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animals (61) 61
mice (60) 60
index medicus (52) 52
biochemistry & molecular biology (40) 40
lipolysis (33) 33
lipase (30) 30
mice, knockout (30) 30
triglycerides - metabolism (30) 30
lipids (28) 28
biochemistry (26) 26
lipase - metabolism (26) 26
adipose triglyceride lipase (25) 25
hormone-sensitive lipase (25) 25
beer (24) 24
chemistry (24) 24
enzymology (24) 24
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microbiology (24) 24
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culture media (23) 23
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humans (23) 23
lipase - genetics (23) 23
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microorganisms or enzymes (23) 23
propagating, preserving or maintaining microorganisms (23) 23
compositions or test papers therefor (22) 22
condition-responsive control in microbiological orenzymological processes (22) 22
measuring or testing processes involving enzymes, nucleicacids or microorganisms (22) 22
processes of preparing such compositions (22) 22
metabolism (21) 21
organic chemistry (21) 21
cell biology (20) 20
nucleic acids (19) 19
adipose tissue - metabolism (18) 18
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testing (17) 17
investigating or analysing materials by determining theirchemical or physical properties (16) 16
measuring (16) 16
adipose tissue - enzymology (15) 15
mice, inbred c57bl (15) 15
fatty acids - metabolism (14) 14
triglycerides (14) 14
chanarin-dorfman-syndrome (13) 13
insulin-resistance (13) 13
sterol esterase - metabolism (13) 13
tissue (13) 13
hygiene (12) 12
lipid storage disease (12) 12
medical or veterinary science (12) 12
obesity (12) 12
preparations for medical, dental, or toilet purposes (12) 12
carboxylic ester hydrolases - genetics (11) 11
carboxylic ester hydrolases - metabolism (11) 11
cos cells (11) 11
energy-metabolism (11) 11
female (11) 11
lipid metabolism (11) 11
physiological aspects (11) 11
triacylglycerol (11) 11
biophysics (10) 10
lipase - deficiency (10) 10
molecular biology (10) 10
myocardium - metabolism (10) 10
sterol esterase - genetics (10) 10
1-acylglycerol-3-phosphate o-acyltransferase - metabolism (9) 9
cercopithecus aethiops (9) 9
cgi-58 (9) 9
diet-induced obesity (9) 9
fermentation or enzyme-using processes to synthesise a desiredchemical compound or composition or to separate optical isomersfrom a racemic mixture (9) 9
ppar-alpha (9) 9
atgl (8) 8
blotting, western (8) 8
coffee mills (8) 8
domestic articles or appliances (8) 8
endocrinology & metabolism (8) 8
expression (8) 8
fatty acids (8) 8
furniture (8) 8
lipolysis - physiology (8) 8
performing operations (8) 8
research (8) 8
skeletal-muscle (8) 8
spice mills (8) 8
sterol esterase - deficiency (8) 8
suction cleaners in general (8) 8
transporting (8) 8
disease models, animal (7) 7
fatty acids, nonesterified - metabolism (7) 7
hydrolysis (7) 7
liver (7) 7
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1. Full Text Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
by Kosteli, Aliki and Sugaru, Eiji and Haemmerle, Guenter and Martin, Jayne F and Lei, Jason and Zechner, Rudolf and Ferrante Jr, Anthony W
Journal of Clinical Investigation, ISSN 0021-9738, 10/2010, Volume 120, Issue 10, pp. 3466 - 3479
Obesity elicits an immune response characterized by myeloid cell recruitment to key metabolic organs, including adipose tissue. However, the response of immune... 
ADIPOCYTE DEATH | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | MACROPHAGE | GENE-EXPRESSION | IKK-BETA | FATTY-ACIDS | DIET-INDUCED OBESITY | CHRONIC INFLAMMATION | T-CELLS | INDUCED INSULIN-RESISTANCE | Macrophages - physiology | Carboxylic Ester Hydrolases - physiology | Mice, Inbred C57BL | Male | Lipolysis - immunology | Adipose Tissue - immunology | Lipase | Adipose Tissue - metabolism | Animals | Weight Loss - immunology | Fatty Acids, Nonesterified - blood | Mice | Cell Movement | Adipose tissues | Obesity | Care and treatment | Immune response | Physiological aspects | Genetic aspects | Research | Macrophages | Health aspects | Risk factors
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2. Full Text Genetically modified mouse models to study hepatic neutral lipid mobilization
by Haemmerle, Guenter and Lass, Achim
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 2018, Volume 1865, Issue 5, pp. 879 - 894
Excessive accumulation of triacylglycerol is the common denominator of a wide range of clinical pathologies of liver diseases, termed non-alcoholic fatty liver... 
Vitamin A | Triacylglycerol | Liver | Fibrosis | Neutral lipid metabolism | Lipase | Non-alcoholic fatty liver disease | Cholesterol | Retinol | Steatosis | RAT-LIVER | ADIPOSE TRIGLYCERIDE LIPASE | HORMONE-SENSITIVE LIPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTER STORAGE DISEASE | ENDOPLASMIC-RETICULUM STRESS | LIVER PARENCHYMAL-CELLS | CHOLESTERYL ESTER | BIOPHYSICS | DECREASES BLOOD-LIPIDS | HYDROLASE ACTIVITY | SWITCH GENE 2 | Liver cancer | Low density lipoproteins | Genetically modified organisms | Physiological aspects | Esters | Lipids | Mice | Liver cirrhosis
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3. Full Text Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
by Suman K. Das and Sandra Eder and Silvia Schauer and Clemens Diwoky and Hannes Temmel and Barbara Guertl and Gregor Gorkiewicz and Kuppusamy P. Tamilarasan and Pooja Kumari and Michael Trauner and Robert Zimmermann and Paul Vesely and Guenter Haemmerle and Rudolf Zechner and Gerald Hoefler
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6039, pp. 233 - 238
Cachexia is a multifactorial wasting syndrome most common in patients with cancer that is characterized by the uncontrolled loss of adipose and muscle mass. We... 
Adipose tissues | Mass | White adipose tissue | REPORTS | Muscles | Lipids | Mice | Cachexia | Lipolysis | Tumors | Cancer | DEFINITION | SKELETAL-MUSCLE | WHOLE-BODY LIPOLYSIS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FATTY-ACID | TISSUE | WEIGHT-LOSS | MICE | MECHANISMS | ENERGY-METABOLISM | Body Weight | Humans | Sterol Esterase - metabolism | Neoplasms, Experimental - enzymology | Sterol Esterase - deficiency | Neoplasms, Experimental - pathology | Neoplasms - complications | Peptides - metabolism | Melanoma, Experimental | Cachexia - etiology | Fatty Acids - blood | Lipase - deficiency | Cytokines - blood | Body Mass Index | Adipose Tissue, White - pathology | Neoplasms, Experimental - complications | Mice, Inbred C57BL | Neoplasms - enzymology | Myocardium - pathology | Lipase - metabolism | Animals | Sterol Esterase - genetics | Glycerol - metabolism | Cachexia - enzymology | Weight Loss | Cachexia - pathology | Adipose Tissue, White - enzymology | Triglycerides - blood | Muscle, Skeletal - pathology | Blood Glucose - metabolism | Neoplasms - pathology | Lipase - genetics | Complications and side effects | Development and progression | Triglycerides | Chemical properties | Lipase | Health aspects | Body fat | Pathogenesis | Medical disorders
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4. Full Text FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
by Zechner, Rudolf and Zimmermann, Robert and Eichmann, Thomas O and Kohlwein, Sepp D and Haemmerle, Guenter and Lass, Achim and Madeo, Frank
Cell Metabolism, ISSN 1550-4131, 03/2012, Volume 15, Issue 3, pp. 279 - 291
Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and... 
ADIPOSE TRIGLYCERIDE LIPASE | EPITHELIUM-DERIVED FACTOR | HORMONE-SENSITIVE LIPASE | ACTIVATED PROTEIN-KINASE | LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE | MONOACYLGLYCEROL LIPASE | ENDOCRINOLOGY & METABOLISM | ENDOCANNABINOID SYSTEM | CHANARIN-DORFMAN-SYNDROME | LIVER-DISEASE | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | Lipolysis - genetics | Animals | Humans | Lipid Metabolism - genetics | Signal Transduction - physiology | Signal Transduction - genetics | Lipase - metabolism | Lipolysis - physiology | Lipid Metabolism - physiology | Lipase - genetics | Physiological aspects | Lipase | Review
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5. Full Text Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism
by Martina Schweiger and Renate Schreiber and Guenter Haemmerle and Achim Lass and Christian Fledelius and Poul Jacobsen and Hans Tornqvist and Rudolf Zechner and Robert Zimmermann and Genomik, diabetes och endokrinologi and Lund University and Genomics, Diabetes and Endocrinology and Lunds universitet
Journal of Biological Chemistry, ISSN 0021-9258, 12/2006, Volume 281, Issue 52, pp. 40236 - 40241
The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities of triacylglycerol lipases. In this study, we demonstrate... 
LIPID STORAGE DISEASE | TRANSLOCATION | OBESITY | PROTEIN | CGI-58 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERILIPIN-A | CHANARIN-DORFMAN-SYNDROME | MICE | A-MEDIATED LIPOLYSIS | IDENTIFICATION | Carboxylic Ester Hydrolases - deficiency | Sterol Esterase - metabolism | Adipose Tissue, White - metabolism | Lipase | Sterol Esterase - deficiency | Lipolysis | Mice, Knockout | Triglycerides - metabolism | 1-Acylglycerol-3-Phosphate O-Acyltransferase | Cytosol - enzymology | Animals | Sterol Esterase - genetics | Adipose Tissue, White - enzymology | Carboxylic Ester Hydrolases - genetics | Mice | Carboxylic Ester Hydrolases - metabolism | Esterases - physiology | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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6. Full Text Cardioprotection and lifespan extension by the natural polyamine spermidine
by Eisenberg, Tobias and Abdellatif, Mahmoud and Schroeder, Sabrina and Primessnig, Uwe and Stekovic, Slaven and Pendl, Tobias and Harger, Alexandra and Schipke, Julia and Zimmermann, Andreas and Schmidt, Albrecht and Tong, Mingming and Ruckenstuhl, Christoph and Dammbrueck, Christopher and Gross, Angelina S and Herbst, Viktoria and Magnes, Christoph and Trausinger, Gert and Narath, Sophie and Meinitzer, Andreas and Hu, Zehan and Kirsch, Alexander and Eller, Kathrin and Carmona-Gutierrez, Didac and Büttner, Sabrina and Pietrocola, Federico and Knittelfelder, Oskar and Schrepfer, Emilie and Rockenfeller, Patrick and Simonini, Corinna and Rahn, Alexandros and Horsch, Marion and Moreth, Kristin and Beckers, Johannes and Fuchs, Helmut and Gailus-Durner, Valerie and Neff, Frauke and Janik, Dirk and Rathkolb, Birgit and Rozman, Jan and De Angelis, Martin Hrabe and Moustafa, Tarek and Haemmerle, Guenter and Mayr, Manuel and Willeit, Peter and Von Frieling-Salewsky, Marion and Pieske, Burkert and Scorrano, Luca and Pieber, Thomas and Pechlaner, Raimund and Willeit, Johann and Sigrist, Stephan J and Linke, Wolfgang A and Mühlfeld, Christian and Sadoshima, Junichi and Dengjel, Joern and Kiechl, Stefan and Kroemer, Guido and Sedej, Simon and Madeo, Frank and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för molekylär biovetenskap, Wenner-Grens institut
Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
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7. Full Text Fate of fat: The role of adipose triglyceride lipase in lipolysis
by Zimmermann, Robert and Lass, Achim and Haemmerle, Guenter and Zechner, Rudolf
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 2009, Volume 1791, Issue 6, pp. 494 - 500
Lipolysis, the coordinated catabolism of triacylglycerol (TG) stored in cellular lipid droplets, provides fatty acids, di-, and monoglycerides. These products... 
HSL | Lipid droplets | ATGL | Lipolysis | 3T3-L1 ADIPOCYTES | HORMONE-SENSITIVE LIPASE | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHANARIN-DORFMAN-SYNDROME | DIET-INDUCED OBESITY | CELL BIOLOGY | LIPID STORAGE DISEASE | EPITHELIUM-DERIVED FACTOR | BIOPHYSICS | PERILIPIN-A | PPAR-GAMMA | TNF-ALPHA | Lipids | Esterases | Lipase | Binding proteins | Protein binding
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8. Full Text Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
by Robert Zimmermann and Juliane G. Strauss and Guenter Haemmerle and Gabriele Schoiswohl and Ruth Birner-Gruenberger and Monika Riederer and Achim Lass and Georg Neuberger and Frank Eisenhaber and Albin Hermetter and Rudolf Zechner
Science, ISSN 0036-8075, 11/2004, Volume 306, Issue 5700, pp. 1383 - 1386
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may... 
Adipose tissues | COS cells | Proteins | Enzymes | Lipids | Brown adipose tissue | Reports | Mice | Triglycerides | Adipocytes | Lipolysis | OBESITY | HORMONE-SENSITIVE LIPASE | METABOLISM | MECHANISM | DATABASE | MULTIDISCIPLINARY SCIENCES | MICE | PROTEINS | DEFICIENCY | ADIPOCYTE | Phosphorylation | Humans | Sterol Esterase - metabolism | Molecular Sequence Data | Substrate Specificity | Adipocytes - enzymology | RNA, Messenger - metabolism | Adipose Tissue - metabolism | Transfection | Diglycerides - metabolism | Lipoprotein Lipase - chemistry | Fatty Acids - metabolism | Lipoprotein Lipase - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Cytoplasm - enzymology | Lipoprotein Lipase - genetics | RNA, Messenger - genetics | Gene Silencing | 3T3-L1 Cells | Lipid Mobilization | Adipose Tissue, Brown - enzymology | Triglycerides - metabolism | Animals | Sterol Esterase - genetics | Glycerol - metabolism | Adipocytes - metabolism | Isoproterenol - pharmacology | Lipoprotein Lipase - immunology | Adipose Tissue - enzymology | Adipose Tissue, Brown - metabolism | COS Cells | DNA, Complementary | Lipase | Research | Tissue | Obesity | Catalysis | Fatty acids
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9. Full Text Fat in the heart: The enzymatic machinery regulating cardiac triacylglycerol metabolism
by Heier, Christoph and Haemmerle, Guenter
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 10/2016, Volume 1861, Issue 10, pp. 1500 - 1512
The heart predominantly utilizes fatty acids (FAs) as energy substrate. FAs that enter cardiomyocytes can be activated and directly oxidized within... 
Triacylglycerol | Cardiomyopathy | Heart lipid and energy metabolism | ADIPOSE TRIGLYCERIDE LIPASE | HORMONE-SENSITIVE LIPASE | COMPARATIVE GENE IDENTIFICATION-58 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHANARIN-DORFMAN-SYNDROME | MICE LACKING | LIPID DROPLET PROTEIN | CELL BIOLOGY | BIOPHYSICS | ACID-BINDING PROTEIN | PERILIPIN 5 | DIFFERENTIATION-RELATED PROTEIN | G0/G1 SWITCH GENE | Physiological aspects | Enzymes | Triglycerides | Magneto-electric machines | Machinery | Fatty acids
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10. Full Text Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
by Zechner, Rudolf and Kienesberger, Petra C and Haemmerle, Guenter and Zimmermann, Robert and Lass, Achim
Journal of Lipid Research, ISSN 0022-2275, 2009, Volume 50, Issue 1, pp. 3 - 21
Fatty acids (FAs) are essential components of all lipid classes and pivotal substrates for energy production in all vertebrates. Additionally, they act... 
Hydrolase | Lipolysis | Neutral lipid storage disease | DORFMAN-CHANARIN-SYNDROME | HORMONE-SENSITIVE LIPASE | HEPATIC INSULIN SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | neutral lipid storage disease | TISSUE-SPECIFIC EXPRESSION | MOUSE MONOGLYCERIDE LIPASE | DIET-INDUCED OBESITY | CHOLESTEROL ESTER HYDROLASE | LIPID STORAGE DISEASE | EPITHELIUM-DERIVED FACTOR | hydrolase | lipolysis | BASAL PHOSPHORYLATION SITES | Humans | Sterol Esterase - metabolism | Lipase - metabolism | Metabolism | Hydrolysis | Adipose Tissue - metabolism | Monoacylglycerol Lipases - metabolism | Lipids - chemistry | Phenotype | Animals | Adipose Tissue - enzymology | Hydrolases - chemistry | Mice | Mutation | Fatty Acids - metabolism
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11. Full Text Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase
by Guenter Haemmerle and Achim Lass and Robert Zimmermann and Gregor Gorkiewicz and Carola Meyer and Jan Rozman and Gerhard Heldmaier and Robert Maier and Christian Theussl and Sandra Eder and Dagmar Kratky and