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American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2011, Volume 45, Issue 2, pp. 311 - 322
Pulmonary vascular remodeling is key to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We recently reported that fibroblast growth... 
FGF-receptors | Proliferation | Growth factors | Survival | Endothelium | endothelium | APOPTOSIS | ACTIVATION | PROTEIN | growth factors | proliferation | BIOCHEMISTRY & MOLECULAR BIOLOGY | survival | CELL-PROLIFERATION | CELL BIOLOGY | INHIBITION | SMOOTH-MUSCLE HYPERPLASIA | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | EXPRESSION | BCL-2 PROMOTER | Endothelium, Vascular - cytology | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | Humans | Middle Aged | bcl-X Protein - genetics | Male | Case-Control Studies | Young Adult | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Autocrine Communication | RNA, Messenger - genetics | Cells, Cultured | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Fibroblast Growth Factor 2 - antagonists & inhibitors | Phenotype | Fibroblast Growth Factor 2 - genetics | Endothelium, Vascular - metabolism | Adolescent | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | bcl-X Protein - metabolism | Hypertension, Pulmonary - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Hypertension, Pulmonary | bcl-X Protein | Fibroblast Growth Factor 2 | RNA, Small Interfering | Proto-Oncogene Proteins c-bcl-2 | RNA, Messenger | Endothelium, Vascular
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2014, Volume 64, Issue 1, pp. 28 - 37
Journal Article
Circulation, ISSN 0009-7322, 2013, Volume 128, Issue 18, pp. 2016 - 2025
Journal Article
Seminars in Respiratory and Critical Care Medicine, ISSN 1069-3424, 10/2017, Volume 38, Issue 5, pp. 571 - 584
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 09/2016, Volume 311, Issue 3, pp. H604 - H612
BIBF1000 is a small molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR),... 
Pulmonary artery banding | Cardiac remodeling | Experimental pulmonary hypertension | Tyrosine kinase inhibitor | BIBF1000 | OVERLOAD | NINTEDANIB | LUNG FIBROSIS | STEM-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | FIBROBLAST-GROWTH-FACTOR | pulmonary artery banding | cardiac remodeling | ARTERIAL-HYPERTENSION | IMATINIB | PERIPHERAL VASCULAR DISEASE | MICE | tyrosine kinase inhibitor | experimental pulmonary hypertension | IDIOPATHIC PULMONARY-FIBROSIS | RIGHT-HEART-FAILURE | Familial Primary Pulmonary Hypertension - diagnostic imaging | Adaptation, Physiological - drug effects | Atrial Natriuretic Factor - drug effects | Male | Mitogen-Activated Protein Kinase 1 - drug effects | Pulmonary Artery - surgery | Heart Ventricles - diagnostic imaging | Familial Primary Pulmonary Hypertension - metabolism | Mitogen-Activated Protein Kinase 3 - drug effects | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Indoles - pharmacology | Ventricular Function, Right - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Heart Ventricles - pathology | Disease Models, Animal | Familial Primary Pulmonary Hypertension - pathology | Echocardiography | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Atrial Natriuretic Factor - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Rats | Pressure | Rats, Sprague-Dawley | Blotting, Western | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Heart Ventricles - metabolism | Protein Kinase Inhibitors - pharmacology | Heart Ventricles - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Tyrosine | Phosphotransferases | Health aspects | Heart ventricle, Right
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 08/2018, Volume 20, Issue 1, pp. 197 - 12
Journal Article
Journal Article
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 06/2014, Volume 3, Issue 3, pp. e000716 - n/a
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2016, Volume 126, Issue 9, pp. 3207 - 3218
Journal Article