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Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the... 
ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MUTATION | KERATOACANTHOMAS | SENSITIVITY | SENESCENCE | SORAFENIB | HUMAN CANCER | PROGRESSION | BRAF(V600E) | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 3, pp. 207 - 215
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7574, pp. 583 - 586
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2015, Volume 373, Issue 5, pp. 428 - 437
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 8, pp. 3041 - 3046
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2011, Volume 29, Issue 11, pp. 981 - 983
  Comprehensive studies of the kinome are setting the stage for discovering the next generation of kinase-directed drugs. Zhang et al common on the work of... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Protein Kinases - chemistry | Protein Kinase Inhibitors - chemistry | High-Throughput Screening Assays | Humans | Drug Design | Biotechnology | Pharmacology | Catalysis | Pharmaceutical industry | Kinases
Journal Article
Nature, ISSN 0028-0836, 05/1995, Volume 375, Issue 6529, pp. 338 - 340
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2011, Volume 29, Issue 11, p. 981
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2013, Volume 110, Issue 14, pp. 5689 - 5694
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches by a growing... 
Receptors | Kidneys | Bones | Osteoclasts | Mast cells | Arthritis | Macrophages | Inhibitory concentration 50 | Tumors | Cancer | CSF1R | Cancer bone metastasis | Rheumatoid arthritis | Scaffold-based drug design | CHRONIC MYELOGENOUS LEUKEMIA | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | scaffold-based drug design | COLONY-STIMULATING FACTOR | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | rheumatoid arthritis | PROTOONCOGENE C-KIT | cancer bone metastasis | GASTROINTESTINAL STROMAL TUMORS | OSTEOCLAST DIFFERENTIATION | IMATINIB MESYLATE | Human Umbilical Vein Endothelial Cells | Escherichia coli | Humans | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Mutation, Missense - genetics | Spodoptera | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Sf9 Cells | Neoplasm Metastasis - drug therapy | Inflammation - drug therapy | Proto-Oncogene Proteins c-kit - genetics | Molecular Structure | Indoles | Cell Survival - drug effects | Oncogene Protein gp140(v-fms) - genetics | Protein Kinase Inhibitors - chemical synthesis | Oncogene Protein gp140(v-fms) - antagonists & inhibitors | Crystallization | Models, Molecular | Mast Cells - drug effects | Aminopyridines - chemical synthesis | Pyrroles - pharmacology | Animals | Chromatography, Affinity | Pyrroles - chemical synthesis | Aminopyridines - pharmacology | Pyrroles - chemistry | Macrophages - drug effects | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Oncogene Protein gp140(v-fms) - chemistry | Proto-Oncogene Proteins c-kit - chemistry | Osteoclasts - drug effects | Cell receptors | Care and treatment | Pharmacology, Experimental | Cancer cells | Physiological aspects | Research | Properties | Oncogenes | Immune system | Inhibitor drugs | Research & development--R&D | Medical treatment | Pharmacology | Kinases | Inflammatory diseases | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2009, Volume 106, Issue 1, pp. 262 - 267
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4711 - 4711
Inhibitors against the bromodomain and extra terminal domain (BET) family of proteins have been pursued as promising oncology agents based on growing... 
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 611 - 623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively... 
NUCLEAR-LOCALIZATION | ADENOVIRUS REPLICATION | CHROMOSOME-TRANSLOCATION | MESSENGER-RNA | ONCOLOGY | E1B 55-KILODALTON PROTEIN | INFECTED-CELLS | TIME QUANTITATIVE PCR | SV40-TRANSFORMED CELLS | NUCLEOPORIN GENE | NECK-CANCER | Gene Expression - genetics | Virus Replication - genetics | Humans | Viral Proteins - metabolism | Cytopathogenic Effect, Viral - genetics | Caspase 3 | RNA Transport | Capsid Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | In Situ Hybridization, Fluorescence | Caspase Inhibitors | Blotting, Western | Proto-Oncogene Proteins c-mdm2 | Models, Biological | Adenovirus E1A Proteins - genetics | Epithelial Cells - virology | Viral Nonstructural Proteins - metabolism | Adenoviruses, Human - genetics | Adenoviridae - metabolism | Mutation | Adenoviruses, Human - metabolism | Capsid Proteins - genetics | Neoplasms - metabolism | Epithelial Cells - metabolism | DNA, Viral - biosynthesis | Neoplasms - virology | Caspases - metabolism | Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Polymerase Chain Reaction | Adenoviridae - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | RNA, Viral - metabolism | Adenovirus E1B Proteins - metabolism | Nuclear Proteins - genetics | Adenovirus E1B Proteins - genetics | Proto-Oncogene Proteins - metabolism | Epithelial Cells - radiation effects | Cyclin-Dependent Kinase Inhibitor p21 | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Viral Nonstructural Proteins - genetics | Viral Plaque Assay | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Poly(ADP-ribose) Polymerases - metabolism | Viral Vaccines | Tumor Suppressor Protein p14ARF - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Index Medicus
Journal Article