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1. Full Text Calcium mobilizing second messengers derived from NAD
by Guse, Andreas H
BBA - Proteins and Proteomics, ISSN 1570-9639, 09/2015, Volume 1854, Issue 9, pp. 1132 - 1137
Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades... 
Calcium signaling | NAD | ADP-ribose | NAADP | Cyclic ADP-ribose | Cofactor | OXIDATIVE STRESS | ADENINE-DINUCLEOTIDE PHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+ RELEASE CHANNEL | NICOTINIC-ACID | BIOPHYSICS | RYANODINE RECEPTOR | SIGNALING PATHWAY | ION CHANNELS | 2-PORE CHANNELS | T-LYMPHOCYTES | Cyclic ADP-Ribose - physiology | Animals | Calcium - metabolism | Humans | NAD - physiology | NADP - analogs & derivatives | Adenosine Diphosphate Ribose - physiology | NADP - physiology | Second Messenger Systems - physiology
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2. Full Text Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)‐dependent calcium signalling
by Guse, Andreas H and Diercks, Björn‐Philipp
The Journal of Physiology, ISSN 0022-3751, 07/2018, Volume 596, Issue 14, pp. 2735 - 2743
Nicotinic acid adenine dinucleotide phosphate (NAADP) is currently the most potent endogenous Ca2+ mobilizing second messenger. Upon specific extracellular... 
calcium release | NAADP | calcium signaling | CYCLIC ADP-RIBOSE | PHYSIOLOGY | CA2+ MICRODOMAINS | SEA-URCHIN EGGS | NEUROSCIENCES | NAADP MOBILIZES CALCIUM | RYANODINE RECEPTOR | MEMBRANE CONTACT SITES | PANCREATIC-ACINAR-CELLS | ENDOPLASMIC-RETICULUM | 2-PORE CHANNELS | T-LYMPHOCYTES | Phosphates | Purines | Cellular signal transduction | T cells | Niacin | Cells | Calcium signalling | Nicotinic acid | Ryanodine receptors | Adenine | Ion channels | Metabolism | Organelles | Eggs | Mammalian cells | Calcium phosphates | Symposium Review | Special section | Intracellular calcium signalling
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3. Full Text Linking NAADP to ion channel activity: A unifying hypothesis
by Guse, Andreas H
Science Signaling, ISSN 1945-0877, 04/2012, Volume 5, Issue 221, pp. pe18 - pe18
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-releasing second messenger that might regulate different ion channels, including the... 
CYCLIC ADP-RIBOSE | NUCLEAR-ENVELOPE | MOBILIZES CALCIUM | PANCREATIC ACINAR | RYANODINE RECEPTOR | ADENINE-DINUCLEOTIDE PHOSPHATE | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2-PORE CHANNELS | RELEASE CHANNEL | T-LYMPHOCYTES | CELL BIOLOGY | Animals | Lysosomes - metabolism | Calcium - metabolism | Transient Receptor Potential Channels - genetics | Humans | Lysosomes - genetics | NADP - analogs & derivatives | Second Messenger Systems - physiology | NADP - metabolism | Transient Receptor Potential Channels - metabolism | NADP - genetics | Gene Knockdown Techniques
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4. Full Text Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)
by Guse, Andreas H
The FEBS Journal, ISSN 1742-464X, 09/2005, Volume 272, Issue 18, pp. 4590 - 4597
Cyclic ADP‐ribose (cADPR) is a Ca2+ mobilizing second messenger found in various cell types, tissues and organisms. Receptor‐mediated formation of cADPR may... 
ADP-RIBOSE ACTIVATION | INFLUX | RYANODINE RECEPTOR | CA2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY | MESSENGERS | PROLIFERATION | RELEASE | REGULATES INTRACELLULAR CALCIUM | EGG-SPECIFIC NADASE | Molecular Chaperones - metabolism | Calcium - metabolism | Humans | Glycoproteins - metabolism | Ryanodine Receptor Calcium Release Channel - metabolism | Cyclic ADP-Ribose - chemistry | Structure-Activity Relationship | Clusterin | Cyclic ADP-Ribose - physiology | Animals | Second Messenger Systems - physiology | Calcium Signaling | Cyclic ADP-Ribose - metabolism
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5. Full Text Second Messenger Signaling: Multiple Receptors for NAADP
by Guse, Andreas H
Current Biology, ISSN 0960-9822, 07/2009, Volume 19, Issue 13, pp. R521 - R523
The second messenger NAADP appears to have an essential role as a universal trigger of Ca signaling. Following on from previously published NAADP receptor... 
RELEASE CHANNEL | RYANODINE RECEPTOR | ORGANELLES | CA2+ RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | T-LYMPHOCYTES | Cell Line | Calcium Channels - metabolism | Calcium Channels - chemistry | Humans | Ryanodine Receptor Calcium Release Channel - chemistry | NADP - analogs & derivatives | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - chemistry | Ryanodine Receptor Calcium Release Channel - metabolism | Second Messenger Systems - physiology | NADP - metabolism
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6. Full Text Full focus on calcium
by Parys, JB and Guse, AH
SCIENCE SIGNALING, ISSN 1945-0877, 09/2019, Volume 12, Issue 599, p. eaaz0961
Intracellular calcium (Ca2+) signals are of prime importance for cellular function and behavior and are underpinned by a plethora of Ca2+ channels, pumps,... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Calcium
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7. Full Text NAADP: A universal Ca2+ trigger
by Guse, Andreas H and Lee, Hon Cheung
Science Signaling, ISSN 1945-0877, 11/2008, Volume 1, Issue 44, pp. re10 - re10
Cells possess multiple calcium ion (Ca2+) stores and multiple messenger molecules to mobilize them. These include D-myo-inositol 1,4,5-trisphosphate (IP3),... 
CYCLIC-ADP-RIBOSE | RYANODINE RECEPTOR | HUMAN CD38 | ADENINE-DINUCLEOTIDE PHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM-RELEASE | SEA-URCHIN EGGS | ARTERIAL SMOOTH-MUSCLE | PANCREATIC-ACINAR-CELLS | INOSITOL TRISPHOSPHATE | T-LYMPHOCYTES | CELL BIOLOGY | Animals | Calcium - metabolism | Humans | NADP - analogs & derivatives | ADP-ribosyl Cyclase 1 - metabolism | NADP - physiology | Calcium Signaling
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8. Full Text Identification With Characters and Discussion of Taboo Topics After Exposure to an Entertainment Narrative About Sexual Health
by Moyer‐Gusé, Emily and Chung, Adrienne H and Jain, Parul
Journal of Communication, ISSN 0021-9916, 06/2011, Volume 61, Issue 3, pp. 387 - 406
Individuals often avoid discussing sexual history and safer sex with sexual partners, increasing the likelihood of negative health consequences. Research and... 
DRAMA | EFFICACY | TRANSPORTATION | PERSUASION | INFORMATION | MEDIA | EDUCATION | TELEVISION | COMMUNICATION | ELABORATION | sexual behavior | dramatic arts | self-efficacy | venereal disease | contraception | television and video | Sex and the City | Safe sex | Analysis | Sex education | Communication research | Sexual behavior | Television programs
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9. Full Text Regulation of calcium signalling by adenine-based second messengers
by Fliegert, R and Gasser, A and Guse, A.H
Biochemical Society Transactions, ISSN 0300-5127, 02/2007, Volume 35, Issue 1, pp. 109 - 114
cADPR [cyclic ADPR (ADP-ribose)], NAADP (nicotinic acid-adenine dinucleotide phosphate) and ADPR belong to the family of adenine-containing second messengers.... 
Calcium signalling | Cyclic ADP-ribose (cADPR) | ADP-ribose (ADPR) | Transient receptor potential melastatin 2 (TRPM2) | Nicotinic acid-adenine dinucleotide phosphate (NAADP) | Second messenger | TRPM2 CHANNELS | ADENOSINE-DIPHOSPHORIBOSE CADPR | BIOCHEMISTRY & MOLECULAR BIOLOGY | NAADP MOBILIZES CA2 | second messenger | calcium signalling | nicotinic acid-adenine | MAMMALIAN-CELLS | DINUCLEOTIDE PHOSPHATE | transient receptor potential melastatin 2 (TRPM2) | CYCLIC-ADP-RIBOSE | RYANODINE RECEPTORS | cyclic ADP-ribose (cADPR) | PANCREATIC-ACINAR-CELLS | INOSITOL TRISPHOSPHATE | dinucleotide phosphate (NAADP) | T-LYMPHOCYTES | Models, Chemical | Signal Transduction | Calcium - metabolism | Humans | Cyclic ADP-Ribose - chemistry | NADP - chemistry | Animals | Models, Biological | Receptors, Purinergic P2 - metabolism | NADP - analogs & derivatives | Adenine - metabolism | TRPM Cation Channels - metabolism | Calcium Signaling | Second Messenger Systems
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10. Full Text Model study programs in medicine. Innovations in medical education in Hamburg and Berlin
by Guse, AH and Kuhlmey, A
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, ISSN 1436-9990, 02/2018, Volume 61, Issue 2, pp. 132 - 140
Medical science is constantly evolving. Teaching and training must keep pace with these innovations and react in a flexible fashion to new requirements. Model... 
Model study programs | IMPLEMENTATION | Curriculum | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Teaching projects | EPAS | Education, Medical, Graduate - organization & administration | Education, Medical - trends | Berlin | Education, Medical - organization & administration | Biomedical Research - trends | Education, Medical, Continuing - legislation & jurisprudence | Licensure, Medical - trends | Forecasting | Biomedical Research - legislation & jurisprudence | Education, Medical, Continuing - organization & administration | Education, Medical, Continuing - trends | Education, Medical, Graduate - legislation & jurisprudence | Models, Educational | Licensure, Medical - legislation & jurisprudence | Curriculum - trends | Education, Medical - legislation & jurisprudence | Education, Medical, Graduate - trends | Germany
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11. Full Text TRPM2 activation: Paradigm shifted?
by Fliegert, Ralf and Hölzer, Hans T and Guse, Andreas H
Cell Calcium, ISSN 0143-4160, 12/2018, Volume 76, pp. 132 - 134
Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or... 
TRP channel | ADPR | Calcium | Ion channel structure | DOMAIN | CHANNEL | ADP-RIBOSE | CELL BIOLOGY | Animals | Adenosine Diphosphate Ribose | Ion Channel Gating | Calcium Signaling | TRPM Cation Channels | Cells
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12. Full Text Functional Ryanodine Receptor Expression Is Required for NAADP-mediated Local Ca2+ Signaling in T-lymphocytes
by Werner Dammermann and Andreas H. Guse
Journal of Biological Chemistry, ISSN 0021-9258, 06/2005, Volume 280, Issue 22, pp. 21394 - 21399
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca 2+ -mobilizing nucleotide involved in T cell Ca 2+ signaling (Berg, I., Potter, B. V. L.,... 
CYCLIC ADP-RIBOSE | ENTRY | PANCREATIC ACINAR-CELLS | ADENINE-DINUCLEOTIDE PHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM-RELEASE | STORE | INOSITOL TRISPHOSPHATE | PROPAGATION | MOBILIZES CA2 | Ryanodine Receptor Calcium Release Channel - biosynthesis | Signal Transduction | Calcium - metabolism | Jurkat Cells | Lymphocyte Activation | Humans | Ryanodine Receptor Calcium Release Channel - metabolism | Imidazoles - pharmacology | Calcium Channel Blockers - pharmacology | NADP - chemistry | Microscopy, Confocal | Ruthenium Red - pharmacology | T-Lymphocytes - metabolism | Time Factors | NADP - analogs & derivatives | NADP - physiology | Cyclic ADP-Ribose - metabolism | Microscopy, Fluorescence | Ryanodine Receptor Calcium Release Channel - physiology
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13. Full Text NAD binding by human CD38 analyzed by Trp189 fluorescence
by Wolters, Valerie and Rosche, Anette and Bauche, Andreas and Kulow, Frederike and Harneit, Angelika and Fliegert, Ralf and Guse, Andreas H
BBA - Molecular Cell Research, ISSN 0167-4889, 07/2019, Volume 1866, Issue 7, pp. 1189 - 1196
The NAD-glycohydrolase/ADP-ribosyl cyclase CD38 catalyzes the metabolism of nicotinamide adenine dinucleotide (NAD) to the Ca mobilizing second messengers... 
Tryptophan | Fluorescence | CD38 | Enzyme mechanism | Conformational change | Nicotinamide adenine dinucleotide (NAD) | CYCLIC ADP-RIBOSE | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROLYSIS | INDUCED CONFORMATIONAL-CHANGES | CELL BIOLOGY | FORMS | STRUCTURAL BASIS | CYCLIZATION | Niacinamide | Enzymes | Physiological aspects | Cells | Sugars | Monosaccharides
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14. Full Text Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations
by Diercks, Björn-Philipp and Fliegert, Ralf and Guse, Andreas H
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2017, Volume 1864, Issue 6, pp. 977 - 986
Ca signaling is a major signal transduction pathway involved in T cell activation, but also in apoptosis of T cells. Since T cells make use of several Ca... 
Mitochondrial Ca2 + concentration | Signal transduction | Mag-Fluo4 | Ca2 + signaling | T cell | Endoplasmic reticular Ca2 + concentration | signaling | Endoplasmic reticular Ca | Mitochondrial Ca | concentration | Ca2+ signaling | BIOCHEMISTRY & MOLECULAR BIOLOGY | Endoplasmic reticular Ca2+ concentration | MITOCHONDRIA | SIGNALS | SARCOPLASMIC-RETICULUM | Mitochondrial Ca2+ concentration | TYPE-1 RYANODINE RECEPTOR | CELL BIOLOGY | MICRODOMAINS | NAADP | INDICATORS | CALCIUM | ENDOPLASMIC-RETICULUM | LYMPHOCYTES
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15. Full Text Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation
by Fliegert, R and Heeren, J and Koch-Nolte, F and Nikolaev, VO and Lohr, C and Meier, C and Guse, AH
BIOCHEMICAL SOCIETY TRANSACTIONS, ISSN 0300-5127, 02/2019, Volume 47, Issue 1, pp. 329 - 337
Adenine nucleotides (AdNs) play important roles in immunity and inflammation. Extracellular AdNs, such as adenosine triphosphate (ATP) or nicotinamide adenine... 
TRPM2 CHANNELS | CYCLIC-ADP-RIBOSE | DINUCLEOTIDE PHOSPHATE NAADP | CA2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATION CHANNEL | CALCIUM | ADENOSINE | CD38 | BROWN ADIPOSE-TISSUE | POTENTIAL MELASTATIN 2
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16. Full Text Effects of mentoring speed dating as an innovative matching tool in undergraduate medical education: A mixed methods study
by Guse, Jennifer and Schweigert, Eva and Kulms, Gerhild and Heinen, Ines and Martens, Claudia and Guse, Andreas H
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0147444
Objectives Choosing the right mentor is crucial for effective mentorship. Yet, many medical students have difficulties finding a suitable mentor. Thus we... 
JUNIOR | FACULTY | PROGRAMS | QUALITATIVE RESEARCH | MULTIDISCIPLINARY SCIENCES | ACADEMIC-MEDICINE | STUDENTS | Faculty, Medical | Humans | Focus Groups | Education, Medical, Undergraduate | Female | Male | Organizational Innovation | Surveys and Questionnaires | Program Evaluation | Interpersonal Relations | Mentors | Personal Satisfaction | Medical students | Psychological aspects | Behavior | Research | Dating (Social customs) | Qualitative research | Dating techniques | Psychology | Colleges & universities | Multivariate analysis | Health education | Variance analysis | Impact analysis | Medicine | Matching | Studies | Medical centres | Teaching methods | Students | Professional development | Dating | Mentoring programs | Content analysis
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17. Full Text The Medical Education in Motion
by Koch-Gromus, U and Guse, AH and van den Bussche, H
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, ISSN 1436-9990, 02/2018, Volume 61, Issue 2, pp. 129 - 131
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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18. Full Text Synthesis of Terminal Ribose Analogues of Adenosine 5 '-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2
by Baszczynski, O and Watt, JM and Rozewitz, MD and Guse, AH and Fliegert, R and Potter, BVL
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 05/2019, Volume 84, Issue 10, pp. 6143 - 6157
TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to oxidative stress and in... 
TARGET | CELLS | OXIDATIVE STRESS | MELASTATIN 2 | ACTIVATION | CHEMOTAXIS | ION-CHANNEL | CHEMISTRY, ORGANIC | ADP-RIBOSE | MEMBER
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