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1. Full Text MiR-142-3p is a paracrine mediator between T cells and endothelium during allograft rejection
by Gupta, Shashi K and Thum, Thomas
Cardiovascular Research, ISSN 0008-6363, 04/2017, Volume 113, Issue 5, pp. 431 - 433
CARDIAC & CARDIOVASCULAR SYSTEMS | MICRORNAS | EXPRESSION | TRANSPLANTATION | Allografts | Capillary Permeability | T-Lymphocytes | Down-Regulation | MicroRNAs | Graft Rejection | Endothelium
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2. Full Text Circulating MicroRNAs as Biomarkers and Potential Paracrine Mediators of Cardiovascular Disease
by Gupta, Shashi K and Bang, Claudia and Thum, Thomas
Circulation: Cardiovascular Genetics, ISSN 1942-325X, 10/2010, Volume 3, Issue 5, pp. 484 - 488
Heart failure | Myocardial infarction | Biomarker | Exosomes | MicroRNAs | microRNAs | heart failure | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | myocardial infarction | HEART-FAILURE | RNAS | MICROVESICLES | SERUM | biomarker | MICROPARTICLES | PLASMA | exosomes | GENETICS & HEREDITY | ACUTE MYOCARDIAL-INFARCTION | Paracrine Communication | Humans | Risk Factors | Cardiovascular Diseases - blood | MicroRNAs - blood | MicroRNAs - genetics | Biomarkers - blood | Cardiovascular Diseases - genetics
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3. Full Text Introgression of productivity and other desirable traits from ricebean (Vigna umbellata) into black gram (Vigna mungo)
by Singh, Inderjit and Sandhu, Jeet S and Gupta, Shashi K and Singh, Sarvjeet and Link, W
Plant Breeding, ISSN 0179-9541, 08/2013, Volume 132, Issue 4, pp. 401 - 406
Crosses were performed to introgress genes for productivity and other desirable traits from ricebean (Vigna umbellata) into black gram (Vigna mungo).... 
Vigna | productivity | disease resistance | interspecific hybridization | introgression | Productivity | Disease resistance | Introgression | Interspecific hybridization | AGRONOMY | CHICKPEA | YIELD | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | YELLOW MOSAIC-VIRUS | RESISTANCE | PLANT SCIENCES
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4. Full Text MicroRNAs in serum and bile of patients with primary sclerosing cholangitis and/or cholangiocarcinoma
by Voigtländer, Torsten and Gupta, Shashi K and Thum, Sabrina and Fendrich, Jasmin and Manns, Michael P and Lankisch, Tim O and Thum, Thomas
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0139305
Background and Aim Patients with primary sclerosing cholangitis (PSC) are at high risk for the development of cholangiocarcinoma (CC). Analysis of micro... 
HEPATOCELLULAR-CARCINOMA | INVASION | MANAGEMENT | METASTASIS | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | LIVER-DISEASE | CONTRIBUTES | EXPRESSION | PROGRESSION | MIR-194 | Care and treatment | MicroRNA | Research | Risk factors | Cholangitis | Liver diseases | Laboratories | MiRNA | Life assessment | Kinases | Gene expression | Medical diagnosis | Patients | Medical schools | Polymerase chain reaction | Hepatitis | MicroRNAs | Hepatology | Gastroenterology | Cell cycle | Diagnostic systems | Endoscopy | Arrays | Cholangiocarcinoma | Endocrinology | Cancer | Bile
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5. Full Text The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
by Ucar, Ahmet and Gupta, Shashi K and Fiedler, Jan and Erikci, Erdem and Kardasinski, Michal and Batkai, Sandor and Dangwal, Seema and Kumarswamy, Regalla and Bang, Claudia and Holzmann, Angelika and Remke, Janet and Caprio, Massimiliano and Jentzsch, Claudia and Engelhardt, Stefan and Geisendorf, Sabine and Glas, Carolina and Hofmann, Thomas G and Nessling, Michelle and Richter, Karsten and Schiffer, Mario and Carrier, Lucie and Napp, L. Christian and Bauersachs, Johann and Chowdhury, Kamal and Thum, Thomas
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, p. 1078
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality... 
ATROPHY | MOUSE MAMMARY-GLAND | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | IN-VIVO | CONDUCTION | MICE | MICRORNAS | TARGETED DELETION | STRESS | EXPRESSION | Oligonucleotides - genetics | Cells, Cultured | Rats | Male | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Animals | Calcineurin - genetics | Myocytes, Cardiac - metabolism | Mice | MicroRNAs - genetics | Autophagy - genetics | Cardiomegaly - genetics
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6. Full Text Differential expression of apoptosis-associated genes in canine mammary tumors
by Mitra, Namita and Verma, Ramneek and Deka, Dipak and Pawar, Hitesh N and Sood, Naresh K and Gupta, Kuldeep and Mahajan, Shashi K and Mohindroo, Jitender
Biologia, ISSN 0006-3088, 6/2015, Volume 70, Issue 6, pp. 846 - 852
B-cell lymphoma 2 (Bcl-2) and heat shock protein (HSP) families are implicated in various processes of carcinogenesis, owing to their role in regulation of... 
Life Sciences | canine mammary tumor | HSP70 | Life Sciences, general | Microbiology | HSP90-β | Zoology | apoptosis-associated genes | Plant Sciences | Cell Biology | Bcl-2 family | PROGNOSTIC FACTORS | HEAT-SHOCK-PROTEIN-70 | NEOPLASMS | HSP90-beta | CLASSIFICATION | NEGATIVE BREAST-CANCER | HEAT-SHOCK PROTEINS | PROSTATE-CANCER | BIOLOGY | STRESS | Breast tumors | Dogs | Genetic aspects | Gene expression | Health aspects | Apoptosis | Diseases
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7. Full Text Short Communication: Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21–Dependent Mechanism
by Fleissner, Felix and Jazbutyte, Virginija and Fiedler, Jan and Gupta, Shashi K and Yin, Xiaoke and Xu, Qingbo and Galuppo, Paolo and Kneitz, Susanne and Mayr, Manuel and Ertl, Georg and Bauersachs, Johann and Thum, Thomas
Circulation Research, ISSN 0009-7330, 07/2010, Volume 107, Issue 1, pp. 138 - 143
RATIONALE:The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may... 
Oxidative stress | ADMA | Coronary artery disease | MicroRNAs | Endothelial progenitor cells | Arginine - physiology | Angiogenesis Inhibitors - physiology | Coronary Artery Disease - metabolism | Humans | Gene Expression Regulation - physiology | MicroRNAs - biosynthesis | Stem Cells - cytology | Stem Cells - metabolism | Arginine - analogs & derivatives | Neovascularization, Pathologic - pathology | Coronary Artery Disease - genetics | Coronary Artery Disease - pathology | Stem Cells - pathology | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - prevention & control | MicroRNAs - genetics | MicroRNAs - physiology
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8. Full Text Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome
by Widera, Christian and Gupta, Shashi K and Lorenzen, Johan M and Bang, Claudia and Bauersachs, Johann and Bethmann, Kerstin and Kempf, Tibor and Wollert, Kai C and Thum, Thomas
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2011, Volume 51, Issue 5, pp. 872 - 875
Abstract Circulating microRNAs may have diagnostic potential in acute coronary syndrome (ACS). Previous studies, however, were based on low patient numbers and... 
Cardiovascular | Myocardial infarction | Biomarker | Prognosis | Acute coronary syndrome | MicroRNAs | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | CELL BIOLOGY | BIOMARKERS | HEART | PLASMA | CARDIOVASCULAR-DISEASE | EXPRESSION | Myocardial Infarction - blood | Myocardial Infarction - genetics | Predictive Value of Tests | Myocardial Infarction - mortality | Prospective Studies | Follow-Up Studies | Humans | Acute Coronary Syndrome - mortality | Angina, Unstable - diagnosis | Male | Troponin T - blood | Female | Myocardial Infarction - diagnosis | Troponin T - genetics | Myocytes, Cardiac - cytology | Risk Factors | Angina, Unstable - mortality | Survival Rate | Biomarkers - blood | Reverse Transcriptase Polymerase Chain Reaction | Acute Coronary Syndrome - blood | Regression Analysis | Angina, Unstable - genetics | Angina, Unstable - blood | Acute Coronary Syndrome - diagnosis | Myocytes, Cardiac - metabolism | MicroRNAs - blood | MicroRNAs - genetics | Acute Coronary Syndrome - genetics | Germany | Coronary heart disease | Analysis | Diagnosis
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9. Full Text Circulating miR-210 Predicts Survival in Critically Ill Patients with Acute Kidney Injury
by Johan M. Lorenzen and Jan T. Kielstein and Carsten Hafer and Shashi K. Gupta and Philipp Kümpers and Robert Faulhaber-Walter and Hermann Haller and Danilo Fliser and Thomas Thum
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 07/2011, Volume 6, Issue 7, pp. 1540 - 1546
Background and objectives MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable... 
BIOMARKERS | MYOCARDIAL-INFARCTION | INTENSIVE-CARE-UNIT | EXTENDED DIALYSIS | HEART-FAILURE | DISEASE | UROLOGY & NEPHROLOGY | ACUTE-RENAL-FAILURE | MICRORNAS | ANGIOPOIETIN-2 | OUTCOMES | Up-Regulation | Humans | Middle Aged | Critical Illness | Male | Acute Kidney Injury - genetics | Case-Control Studies | Time Factors | Polymerase Chain Reaction | Adult | Female | Risk Assessment | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Renal Replacement Therapy | Survival Rate | Treatment Outcome | Genetic Markers | Chi-Square Distribution | Acute Kidney Injury - mortality | Analysis of Variance | Acute Kidney Injury - diagnosis | Acute Kidney Injury - therapy | MicroRNAs - blood | Germany
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10. Full Text Role of miR-21 in the pathogenesis of atrial fibrosis
by Adam, Oliver and Löhfelm, Björn and Thum, Thomas and Gupta, Shashi K and Puhl, Sarah-Lena and Schäfers, Hans-Joachim and Böhm, Michael and Laufs, Ulrich
Basic Research in Cardiology, ISSN 0300-8428, 9/2012, Volume 107, Issue 5, pp. 1 - 12
Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore... 
MicroRNA | Medicine & Public Health | Atrial fibrosis | Atrial fibrillation | miR-21 | Cardiology | Lysyl oxidase | MiR-21 | FIBRILLATION | SMALL SILENCING RNAS | CARDIAC & CARDIOVASCULAR SYSTEMS | REDOX STATE | HEART-FAILURE | ANGIOTENSIN-II | MICRORNAS | TISSUE GROWTH-FACTOR | MICE | RAC1
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11. Full Text MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
by Watson, Chris J and Gupta, Shashi K and O'Connell, Eoin and Thum, Sabrina and Glezeva, Nadezhda and Fendrich, Jasmin and Gallagher, Joe and Ledwidge, Mark and Grote‐Levi, Lea and McDonald, Kenneth and Thum, Thomas
European Journal of Heart Failure, ISSN 1388-9842, 04/2015, Volume 17, Issue 4, pp. 405 - 415
Aims Differentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction independent of echocardiography is challenging in the... 
Heart failure | Biomarker | MicroRNA | Diagnosis | Natriuretic peptide | Ejection fraction | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | FOLLOW-UP | EUROPEAN-SOCIETY | BIOMARKERS | CARDIAC-HYPERTROPHY | COLLABORATION | ECHOCARDIOGRAPHIC HEART | DYSFUNCTION | ASSOCIATION | EXPRESSION | Humans | Middle Aged | Heart Failure - physiopathology | Stroke Volume - physiology | Male | Biomarkers - blood | Natriuretic Peptides | Heart Ventricles - physiopathology | Aged, 80 and over | Female | Aged | Heart Failure - diagnosis | MicroRNAs - blood | Ventricular Dysfunction - physiopathology | Cohort Studies
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12. Full Text Circulating long noncoding RNA TapSAKI is a predictor of mortality in critically Ill patients with acute kidney injury
by Lorenzen, Johan M and Schauerte, Celina and Kielstein, Jan T and Hübner, Anika and Martino, Filippo and Fiedler, Jan and Gupta, Shashi K and Faulhaber-Walter, Robert and Kumarswamy, Regalla and Hafer, Carsten and Haller, Hermann and Fliser, Danilo and Thum, Thomas
Clinical Chemistry, ISSN 0009-9147, 01/2015, Volume 61, Issue 1, pp. 191 - 201
BACKGROUND: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating gene expression. Intriguingly, these RNA transcripts are... 
PROSTATE | INTENSIVE-CARE-UNIT | EXTENDED DIALYSIS | DISEASE | TRANSCRIPTION | ACUTE-RENAL-FAILURE | MICRORNAS | OUTCOMES | MEDICAL LABORATORY TECHNOLOGY | CANCER | RNA sequencing | Genetic aspects | Mortality | Methods | Acute renal failure | Proteins | Studies | Urine | Plasma | Intensive care | Heart attacks | Consent | Biomarkers | Genomes | Kidney diseases
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13. Full Text MicroRNA-24 regulates vascularity after myocardial infarction
by Fiedler, J and Jazbutyte, V and Kirchmaier, B.C and Gupta, S.K and Lorenzen, J and Hartmann, D and Galuppo, P and Kneitz, S and Pena, J and Sohn-Lee, C and Loyer, X and Soutschek, J and Brand, T and Tuschl, T and Heineke, J and Martin, U and Schulte-Merker, S and Ertl, G and Engelhardt, S and Bauersachs, J and Thum, T
Circulation, ISSN 0009-7322, 2011, Volume 124, Issue 6, pp. 720 - 730
BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial... 
microRNAs | heart failure | antagomir | angiogenesis | gene expression | myocardial infarction | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ZEBRAFISH | HEART-FAILURE | DOWN-REGULATION | KAPPA-B | HUMAN ENDOTHELIAL-CELLS | CONTROLS ANGIOGENESIS | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | NEOVASCULARIZATION | HEMATOLOGY | Myocardial Infarction - genetics | Neovascularization, Physiologic - drug effects | MicroRNAs - antagonists & inhibitors | Capillaries - pathology | Apoptosis - drug effects | Male | Gene Expression Profiling | Zebrafish - embryology | Cell Hypoxia | Oligoribonucleotides - pharmacology | Heme Oxygenase-1 - genetics | GATA2 Transcription Factor - biosynthesis | Ventricular Remodeling | Laminin | RNA Interference | Myocardial Infarction - physiopathology | Drug Evaluation, Preclinical | Spheroids, Cellular | Heart Failure - etiology | GATA2 Transcription Factor - genetics | Cells, Cultured - drug effects | Zebrafish Proteins - biosynthesis | Heme Oxygenase-1 - biosynthesis | Proteoglycans | p21-Activated Kinases - genetics | Endothelial Cells - metabolism | Neovascularization, Physiologic - genetics | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | p21-Activated Kinases - biosynthesis | Arterioles - pathology | Myocardial Infarction - complications | Animals | RNA, Small Interfering - therapeutic use | Collagen | Cells, Cultured - metabolism | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Zebrafish Proteins - genetics | Endothelial Cells - pathology | Drug Combinations | Heart failure | MicroRNA | Patient outcomes | Physiological aspects | Development and progression | Genetic aspects | Neovascularization | Research | Heart attack
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14. Full Text Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis
by Lorenzen, Johan M and Schauerte, Celina and Hübner, Anika and Kölling, Malte and Martino, Filippo and Scherf, Kristian and Batkai, Sandor and Zimmer, Karina and Foinquinos, Ariana and Kaucsar, Tamas and Fiedler, Jan and Kumarswamy, Regalla and Bang, Claudia and Hartmann, Dorothee and Gupta, Shashi K and Kielstein, Jan and Jungmann, Andreas and Katus, Hugo A and Weidemann, Frank and Müller, Oliver J and Haller, Hermann and Thum, Thomas
European Heart Journal, ISSN 0195-668X, 08/2015, Volume 36, Issue 32, pp. 2184 - 2196
Aims Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding... 
Osteopontin | Cardiac fibrosis | microRNA | miR-21 | Angiotensin II | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | HEART-FAILURE | PROMATRIX METALLOPROTEINASE-9 ACTIVATION | MESSENGER-RNA | INFLAMMATION | SMOOTH-MUSCLE-CELLS | ESSENTIAL-HYPERTENSION | CHRONIC KIDNEY-DISEASE | EXPRESSION | BLOCKER | Adenoviridae | Genetic Vectors - administration & dosage | Myofibroblasts - physiology | Humans | Male | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Osteopontin - pharmacology | Female | Osteopontin - physiology | Fibrosis - genetics | Cell Survival | Cells, Cultured | Gene Silencing | PTEN Phosphohydrolase - metabolism | Myocardium - pathology | Recombinant Proteins - pharmacology | Mice, Knockout | Collagen - metabolism | Animals | Aged | MicroRNAs - genetics | Transcription Factors | In Vitro Techniques | Angiotensin II - physiology | Basic Science
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