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Hepatology, ISSN 0270-9139, 11/2019, Volume 70, Issue 5, pp. 1770 - 1784
Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse... 
Circadian rhythms | Chromatin | Immunoprecipitation | Transcription | Gene regulation | Methyltransferase | Methionine | Homeostasis | Amino acids | Arginase | Betaine-homocysteine S-methyltransferase | Metabolism | Urea | Ammonia | Antagonism | Enzymatic activity | Hepatocytes | Betaine | Electrophoretic mobility | Ornithine | Homocysteine | Index Medicus
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, p. 89
Abbreviations * Corresponding author. 
Chromatin | Phosphatases | RNA | Liver | Luciferase | Physiological aspects | Morphine | Liquid chromatography
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2018, Volume 152, p. 293
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bcp.2018.04.005... 
RNA | Cytochrome P-450 | Colorectal cancer | Physiological aspects | Mice | DNA binding proteins | Protein binding
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2018, Volume 46, Issue 7, pp. 980 - 988
Organic anion transporter 2 (OAT2/SLC22A7) is an uptake transporter that plays an important role in drug disposition. Here, we investigate a potential role of... 
LRH-1 | X RECEPTOR | DRUGS | PHARMACOLOGY & PHARMACY | ACID SYNTHESIS | KIDNEY | TRANSCRIPTION FACTOR | POTENTIAL ROLE | EXPRESSION | CANCER | ORPHAN NUCLEAR RECEPTOR | Chromatin | Immunoprecipitation | Transcription | Liver | Gene regulation | Prostaglandin E2 | Mobility | Homology | Pharmacology | siRNA | Hepatoma | Gene expression | Assaying | Substrates | Western blotting | Proteins | Anions | Electrophoretic mobility | Mice | Pharmacokinetics | Transporter
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2017, Volume 145, p. 202
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bcp.2017.08.023... 
Yuan (China) | Chromatin | RNA | Estrogen | Cytochrome P-450 | Dimethyl sulfoxide | Physiological aspects | Liquid chromatography | Mass spectrometry | Isoflavones
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, pp. 89 - 97
[Display omitted] Circadian clock is known to modulate phase I metabolism, however whether and how the phase II enzymes UDP-glucuronosyltransferases (UGTs) are... 
Circadian clock | Morphine | UGT | Pharmacokinetics | Rev-erbα | HEPATIC EXPRESSION | Rev-erb alpha | GLUCURONIDATION | TRANSCRIPTION | MORPHINE-6-GLUCURONIDE | CROSS-TALK | UDP-GLUCURONOSYLTRANSFERASES | METABOLISM | GENE | PHARMACOLOGY & PHARMACY | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, pp. 248 - 258
Nuclear heme receptor reverse erythroblastosis virus (REV-ERB) alpha (a transcriptional repressor) is known to regulate cholesterol 7 alpha-hydroxylase... 
CIRCADIAN CLOCK | TRANSPORT INTERPLAY | METABOLISM | TRANSCRIPTION | PHARMACOLOGY & PHARMACY | LIGAND | CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE | EXPRESSION | ORPHAN NUCLEAR RECEPTOR | BILE-ACID-HOMEOSTASIS | BETA
Journal Article
Theranostics, ISSN 1838-7640, 2019, Volume 9, Issue 10, pp. 2754 - 2767
The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian... 
MTX | E4bp4 | Dbp | MRP2 | Chronotoxicity | Bmal1 | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSCRIPTION | METHOTREXATE | COMPONENTS | LIMB | TRANSPORT | MICE | MULTIDRUG-RESISTANCE | EXPRESSION | RHYTHMICITY
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, pp. 163 - 172
[Display omitted] In this study, we aimed to investigate a potential role of small heterodimer partner (Shp, a nuclear receptor) in regulation of morphine... 
Morphine | Shp | Somatic opiate withdrawal | Ugt2b | Pharmacokinetics | GLUCURONIDATION | ALPHA | HETERODIMER PARTNER INTERACTS | INDUCTION | IDENTIFICATION | PREGNANE X RECEPTOR | REPRESSES | ENZYME | ARYL-HYDROCARBON RECEPTOR | LIVER | PHARMACOLOGY & PHARMACY | Enzymes | Chromatin | RNA | Liver | Physiological aspects | Protein-protein interactions | Protein binding | Index Medicus
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, 12/2017
REV-ERBα is a nuclear heme receptor (as known as a transcriptional repressor) that orchestrates circadian rhythms and cell metabolism. Here we investigate the... 
Journal Article