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NATURE PROTOCOLS, ISSN 1754-2189, 09/2011, Volume 6, Issue 9, pp. 1341 - 1354
Prediction of protein-protein interactions at the structural level on the proteome scale is important because it allows prediction of protein function, helps... 
DATABASE | DOCKING | DRUG DISCOVERY | SEQUENCE | COMPLEXES | ALGORITHM | BIOCHEMICAL RESEARCH METHODS | FUNCTIONAL COVERAGE | HOT-SPOTS | BINDING-SITES | ARCHITECTURES | Cysteine Endopeptidases - chemistry | Protein Interaction Mapping - methods | Computational Biology - methods | Algorithms | Cystatins - chemistry | Proteome | Software | Proteins - chemistry | Evolution, Molecular
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 2014, Volume 10, Issue 2, p. e1003470
Interleukin-1 (IL-1) is a large cytokine family closely related to innate immunity and inflammation. IL-1 proteins are key players in signaling pathways such... 
DATA-BANK | KINASE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | INTERFACES | PROTEIN-PROTEIN INTERACTIONS | RECEPTOR | SCALE | MOLECULAR DOCKING | EXPRESSION | SOMATIC MUTATIONS | BRAIN-TUMORS | Interleukin-1 Receptor Accessory Protein - genetics | MAP Kinase Kinase 7 - genetics | Neoplasms - metabolism | Interleukin-1 - genetics | Interleukin-1 Receptor Accessory Protein - chemistry | Humans | MAP Kinase Kinase 7 - chemistry | Mitogen-Activated Protein Kinase 9 - genetics | Mitogen-Activated Protein Kinase 10 - genetics | MAP Kinase Kinase 7 - metabolism | Interleukin-1 Receptor Accessory Protein - metabolism | Receptors, Interleukin-1 Type I - metabolism | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neoplasms - genetics | Computer Simulation | Receptors, Interleukin-1 Type I - chemistry | Interleukin-1 - chemistry | Oncogenes | Mitogen-Activated Protein Kinase 9 - chemistry | Interleukin-1 - metabolism | Protein Interaction Maps - immunology | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Computational Biology | Models, Molecular | Inflammation - immunology | Mitogen-Activated Protein Kinase 10 - metabolism | Mitogen-Activated Protein Kinase 10 - chemistry | Mutagenesis | Protein Interaction Maps - genetics | Models, Biological | Neoplasms - immunology | Receptors, Interleukin-1 Type I - genetics | Inflammation - genetics | MAP Kinase Kinase 4 - chemistry | MAP Kinase Kinase 4 - genetics | Polymorphism, Single Nucleotide | Mutation | Complications and side effects | Interleukin-1 | Patient outcomes | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | Risk factors | Genetic polymorphisms | Apoptosis | Proteins | Cytokines | Disease | Kinases | Cancer
Journal Article
Acta Crystallographica Section D, ISSN 2059-7983, 01/2018, Volume 74, Issue 1, pp. 65 - 66
A revised Table 6 and Supporting Information are provided for the article by Kuzu et al. [(2016 ), Acta Cryst. D72, 1137–1148]. The article by Kuzu et al.... 
multimolecular protein complexes | PRISM‐EM | three‐dimensional electron microscopy | protein structure prediction | modelling protein assemblies | Electron microscopy | Maps
Journal Article
Chemical Reviews, ISSN 0009-2665, 04/2016, Volume 116, Issue 8, p. 4884
  Identification of protein-protein interactions (PPIs) is at the center of molecular biology considering the unquestionable role of proteins in cells.... 
RNA-protein interactions | Research & development--R&D | Proteomics | Molecular biology | Cells
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 1/2008, Volume 36, Issue suppl_1, pp. D662 - D666
We present a new database of computational hot spots in protein interfaces: HotSprint. Hot spots are residues comprising only a small fraction of interfaces... 
PTB DOMAIN | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | SEQUENCE | REGIONS | SITES | BINDING-ENERGY | MUTATIONS | STRUCTURALLY CONSERVED RESIDUES | CHALLENGES | User-Computer Interface | Databases, Protein | Computational Biology | Amino Acids - chemistry | Protein Binding | Protein Conformation | Internet | Proteins - chemistry | Protein Interaction Mapping
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2010, Volume 38, Issue 2, pp. W402 - W406
The energy distribution along the protein-protein interface is not homogenous; certain residues contribute more to the binding free energy, called 'hot spots'.... 
RECEPTOR | BINDING-ENERGY | DATABASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Protein Interaction Mapping - methods | User-Computer Interface | Multiprotein Complexes - chemistry | Interleukin-2 - chemistry | Receptors, Interleukin-2 - chemistry | Software | Internet | Binding Sites
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2010, Volume 10, Issue 6, pp. 715 - 722
Proteins can exist in a large number of conformations around their native states that can be characterized by an energy landscape. The landscape illustrates... 
Internal Medicine | Medical Education | CATALYSIS | SMALL MOLECULES | MECHANISM | LIGANDS | PROTEIN INTERFACES | DYNAMICS | PHARMACOLOGY & PHARMACY | ENERGY LANDSCAPES | SWITCH | MOTIONS | BINDING CASCADES | Proteins - metabolism | Allosteric Regulation | Humans | Molecular Conformation | Models, Molecular | Protein Binding | Protein Conformation | Proteins - chemistry | Binding Sites | Drug Discovery
Journal Article