCER | CDC25A | DNA-DAMAGE CHECKPOINT | CHK1 | ONCOLOGY | IONIZING-RADIATION | HEMATOLOGY | PHASE-I | Protein Kinases - metabolism | Cell Cycle - genetics | Protein Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Dose-Response Relationship, Drug | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Leukemia, Experimental - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia, Experimental - drug therapy | Benzodiazepinones - pharmacology | Mice, Inbred C57BL | Gene Expression Regulation, Leukemic - drug effects | Gene Expression Profiling - methods | Blotting, Western | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Survival Analysis | Cell Line, Tumor | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Leukemia, Experimental - metabolism | Microscopy, Fluorescence | Complications and side effects | Care and treatment | Analysis | Acute lymphocytic leukemia | Research | Apoptosis
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2478 - 2478
Abstract Nowadays the effectiveness of the treatments for adult Acute Lymphoblastic Leukemia (ALL) patients is still inadequate and frequently many patients... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4507 - 4507
Acute Myeloid Leukemia (AML) is a clonal hematopoietic disorder characterized by an abnormal proliferation and differentiation of immature blast cells in the... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 113 - 113
Acute Myeloid Leukemia (AML) is a highly heterogeneous disease and somatic mutations and fusion genes have a crucial diagnostic, prognostic and therapeutic... 
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2243 - 2243
Journal Article
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