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Scientific Reports, ISSN 2045-2322, 12/2015, Volume 5, Issue 1, p. 17943
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e17887
The antigen-binding site of Herceptin, an anti-human Epidermal Growth Factor Receptor 2 (HER2) antibody, was engineered to add a second specificity toward... 
HIV-1 MONOCLONAL-ANTIBODY | PROTEIN DYNAMICS | MOLECULAR RECOGNITION | THERMODYNAMIC ANALYSIS | CRYSTAL-STRUCTURE | FAB | BIOLOGY | CROSS-REACTIVITY | BINDING INTERFACES | MUTATIONAL ANALYSIS | RECEPTOR-BINDING | Amino Acid Sequence | Temperature | Humans | Models, Molecular | Molecular Sequence Data | Antibody Affinity - immunology | Vascular Endothelial Growth Factor A - immunology | Entropy | Protein Interaction Mapping | Antibodies, Monoclonal, Humanized | Sequence Alignment | Antibody Specificity - immunology | Complementarity Determining Regions - immunology | Conserved Sequence | Hydrophobic and Hydrophilic Interactions | Protein Binding | Antigens - immunology | Protein Conformation | Mutant Proteins - immunology | Receptor, ErbB-2 - immunology | Kinetics | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Trastuzumab | Viral antibodies | Antimitotic agents | Thermodynamics | Antigens | Analysis | Crystals | Antibodies | B cells | Antineoplastic agents | Structure | Vascular endothelial growth factor | Protein binding | Peptides | Enthalpy | Proteins | Engineering | Architectural engineering | Immunology | Epidermal growth factor | Plasticity | Crystal structure | Immunoglobulins | ErbB-2 protein | Mutagenesis | Growth hormones | Affinity | Plastic properties | Mutation | Thermodynamic properties | Biosensors | Binding sites | Recognition
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 472 - 486
Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential to effectively treat cancer and... 
CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | GROWTH-FACTOR RECEPTOR | ACTIVATION | GEFITINIB | THERAPY | ERBB3 | ONCOLOGY | ACQUIRED-RESISTANCE | MONOCLONAL-ANTIBODY | METASTATIC COLORECTAL-CANCER | CELL BIOLOGY | Antibody Specificity | Phosphorylation | Humans | Antibodies, Monoclonal - adverse effects | Macaca fascicularis | Antibodies, Monoclonal - therapeutic use | Crystallography, X-Ray | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Receptor, ErbB-3 - chemistry | Antineoplastic Agents - toxicity | MAP Kinase Signaling System | Antibodies, Monoclonal, Humanized | Receptor, ErbB-3 - immunology | Female | Cetuximab | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | Binding, Competitive | Receptor, Epidermal Growth Factor - immunology | Signal Transduction | Immunoglobulin G - chemistry | Immunoglobulin G - therapeutic use | Receptor, ErbB-3 - antagonists & inhibitors | Antineoplastic Agents - chemistry | Receptor, Epidermal Growth Factor - chemistry | Immunoglobulin G - adverse effects | Antibodies, Bispecific - therapeutic use | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Antibodies, Bispecific - chemistry | Mice | Antibodies, Bispecific - toxicity | Binding Sites, Antibody | Care and treatment | Immunoglobulin G | Comparative analysis | Drug resistance | Saturated fatty acids | Antigenic determinants | Cancer
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 4501 - 4501
Abstract Bispecific antibodies that redirect effector T cells to kill tumor cells have shown considerable promise in both pre-clinical and clinical studies.... 
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. A193 - A193
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 06/2019, Volume 11, Issue 497, p. eaau7534
Advanced ovarian cancer is frequently treated with combination chemotherapy, but high recurrence rates show the need for therapies that can produce durable... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUC16 | CYTOKINE RELEASE SYNDROME | TUMOR | HUMANIZATION | PD-L1 | MICE | BLINATUMOMAB | EXPRESSION | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2005, Volume 102, Issue 24, p. 8466
  Look-through mutagenesis (LTM) is a multidimensional mutagenesis method that simultaneously assesses and optimizes combinatorial mutations of selected amino... 
Proteins | Amino acids | Biochemistry | Mutation
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 06/2005, Volume 102, Issue 24, pp. 8466 - 8471
Look-through mutagenesis (LTM) is a multidimensional mutagenesis method that simultaneously assesses and optimizes combinatorial mutations of selected amino... 
Journal Article
12/2018
The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
10/2018
a presente invenção refere-se a anticorpos que se ligam a cd3 com afinidade fraca ou nula de ligação detectável e métodos de uso dos mesmos. de acordo com... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
08/2018
The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
07/2018
The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
05/2018
The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
05/2018
The invention provides bispecific antibodies with a single antigen-binding domain specific for both HER3 and EGFR, compositions comprising and methods of using... 
METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
05/2018
본 발명은 약한 결합 친화도 또는 검출 가능하지 않은 결합 친화도로 CD3에 결합하는 항체, 및 이의 사용 방법을 제공한다. 특정 실시형태에 따라서, 본 발명의 항체는 낮은 친화도로 인간 CD3에 결합하여, 인간 T 세포 증식을 유도하고, 따라서 높은 효능으로 종양 세포의 T... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
04/2018
The present invention provides antibodies that bind to CD3 with weak or no detectable binding affinity and methods of using the same. According to certain... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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