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Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 281
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1806
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 2020
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1453 - 1463
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in... 
PPAR-ALPHA | BODY-WEIGHT | METABOLISM | FIBROBLAST-GROWTH-FACTOR-21 | PHARMACOLOGY | INCREASES ENERGY-EXPENDITURE | ENDOCRINOLOGY & METABOLISM | DEGRADATION | MICE | INSULIN SENSITIVITY | FGF21 | Obesity - drug therapy | Humans | Peptides - pharmacokinetics | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - secretion | Obesity - blood | Anti-Obesity Agents - therapeutic use | Glucagon - agonists | Fibroblast Growth Factors - metabolism | Anti-Obesity Agents - pharmacokinetics | Peptides - chemical synthesis | Hepatocytes - secretion | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Hypoglycemic Agents - pharmacokinetics | Peptides - physiology | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Cross-Over Studies | Anti-Obesity Agents - chemical synthesis | Mice | Anti-Obesity Agents - pharmacology | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Molecular Targeted Therapy | Mice, Mutant Strains | HEK293 Cells | Adult | Female | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Double-Blind Method | Cells, Cultured | Insulin Resistance | Receptors, Glucagon - metabolism | Recombinant Proteins - agonists | Glucagon - pharmacology | Obesity - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Fibroblast Growth Factors - blood | Hypoglycemic Agents - chemical synthesis | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Peptides - therapeutic use | Physiological aspects | Fibroblast growth factors | Research | Glucagon | Analysis | Original Research
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 21, Issue 1, pp. 27 - 36
Journal Article
Cell, ISSN 0092-8674, 10/2016, Volume 167, Issue 3, pp. 843 - 857.e14
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1870
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra151 - 209ra151
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | GLYCEMIC CONTROL | HIGH-FAT DIET | GLUCOSE-INTOLERANCE | ENTEROINSULAR AXIS | PANCREATIC BETA-CELLS | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | PEPTIDE YY3-36 | CELL BIOLOGY | Acylation - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Middle Aged | Male | Rodentia - metabolism | Weight Loss - drug effects | Hyperglycemia - drug therapy | Young Adult | Incretins - pharmacology | Adult | Female | Gastric Inhibitory Polypeptide - pharmacology | Receptors, Glucagon - agonists | Glucose Tolerance Test | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Haplorhini - metabolism | Gastric Inhibitory Polypeptide - administration & dosage | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Adolescent | Aged | Mice | Venoms - pharmacology | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Gastrointestinal Hormone | Incretins - administration & dosage | Liraglutide | Medicin och hälsovetenskap | Medicinsk bioteknologi (inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
Endocrinology, ISSN 0013-7227, 01/2011, Volume 152, Issue 9, pp. 3373 - 3384
Hyperinsulinemia is known to promote the progression/worsening of insulin resistance. Evidence reveals a hidden cost of hyperinsulinemia on plasma membrane... 
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1965
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 400 - 413
In response to an acute threat to homeostasis or well-being, the hypothalamic-pituitary-adrenocortical (HPA) axis is engaged. A major outcome of this HPA axis... 
GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | C-FOS | SOCIAL STRESS | ENDOCRINOLOGY & METABOLISM | LOW-FAT DIET | MEDIUM-CHAIN TRIGLYCERIDES | CHRONIC STRESS | LOW-CARBOHYDRATE | PITUITARY-ADRENAL AXIS | KETOGENIC DIET | Neurons - pathology | Diet, Ketogenic - adverse effects | Humans | Rats, Long-Evans | Fibroblast Growth Factors - genetics | Male | Pituitary-Adrenal System - pathology | Atrophy | Behavior, Animal | Fibroblast Growth Factors - metabolism | Ketosis - pathology | Fibroblast Growth Factors - administration & dosage | Thymus Gland - pathology | Neurons - metabolism | Corticosterone - blood | Hypothalamo-Hypophyseal System - physiopathology | Ketosis - physiopathology | Recombinant Proteins - metabolism | Pituitary-Adrenal System - physiopathology | Hypothalamo-Hypophyseal System - pathology | Mice, Inbred C57BL | Organ Size | Ketosis - etiology | Biomarkers - blood | Recombinant Proteins - administration & dosage | Mice, Knockout | Animals | Fibroblast Growth Factors - blood | Ketosis - blood | Paraventricular Hypothalamic Nucleus - metabolism | Infusions, Intraventricular | Paraventricular Hypothalamic Nucleus - pathology | Fibroblast growth factor | Glucocorticoids | Adrenal glands | Ketogenesis | Corticosterone | Menopause | Homeostasis | Hypothalamus | Paraventricular nucleus | High carbohydrate diet | High fat diet | Thymus | Low carbohydrate diet | Rodents | Fibroblasts | Adrenocorticotropin (ACTH) | Growth factors | c-Fos protein | Carbohydrates | Nutrient deficiency | Markers | Hypothalamic-pituitary-adrenal axis | Triglycerides | Stress | Internal energy | Depletion | Diet | Pituitary | Low fat diet | Mice
Journal Article