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The Journal of organic chemistry, ISSN 0022-3263, 03/2019, Volume 84, Issue 7, pp. 4575 - 4575
Journal Article
MedChemComm, ISSN 2040-2503, 2018, Volume 9, Issue 1, pp. 27 - 43
Over the years, rapamycin has attracted serious attention due to its remarkable biological properties and as a potent inhibitor of the mammalian target of... 
Journal Article
Organic Letters, ISSN 1523-7060, 02/2015, Volume 17, Issue 3, pp. 468 - 471
Journal Article
MedChemComm, ISSN 2040-2503, 1/2018, Volume 9, Issue 1, pp. 27 - 43
Journal Article
Chemical Reviews, ISSN 0009-2665, 05/2014, Volume 114, Issue 9, p. 4640
  The authors examine selected case studies on small molecule modulators of protein-protein interactions. 
Case studies | Proteins | Molecules
Journal Article
Organic Letters, ISSN 1523-7060, 02/2015, Volume 17, Issue 3, pp. 480 - 483
A stereoselective synthesis of a rapamycin fragment is developed and further utilized toward building a macrocyclic chemical toolbox. The amino alcohol moiety... 
MAMMALIAN TARGET | LIFE-SPAN | INHIBITION | ANALOGS | SENSITIVITY | CHEMISTRY, ORGANIC | CARBANIONS | AUTOPHAGY | EFFECTOR DOMAIN | SIROLIMUS | ZOTAROLIMUS | Pyrans - chemistry | Stereoisomerism | Sirolimus - chemical synthesis | Molecular Structure | Sirolimus - chemistry | Amino Alcohols - chemistry | Pipecolic Acids - chemistry
Journal Article
ISSN 1611-2156, 2017
A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4]diazonine-2,5-dione (6a-f) analogues were synthesized from... 
synthesis | coupling reaction | docking | lactam | anti-bacterial | bacillus subtilis | medium size ring
Journal Article
EXCLI Journal, ISSN 1611-2156, 08/2017, Volume 16, pp. 1090 - 1098
A novel series of medium size (S)-3-alkyl-3,4,6,7-tetrahydro-1H-benzo[e][1,4] diazonine-2,5-dione (6a-f) analogues were synthesized from (E)-3-(2-nitrophenyl)... 
Synthesis | Bacillus subtilis | Lactam | Medium size ring | Docking | Anti-bacterial | Coupling reaction | synthesis | coupling reaction | lactam | anti-bacterial | MACROCYCLES | bacillus subtilis | ANTIBIOTIC-RESISTANCE | LIBRARY | medium size ring | TOXICITY | DISCOVERY | docking | BIOLOGY
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2018, Volume 83, Issue 19, pp. 11777 - 11793
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring... 
ENANTIOPURE | DIAZABICYCLOALKANES | CATALYZED SYNTHESIS | EFFICIENT SYNTHESIS | MAGNETIC-RESONANCE | CHEMISTRY, ORGANIC | INHIBITORS | DERIVATIVES | CYCLIZATION | DISCOVERY | ORIENTED SYNTHESIS
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2018, Volume 83, Issue 12, pp. 6541 - 6555
The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring... 
ORGANIC-SYNTHESIS | FRAGMENTS | ASYMMETRIC-SYNTHESIS | BUILDING-BLOCKS | AMINO-ACIDS | COMPLEXITY | CHEMISTRY, ORGANIC | DIVERSITY | SUBSTITUTED PIPERAZINES | DISCOVERY | ORIENTED SYNTHESIS
Journal Article
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