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The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Adolescence | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B | Cell lines
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 2/2012, Volume 138, Issue 2, pp. 347 - 357
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 10, pp. 1226 - 1231
Journal Article
Nature Genetics, ISSN 1061-4036, 2016, Volume 48, Issue 12, pp. 1481 - 1489
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2013, Volume 45, Issue 6, pp. 602 - 612
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 157 - 163
Journal Article
Nature Communications, ISSN 2041-1723, 04/2014, Volume 5, Issue 1, p. 3630
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 451 - 456
Journal Article
by Holmfeldt, Linda and Wei, Lei and Diaz-Flores, Ernesto and Walsh, Michael and Zhang, Jinghui and Ding, Li and Payne-Turner, Debbie and Churchman, Michelle and Andersson, Anna and Chen, Shann-Ching and Mccastlain, Kelly and Becksfort, Jared and Ma, Jing and Wu, Gang and Patel, Samir N and Heatley, Susan L and Phillips, Letha A and Song, Guangchun and Easton, John and Parker, Matthew and Chen, Xiang and Rusch, Michael and Boggs, Kristy and Vadodaria, Bhavin and Hedlund, Erin and Drenberg, Christina and Baker, Sharyn and Pei, Deqing and Cheng, Cheng and Huether, Robert and Lu, Charles and Fulton, Robert S and Fulton, Lucinda L and Tabib, Yashodhan and Dooling, David J and Ochoa, Kerri and Minden, Mark and Lewis, Ian D and To, L. Bik and Marlton, Paula and Roberts, Andrew W and Raca, Gordana and Stock, Wendy and Neale, Geoffrey and Drexler, Hans G and Dickins, Ross A and Ellison, David W and Shurtleff, Sheila A and Pui, Ching-Hon and Ribeiro, Raul C and Devidas, Meenakshi and Carroll, Andrew J and Heerema, Nyla A and Wood, Brent and Borowitz, Michael J and Gastier-Foster, Julie M and Raimondi, Susana C and Mardis, Elaine R and Wilson, Richard K and Downing, James R and Hunger, Stephen P and Loh, Mignon L and Mullighan, Charles G and Lund University and Division of Clinical Genetics and Avdelningen för klinisk genetik and The pathogenetic mechanisms behind MLL-rearranged acute leukemia in infancy and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Lunds universitet and MLL-rearrangerad leukemi hos spädbarn
Nature Genetics, ISSN 1061-4036, 03/2013, Volume 45, Issue 3, pp. 242 - 252
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic... 
P53 MUTATIONS | NEUROFIBROMATOSIS TYPE-1 GENE | TRANSMEMBRANE ADAPTER | IKAROS | GENETICS & HEREDITY | JUVENILE MYELOMONOCYTIC LEUKEMIA | REGULATORY T-CELLS | MUTANT P53 | HUMAN CANCERS | HEMATOLOGIC MALIGNANCIES | CHILDHOOD | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Aneuploidy | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Tumor Suppressor Protein p53 - genetics | Ikaros Transcription Factor - genetics | Haploidy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Base Sequence | Ikaros Transcription Factor - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Signal Transduction | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Treatment Outcome | Phosphatidylinositol 3-Kinases - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Retinoblastoma Protein - genetics | Chromosome Aberrations | Cell Line, Tumor | Mice | Mutation | Care and treatment | Genomics | Physiological aspects | Genetic aspects | Research | Acute lymphocytic leukemia | Cancer | Medical research | Pediatrics | Cloning | Genetics | Genomes | Kinases | Chromosomes | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article