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1. Full Text CuSO 4-glucose for in situ generation of controlled Cu(I)-Cu(II) bicatalysts: Multicomponent reaction of heterocyclic azine and aldehyde with alkyne, and cycloisomerization toward synthesis of N-fused imidazoles
by Guchhait, Sankar K and Chandgude, Ajay L and Priyadarshani, Garima
Journal of Organic Chemistry, ISSN 0022-3263, 05/2012, Volume 77, Issue 9, pp. 4438 - 4444
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2. Full Text C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules
by Kumari, Anuradha and Srivastava, Shalini and Manne, Rajesh K and Sisodiya, Shailendra and Santra, Manas K and Guchhait, Sankar K and Panda, Dulal
Biochemical Pharmacology, ISSN 0006-2952, 12/2019, Volume 170, p. 113663
Combretastatin A4 and its analogs are undergoing various clinical trials for the treatment of different cancers. This study illustrated the molecular mechanism... 
Anticancer agent | Microtubule targeting agents | Spindle assembly checkpoint | Microtubules | Cancer | Apoptosis
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3. Full Text A Combretastatin Analogue C12 Binds to Colchicine Site in Tubulin, Inhibits Spindle Microtubule Dynamics, Activates Mitotic Checkpoint and Induces Apoptosis in Cancer Cells
by Kumari, Anuradha and Srivastava, Shalini and Shyam Prassanawar, Shweta and Sisodiya, Shailendra and Guchhait, Sankar K and Panda, Dulal
Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 415a - 415a
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4. Full Text Pharmacoinformatics analysis of merbarone binding site in human topoisomerase II[alpha]
by Tripathi, Neha and Guchhait, Sankar K and Bharatam, Prasad V
Journal of Molecular Graphics and Modelling, ISSN 1093-3263, 01/2019, Volume 86, p. 1
Merbarone is a derivative of thiobarbituric acid, possessing catalytic inhibitory potential against human topoisomerase II[alpha] (hTopoII[alpha]). Merbarone... 
Enzymes | Analysis | Force and energy | Crystals | Molecular dynamics | Structure
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5. A nitrile-stabilized ammonium ylide as a masked C-C&z.dbd; N synthon in heterocyclization with amidine-imine: 3-component assembly to fused pyrimidine scaffolds
by Guchhait, Sankar K and Saini, Meenu and Sumkaria, Divyani and Chaudhary, Vikas
Chemical Communications: Chem Comm, ISSN 1359-7345, 06/2017, Volume 53, Issue 51, pp. 6941 - 6944
A unique reactivity of a nitrile-stabilized quaternary ammonium ylide as a masked C-C&z.dbd; N synthon in contrast to its usual sigmatropic rearrangement has... 
Pyrimidines | Scaffolds | Assembly
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6. Full Text Synthesis of Polysubstituted 2‑Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α‑Bromoalkenones
by Guchhait, Sankar K and Hura, Neha and Shah, Archana P
The Journal of Organic Chemistry, ISSN 0022-3263, 03/2017, Volume 82, Issue 5, pp. 2745 - 2752
A step-economical access to polysubstituted aminoimidazoles has been accomplished via alkene vicinal C–N bonds formation of 2-bromo-2-alkenones with guanidine... 
OXIDATION | INTRAMOLECULAR DIAMINATION | PALLADIUM | KETONES | AMIDINES | HETEROCYCLES | CHEMISTRY | CHEMISTRY, ORGANIC | BROMIDE | IMIDAZOLES | ALKALOIDS | Research | Chemical properties | Chemical synthesis | Guanidine | Amino compounds
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7. Full Text Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα
by Tripathi, Neha and Guchhait, Sankar K and Bharatam, Prasad V
Journal of Molecular Graphics and Modelling, ISSN 1093-3263, 01/2019, Volume 86, pp. 1 - 18
Merbarone is a derivative of thiobarbituric acid, possessing catalytic inhibitory potential against human topoisomerase IIα (hTopoIIα). Merbarone was reported... 
Molecular dynamics | Virtual screening | Merbarone | Human topoisomerase IIα | Binding energy | DNA-Cleavage inhibitors | TARGET | DNA TOPOISOMERASE | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | BIOCHEMICAL RESEARCH METHODS | CRYSTALLOGRAPHY | Human topoisomerase II alpha | 5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID | PREDICTION | BETA | FORMS | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | STRUCTURAL BASIS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | INHIBITORS
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8. Full Text Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines
by Guchhait, Sankar K and Hura, Neha and Sinha, Kanchan and Panda, Dulal
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 14, pp. 8323 - 8331
An efficient route for the synthesis of penta-substituted/functionalized-3,4-diarylated pyridines, biologically important templates, via pyridine C3-arylation... 
C3-SELECTIVE ARYLATION | CROSS-COUPLING REACTION | HANTZSCH 1,4-DIHYDROPYRIDINES | ANALOGS | ANTICANCER AGENTS | ONE-POT REACTIONS | SUZUKI-MIYAURA REACTIONS | POLYSUBSTITUTED PYRIDINES | CHEMISTRY, MULTIDISCIPLINARY | SUBSTITUTED PYRIDINES | ALKALOIDS | Pyridines | Synthesis | Accessibility | Precursors | Condensation | Nicotinic acid
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9. Full Text A nitrile-stabilized ammonium ylide as a masked C-C&z.dbd;N synthon in heterocyclization with amidine-imine: 3-component assembly to fused pyrimidine scaffoldsElectronic supplementary information (ESI) available: Experimental procedures, analytical data, copies of 1H and 13C NMR-spectra, and X-ray crystallographic data for products. CCDC 1505625 and 1505629. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7cc02946b
by Guchhait, Sankar K and Saini, Meenu and Sumkaria, Divyani and Chaudhary, Vikas
ISSN 1359-7345, 6/2017, Volume 53, Issue 51, pp. 6941 - 6944
A unique reactivity of a nitrile-stabilized quaternary ammonium ylide as a masked C-C&z.dbd;N synthon in contrast to its usual sigmatropic rearrangement has... 
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10. Full Text Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase II[alpha]
by Priyadarshani, Garima and Amrutkar, Suyog and Nayak, Anmada and Banerjee, Uttam C and Kundu, Chanakya N and Guchhait, Sankar K
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 122, p. 43
A strategy of scaffold-hopping of bioactive natural products, flavones and isoflavones, leading to target-based discovery of potent anticancer agents has been... 
Etoposide | Care and treatment | Drug discovery | Cancer | Isoflavones | Antimitotic agents | Antineoplastic agents
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11. Full Text Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purinesElectronic supplementary information (ESI) available: Spectra of synthesized compounds (Tables 2-4, and intermediates 2, 3, 5, 6a and 6b). See DOI: 10.1039/c4ob00882k
by Guchhait, Sankar K and Chaudhary, Vikas
ISSN 1477-0520, 8/2014, Volume 12, Issue 34, pp. 6694 - 675
A pathway of desilylative activation of TMSCN as a functional isonitrile equivalent, and DABCO-THF as an appropriate system for activation in a chemoselective... 
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12. Full Text α,β-Epoxy esters in multiple C-O/C-N bond-breaking/formation with 2-aminopyridines; Synthesis of biologically relevant (Z)-2- methyleneimidazo[1,2- a ]pyridin-3-ones
by Guchhait, Sankar K and Priyadarshani, Garima and Hura, Neha
Synlett, ISSN 0936-5214, 2014, Volume 25, Issue 12, pp. 1692 - 1696
A new reaction of aryl 2,3-epoxy esters with 2-aminopyridines has been developed that involves multiple C-O/C-N bond-breaking/formation reactions in one... 
fused-ring systems | epoxides | domino reactions | heterocycles | amino alcohols | AURONES | ACID | DIASTEREOSELECTIVITY | CHEMISTRY, ORGANIC | CATALYST | AMINOLYSIS | YLIDES | CYCLOADDITION
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13. Full Text CuSO4–Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles
by Guchhait, Sankar K and Chandgude, Ajay L and Priyadarshani, Garima
The Journal of Organic Chemistry, ISSN 0022-3263, 05/2012, Volume 77, Issue 9, pp. 4438 - 4444
The catalytic efficiency of mixed Cu(I)–Cu(II) system in situ generated by partial reduction of CuSO4 with glucose in ethanol (nonanhydrous) under open air has... 
alcohol | glucose | fused alicyclic compound | imidazole | isomerization | copper sulfate | aldehyde | catalysis | amidine | article | biocatalysis | alkyne | reduction | ZOLPIDEM | 3-COMPONENT COUPLING REACTION | SOLVENT-FREE CONDITIONS | ONE-POT SYNTHESIS | AMINES | CLICK CHEMISTRY | IMINES | DIRECT ADDITION | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | EFFICIENT | Copper - chemistry | Cyclization | Heterocyclic Compounds - chemistry | Stereoisomerism | Glucose - chemistry | Imidazoles - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Imidazoles - chemical synthesis | Aldehydes - chemistry | Copper Sulfate - chemistry
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14. Full Text Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα
by Tripathi, Neha and Guchhait, Sankar K and Bharatam, Prasad V
Journal of molecular graphics & modelling, 09/2018, Volume 86, p. 1
Merbarone is a derivative of thiobarbituric acid, possessing catalytic inhibitory potential against human topoisomerase IIα (hTopoIIα). Merbarone was reported... 
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15. Full Text ZrCl4-Mediated Regio- and Chemoselective Friedel–Crafts Acylation of Indole
by Guchhait, Sankar K and Kashyap, Maneesh and Kamble, Harshad
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2011, Volume 76, Issue 11, pp. 4753 - 4758
An efficient method for regio- and chemoselective Friedel–Crafts acylation of indole using acyl chlorides in the presence of ZrCl4 has been discovered. It... 
ORGANIC-SYNTHESIS | ONE-POT | CHEMISTRY, ORGANIC | IONIC LIQUID | AGENTS | PYRROLES | CATALYST | 3-ACYLINDOLES | DERIVATIVES | SALTS | CHLORIDE | Zinc Compounds - chemistry | Stereoisomerism | Substrate Specificity | Catalysis | Chlorides - chemistry | Indoles - chemistry | Acylation
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16. Full Text An Efficient, Regioselective, Versatile Synthesis of N-Fused 2- and 3-Aminoimidazoles via Ugi-Type Multicomponent Reaction Mediated by Zirconium(IV) Chloride in Polyethylene Glycol-400
by Guchhait, Sankar K and Madaan, Chetna
Synlett, ISSN 0936-5214, 03/2009, Volume 2009, Issue 4, pp. 628 - 632
Abstract An Ugi-type multicomponent reaction of heterocyclic amidines with aldehydes and isocyanides catalyzed by zirconium(IV) chloride in PEG-400 was... 
letter | Multicomponent reaction | Regioselective synthesis | Zirconium(IV) chloride | Polyethylene glycol | N-heterocycles | polyethylene glycol | ANNULATED PYRIDINES | SOLID-PHASE SYNTHESIS | ONE-POT | PYRIMIDINES | CHEMISTRY, ORGANIC | regioselective synthesis | ISONITRILES | HETEROCYCLES | 3-COMPONENT CONDENSATION | ANTIVIRAL ACTIVITY | INHIBITORS | multicomponent reaction | DERIVATIVES | zirconium(IV) chloride
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17. Full Text Scaffold-hopping and hybridization based design and building block strategic synthesis of pyridine-annulated purines: Discovery of novel apoptotic anticancer agents
by Chaudhary, Vikas and Das, Sarita and Nayak, Anmada and Guchhait, Sankar K and Kundu, Chanakya N
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 33, pp. 26051 - 26060
A set of novel pyridine-annulated analogs of purinones, adenines and their oxo/thio congeners, xanthines, guanines, and purine-2,4-diamines as potential... 
POTENT | TOPOISOMERASE-II | INHIBITORY-ACTIVITY | AZATOXIN | TUBULIN POLYMERIZATION | ADENINE-DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | HYBRID | Analogs | Drugs | Purines | Synthesis | Derivatives | Adenines | Xanthines | Anticancer properties
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18. Full Text Zr[Cl.sub.4]-mediated regio- and chemoselective friedel-crafts acylation of indole
by Guchhait, Sankar K and Kashyap, Maneesh and Kamble, Harshad
Journal of Organic Chemistry, ISSN 0022-3263, 06/2011, Volume 76, Issue 11, p. 4753
Zirconium | Dichloropropane | Chlorides | Olefins | Indole | Chemical properties
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19. Full Text Towards molecular diversity: Dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile
by Guchhait, Sankar K and Madaan, Chetna
Organic and Biomolecular Chemistry, ISSN 1477-0520, 08/2010, Volume 8, Issue 16, pp. 3631 - 3634
With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product,... 
PHASE SYNTHESIS | 1,4-BENZODIAZEPINE-2,5-DIONES | 2,5-DIKETOPIPERAZINES | ONE-POT | CHEMISTRY | CHEMISTRY, ORGANIC | 3-COMPONENT CONDENSATION | 4-COMPONENT CONDENSATION | ANTAGONISTS | INHIBITOR | PARALLEL SYNTHESIS | Molecular Structure | Cyclization | Dealkylation | Butylamines - chemistry | Nitriles - chemistry
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20. Full Text α,β-Epoxy Esters in Multiple C–O/C–N Bond-Breaking/Formation with 2-Aminopyridines; Synthesis of Biologically Relevant (Z)-2-Methylene­imidazo[1,2-a]pyridin-3-ones
by Guchhait, Sankar K and Priyadarshani, Garima and Hura, Neha
Synlett, ISSN 0936-5214, 07/2014, Volume 25, Issue 12, pp. 1692 - 1696
Abstract A new reaction of aryl 2,3-epoxy esters with 2-aminopyridines has been developed that involves multiple C–O/C–N bond-breaking/formation reactions in... 
letter
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