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ISSN 1477-0520, 5/2017, Volume 15, Issue 21, pp. 4644 - 4654
A high-affinity polypeptide conjugate 4-C25L22-DQ, has been developed for the molecular recognition of the human C-reactive protein, CRP, a well-known... 
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 38, pp. 27456 - 27468
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 21, pp. 4644 - 4654
A high-affinity polypeptide conjugate 4-C25L22-DQ, has been developed for the molecular recognition of the human C-reactive protein, CRP, a well-known... 
CHEMISTRY, ORGANIC | BINDING | Index Medicus
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 05/2017, Volume 15, Issue 21, pp. 4644 - 4654
A high-affinity polypeptide conjugate 4-C25L22-DQ, has been developed for the molecular recognition of the human C-reactive protein, CRP, a well-known... 
Amino Acid Sequence | C-Reactive Protein - metabolism | Humans | Drug Design | Models, Molecular | Protein Conformation | C-Reactive Protein - chemistry | Phosphorylcholine - metabolism | Naturvetenskap | Natural Sciences | Organisk kemi | Kemi | Chemical Sciences | Organic Chemistry
Journal Article
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 07/2018, Volume 92, Issue 1, pp. 1255 - 1271
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 250 - 14
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been... 
THERMAL SHIFT ASSAY | POLY(ADP-RIBOSE) | PROTEIN | STRUCTURE REFINEMENT | STABILITY | ENZYMES | MULTIDISCIPLINARY SCIENCES | NUDIX HYDROLASES | CHEMICAL PROBES | ENGAGEMENT | MECHANISMS | Cell Proliferation - genetics | Progestins - metabolism | Enzyme Inhibitors - metabolism | Humans | Adenosine Diphosphate Ribose - metabolism | Enzyme Inhibitors - pharmacology | Pyrophosphatases - genetics | Substrate Specificity | Breast Neoplasms - metabolism | Pyrophosphatases - antagonists & inhibitors | Pyrophosphatases - metabolism | Breast Neoplasms - genetics | Cell Nucleus - metabolism | RNA Interference | Signal Transduction - drug effects | Breast Neoplasms - pathology | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Cell Line, Tumor | HL-60 Cells | Female | Cell Proliferation - drug effects | Molecular Structure | Cell Nucleus - drug effects | Cell proliferation | Chromatin | Gene regulation | Sanitation | Breast cancer | Metabolism | Gene expression | ADP | Substrates | Guanine | Chromatin remodeling | Signaling | Inhibitors | Ribose | Progestin | Breast | Adenosine triphosphate | Cancer | Index Medicus | Biological Sciences | Medical Biotechnology | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinsk bioteknologi | Natural Sciences | Cellbiologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Cell Biology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2013, Volume 56, Issue 24, pp. 9861 - 9873
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 24, pp. 10075 - 10084
A beta, the product of APP (amyloid precursor protein), has been implicated in the pathophysiology of Alzheimer's disease (AD). beta-Site APP cleaving enzyme1... 
NERVOUS-SYSTEM | REDUCTION | ALZHEIMERS-DISEASE | MOUSE MODEL | BETA-SECRETASE BACE1 | A-BETA | PRECURSOR PROTEIN | PATHOLOGY | NEUROSCIENCES | BRAIN | TRANSGENIC MICE | Embryo, Mammalian | Humans | Cerebral Cortex - pathology | Male | Alzheimer Disease - pathology | Dose-Response Relationship, Drug | Amyloid - metabolism | Time Factors | Enzyme Inhibitors - chemistry | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Isoindoles - therapeutic use | Female | Neurons - metabolism | Isoindoles - pharmacology | Neurons - drug effects | Disease Models, Animal | Peptide Fragments - metabolism | Guinea Pigs | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Mutation - genetics | Enzyme Inhibitors - therapeutic use | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Aspartic Acid Endopeptidases - metabolism | Mice | Pyridones - therapeutic use | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Alzheimer Disease - genetics | Pyridones - pharmacology | Index Medicus | Naturvetenskap | Kemi | neurokemi med molekylär neurobiologi | Natural Sciences | Annan kemi | Chemical Sciences | Other Chemistry Topics | Neurochemistry with Molecular Neurobiology
Journal Article
BMC Biology, ISSN 1741-7007, 09/2017, Volume 15, Issue 1, pp. 88 - 88
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1107 - 14
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 38, pp. 27456 - 27468
Journal Article