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Journal of Clinical Oncology, ISSN 0732-183X, 08/2019, Volume 37, Issue 22, pp. 1984 - 1985
Journal Article
by Okada, Yukinori and Wu, Di and Trynka, Gosia and Raj, Towfique and Terao, Chikashi and Ikari, Katsunori and Kochi, Yuta and Ohmura, Koichiro and Suzuki, Akari and Yoshida, Shinji and Graham, Robert R and Manoharan, Arun and Ortmann, Ward and Bhangale, Tushar and Denny, Joshua C and Carroll, Robert J and Eyler, Anne E and Greenberg, Jeffrey D and Kremer, Joel M and Pappas, Dimitrios A and Jiang, Lei and Yin, Jian and Ye, Lingying and Su, Ding-Feng and Yang, Jian and Xie, Gang and Keystone, Ed and Westra, Harm-Jan and Esko, Tõnu and Metspalu, Anes and Zhou, Xuezhong and Gupta, Namrata and Mirel, Daniel and Stahl, Eli A and Diogo, Dorothée and Cui, Jing and Liao, Katherine and Guo, Michael H and Myouzen, Keiko and Kawaguchi, Takahisa and Coenen, Marieke J. H and van Riel, Piet L. C. M and van de Laar, Mart A. F. J and Guchelaar, Henk-Jan and Huizinga, Tom W. J and Dieudé, Philippe and Mariette, Xavier and Bridges, S. Louis and Zhernakova, Alexana and Toes, Rene E. M and Tak, Paul P and Miceli-Richard, Corinne and Bang, So-Young and Lee, Hye-Soon and Martin, Javier and Gonzalez-Gay, Miguel A and Roiguez-Roiguez, Luis and Rantapää-Dahlqvist, Solbritt and Arlestig, Lisbeth and Choi, Hyon K and Kamatani, Yoichiro and Galan, Pilar and Lathrop, Mark and Eyre, Steve and Bowes, John and Barton, Anne and de Vries, Niek and Moreland, Larry W and Criswell, Lindsey A and Karlson, Elizabeth W and Taniguchi, Atsuo and Yamada, Ryo and Kubo, Michiaki and Liu, Jun S and Bae, Sang-Cheol and Worthington, Jane and Padyukov, Leonid and Klareskog, Lars and Gregersen, Peter K and Raychaudhuri, Soumya and Stranger, Barbara E and de Jager, Philip L and Franke, Lude and Visscher, Peter M and Brown, Matthew A and Yamanaka, Hisashi and Mimori, Tsuneyo and Takahashi, Atsushi and Xu, Huji and Behrens, Timothy W and Siminovitch, Katherine A and Momohara, Shigeki and Matsuda, Fumihiko and Yamamoto, Kazuhiko and Plenge, Robert M and Lee, Annette and Martin, Paul and Stahl, Eli and Viatte, Sebastien and McAllister, Kate and ... and RACI Consortium and GARNET Consortium and RACI consortium and GARNET consortium and the RACI consortium and the GARNET consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Reumatologi
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 376 - +
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets... 
RECEPTOR INHIBITION | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | SUSCEPTIBILITY | RISK | LOCI | IDENTIFICATION | TRAITS | GENOME-WIDE ASSOCIATION | RESOURCE | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Asian Continental Ancestry Group - genetics | Computational Biology | Male | Drug Repositioning | Molecular Targeted Therapy | Drug Discovery | Case-Control Studies | Arthritis, Rheumatoid - pathology | Mice, Knockout | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - genetics | Animals | Arthritis, Rheumatoid - drug therapy | Alleles | Polymorphism, Single Nucleotide - genetics | Female | Hematologic Neoplasms - genetics | Mice | Hematologic Neoplasms - metabolism | Quantitative trait loci | Genome-wide association studies | Rheumatoid arthritis | Genetic research | Genetic aspects | Research | Human genetics | Disease | Hematology | Cytokines | Genes | Genomics | Genomes | Meta-analysis | Proteins | Confidence intervals | Hypotheses | Quality control | Epigenetics | Population | Genetics | Health risk assessment | Asians | Cancer | Index Medicus | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Virtual screening | Klinisk medicin
Journal Article
Pharmacogenomics, ISSN 1462-2416, 05/2018, Volume 19, Issue 7, pp. 613 - 619
A third of rheumatoid arthritis patients discontinue methotrexate treatment due to inefficacy or toxic side effects. Recently, an association between SLC04A1... 
methotrexate | SLC | rheumatoid arthritis | pharmacogenetics | solute carrier | Index Medicus
Journal Article
Drug Discovery Today, ISSN 1359-6446, 03/2019, Volume 24, Issue 3, pp. 890 - 897
Adverse drug reactions (ADRs) that diminish sexual functioning can seriously affect a person’s quality of life and can also affect drug adherence. However, no... 
BENIGN PROSTATIC HYPERPLASIA | HORMONAL CONTRACEPTIVES | ANTIDEPRESSANT | IMPACT | URINARY-TRACT SYMPTOMS | HYPERPROLACTINEMIA | PSYCHOTROPIC-DRUGS | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSIVE DISORDER | DYSFUNCTION | CANCER | Drugs | Drugstores | Complications and side effects | Sexual disorders | Pharmacy
Journal Article
Drug Discovery Today, ISSN 1359-6446, 08/2016, Volume 21, Issue 8, pp. 1206 - 1212
In the rapidly evolving fields of cellular immunotherapy, gene therapy and regenerative medicine, a wide range of promising cell therapy medicinal products are... 
Journal Article
European journal of human genetics : EJHG, ISSN 1018-4813, 06/2019
Despite the nationwide availability of pharmacogenomic (PGx) guidelines in electronic medication surveillance systems in The Netherlands, PGx guided... 
Journal Article
European Urology, ISSN 0302-2838, 2015, Volume 68, Issue 4, pp. 621 - 629
Abstract Background In our exploratory studies, we associated single nucleotide polymorphisms (SNPs) in candidate genes with the efficacy and toxicities of... 
Urology | Metastatic renal cell carcinoma | Association analysis | Sunitinib | Pharmacogenetics | Biomarker | Single nucleotide polymorphism | VEGF | SU11248 | PHARMACOKINETICS | UROLOGY & NEPHROLOGY | HYPERTENSION | INHIBITOR | ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | Haplotypes | Pyrroles - pharmacokinetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Netherlands | Cytochrome P-450 CYP3A - genetics | Time Factors | Antineoplastic Agents - adverse effects | Pyrroles - adverse effects | Female | Antineoplastic Agents - pharmacokinetics | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Protein Kinase Inhibitors - pharmacokinetics | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Kidney Neoplasms - mortality | Disease Progression | Spain | Carcinoma, Renal Cell - mortality | Disease-Free Survival | Indoles - adverse effects | Cytochrome P-450 CYP3A - metabolism | Protein Kinase Inhibitors - therapeutic use | Carcinoma, Renal Cell - secondary | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Indoles - pharmacokinetics | Indoles - therapeutic use | Kidney Neoplasms - pathology | Aged | Ohio | Polymorphism, Single Nucleotide | Kidney Neoplasms - drug therapy | ATP Binding Cassette Transporter, Sub-Family B - genetics | Antimitotic agents | Pharmacy | Drugstores | Genetic aspects | Carcinoma, Renal cell | Metastasis | Single nucleotide polymorphisms | Antineoplastic agents | Chromosomes | Index Medicus
Journal Article
Pharmaceutisch Weekblad, ISSN 0031-6911, 02/2018, Volume 153, Issue 7, pp. 20 - 21
Journal Article
Drug Discovery Today, ISSN 1359-6446, 11/2016, Volume 21, Issue 11, pp. 1775 - 1786
In osteosarcoma, large variation is observed in the efficacy and toxicity of chemotherapeutic drugs among similarly treated patients. Treatment optimization... 
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 03/2019, Volume 490, pp. 77 - 80
Pharmacogenetic testing is increasingly implemented in routine diagnostics. However, quality control measures, in particular confirmation practices e.g. the... 
Pharmacogenetics | Genotyping | Confirmation | Quality | GENOTYPE | FLUOROPYRIMIDINE | RISK | MEDICAL LABORATORY TECHNOLOGY | Index Medicus
Journal Article
Cancer journal (Sudbury, Mass.), ISSN 1528-9117, 03/2019, Volume 25, Issue 2, pp. 147 - 148
Journal Article