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Cancer research, ISSN 0008-5472, 07/2019, Volume 79, Issue 20, pp. 5191 - 5203
Chemotherapies alter cellular redox balance and reactive oxygen species (ROS) content. Recent studies have reported that chemoresistant cells have an increased... 
Journal Article
Molecular Cancer, ISSN 1476-4598, 07/2013, Volume 12, Issue 1, pp. 83 - 83
Journal Article
Molecular Cancer, ISSN 1476-4598, 10/2012, Volume 11, Issue 1, pp. 81 - 81
Background: Pancreatic ductal adenocarcinoma is a deadly malignancy resistant to current therapies. It is critical to test new strategies, including... 
Pancreatic adenocarcinoma | Targeted therapy | Surface marker | SYSTEM | THERAPY | CANCER CELLS | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | LENTIVIRAL VECTORS | DELIVERY | Gene Targeting - methods | Luciferases - metabolism | Humans | Green Fluorescent Proteins - genetics | Viral Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Drug Delivery Systems | Luciferases - genetics | Claudins - metabolism | Antigens, Surface - metabolism | Ganciclovir - pharmacology | Lentivirus - genetics | Claudins - genetics | Gene Transfer Techniques | Green Fluorescent Proteins - metabolism | Thymidine Kinase - genetics | Mucin-4 - metabolism | Viral Proteins - genetics | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Mice, SCID | Mucin-4 - genetics | Xenograft Model Antitumor Assays | Animals | Thymidine Kinase - metabolism | Cell Line, Tumor | Mice | Genetic Therapy - methods | Pancreatic Neoplasms - therapy | Adenocarcinoma | Antigens | Medical equipment and supplies industry | Medical test kit industry | Genes | Fluorescence | Proteins | Analysis | Pancreatic cancer | Genetic research | Genetic aspects | Gene therapy | Health aspects | Biotechnology industry | Cancer | Studies | Stem cells | Kinases | Cancer therapies | Prostate cancer | Tumors | Apoptosis | Life Sciences | Biochemistry, Molecular Biology | Genomics
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 03/2019, Volume 10, Issue 1, pp. 1136 - 14
CRISPR-Cas9 is a promising technology for genome editing. Here we use Cas9 nuclease-induced double-strand break DNA (DSB) at the UROS locus to model and... 
TARGET | CONGENITAL ERYTHROPOIETIC PORPHYRIA | CRISPR/CAS9 | SPECIFICITY | DNA | MULTIDISCIPLINARY SCIENCES | HOMOLOGY-DIRECTED REPAIR | GENE-THERAPY | GENERATION | REARRANGEMENTS | EFFICIENCY | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | Porphyria, Erythropoietic - therapy | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Porphyria, Erythropoietic - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | HEK293 Cells | Porphyria, Erythropoietic - metabolism | Fibroblasts - metabolism | Chromosome Deletion | Recombinational DNA Repair | Deoxyribonuclease I - genetics | Tumor Suppressor Protein p53 - metabolism | Uroporphyrinogen III Synthetase - genetics | Uroporphyrinogen III Synthetase - metabolism | Porphyria, Erythropoietic - pathology | DNA - metabolism | DNA - genetics | Deoxyribonuclease I - metabolism | Models, Biological | CRISPR-Cas Systems | K562 Cells | Fibroblasts - cytology | Gene Editing - methods | High-Throughput Nucleotide Sequencing | Primary Cell Culture | Genome, Human | Chromosomes, Human, Pair 10 | Genetic Therapy - methods | Porphyria | CRISPR | p53 Protein | DNA damage | Editing | Homology | Genomes | Double-strand break repair | Disease control | Proteins | Side effects | Cell lines | Non-homologous end joining | Modelling | Nuclease | Gene therapy | Deoxyribonucleic acid--DNA
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 19100 - 19108
DNA-damaging agents can induce premature senescence in cancer cells, which contributes to the static effects of cancer. However, senescent cancer cells may... 
ARREST | PHOSPHORYLATION | PATHWAY | PRAS40 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | INDUCTION | STRESS | MTOR | CHEMOTHERAPY | P53 | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Apoptosis - genetics | Mutation, Missense | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ultraviolet Rays | Cellular Senescence | Caspase 3 - genetics | Regulatory-Associated Protein of mTOR | Phosphorylation - drug effects | Cell Survival - drug effects | Enzyme Activation - radiation effects | Mice, Knockout | Acetylation - drug effects | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | DNA Damage | Oxidative Stress - drug effects | Enzyme Activation - genetics | Sirtuin 1 - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - radiation effects | Minor Histocompatibility Antigens | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Sirtuin 1 - genetics | Transcription Factor RelA - genetics | Tumor Suppressor Protein p53 - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Oxidative Stress - radiation effects | Oxidative Stress - genetics | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Cell Survival - radiation effects | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Acetylation - radiation effects | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Amino Acid Substitution | Sirtuins | Reactive Oxygen Species (ROS) | Signal Transduction | Resveratrol | Premature Senescence | mTOR
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 19100 - 19108
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 42, pp. 68734 - 68748
Journal Article
American Journal of Human Genetics, ISSN 0002-9297, 04/2014, Volume 94, Issue 4, p. 611
  In 90% of people with erythropoietic protoporphyria (EPP), the disease results from the inheritance of a common hypomorphic FECH allele, encoding... 
Enzymes | Bone marrow | Mutation | Cells | Metabolic disorders | Polymorphism
Journal Article
Journal Article
by Schmidt, Manfred and Verhoeyen, Els and Gobbo, Emilie and Divers, Dominique and Oudrhiri, Noufissa and Griscelli, Frank and Bennaceur-Griscelli, Annelise and Klatzmann, David and Anguela, Xavier M and Sharma, Rajiv and Sharma, Rajiv and Li, Hojun and Li, Hojun and Haurigot, Virginia and Haurigot, Virginia and Haurigot, Virginia and Bhagwat, Anand and Bhagwat, Anand and Davidson, Robert and Davidson, Robert and Zhou, Shangzhen and Zhou, Shangzhen and Zhou, Shangzhen and Doyon, Yannick and Gregory, Philip D and Gregory, Philip D and Gregory, Philip D and Holmes, Michael C and Holmes, Michael C and Holmes, Michael C and High, Katherine A and Carbonaro, Denise and Shaw, Kit and Jin, Xiangyang and Geiger, Sabine and Mishra, Suparna and Cooper, Aaron and DeOliveira, Satiro and Sokolic, Rob and Candotti, Fabio and Carmo, Marlene and Arumugam, Paritha and Alonso-Ferrero, Maria and Schambach, Axel and Schambach, Axel and Baum, Christopher and Baum, Christopher and Baum, Christopher and Risma, Kimberly and Malik, Punam and Jordan, Michael and Rivat, Christine and Booth, Claire and Thrasher, Adrian and Whilding, Lynsey and Archibald, Kyra and Oberg, Daniel and Golan, Talia and Hubert, Ayala and Shemi, Amotz and Khvalevsky, Elina Zorde and Gabai-Malka, Racheli and Focht, Gili and Brunschwig, Zivia and Raskin, Stephen and Goldberg, Nahum and Ben-David, Eli and Peretz, Tamar and Eliakim, Rami and Dankur, Alan and Galun and Rachmur, Itzik and Domb, Avi and Kopelman, Yael and Hantz, Yael and Lahav, Mor and Arbel-Alon, Sagit and Dickson, George and Barkats, Martine and Daboussi, Fayza and Silva, Georges and Cedrone, Frederic and Epinat, Jean Charles and Juillerat, Alexandre and Valton, Julien and Montini, Eugenio and Biffi, Alessandra and Biffi, Alessandra and Calabria, Andrea and Calabria, Andrea and Biasco, Luca and Biasco, Luca and Cesani, Martina and Cesani, Martina and Benedicenti, Fabrizio and Benedicenti, Fabrizio and Plati, Tiziana and Leo, Simone and Zanetti, Gianluigi and Aiuti, Alessandro and ...
Human Gene Therapy, ISSN 1043-0342, 10/2012, Volume 23, Issue 10, pp. A1 - A173
Journal Article
STEM CELLS Translational Medicine, ISSN 2157-6564, 02/2017, Volume 6, Issue 2, pp. 382 - 393
Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem cells (hiPSCs) in hematology. The teratoma risk comes from the... 
Thymidine kinase | Teratoma | Survivin inhibitor | Hematology | Induced pluripotent stem cells | Hematopoietic stem cell | Regenerative medicine | Safety | Suicide gene | iCaspase‐9 | Teratoma x Hematology | iCaspase-9 | TUMORIGENICITY | CELL & TISSUE ENGINEERING | INHIBITION | EMBRYONIC STEM-CELLS | TARGETS | Caspase 9 - genetics | Caspase 9 - metabolism | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Hematologic Diseases - surgery | Hematopoietic Stem Cells - pathology | Tacrolimus - analogs & derivatives | Regenerative Medicine - methods | Teratoma - metabolism | Dose-Response Relationship, Drug | Time Factors | Cell Transformation, Neoplastic - genetics | Hematopoietic Stem Cell Transplantation - adverse effects | Tacrolimus - pharmacology | Induced Pluripotent Stem Cells - metabolism | Hematopoietic Stem Cells - drug effects | Induced Pluripotent Stem Cells - pathology | Survivin - metabolism | Cell Line | Genes, Transgenic, Suicide | Induced Pluripotent Stem Cells - drug effects | Risk Assessment | Teratoma - prevention & control | Induced Pluripotent Stem Cells - transplantation | Naphthoquinones - pharmacology | Survivin - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Imidazoles - pharmacology | Tumor Burden | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Xenograft Model Antitumor Assays | Phenotype | Teratoma - pathology | Animals | Teratoma - genetics | Mice, Inbred NOD | Cell Transformation, Neoplastic - drug effects | Hematopoietic Stem Cell Transplantation - methods | Cell Transformation, Neoplastic - pathology | Flow cytometry | Transplants & implants | Toxicity | Stem cell transplantation | Thymidine | Kinases | Suicide | Ganciclovir | Reporter gene | Efficiency | Population | Tumorigenesis | Suicide genes | CD34 antigen | Repopulation | Caspase | Injection | Survivin | Cell differentiation | Gene expression | Embryos | Hemopoiesis | Medicine | Regeneration | Stem cells | Pluripotency | Cancer | Apoptosis | Pluripotent Stem Cells | Translational s and Reviews
Journal Article