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1. Full Text Landscape connectivity as a tool in green space evaluation and optimization of the Haidan District, Beijing
by Guo, Shiyi and Saito, Kaoru and Yin, Weida and Su, Chang
Sustainability (Switzerland), ISSN 2071-1050, 06/2018, Volume 10, Issue 6, p. 1979
The demand for urban construction has placed growing pressure on biodiversity conservation. In China, landscape fragmentation caused by rapid urbanization has... 
Green space | Morphological spatial pattern analysis | Least-cost path | Focal species | Landscape connectivity | HABITAT PATCHES | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | landscape connectivity | green space | least-cost path | focal species | FRAGMENTATION | IDENTIFICATION | SPATIAL-PATTERN | NETWORK ANALYSIS | ENVIRONMENTAL SCIENCES | METHODOLOGY | AREA | morphological spatial pattern analysis | SEGMENTATION | ECOLOGY | SCALE | ENVIRONMENTAL STUDIES | Landscape | Wildlife conservation | Computer simulation | Habitats | Spatial discrimination | Spatial analysis | Biodiversity | Optimization | Case studies | Ecological effects | Urbanization | Corridors | Connectivity | Ecological monitoring | Modelling | Cost analysis | Species | Pattern analysis
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2. Full Text A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
by Dey, Bappaditya and Dey, Ruchi Jain and Cheung, Laurene S and Pokkali, Supriya and Guo, Haidan and Lee, Jong-Hee and Bishai, William R
Nature Medicine, ISSN 1078-8956, 04/2015, Volume 21, Issue 4, pp. 401 - 408
Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger, by the host cytoplasmic surveillance pathway (CSP) is known to elicit... 
MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | I INTERFERON RESPONSE | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | GMP | C-DI-AMP | CELL BIOLOGY | HOST-CELL | DNA | INFECTION | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Virulence | Interferon-gamma - metabolism | Dinucleoside Phosphates - metabolism | Autophagy | Genetic Complementation Test | Macrophages - metabolism | Animals | Interferon-beta - metabolism | Mycobacterium tuberculosis | Tuberculosis - prevention & control | Bacterial Proteins - metabolism | Cytosol - metabolism | Female | Mice | Mice, Inbred BALB C | Nucleotidyltransferases - metabolism | Phosphorus-Oxygen Lyases - metabolism | Tuberculosis - metabolism | Medicine, Experimental | Medical research | Care and treatment | Tuberculosis | Research | Immunotherapy | Signal transduction | Gene expression | Molecular biology | Immune system
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3. Full Text Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
by Forde, Patrick M and Chaft, Jamie E and Smith, Kellie N and Anagnostou, Valsamo and Cottrell, Tricia R and Hellmann, Matthew D and Zahurak, Marianna and Yang, Stephen C and Jones, David R and Broderick, Stephen and Battafarano, Richard J and Velez, Moises J and Rekhtman, Natasha and Olah, Zachary and Naidoo, Jarushka and Marrone, Kristen A and Verde, Franco and Guo, Haidan and Zhang, Jiajia and Caushi, Justina X and Chan, Hok Yee and Sidhom, John-William and Scharpf, Robert B and White, James and Gabrielson, Edward and Wang, Hao and Rosner, Gary L and Rusch, Valerie and Wolchok, Jedd D and Merghoub, Taha and Taube, Janis M and Velculescu, Victor E and Topalian, Suzanne L and Brahmer, Julie R and Pardoll, Drew M
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 21, pp. 1976 - 1986
In a pilot study, two doses of neoadjuvant nivolumab administered to patients with resectable lung cancer resulted in a major pathological response in 45% and... 
MISMATCH-REPAIR DEFICIENCY | TRIAL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | PEMBROLIZUMAB | RESPONSE CRITERIA | SOLID TUMORS | IMMUNE CHECKPOINT BLOCKADE | IMMUNOTHERAPY | OPEN-LABEL | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - adverse effects | Aged, 80 and over | Female | Neoadjuvant Therapy | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - surgery | Carcinoma, Non-Small-Cell Lung - genetics | Pilot Projects | B7-H1 Antigen - antagonists & inhibitors | Biopsy | Nivolumab | Lung Neoplasms - surgery | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Drug therapy | Lung cancer | Peptides | PD-1 protein | Body weight | Lymphocytes T | Cancer therapies | Lymphocytes | Immunotherapy | Surgery | Peripheral blood | Drug dosages | Antigens | Lymphatic system | Cell survival | Cloning | Feasibility studies | Non-small cell lung carcinoma | T cell receptors | Gene expression | Patients | Side effects | Chemotherapy | PD-L1 protein | Tumors | Apoptosis
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4. Full Text A qualitative and quantitative evaluation of the peptide characteristics of microwave‐ and ultrasound‐assisted digestion in discovery and targeted proteomic analyses
by Guo, Zhengguang and Cheng, Jie and Sun, Haidan and Sun, Wei
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 08/2017, Volume 31, Issue 16, pp. 1353 - 1362
Rationale Fast digestion methods can dramatically accelerate enzyme digestion and increase the throughput of proteomic analysis. However, the peptide... 
PROTEOLYTIC DIGESTION | CHEMISTRY, ANALYTICAL | SPECTROSCOPY | TRYPSIN DIGESTION | BIOCHEMICAL RESEARCH METHODS | ACID-HYDROLYSIS | MS/MS | EFFICIENCY | MASS-SPECTROMETRY | PROTEIN IDENTIFICATION | REVEALS | Enzymes | Peptides | Proteolysis | Analysis | Proteins | Trypsin | Reproducibility | Proteomics | Cleavage | Abundance | Digestion | Methods | Quantitative analysis
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5. Full Text Aerosol mycobacterium tuberculosis infection causes rapid loss of diversity in gut microbiota
by Winglee, Kathryn and Eloe-Fadrosh, Emiley and Gupta, Shashank and Guo, Haidan and Fraser, Claire and Bishai, William
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97048
Mycobacterium tuberculosis is an important human pathogen, and yet diagnosis remains challenging. Little research has focused on the impact of M. tuberculosis... 
IMMUNE-SYSTEM | DISEASES | INTESTINAL MICROBIOTA | MULTIDISCIPLINARY SCIENCES | Microbiota | Animals | Sequence Analysis, RNA | Mycobacterium tuberculosis - physiology | Aerosols | Gastrointestinal Tract - microbiology | RNA, Ribosomal, 16S - genetics | Female | Mice | Biodiversity | Tuberculosis | Microbiota (Symbiotic organisms) | RNA | Analysis | Gastrointestinal system | Health aspects | Biological diversity | rRNA 16S | Digestive system | Infections | Gastrointestinal tract | Genomes | Patients | Asthma | Medicine | Ecological effects | Microorganisms | Immunology | Antibiotics | Lungs | Phylogenetics | Bacteria | Ecological monitoring | Feces | Digestive tract | Immune system
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6. Full Text Indoleamides are active against drug-resistant mycobacterium tuberculosis
by Lun, Shichun and Guo, Haidan and Onajole, Oluseye K and Pieroni, Marco and Gunosewoyo, Hendra and Chen, Gang and Tipparaju, Suresh K and Ammerman, Nicole C and Kozikowski, Alan P and Bishai, William R
Nature Communications, ISSN 2041-1723, 12/2013, Volume 4, Issue 1, pp. 2907 - 2907
Responsible for nearly two million deaths each year, the infectious disease tuberculosis remains a serious global health challenge. The emergence of... 
SYSTEM | DESIGN | MECHANISM | MEMBRANE | MMPL3 | MULTIDISCIPLINARY SCIENCES | SQ109 | DERIVATIVES | DISCOVERY | Antitubercular Agents - chemistry | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Cercopithecus aethiops | Molecular Targeted Therapy | Mycobacterium tuberculosis - drug effects | Dose-Response Relationship, Drug | Animals | Antitubercular Agents - pharmacokinetics | Tuberculosis, Multidrug-Resistant - microbiology | Vero Cells - drug effects | Drug Design | Female | Mice | Mice, Inbred BALB C | Polymorphism, Single Nucleotide | Mutation | Drug Resistance, Multiple, Bacterial - genetics | Vero Cells - microbiology | Drug Resistance, Multiple, Bacterial - drug effects | Indoles - chemistry | Anion Transport Proteins - genetics
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7. Full Text Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase
by Dey, RJ and Dey, B and Zheng, Y and Cheung, LS and Zhou, J and Sayre, D and Kumar, P and Guo, HD and Lamichhane, G and Sintim, H and Bishai, WR
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 02/2017, Volume 13, Issue 2, pp. 210 - 217
Mycobacterium tuberculosis infection leads to cytosolic release of the bacterial cyclic dinucleotide (CDN) c-di-AMP and a host-generated CDN, cGAMP, both of... 
MYCOBACTERIUM-TUBERCULOSIS | SYNTHASE | 2ND-MESSENGER | DNA SENSOR | IFN-BETA | CYCLIC GMP-AMP | PROTEIN | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CGAS | C-DI-AMP | Cytosol - microbiology | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Immunity, Innate | Cytosol - immunology | Mycobacterium tuberculosis - enzymology | Signal transduction | Enzymes | Bacteria | Tuberculosis
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8. Full Text Author Correction: Urinary metabolic variation analysis during pregnancy and application in Gestational Diabetes Mellitus and spontaneous abortion biomarker discovery
by Liu, Xiaoyan and Wang, Xiangqing and Sun, Haidan and Guo, Zhengguang and Liu, Xiang and Yuan, Tao and Fu, Yong and Tang, Xiaoyue and Li, Jing and Sun, Wei and Zhao, Weigang
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 1
An amendment to this paper has been published and can be accessed via a link at the top of the paper. 
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9. Full Text Differential urinary proteins to diagnose coronary heart disease based on iTRAQ quantitative proteomics
by Sun, Haidan and Wang, Danqi and Liu, Dongfang and Guo, Zhengguang and Shao, Chen and Sun, Wei and Zeng, Yong
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 4/2019, Volume 411, Issue 11, pp. 2273 - 2282
Coronary artery disease (CAD) is a manifestation of systemic atherosclerotic disease. It is assessed by intervention or traditional scoring risk factors.... 
Biochemistry, general | Urine | Chemistry | Analytical Chemistry | Food Science | Monitoring/Environmental Analysis | Atherosclerosis | Proteomics | iTRAQ | Characterization and Evaluation of Materials | MRM | Laboratory Medicine | DIGESTION | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | APOLIPOPROTEIN D | IDENTIFICATION | DISCOVERY | Reactive oxygen species | Liver X receptors | Liver | Coronary artery | Data processing | Cardiovascular disease | Functional analysis | Risk analysis | Retinoid X receptors | Coronary artery disease | Risk factors | Proteins | Apolipoprotein E | Nitric oxide | Arteriosclerosis | Diagnostic software | Diagnostic systems | Cardiovascular diseases | Heart diseases
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10. Full Text Identification and characterization of genes with absolute mRNA abundances changes in tumor cells with varied transcriptome sizes
by Cai, Hao and Li, Xiangyu and He, Jun and Zhou, Wenbin and Song, Kai and Guo, You and Liu, Huaping and Guan, Qingzhou and Yan, Haidan and Wang, Xianlong and Guo, Zheng
BMC Genomics, ISSN 1471-2164, 02/2019, Volume 20, Issue 1, pp. 134 - 134
Background: The amount of RNA per cell, namely the transcriptome size, may vary under many biological conditions including tumor. If the transcriptome size of... 
Relative expression ordering | Differentially expressed gene | Absolute mRNA abundances | Cellular mRNA concentration | COPY NUMBER ALTERATIONS | DIFFERENTIAL EXPRESSION | SIGNATURES | DRIVERS | ENABLES | CANCER | FALSE DISCOVERY RATE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | NORMALIZATION | MICROARRAYS | Research | Genetic transcription | Gene expression | Carcinogenesis | Cancer cells | Computer simulation | Identification methods | Tumor cells | Genes | Genomics | Lung cancer | DNA damage | Data processing | Identification | Genomes | Metabolism | Experiments | Carcinogens | Algorithms | Pathways | Ribonucleic acids | DNA methylation | Cell size | Bioinformatics | Deoxyribonucleic acid--DNA | Cancer | Tumors
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11. Full Text A qualitative transcriptional signature for predicting pathological response of colorectal cancer to FOLFOX therapy
by He, Jun and Cheng, Jun and Guan, Qingzhou and Yan, Haidan and Li, Yawei and Zhao, Wenyuan and Guo, Zheng and Wang, Xianlong
Cancer Science, ISSN 1347-9032, 11/2019
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12. Full Text Novel coordination imprinted polymer monolithic column applied to the solid-phase extraction of flumequine from fish samples
by Zhai, Haiyun and Liang, Guohuan and Guo, Xiaojing and Chen, Zuanguang and Yu, Jiaer and Lin, Haidan and Zhou, Qing
Journal of Chromatography B, ISSN 1570-0232, 06/2019, Volume 1118-1119, pp. 55 - 62
In this study, a coordination imprinted polymer (CIP) solid-phase extraction (SPE) method was developed to determine the residues of flumequine (FLU) in fish... 
Flumequine | Graphene oxide | Coordination imprinted polymer | High-performance liquid chromatography | Zinc compounds | Adsorption | Graphene | Analysis | Influenza | Graphite | Detectors | Polymer industry | Polymers | High performance liquid chromatography
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13. Full Text Quantitative or qualitative transcriptional diagnostic signatures? A case study for colorectal cancer
by Guan, Qingzhou and Yan, Haidan and Chen, Yanhua and Zheng, Baotong and Cai, Hao and He, Jun and Song, Kai and Guo, You and Ao, Lu and Liu, Huaping and Zhao, Wenyuan and Wang, Xianlong and Guo, Zheng
BMC Genomics, ISSN 1471-2164, 01/2018, Volume 19, Issue 1, pp. 99 - 11
Background: Due to experimental batch effects, the application of a quantitative transcriptional signature for disease diagnoses commonly requires inter-sample... 
Classifiers | Platform | Relative expression orderings | Batch effects | Diagnostic signature | EXPRESSION ANALYSIS | REJECTION SURVEILLANCE | ULCERATIVE-COLITIS | COLONOSCOPIC SURVEILLANCE | CELL LUNG-CANCER | BREAST-CANCER | PROGNOSTIC SIGNATURE | INFLAMMATORY-BOWEL-DISEASE | FINE-NEEDLE-ASPIRATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TREATMENT DECISIONS | GENETICS & HEREDITY | Colorectal cancer | Physiological aspects | Genetic aspects | Diagnosis | Research | Genetic transcription | Cancer | Case studies | Gastrointestinal diseases | Genes | Quality control | Genetic research
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14. Full Text UPLC-MS based urine untargeted metabolomic analyses to differentiate bladder cancer from renal cell carcinoma
by Wang, Zhan and Liu, Xiaoyan and Liu, Xiang and Sun, Haidan and Guo, Zhengguang and Zheng, Guoyang and Zhang, Yushi and Sun, Wei
BMC Cancer, ISSN 1471-2407, 12/2019, Volume 19, Issue 1
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15. Full Text Urinary metabolic variation analysis during pregnancy and application in Gestational Diabetes Mellitus and spontaneous abortion biomarker discovery
by Liu, Xiaoyan and Wang, Xiangqing and Sun, Haidan and Guo, Zhengguang and Liu, Xiang and Yuan, Tao and Fu, Yong and Tang, Xiaoyue and Li, Jing and Sun, Wei and Zhao, Weigang
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 2605 - 9
Pregnancy is associated with the onset of many adaptation processes that are likely to change over the course of gestation. Understanding normal metabolites'... 
MATERNAL BMI | WOMEN | PROFILES | ASSOCIATIONS | TYROSINE | INSULIN-RESISTANCE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | LONGITUDINAL METABOLOMICS | Tyrosine | Urine | Metabolomics | Diabetes mellitus | Fetuses | Pregnancy complications | Liquid chromatography | Gestation | Metabolites | Biomarkers | Nutrients | Diabetes | Variation | Health risk assessment | Miscarriage | Gravity
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