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1. Full Text Potentiating prostate cancer immunotherapy with oncolytic viruses
by Lee, Patrick and Gujar, Shashi
Nature Reviews Urology, ISSN 1759-4812, 04/2018, Volume 15, Issue 4, pp. 235 - 250
The clinical effectiveness of immunotherapies for prostate cancer remains subpar compared with that for other cancers. The goal of most immunotherapies is the... 
HERPES-SIMPLEX-VIRUS | DENDRITIC CELLS | PHASE-I TRIAL | UROLOGY & NEPHROLOGY | ANTIGEN-PRESENTING CELLS | ACID-PHOSPHATASE | REPLICATION-COMPETENT | VESICULAR STOMATITIS-VIRUS | IMMUNE-CHECKPOINT BLOCKADE | SUICIDE GENE-THERAPY | T-CELLS | Oncolytic Virotherapy - methods | Immunotherapy - methods | Humans | Male | Oncolytic Viruses | Immunity, Cellular | Prostatic Neoplasms - therapy | Care and treatment | Usage | Research | Prostate cancer | Immunotherapy | Viruses | Apoptosis
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2. Full Text SnapShot: Cancer Immunotherapy with Oncolytic Viruses
by Gujar, Shashi and Bell, John and Diallo, Jean-Simon
Cell, ISSN 0092-8674, 02/2019, Volume 176, Issue 5, pp. 1240 - 1240.e1
Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and... 
Metastasis | Drug therapy | Health aspects | Immunotherapy | Cancer
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3. Full Text Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
by Monro, Susan and Colón, Katsuya L and Yin, Huimin and Roque, John and Konda, Prathyusha and Gujar, Shashi and Thummel, Randolph P and Lilge, Lothar and Cameron, Colin G and McFarland, Sherri A
Chemical Reviews, ISSN 0009-2665, 01/2019, Volume 119, Issue 2, pp. 797 - 828
Transition metal complexes are of increasing interest as photosensitizers in photodynamic therapy (PDT) and, more recently, for photochemotherapy (PCT). In... 
RU(II) POLYPYRIDINE COMPLEXES | TRIPLET ENERGY-TRANSFER | IN-VITRO | ALPHA-TERTHIENYL | ELECTRON-TRANSFER | RUTHENIUM COMPLEXES | SINGLET OXYGEN | LIGHT INDUCED PHOTOCLEAVAGE | ANTITUMOR IMMUNITY | CHEMISTRY, MULTIDISCIPLINARY | EXCITED-STATES | Oxygen | Photodynamic therapy | Ruthenium | Electron transfer | Bladder | Muscles | Photochemicals | Cancer therapies | Organic chemistry | Atmospheric chemistry | Transition metal compounds | Infrared radiation | Coordination compounds | Configurations | Metal complexes | Tumors | Cancer
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4. Full Text Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies
by Gujar, Shashi and Pol, Jonathan G and Kim, Youra and Lee, Patrick W and Kroemer, Guido
Trends in Immunology, ISSN 1471-4906, 03/2018, Volume 39, Issue 3, pp. 209 - 221
Oncolytic viruses (OVs) represent a new class of cancer immunotherapeutics. Administration of OVs to cancer-bearing hosts induces two distinct immunities:... 
PLASMACYTOID DENDRITIC CELLS | REOVIRUS ONCOLYSIS | VIRUS | SIGNALING PATHWAY | IMMUNOGENIC CELL-DEATH | CD4(+) T-CELLS | IMMUNOLOGY | MYELOID CELLS | CANCER | CHECKPOINT BLOCKADE | CROSS-PRESENTATION | Neoplasms - virology | Oncolytic Virotherapy - methods | Immunization | Immunotherapy - methods | Neoplasms - therapy | Animals | Virus Replication | Antigens, Neoplasm - immunology | Neoplasms - immunology | Humans | Oncolytic Viruses - physiology | Immunity | Strategic management | Antigens | Immune response | Cytokines | Viruses | Metastasis | Cancer therapies | Immunology | Lymphocytes | Immunotherapy | Herpes viruses | Influenza | Cell cycle | Oncolysis | Tumor necrosis factor-TNF | Ligands | Adapter proteins | Chemokines | Cancer | Tumors | Apoptosis
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5. Full Text Heating it up: Oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies
by Gujar, Shashi and Pol, Jonathan G and Kroemer, Guido
OncoImmunology, ISSN 2162-4011, 08/2018, Volume 7, Issue 8, p. e1442169
Immune checkpoint blockade is less efficient in patients bearing immunologically 'cold' tumors. Oncolytic viruses, which were originally discovered for their... 
Inflammation and cancer | therapeutic antibodies | immunosurveillance | antiviral response | antitumor response | models of immunostimulation | oncolytic virus | immunotherapy | immune checkpoint | PD-L1 | antibodies | CTLA-4 | PD-1
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6. Full Text Improving MHC‐I Ligand Identifications from LC‐MS/MS Data by Incorporating Allelic Peptide Motifs
by Konda, Prathyusha and Murphy, J. Patrick and Gujar, Shashi
PROTEOMICS, ISSN 1615-9853, 03/2019, Volume 19, Issue 5, pp. e1800458 - n/a
MHC class I (MHC‐I)‐bound ligands play a pivotal role in CD8 T cell immunity and are hence of major interest in understanding and designing immunotherapies.... 
MHC ligandome | mass spectrometry | Bioinformatics | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | Algorithms | Peptides | T cells | Mass spectrometry | Analysis | Immunotherapy | Major histocompatibility complex | Statistical analysis | Search algorithms | CD8 antigen | Lymphocytes | Proteomics | Ligands | Lymphocytes T | Tryptic peptides | Immunity
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7. Full Text Regulation of Cancer and Cancer-Related Genes via NAD
by Sharif, Tanveer and Martell, Emma and Dai, Cathleen and Ghassemi-Rad, Mohammad Saleh and Kennedy, Barry E and Lee, Patrick W.K and Gujar, Shashi
Antioxidants & Redox Signaling, ISSN 1523-0864, 02/2019, Volume 30, Issue 6, pp. 96 - 923
Significance: NAD + is an essential redox cofactor in cellular metabolism and has emerged as an important regulator of a wide spectrum of disease conditions,... 
Forum Review Articles | POLY(ADP-RIBOSE) POLYMERASE | KYNURENINE PATHWAY | sirtuins | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | NMN/NAMN ADENYLYLTRANSFERASE NMNAT | ADP-RIBOSE | NICOTINAMIDE ADENINE-DINUCLEOTIDE | redox signaling | ENDOCRINOLOGY & METABOLISM | NAD(+) | TUMOR-SUPPRESSOR | SUBCELLULAR COMPARTMENTATION | cancer | metabolism | PHASE-I | HISTONE DEACETYLASE | Sirtuins | Cell proliferation | Medical research | Adenosine | Calcium | Clinical trials | Adenosine diphosphate | Metabolism | Gene expression | ADP | DNA repair | Substrates | Anticancer properties | NAD | Ribose | Cell cycle | Biomolecules | Deoxyribonucleic acid--DNA | Cancer
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8. Full Text Dendritic cells in oncolytic virus-based anti-cancer therapy
by Kim, Youra and Clements, Derek R and Sterea, Andra M and Jang, Hyun Woo and Gujar, Shashi A and Lee, Patrick W. K
Viruses, ISSN 1999-4915, 12/2015, Volume 7, Issue 12, pp. 6506 - 6525
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune... 
Anti-viral immunity | Oncolytic virus | Dendritic cells | Tumor microenvironment | Immunotherapy | Anti-tumor immunity | NATURAL-KILLER-CELLS | MURINE CYTOMEGALOVIRUS-INFECTION | anti-viral immunity | COLONY-STIMULATING FACTOR | INNATE IMMUNE-RESPONSE | NECROSIS-FACTOR-ALPHA | HUMAN-IMMUNODEFICIENCY-VIRUS | PERIPHERAL LYMPHOID ORGANS | dendritic cells | VIROLOGY | TUMOR-ANTIGEN PRESENTATION | oncolytic virus | immunotherapy | REGULATORY T-CELLS | TOLL-LIKE RECEPTORS | tumor microenvironment | anti-tumor immunity | Neoplasms - therapy | Immunity, Cellular | Dendritic Cells - immunology | Oncolytic Viruses - immunology | Oncolytic Virotherapy
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9. Full Text Sharpening the edge for precision cancer immunotherapy: Targeting tumor antigens through oncolytic vaccines
by Holay, Namit and Kim, Youra and Lee, Patrick and Gujar, Shashi
Frontiers in Immunology, ISSN 1664-3224, 07/2017, Volume 8, p. 800
Cancer immunotherapy represents a promising, modern-age option for treatment of cancers. Among the many immunotherapies being developed, oncolytic viruses... 
Tumor major histocompatibility complex ligandome | Oncolytic vaccines | Antitumor immunity | Cancer immunotherapy | T cells | Tumor antigens | T-CELL EPITOPES | IMMUNOLOGY | tumor antigens | oncolytic vaccines | antitumor immunity | MASS-SPECTROMETRY | tumor major histocompatibility complex ligandome | HERPES-SIMPLEX-VIRUS | VIRAL ONCOLYSIS | THERAPY | MELANOMA | IMMUNE CHECKPOINT BLOCKADE | cancer immunotherapy | VESICULAR STOMATITIS-VIRUS | ESTABLISHED TUMORS
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10. Full Text TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway
by Almasi, Shekoufeh and Sterea, Andra M and Fernando, Wasundara and Clements, Derek R and Marcato, Paola and Hoskin, David W and Gujar, Shashi and El Hiani, Yassine
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 4182 - 11
Transient Receptor Potential Melastatin-2 (TRPM2) ion channel is emerging as a great therapeutic target in many types of cancer, including gastric cancer - a... 
EPITHELIAL-MESENCHYMAL TRANSITION | OXIDATIVE STRESS | ACTIVATION | METASTASIS | INHIBITION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | CALCIUM | PTEN | CELL-SURVIVAL | EMT | Cell survival | Leukocyte migration | Therapeutic applications | AKT protein | Metastasis | Stomach cancer | Metastases | Transient receptor potential proteins | Signal transduction | Reversion | Gastric cancer | Cell migration | PTEN protein
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11. Full Text Dying to be noticed: Epigenetic regulation of immunogenic cell death for cancer immunotherapy
by Cruickshank, Brianne and Giacomantonio, Michael and Marcato, Paola and McFarland, Sherri and Pol, Jonathan and Gujar, Shashi
Frontiers in Immunology, ISSN 1664-3224, 04/2018, Volume 9, p. 654
Immunogenic cell death (ICD) activates both innate and adaptive arms of the immune system during apoptotic cancer cell death. With respect to cancer... 
Epigenetics | T cell immunity | Immune evasion | Tumor microenvironment | Cancer immunotherapy | Immunogenic cell death | UNFOLDED-PROTEIN RESPONSE | DNA METHYLATION | PROMOTER METHYLATION | immunogenic cell death | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | ATP SECRETION | epigenetics | BREAST-CANCER | CALRETICULIN EXPOSURE | LUNG-CANCER | immune evasion | cancer immunotherapy | tumor microenvironment | ANTITUMOR IMMUNITY | HISTONE LYSINE METHYLTRANSFERASES | Usage | Research | Cell death | Immunotherapy | Oncology, Experimental | Cancer | Life Sciences | Immunology
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12. Full Text Oncolytic virus-mediated reversal of impaired tumor antigen presentation
by Gujar, Shashi A and Lee, Patrick W.K
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 77
Anti-tumor immunity can eliminate existing cancer cells and also maintain a constant surveillance against possible relapse. Such an antigen-specific adaptive... 
Antigen presentation | Oncolytic virus | Immunotherapy | Reovirus | Anti-tumor immunity | Immune Evasion | Antigen Presentation | reovirus | oncolytic virus | Tumor antigens
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13. Full Text Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorubicin
by Murphy, JP and Yu, QJ and Konda, P and Paulo, JA and Jedrychowski, MP and Kowalewski, DJ and Schuster, H and Kim, Y and Clements, D and Jain, A and Stevanovic, S and Gygi, SP and Mancias, JD and Gujar, S
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 04/2019, Volume 91, Issue 8, pp. 5106 - 5115
MHC-I peptides are intracellular-cleaved peptides, usually 8-11 amino acids in length, which are presented on the cell surface and facilitate CD8+ T cell... 
CAPACITY | CHEMISTRY, ANALYTICAL | IMMUNOGENICITY | EXTRACTION | ACCURATE | TURNOVER | DATABASE | GENERATION | ANTHRACYCLINES | Multiplexing | Peptides | CD8 antigen | Amino acids | Mass spectroscopy | Lymphocytes T | Quantitation | Doxorubicin | Cell surface | Proteins | Major histocompatibility complex | Lymphocytes | Tagging | Antitumor activity | Ligands | Coordination compounds | Mass spectrometry | Histocompatibility | Cancer
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