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1. Full Text Liposomal drug formulations in cancer therapy: 15 years along the road
by Slingerland, Marije and Guchelaar, Henk-Jan and Gelderblom, Hans
Drug discovery today, ISSN 1359-6446, 02/2012, Volume 17, Issue 3-4, pp. 160 - 166
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Doxorubicin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Drug Approval | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Drug Design | Liposomes | Neoplasms - pathology | Doxorubicin - adverse effects | Doxorubicin - administration & dosage | Drugs | Anthracyclines | Drug delivery systems | Care and treatment | Health aspects | Vehicles | Cancer | Index Medicus
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2. Full Text Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors
by Slingerland, Marije and Guchelaar, Henk-Jan and Gelderblom, Hans
Anti-cancer drugs, ISSN 0959-4973, 02/2014, Volume 25, Issue 2, pp. 140 - 149
cancer | histone deacetylase | solid tumors | histone deacetylase inhibitors | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Animals | Humans | Histone Deacetylase Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Histone Deacetylase Inhibitors - therapeutic use | Neoplasms - drug therapy | Index Medicus
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3. Full Text Pharmacogenomics, a novel section in the European Journal of Human Genetics
by Guchelaar, Henk-Jan
European journal of human genetics : EJHG, ISSN 1018-4813, 10/2018, Volume 26, Issue 10, pp. 1399 - 1400
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Human Genetics - trends | Peer Review, Research - trends | Pharmacogenetics - trends | Humans | Index Medicus
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4. Full Text Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy
by Goetz, Matthew P and Sangkuhl, Katrin and Guchelaar, Henk‐Jan and Schwab, Matthias and Province, Michael and Whirl‐Carrillo, Michelle and Symmans, W. Fraser and McLeod, Howard L and Ratain, Mark J and Zembutsu, Hitoshi and Gaedigk, Andrea and van Schaik, Ron H and Ingle, James N and Caudle, Kelly E and Klein, Teri E
Clinical pharmacology and therapeutics, ISSN 0009-9236, 05/2018, Volume 103, Issue 5, pp. 770 - 777
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tamoxifen - metabolism | Cytochrome P-450 CYP2D6 - genetics | Cytochrome P-450 CYP2D6 Inhibitors - therapeutic use | Humans | Genotype | Breast Neoplasms - drug therapy | Breast Neoplasms - genetics | Pharmacogenetics - legislation & jurisprudence | Antineoplastic Agents, Hormonal - therapeutic use | Tamoxifen - therapeutic use | Tamoxifen - analogs & derivatives | Female | Neoplasm Recurrence, Local - genetics | Index Medicus | Abridged Index Medicus
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5. Full Text Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review
by Baas, Jara M and Krens, Lisanne L and Guchelaar, Henk‐Jan and Morreau, Hans and Gelderblom, Hans
The oncologist (Dayton, Ohio), ISSN 1083-7159, 09/2011, Volume 16, Issue 9, pp. 1239 - 1249
Monoclonal antibodies | KRAS | EGFR inhibitors | Concordance | Colorectal cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Proto-Oncogene Proteins - metabolism | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colorectal Neoplasms - enzymology | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | ras Proteins - metabolism | Proto-Oncogene Proteins - genetics | Neoplasm Metastasis | Receptor, Epidermal Growth Factor - metabolism | Animals | Colorectal Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Mutation | Colorectal Neoplasms - pathology | Index Medicus | Gastrointestinal Cancer
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6. Full Text Genetics of rheumatoid arthritis contributes to biology and drug discovery
by Okada, Yukinori and Wu, Di and Trynka, Gosia and Raj, Towfique and Terao, Chikashi and Ikari, Katsunori and Kochi, Yuta and Ohmura, Koichiro and Suzuki, Akari and Yoshida, Shinji and Graham, Robert R and Manoharan, Arun and Ortmann, Ward and Bhangale, Tushar and Denny, Joshua C and Carroll, Robert J and Eyler, Anne E and Greenberg, Jeffrey D and Kremer, Joel M and Pappas, Dimitrios A and Jiang, Lei and Yin, Jian and Ye, Lingying and Su, Ding-Feng and Yang, Jian and Xie, Gang and Keystone, Ed and Westra, Harm-Jan and Esko, Tõnu and Metspalu, Anes and Zhou, Xuezhong and Gupta, Namrata and Mirel, Daniel and Stahl, Eli A and Diogo, Dorothée and Cui, Jing and Liao, Katherine and Guo, Michael H and Myouzen, Keiko and Kawaguchi, Takahisa and Coenen, Marieke J. H and van Riel, Piet L. C. M and van de Laar, Mart A. F. J and Guchelaar, Henk-Jan and Huizinga, Tom W. J and Dieudé, Philippe and Mariette, Xavier and Bridges, S. Louis and Tak, Paul P and de Vries, Niek and RACI Consortium and GARNET Consortium and RACI consortium and GARNET consortium and the RACI consortium and the GARNET consortium
Nature (London), ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 376 - +
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Asian Continental Ancestry Group - genetics | Computational Biology | Male | Drug Repositioning | Molecular Targeted Therapy | Drug Discovery | Case-Control Studies | Arthritis, Rheumatoid - pathology | Mice, Knockout | Arthritis, Rheumatoid - metabolism | Arthritis, Rheumatoid - genetics | Animals | Arthritis, Rheumatoid - drug therapy | Alleles | Polymorphism, Single Nucleotide - genetics | Female | Hematologic Neoplasms - genetics | Mice | Hematologic Neoplasms - metabolism | Quantitative trait loci | Genome-wide association studies | Rheumatoid arthritis | Genetic research | Genetic aspects | Research | Human genetics | Disease | Hematology | Cytokines | Genes | Genomics | Genomes | Meta-analysis | Proteins | Confidence intervals | Hypotheses | Quality control | Epigenetics | Population | Genetics | Health risk assessment | Asians | Cancer | Index Medicus | Life Sciences | Medicin och hälsovetenskap
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7. Full Text Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx)
by Just, Katja Susanne and Steffens, Michael and Swen, Jesse Joachim and Patrinos, George P and Guchelaar, Henk-Jan and Stingl, Julia Carolin
European journal of clinical pharmacology, ISSN 0031-6970, 10/2017, Volume 73, Issue 10, pp. 1247 - 1252
Pharmacogenetics | Biomedicine | Clinical pharmacology | Medical education | Cultural diversity | Pharmacology/Toxicology | Pharmacogenomics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Health Personnel - education | Pharmacogenetics - education | Education, Medical - organization & administration | Europe | Humans | Pharmacogenomic Variants | Surveys and Questionnaires | Pharmacogenomic Testing | Pharmacology, Clinical - education | Medical personnel | Surveys | Training | Health care | Drugs | Education | Drug metabolism | Pharmacology | Metabolism | Index Medicus
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8. Full Text A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices
by Knikman, Jonathan E and Rosing, Hilde and Guchelaar, Henk-Jan and Cats, A and Beijnen, Jos H
Biomedical chromatography, ISSN 0269-3879, 01/2020, Volume 34, Issue 1, pp. e4732 - n/a
Fluoropyrimidines | capecitabine | mass spectrometry | bioanalysis | chromatography | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Pharmacology & Pharmacy | Chemistry, Analytical | Science & Technology | Capecitabine - analysis | Animals | Chemical Fractionation | Capecitabine - isolation & purification | Humans | Mass Spectrometry | Chromatography, Liquid | Mice | Capecitabine - chemistry | Index Medicus
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9. Full Text High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study
by van der Stoep, M. Y. Eileen C and Bertaina, Alice and ten Brink, Marloes H and Bredius, Robbert G and Smiers, Frans J and Wanders, Dominique C. M and Moes, Dirk Jan A.R and Locatelli, Franco and Guchelaar, Henk‐Jan and Zwaveling, Juliëtte and Lankester, Arjan C
British journal of haematology, ISSN 0007-1048, 12/2017, Volume 179, Issue 5, pp. 772 - 780
toxicity | paediatrics | pharmacokinetics | treosulfan | conditioning regimen | Life Sciences & Biomedicine | Hematology | Science & Technology | Busulfan - analogs & derivatives | Prospective Studies | Humans | Child, Preschool | Infant | Male | Antineoplastic Agents, Alkylating - administration & dosage | Busulfan - administration & dosage | Hematopoietic Stem Cell Transplantation - adverse effects | Antineoplastic Agents, Alkylating - blood | Female | Transplantation Conditioning - adverse effects | Transplantation Conditioning - methods | Child | Graft vs Host Disease - etiology | Chemical and Drug Induced Liver Injury - etiology | Busulfan - blood | Drug Eruptions - etiology | Busulfan - adverse effects | Graft Survival | Transplantation Chimera | Mucositis - chemically induced | Hematologic Diseases - therapy | Hematologic Diseases - blood | Hematopoietic Stem Cell Transplantation - methods | Antineoplastic Agents, Alkylating - adverse effects | Medicine, Experimental | Pediatrics | Medical research | Transplantation | Hematopoietic stem cells | Stem cells | Graft-versus-host reaction | Toxicity | Variability | Mucosa | Medical treatment | Stem cell transplantation | Infants | Pharmacology | Exposure | Treosulfan | Patients | Clinical outcomes | Confidence intervals | Skin | Chimerism | Children | Pharmacokinetics | Index Medicus
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