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Hepatology, ISSN 0270-9139, 11/2019, Volume 70, Issue 5, pp. 1770 - 1784
Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse... 
Circadian rhythms | Chromatin | Immunoprecipitation | Transcription | Gene regulation | Methyltransferase | Methionine | Homeostasis | Amino acids | Arginase | Betaine-homocysteine S-methyltransferase | Metabolism | Urea | Ammonia | Antagonism | Enzymatic activity | Hepatocytes | Betaine | Electrophoretic mobility | Ornithine | Homocysteine | Index Medicus
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2019, Volume 176, Issue 24, pp. 4639 - 4652
Background and Purpose Whether and how circadian clock proteins regulate drug detoxification are not known. Here, we have assessed the effects of CLOCK (a core... 
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, p. 89
Abbreviations * Corresponding author. 
Chromatin | Phosphatases | RNA | Liver | Luciferase | Physiological aspects | Morphine | Liquid chromatography
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2018, Volume 152, p. 293
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bcp.2018.04.005... 
RNA | Cytochrome P-450 | Colorectal cancer | Physiological aspects | Mice | DNA binding proteins | Protein binding
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2018, Volume 46, Issue 7, pp. 980 - 988
Organic anion transporter 2 (OAT2/SLC22A7) is an uptake transporter that plays an important role in drug disposition. Here, we investigate a potential role of... 
LRH-1 | X RECEPTOR | DRUGS | PHARMACOLOGY & PHARMACY | ACID SYNTHESIS | KIDNEY | TRANSCRIPTION FACTOR | POTENTIAL ROLE | EXPRESSION | CANCER | ORPHAN NUCLEAR RECEPTOR | Chromatin | Immunoprecipitation | Transcription | Liver | Gene regulation | Prostaglandin E2 | Mobility | Homology | Pharmacology | siRNA | Hepatoma | Gene expression | Assaying | Substrates | Western blotting | Proteins | Anions | Electrophoretic mobility | Mice | Pharmacokinetics | Transporter
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2017, Volume 145, p. 202
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bcp.2017.08.023... 
Yuan (China) | Chromatin | RNA | Estrogen | Cytochrome P-450 | Dimethyl sulfoxide | Physiological aspects | Liquid chromatography | Mass spectrometry | Isoflavones
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, pp. 89 - 97
[Display omitted] Circadian clock is known to modulate phase I metabolism, however whether and how the phase II enzymes UDP-glucuronosyltransferases (UGTs) are... 
Circadian clock | Morphine | UGT | Pharmacokinetics | Rev-erbα | HEPATIC EXPRESSION | Rev-erb alpha | GLUCURONIDATION | TRANSCRIPTION | MORPHINE-6-GLUCURONIDE | CROSS-TALK | UDP-GLUCURONOSYLTRANSFERASES | METABOLISM | GENE | PHARMACOLOGY & PHARMACY | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, pp. 248 - 258
Nuclear heme receptor reverse erythroblastosis virus (REV-ERB) alpha (a transcriptional repressor) is known to regulate cholesterol 7 alpha-hydroxylase... 
CIRCADIAN CLOCK | TRANSPORT INTERPLAY | METABOLISM | TRANSCRIPTION | PHARMACOLOGY & PHARMACY | LIGAND | CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE | EXPRESSION | ORPHAN NUCLEAR RECEPTOR | BILE-ACID-HOMEOSTASIS | BETA
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, pp. 163 - 172
[Display omitted] In this study, we aimed to investigate a potential role of small heterodimer partner (Shp, a nuclear receptor) in regulation of morphine... 
Morphine | Shp | Somatic opiate withdrawal | Ugt2b | Pharmacokinetics | GLUCURONIDATION | ALPHA | HETERODIMER PARTNER INTERACTS | INDUCTION | IDENTIFICATION | PREGNANE X RECEPTOR | REPRESSES | ENZYME | ARYL-HYDROCARBON RECEPTOR | LIVER | PHARMACOLOGY & PHARMACY | Enzymes | Chromatin | RNA | Liver | Physiological aspects | Protein-protein interactions | Protein binding | Index Medicus
Journal Article
Theranostics, ISSN 1838-7640, 2019, Volume 9, Issue 10, pp. 2754 - 2767
The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian... 
MTX | E4bp4 | Dbp | MRP2 | Chronotoxicity | Bmal1 | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSCRIPTION | METHOTREXATE | COMPONENTS | LIMB | TRANSPORT | MICE | MULTIDRUG-RESISTANCE | EXPRESSION | RHYTHMICITY
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, 12/2017
REV-ERBα is a nuclear heme receptor (as known as a transcriptional repressor) that orchestrates circadian rhythms and cell metabolism. Here we investigate the... 
Journal Article