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Biochemical Pharmacology, ISSN 0006-2952, 12/2019, Volume 170, p. 113663
Combretastatin A4 and its analogs are undergoing various clinical trials for the treatment of different cancers. This study illustrated the molecular mechanism... 
Anticancer agent | Microtubule targeting agents | Spindle assembly checkpoint | Microtubules | Cancer | Apoptosis
Journal Article
Journal of Molecular Graphics and Modelling, ISSN 1093-3263, 01/2019, Volume 86, p. 1
Merbarone is a derivative of thiobarbituric acid, possessing catalytic inhibitory potential against human topoisomerase II[alpha] (hTopoII[alpha]). Merbarone... 
Enzymes | Analysis | Force and energy | Crystals | Molecular dynamics | Structure
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 06/2017, Volume 53, Issue 51, pp. 6941 - 6944
A unique reactivity of a nitrile-stabilized quaternary ammonium ylide as a masked C-C&z.dbd; N synthon in contrast to its usual sigmatropic rearrangement has... 
Pyrimidines | Scaffolds | Assembly
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 03/2017, Volume 82, Issue 5, pp. 2745 - 2752
A step-economical access to polysubstituted aminoimidazoles has been accomplished via alkene vicinal C–N bonds formation of 2-bromo-2-alkenones with guanidine... 
OXIDATION | INTRAMOLECULAR DIAMINATION | PALLADIUM | KETONES | AMIDINES | HETEROCYCLES | CHEMISTRY | CHEMISTRY, ORGANIC | BROMIDE | IMIDAZOLES | ALKALOIDS | Research | Chemical properties | Chemical synthesis | Guanidine | Amino compounds
Journal Article
Journal of Molecular Graphics and Modelling, ISSN 1093-3263, 01/2019, Volume 86, pp. 1 - 18
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 14, pp. 8323 - 8331
An efficient route for the synthesis of penta-substituted/functionalized-3,4-diarylated pyridines, biologically important templates, via pyridine C3-arylation... 
C3-SELECTIVE ARYLATION | CROSS-COUPLING REACTION | HANTZSCH 1,4-DIHYDROPYRIDINES | ANALOGS | ANTICANCER AGENTS | ONE-POT REACTIONS | SUZUKI-MIYAURA REACTIONS | POLYSUBSTITUTED PYRIDINES | CHEMISTRY, MULTIDISCIPLINARY | SUBSTITUTED PYRIDINES | ALKALOIDS | Pyridines | Synthesis | Accessibility | Precursors | Condensation | Nicotinic acid
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 122, p. 43
A strategy of scaffold-hopping of bioactive natural products, flavones and isoflavones, leading to target-based discovery of potent anticancer agents has been... 
Etoposide | Care and treatment | Drug discovery | Cancer | Isoflavones | Antimitotic agents | Antineoplastic agents
Journal Article
ISSN 1477-0520, 8/2014, Volume 12, Issue 34, pp. 6694 - 675
A pathway of desilylative activation of TMSCN as a functional isonitrile equivalent, and DABCO-THF as an appropriate system for activation in a chemoselective... 
Journal Article
Synlett, ISSN 0936-5214, 2014, Volume 25, Issue 12, pp. 1692 - 1696
A new reaction of aryl 2,3-epoxy esters with 2-aminopyridines has been developed that involves multiple C-O/C-N bond-breaking/formation reactions in one... 
fused-ring systems | epoxides | domino reactions | heterocycles | amino alcohols | AURONES | ACID | DIASTEREOSELECTIVITY | CHEMISTRY, ORGANIC | CATALYST | AMINOLYSIS | YLIDES | CYCLOADDITION
Journal Article
Journal of molecular graphics & modelling, 09/2018, Volume 86, p. 1
Merbarone is a derivative of thiobarbituric acid, possessing catalytic inhibitory potential against human topoisomerase IIα (hTopoIIα). Merbarone was reported... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2011, Volume 76, Issue 11, pp. 4753 - 4758
An efficient method for regio- and chemoselective Friedel–Crafts acylation of indole using acyl chlorides in the presence of ZrCl4 has been discovered. It... 
ORGANIC-SYNTHESIS | ONE-POT | CHEMISTRY, ORGANIC | IONIC LIQUID | AGENTS | PYRROLES | CATALYST | 3-ACYLINDOLES | DERIVATIVES | SALTS | CHLORIDE | Zinc Compounds - chemistry | Stereoisomerism | Substrate Specificity | Catalysis | Chlorides - chemistry | Indoles - chemistry | Acylation
Journal Article
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 33, pp. 26051 - 26060
A set of novel pyridine-annulated analogs of purinones, adenines and their oxo/thio congeners, xanthines, guanines, and purine-2,4-diamines as potential... 
POTENT | TOPOISOMERASE-II | INHIBITORY-ACTIVITY | AZATOXIN | TUBULIN POLYMERIZATION | ADENINE-DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | HYBRID | Analogs | Drugs | Purines | Synthesis | Derivatives | Adenines | Xanthines | Anticancer properties
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 06/2011, Volume 76, Issue 11, p. 4753
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 08/2010, Volume 8, Issue 16, pp. 3631 - 3634
With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product,... 
PHASE SYNTHESIS | 1,4-BENZODIAZEPINE-2,5-DIONES | 2,5-DIKETOPIPERAZINES | ONE-POT | CHEMISTRY | CHEMISTRY, ORGANIC | 3-COMPONENT CONDENSATION | 4-COMPONENT CONDENSATION | ANTAGONISTS | INHIBITOR | PARALLEL SYNTHESIS | Molecular Structure | Cyclization | Dealkylation | Butylamines - chemistry | Nitriles - chemistry
Journal Article
Synlett, ISSN 0936-5214, 07/2014, Volume 25, Issue 12, pp. 1692 - 1696
Abstract A new reaction of aryl 2,3-epoxy esters with 2-aminopyridines has been developed that involves multiple C–O/C–N bond-breaking/formation reactions in... 
letter
Journal Article
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