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1. Full Text A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci
by Pillai, S.G and Ge, D.L and Zhu, G.H and Kong, X.Y and Shianna, K.V and Need, A.C and Feng, S and Hersh, C.P and Bakke, P and Gulsvik, A and Ruppert, A and Carlsen, K.C.L and Roses, A and Anderson, W and Rennard, S.I and Lomas, D.A and Silverman, E.K and Goldstein, D.B and ICGN Investigators incl. Wouters, E.F.M and ICGN Investigators
Plos Genetics, ISSN 1553-7390, 01/2009, Volume 5, Issue 3, pp. e1000421 - e1000421
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor... 
LUNG-CANCER | NICOTINE DEPENDENCE | CIGARETTE-SMOKING | TWINS | SURFACTANT PROTEIN-B | ACETYLCHOLINE | GENES | GENETICS & HEREDITY | RISK | HEALTH | EXPRESSION | Smoking - adverse effects | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Risk Factors | European Continental Ancestry Group | Pulmonary Disease, Chronic Obstructive - etiology | Case-Control Studies | Chromosomes, Human, Pair 4 | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Regression Analysis | Norway | Pedigree | Polymorphism, Single Nucleotide | Pulmonary Disease, Chronic Obstructive - genetics | Quantitative trait loci | Lung diseases, Obstructive | Genetic aspects | Disease susceptibility | Diagnosis | Research | Health aspects | Identification and classification | Malalties pulmonars obstructives cròniques | Chronic obstructive pulmonary diseases | Genomics | Lung cancer | Genòmica | Càncer de pulmó | Hospitals | Aging | Genetics | Population | Chronic obstructive pulmonary disease | Genomes | Health risk assessment | Epidemiology | Emphysema | Risk factors | Smoking
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2. Kjell Holten
by Gulsvik, Amund and Gallefoss, Frode
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 05/2018, Volume 138, Issue 8
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3. Full Text Asthma control in Europe: A real-world evaluation based on an international population-based study
by Cazzoletti, Lucia, MSc and Marcon, Alessandro, MSc and Janson, Christer, MD and Corsico, Angelo, MD, PhD and Jarvis, Deborah, FFPHM and Pin, Isabelle, MD and Accordini, Simone, MSc and Almar, Enrique, MD and Bugiani, Massimiliano, MD and Carolei, Adriana, MSc and Cerveri, Isa, MD and Duran-Tauleria, Enric, BS, MB and Gislason, David, MD and Gulsvik, Amund, MD, PhD and Jõgi, Rain, PhD and Marinoni, Alessandra, PhD and Martínez-Moratalla, Jesús, MD and Vermeire, Paul, MD and de Marco, Roberto, PhD and Therapy & Hlth Economics Grp Europ and Therapy and Health Economics Group of the European Community Respiratory Health Survey and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 120, Issue 6, pp. 1360 - 1367
Background Epidemiologic evidence related to asthma control in patients from the general population is scanty. Objectives We sought to assess asthma control in... 
Allergy and Immunology | Asthma control | total IgE | Global Initiative for Asthma | European Community Respiratory Health Survey | body mass index | predictors of uncontrolled asthma | population-based study | cross-sectional study | Cladosporium species | inhaled corticosteroids | LUNG-FUNCTION | ADULTS | asthma control | IMMUNOLOGY | ALLERGY | COHORT | RESPIRATORY-HEALTH-SURVEY | SEVERITY | Asthma - diagnosis | Severity of Illness Index | Allergens - adverse effects | Prevalence | Cross-Sectional Studies | Practice Guidelines as Topic - standards | Humans | Risk Factors | Male | Asthma - drug therapy | Randomized Controlled Trials as Topic | Animals | European Union | Adult | Female | Surveys and Questionnaires | Disease Management | Asthma - epidemiology | Asthma | Body mass index | Questionnaires | Population | Allergies | Age | Family physicians | Allergens | Life Sciences | Santé publique et épidémiologie | Practice Guidelines as Topic | Medical and Health Sciences | Medicin och hälsovetenskap | Asthma/diagnosis/drug therapy/epidemiology | MEDICINE | MEDICIN | Allergens/adverse effects | Practice Guidelines as Topic/standards
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4. Full Text Comparison of 2011 and 2007 global initiative for chronic obstructive lung disease guidelines for predicting mortality and hospitalization
by Johannessen, Ane and Nilsen, Roy M and Storebø, Michael and Gulsvik, Amund and Eagan, Tomas and Bakke, Per
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2013, Volume 188, Issue 1, pp. 51 - 59
Rationale: The GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2011 update on chronic obstructive pulmonary disease (COPD) bases disease... 
Severity classification | Exacerbations | Mortality | COPD | severity classification | RESPIRATORY SYSTEM | exacerbations | DYSPNEA | mortality | CLASSIFICATION | RESPIRATORY SYMPTOMS | PULMONARY-DISEASE | CRITICAL CARE MEDICINE | Severity of Illness Index | Predictive Value of Tests | Pulmonary Disease, Chronic Obstructive - diagnosis | Follow-Up Studies | Area Under Curve | Respiratory Function Tests - statistics & numerical data | Humans | Middle Aged | Respiratory Function Tests - methods | Hospitalization - statistics & numerical data | Male | Survival Rate | Pulmonary Disease, Chronic Obstructive - epidemiology | Internationality | Aged, 80 and over | Adult | Female | ROC Curve | Surveys and Questionnaires | Aged | Odds Ratio | Length of Stay - statistics & numerical data | Population Surveillance - methods | Cohort Studies
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5. Full Text Mortality by level of emphysema and airway wall thickness
by Johannessen, Ane and Skorge, Trude Duelien and Bottai, Matteo and Grydeland, Thomas Blix and Nilsen, Roy Miodini and Coxson, Harvey and Dirksen, Asger and Omenaas, Ernst and Gulsvik, Amund and Bakke, Per
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2013, Volume 187, Issue 6, pp. 602 - 608
Rationale: There is limited knowledge of the prognostic value of quantitative computed tomography (CT) measures of emphysema and airway wall thickness (AWT) on... 
Mortality predictors | Quantitative CT imaging | Chronic obstructive pulmonary disease | FLOW OBSTRUCTION | COR-PULMONALE | INVOLVEMENT | DEATH | COMPUTED-TOMOGRAPHY | PATHOPHYSIOLOGY | mortality predictors | DIMENSIONS | OBSTRUCTIVE PULMONARY-DISEASE | quantitative CT imaging | RESPIRATORY SYSTEM | PREDICTORS | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Spirometry | Pulmonary Emphysema - physiopathology | Prognosis | Humans | Middle Aged | Risk Factors | Kaplan-Meier Estimate | Pulmonary Emphysema - pathology | Male | Tomography, X-Ray Computed | Pulmonary Emphysema - diagnostic imaging | Bronchography | Female | Aged | Pulmonary Emphysema - mortality | Bronchi - pathology
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6. Full Text International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study
by Buist, A Sonia, Prof and McBurnie, Mary Ann, PhD and Vollmer, William M, PhD and Gillespie, Suzanne, MS and Burney, Peter, Prof and Mannino, David M, MD and Menezes, Ana MB, Prof and Sullivan, Sean D, Prof and Lee, Todd A, PhD and Weiss, Kevin B, Prof and Jensen, Robert L, Prof and Marks, Guy B, PhD and Gulsvik, Amund, Prof and Nizankowska-Mogilnicka, Ewa, Prof and BOLD Collaborative Res Grp and BOLD Collaborative Research Group
Lancet, The, ISSN 0140-6736, 2007, Volume 370, Issue 9589, pp. 741 - 750
Summary Background Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide, and accurate estimates of the... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | IMPACT | STANDARDIZATION | US POPULATION | ADULT LUNG-FUNCTION | SMOKERS | GENDER | CHILDHOOD RESPIRATORY-INFECTION | HEALTH | BURDEN | Smoking - adverse effects | Age Distribution | Prevalence | Humans | Middle Aged | Risk Factors | Logistic Models | Male | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - epidemiology | Multicenter Studies as Topic | Smoking - epidemiology | Sex Distribution | Adult | Female | Surveys and Questionnaires | Aged | Population Surveillance - methods | Lung diseases, Obstructive | Research | Demographic aspects | Statistics | Medical research | Data analysis | Sample size | Mortality | Risk factors | Hospitals | Quality control | Data collection | Population | Chronic obstructive pulmonary disease | Pharmaceutical industry | Smoking | International
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7. Full Text Gender differences in COPD: are women more susceptible to smoking effects than men?
by Sørheim, Inga-Cecilie and Johannessen, Ane and Gulsvik, Amund and Bakke, Per S and Silverman, Edwin K and DeMeo, Dawn L
Thorax, ISSN 0040-6376, 06/2010, Volume 65, Issue 6, pp. 480 - 485
BackgroundThe number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a... 
OBSTRUCTIVE PULMONARY-DISEASE | METAANALYSIS | COMMUNITY | RESPIRATORY SYSTEM | EMPHYSEMA | RISK | SEX-DIFFERENCES | PREVALENCE | FEMALE SMOKERS | EXPOSURE | HABITS | Smoking - adverse effects | Disease Susceptibility | Age Factors | Humans | Middle Aged | Risk Factors | Male | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - etiology | Pulmonary Disease, Chronic Obstructive - epidemiology | Forced Expiratory Volume | Asthma - complications | Smoking - epidemiology | Norway - epidemiology | Smoking - physiopathology | Sex Factors | Adult | Female | Aged | Asthma - epidemiology | Lung diseases, Obstructive | Demographic aspects | Sex factors in disease | Research | Health aspects | Risk factors | Smoking
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8. Full Text The Cost of Persistent Asthma in Europe: An International Population-Based Study in Adults
by Accordini, Simone and Corsico, Angelo G and Braggion, Marco and Gerbase, Margaret W and Gislason, David and Gulsvik, Amund and Heinrich, Joachim and Janson, Christer and Jarvis, Deborah and Jõgi, Rain and Pin, Isabelle and Schoefer, Yvonne and Bugiani, Massimiliano and Cazzoletti, Lucia and Cerveri, Isa and Marcon, Alessandro and de Marco, Roberto and Therapy Hlth Economics Working Grp and European Community Resp Hlth Surve and Therapy and Health Economics Working Group of the European Community Respiratory Health Survey II and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
International Archives of Allergy and Immunology, ISSN 1018-2438, 12/2012, Volume 160, Issue 1, pp. 93 - 101
Background: This study is aimed at providing a real-world evaluation of the economic cost of persistent asthma among European adults according to the degree of... 
Original Paper | YOUNG-ADULTS | Cost of illness | ILLNESS | IMMUNOLOGY | Disease control | Asthma | OBSTRUCTIVE PULMONARY-DISEASE | ALLERGY | ECONOMIC-IMPACT | COHORT | QUALITY-OF-LIFE | RESPIRATORY-HEALTH-SURVEY | BURDEN | SEVERITY | Body Mass Index | Cough - economics | Europe | Health Care Costs - statistics & numerical data | Humans | Middle Aged | Cost of Illness | Adult | Disease Management | Population Surveillance | Asthma - economics | Health care expenditures | Medical and Health Sciences | Medicin och hälsovetenskap
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9. Full Text Variants in FAM13A are associated with chronic obstructive pulmonary disease
by Cho, Michael H and Kong, Xiangyang and Regan, Elizabeth A and Lomas, David A and Klanderman, Barbara J and Sparrow, David and Hokanson, John E and Ziniti, John P and Hunninghake, Gary M and Make, Barry J and Crapo, James D and Lange, Christoph and Murphy, James R and Anderson, Wayne H and Beaty, Terri H and Tal-Singer, Ruth and Sylvia, Jody S and Hersh, Craig P and Boutaoui, Nadia and Bakke, Per and Gulsvik, Amund and Pillai, Sreekumar G and Litonjua, Augusto A and Silverman, Edwin K and Won, Sungho and DeMeo, Dawn L
Nature Genetics, ISSN 1061-4036, 03/2010, Volume 42, Issue 3, pp. 200 - 202
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380... 
GENE-EXPRESSION | GENETICS & HEREDITY | Smoking - adverse effects | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Smoking - genetics | Pulmonary Disease, Chronic Obstructive - etiology | Case-Control Studies | Chromosomes, Human, Pair 4 | Linkage Disequilibrium | Multicenter Studies as Topic | Family | Polymorphism, Single Nucleotide | Receptors, G-Protein-Coupled - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Receptors, G-Protein-Coupled - physiology | Lung diseases, Obstructive | Genetic aspects | Genetic variation | Health aspects | Risk factors | Studies | Signal transduction | Mortality | Genetics | Population | Regression analysis | Gene expression | Methods | Smoking
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10. Full Text A genome-wide association study of emphysema and airway quantitative imaging phenotypes
by Cho, Michael H and Castaldi, Peter J and Hersh, Craig P and Hobbs, Brian D and Barr, R. Graham and Tal-Singer, Ruth and Bakke, Per and Gulsvik, Amund and San José Estépar, Raúl and Van Beek, Edwin J.R and Coxson, Harvey O and Lynch, David A and Washko, George R and Laird, Nan M and Crapo, James D and Beaty, Terri H and Silverman, Edwin K and COPDGene Investigators and NETT Genetics and ECLIPSE and NETT Genetics, ECLIPSE, and COPDGene Investigators
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 5, pp. 559 - 569
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked... 
Genetics | Chronic obstructive pulmonary disease | Airway | Emphysema | FLOW OBSTRUCTION | VARIANTS | airway | CELL APOPTOSIS | IDENTIFICATION | emphysema | OBSTRUCTIVE PULMONARY-DISEASE | RISK LOCI | genetics | RESPIRATORY SYSTEM | SMOKERS | ENRICHMENT ANALYSIS | RADIOGRAPHIC EMPHYSEMA | chronic obstructive pulmonary disease | COPD | CRITICAL CARE MEDICINE | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Lung - diagnostic imaging | Tumor Suppressor Proteins - genetics | Pulmonary Emphysema - genetics | Female | Pulmonary Disease, Chronic Obstructive - diagnostic imaging | Receptor for Advanced Glycation End Products - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Serpins - genetics | Pulmonary Emphysema - diagnostic imaging | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phenotype | Image Processing, Computer-Assisted | Iron Regulatory Protein 2 - genetics | Aged | GTPase-Activating Proteins - genetics | Longitudinal Studies | Receptors, Nicotinic - genetics | Cohort Studies | Original
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11. Full Text Meta-analysis and imputation refines the association of 15q25 with smoking quantity
by Liu, Jason Z and Tozzi, Federica and Waterworth, Dawn M and Pillai, Sreekumar G and Muglia, Pierandrea and Middleton, Lefkos and Berrettini, Wade and Knouff, Christopher W and Yuan, Xin and Waeber, Gérard and Vollenweider, Peter and Preisig, Martin and Wareham, Nicholas J and Zhao, Jing Hua and Loos, Ruth J.F and Barroso, Ins and Khaw, Kay-Tee and Grundy, Scott and Barter, Philip and Mahley, Robert and Kesaniemi, Antero and McPherson, Ruth and Vincent, John B and Strauss, John and Kennedy, James L and Farmer, Anne and McGuffin, Peter and Day, Richard and Matthews, Keith and Bakke, Per and Gulsvik, Amund and Lucae, Susanne and Ising, Marcus and Brueckl, Tanja and Horstmann, Sonja and Wichmann, H-Erich and Rawal, Rajesh and Dahmen, Norbert and Lamina, Claudia and Polasek, Ozren and Zgaga, Lina and Huffman, Jennifer and Campbell, Susan and Kooner, Jaspal and Chambers, John C and Burnett, Mary Susan and Devaney, Joseph M and Pichard, Augusto D and Kent, Kenneth M and Satler, Lowell and Lindsay, Joseph M and Waksman, Ron and Epstein, Stephen and Wilson, James F and Wild, Sarah H and Campbell, Harry and Vitart, Veronique and Reilly, Muredach P and Li, Mingyao and Qu, Liming and Wilensky, Robert and Matthai, William and Hakonarson, Hakon H and Rader, Daniel J and Franke, Andre and Wittig, Michael and Schäfer, Arne and Uda, Manuela and Terracciano, Antonio and Xiao, Xiangjun and Busonero, Fabio and Scheet, Paul and Schlessinger, David and Clair, David St and Rujescu, Dan and Abecasis, Gonçalo R and Grabe, Hans Jörgen and Teumer, Alexander and Völzke, Henry and Petersmann, Astrid and John, Ulrich and Rudan, Igor and Hayward, Caroline and Wright, Alan F and Kolcic, Ivana and Wright, Benjamin J and Thompson, John R and Balmforth, Anthony J and Hall, Alistair S and Samani, Nilesh J and Anderson, Carl A and Ahmad, Tariq and Mathew, Christopher G and Parkes, Miles and Satsangi, Jack and Caulfield, Mark and Munroe, Patricia B and Farrall, Martin and Dominiczak, Anna and Worthington, Jane and ... and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature Genetics, ISSN 1061-4036, 05/2010, Volume 42, Issue 5, pp. 436 - 440
Smoking is a leading global cause of disease and mortality(1). We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis... 
NICOTINE DEPENDENCE | LUNG-CANCER | RISK-FACTORS | VARIANTS | BEHAVIOR | DISEASE | GENES | GENETICS & HEREDITY | SNPS | SUSCEPTIBILITY LOCUS | GENOME-WIDE ASSOCIATION | Receptors, Nicotinic - metabolism | Humans | Middle Aged | Male | Chromosome Mapping - methods | Chromosomes, Human, Pair 15 | Genetic Markers - genetics | Alleles | Adult | Female | Aged | Models, Genetic | Neurons - metabolism | Polymorphism, Single Nucleotide | Genome, Human | Cohort Studies | Smoking | Genetic aspects | Research | Single nucleotide polymorphisms | Genetic susceptibility | Risk factors | Tobacco habit | Confidence intervals | Neurosciences | Software | Chromosomes | Meta-analysis | Nicotine
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12. Full Text Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
by Hobbs, Brian D and de Jong, Kim and Lamontagne, Maxime and Bosse, Yohan and Shrine, Nick and Artigas, Maria Soler and Wain, Louise V and Hall, Ian P and Jackson, Victoria E and Wyss, Annah B and London, Stephanie J and North, Kari E and Franceschini, Nora and Strachan, David P and Beaty, Terri H and Hokanson, John E and Crapo, James D and Castaldi, Peter J and Chase, Robert P and Bartz, Traci M and Heckbert, Susan R and Psaty, Bruce M and Gharib, Sina A and Zanen, Pieter and Lammers, Jan W and Oudkerk, Matthijs and Groen, H. J and Locantore, Nicholas and Tal-Singer, Ruth and Rennard, Stephen I and Vestbo, Jurgen and Timens, Wim and Pare, Peter D and Latourelle, Jeanne C and Dupuis, Josee and O'Connor, George T and Wilk, Jemma B and Kim, Woo Jin and Lee, Mi Kyeong and Oh, Yeon-Mok and Vonk, Judith M and de Koning, Harry J and Leng, Shuguang and Belinsky, Steven A and Tesfaigzi, Yohannes and Manichaikul, Ani and Wang, Xin-Qun and Rich, Stephen S and Barr, R. Graham and Sparrow, David and Litonjua, Augusto A and Bakke, Per and Gulsvik, Amund and Lahousse, Lies and Brusselle, Guy G and Stricker, Bruno H and Uitterlinden, Ane G and Ampleford, Elizabeth J and Bleecker, Eugene R and Woouff, Prescott G and Meyers, Deborah A and Qiao, Dandi and Lomas, David A and Yim, Jae-Joon and Kim, Deog Kyeom and Hawrylkiewicz, Iwona and Sliwinski, Pawel and Hardin, Megan and Fingerlin, Tasha E and Schwartz, David A and Postma, Dirkje S and MacNee, William and Tobin, Martin D and Silverman, Edwin K and Boezen, H. Marike and Cho, Michael H and UK BiLEVE Investigators and COPDGene Investigators and ECLIPSE Investigators and SPIROMICS Res Grp and Int COPD Genetics Network and LifeLines Investigators and Int COPD Genetics Consortium and SPIROMICS Research Group and International COPD Genetics Network Investigators and International COPD Genetics Consortium
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 426 - 432
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide(1). We performed a genetic association study in 15,256 cases and 47,936... 
SURFACTANT PROTEIN-D | NLRX1 | VARIANTS | MICROTUBULES | SUSCEPTIBILITY | GENETICS & HEREDITY | DESMOPLAKIN | COMPLEX TRAITS | GENOME-WIDE ASSOCIATION | I INTERFERON | COPD | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Risk Factors | Genetic Loci - genetics | Male | Smoking - genetics | Pulmonary Fibrosis - genetics | Lung - physiology | Asthma - genetics | Phenotype | Alleles | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods | Pulmonary Disease, Chronic Obstructive - genetics | Quantitative trait loci | Complications and side effects | Lung diseases, Obstructive | Care and treatment | Pulmonary fibrosis | Genetic aspects | Health aspects | Risk factors | Data analysis | Genomes | Cigarettes | Surfactants | Asthma | Proteins | Studies | Airway management | Data collection | Gene loci | Chronic obstructive pulmonary disease | Smoking
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