CA: A Cancer Journal for Clinicians, ISSN 0007-9235, 05/2010, Volume 60, Issue 3, pp. 166 - 193
Malignant gliomas are the most common and deadly brain tumors. Nevertheless, survival for patients with glioblastoma, the most aggressive glioma, although...
CHEMOATTRACTANT PROTEIN-1 MCP-1 | PHASE-II TRIAL | ONCOLOGY | BRAIN-TUMOR CONSORTIUM | INTEGRATED GENOMIC ANALYSIS | BEVACIZUMAB PLUS IRINOTECAN | RECURRENT GLIOBLASTOMA-MULTIFORME | HIGH-GRADE GLIOMAS | CEREBROSPINAL-FLUID | FACTOR RECEPTOR | ENDOTHELIAL GROWTH-FACTOR | Molecular Biology | Signal Transduction | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Epidermal Growth Factor - drug effects | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Biomarkers, Tumor | Glioblastoma - therapy | Glioblastoma - genetics | Glioblastoma - pathology | Treatment Failure | Brain Neoplasms - therapy | Angiogenesis Inhibitors - therapeutic use | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Apoptosis | Development and progression | Care and treatment | Forecasts and trends | Diagnosis | Gliomas | Cancer | Oncology | Clinical medicine | Radiation therapy | Medical diagnosis | Brain cancer | Tumors
CHEMOATTRACTANT PROTEIN-1 MCP-1 | PHASE-II TRIAL | ONCOLOGY | BRAIN-TUMOR CONSORTIUM | INTEGRATED GENOMIC ANALYSIS | BEVACIZUMAB PLUS IRINOTECAN | RECURRENT GLIOBLASTOMA-MULTIFORME | HIGH-GRADE GLIOMAS | CEREBROSPINAL-FLUID | FACTOR RECEPTOR | ENDOTHELIAL GROWTH-FACTOR | Molecular Biology | Signal Transduction | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Epidermal Growth Factor - drug effects | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Biomarkers, Tumor | Glioblastoma - therapy | Glioblastoma - genetics | Glioblastoma - pathology | Treatment Failure | Brain Neoplasms - therapy | Angiogenesis Inhibitors - therapeutic use | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Apoptosis | Development and progression | Care and treatment | Forecasts and trends | Diagnosis | Gliomas | Cancer | Oncology | Clinical medicine | Radiation therapy | Medical diagnosis | Brain cancer | Tumors
Journal Article
Neurosurgery, ISSN 0148-396X, 2015, Volume 76, Issue 2, p. 123
Journal Article
Neurosurgery, ISSN 0148-396X, 11/2015, Volume 77, Issue 5, pp. 663 - 673
Abstract The current neurosurgical goal for patients with malignant gliomas is maximal safe resection of the contrast-enhancing tumor. However, a complete...
5-Aminolevulinic acid | Glioma | Glioblastoma multiforme | Fluorescence-guided surgery | INDUCED PROTOPORPHYRIN-IX | VISUALIZATION | SURGERY | VOLUMETRIC-ANALYSIS | GLIOBLASTOMA-MULTIFORME | RESECTION | INTRAOPERATIVE MRI | CLINICAL NEUROLOGY | BRAIN-TUMORS | GRADE GLIOMAS | EXTENT | 5-ALA | Neuronavigation - methods | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Fluorescence | Magnetic Resonance Imaging - methods | Photosensitizing Agents - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Glioma - metabolism | Aminolevulinic Acid - metabolism | Monitoring, Intraoperative - methods | Glioma - surgery
5-Aminolevulinic acid | Glioma | Glioblastoma multiforme | Fluorescence-guided surgery | INDUCED PROTOPORPHYRIN-IX | VISUALIZATION | SURGERY | VOLUMETRIC-ANALYSIS | GLIOBLASTOMA-MULTIFORME | RESECTION | INTRAOPERATIVE MRI | CLINICAL NEUROLOGY | BRAIN-TUMORS | GRADE GLIOMAS | EXTENT | 5-ALA | Neuronavigation - methods | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Fluorescence | Magnetic Resonance Imaging - methods | Photosensitizing Agents - metabolism | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Glioma - metabolism | Aminolevulinic Acid - metabolism | Monitoring, Intraoperative - methods | Glioma - surgery
Journal Article
The Lancet Oncology, ISSN 1470-2045, 08/2017, Volume 18, Issue 8, pp. 1049 - 1060
Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial control following resection of brain metastasis. However, stereotactic...
SURGERY | ONCOLOGY | NEUROCOGNITIVE FUNCTION | SINGLE METASTASES | RECURRENCE | QUALITY-OF-LIFE | SURGICAL RESECTION | CANCER | TUMORS | PROGRESSION | RADIATION-THERAPY | Follow-Up Studies | Humans | Middle Aged | Male | Survival Rate | Radiosurgery - adverse effects | Brain Neoplasms - surgery | Disease Progression | Activities of Daily Living | Young Adult | Disease-Free Survival | Magnetic Resonance Imaging | Brain Neoplasms - secondary | Metastasectomy | Dose Fractionation, Radiation | Neoplasm Recurrence, Local - diagnostic imaging | Cognition Disorders - etiology | Adolescent | Intention to Treat Analysis | Quality of Life | Adult | Female | Brain Neoplasms - radiotherapy | Radiotherapy, Adjuvant | Metastasis | Comparative analysis | Surgery | Radiosurgery | Index Medicus
SURGERY | ONCOLOGY | NEUROCOGNITIVE FUNCTION | SINGLE METASTASES | RECURRENCE | QUALITY-OF-LIFE | SURGICAL RESECTION | CANCER | TUMORS | PROGRESSION | RADIATION-THERAPY | Follow-Up Studies | Humans | Middle Aged | Male | Survival Rate | Radiosurgery - adverse effects | Brain Neoplasms - surgery | Disease Progression | Activities of Daily Living | Young Adult | Disease-Free Survival | Magnetic Resonance Imaging | Brain Neoplasms - secondary | Metastasectomy | Dose Fractionation, Radiation | Neoplasm Recurrence, Local - diagnostic imaging | Cognition Disorders - etiology | Adolescent | Intention to Treat Analysis | Quality of Life | Adult | Female | Brain Neoplasms - radiotherapy | Radiotherapy, Adjuvant | Metastasis | Comparative analysis | Surgery | Radiosurgery | Index Medicus
Journal Article
Neurosurgery, ISSN 0148-396X, 11/2012, Volume 71, Issue 5, p. 935
Journal Article
Oncotarget, 2015, Volume 6, Issue 11, pp. 8788 - 8806
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 8/2015, Volume 124, Issue 1, pp. 13 - 22
The epidermal growth factor receptor deletion variant EGFRvIII is known to be expressed in a subset of patients with glioblastoma (GBM) tumors that enhances...
Neurology | Ionizing radiation | Medicine & Public Health | Iron oxide nanoparticles | Convection-enhanced delivery | Magnetic resonance imaging | Glioblastoma | Oncology | Epidermal growth factor receptor | TARGETED THERAPY | GLIOMAS | CELLS | MULTIFORME | RADIATION | CANCER | CLINICAL NEUROLOGY | BRAIN-TUMORS | CETUXIMAB | REACTIVE OXYGEN | ONCOLOGY | IN-VIVO | DNA Damage - drug effects | Receptor, Epidermal Growth Factor - immunology | Reactive Oxygen Species | Apoptosis - drug effects | Humans | Radiation Tolerance | Brain Neoplasms - pathology | Ferric Compounds - chemistry | Antineoplastic Agents - administration & dosage | Brain Neoplasms - drug therapy | Glioblastoma - radiotherapy | Drug Delivery Systems | Magnetite Nanoparticles - chemistry | Animals | Glioblastoma - pathology | Cell Line, Tumor | Cetuximab - administration & dosage | Mice | Brain Neoplasms - radiotherapy | Glioblastoma - drug therapy | Receptor, Epidermal Growth Factor - administration & dosage | Drugs | Medical colleges | Drug delivery systems | Antibodies | Glioblastoma multiforme | Vehicles | Viral antibodies | Nanoparticles | Chemotherapy | Epidermal growth factor | Iron compounds | Ferric oxide | Nanotechnology | Cancer | magnetic resonance imaging | convection-enhanced delivery | iron oxide nanoparticles | epidermal growth factor receptor | ionizing radiation
Neurology | Ionizing radiation | Medicine & Public Health | Iron oxide nanoparticles | Convection-enhanced delivery | Magnetic resonance imaging | Glioblastoma | Oncology | Epidermal growth factor receptor | TARGETED THERAPY | GLIOMAS | CELLS | MULTIFORME | RADIATION | CANCER | CLINICAL NEUROLOGY | BRAIN-TUMORS | CETUXIMAB | REACTIVE OXYGEN | ONCOLOGY | IN-VIVO | DNA Damage - drug effects | Receptor, Epidermal Growth Factor - immunology | Reactive Oxygen Species | Apoptosis - drug effects | Humans | Radiation Tolerance | Brain Neoplasms - pathology | Ferric Compounds - chemistry | Antineoplastic Agents - administration & dosage | Brain Neoplasms - drug therapy | Glioblastoma - radiotherapy | Drug Delivery Systems | Magnetite Nanoparticles - chemistry | Animals | Glioblastoma - pathology | Cell Line, Tumor | Cetuximab - administration & dosage | Mice | Brain Neoplasms - radiotherapy | Glioblastoma - drug therapy | Receptor, Epidermal Growth Factor - administration & dosage | Drugs | Medical colleges | Drug delivery systems | Antibodies | Glioblastoma multiforme | Vehicles | Viral antibodies | Nanoparticles | Chemotherapy | Epidermal growth factor | Iron compounds | Ferric oxide | Nanotechnology | Cancer | magnetic resonance imaging | convection-enhanced delivery | iron oxide nanoparticles | epidermal growth factor receptor | ionizing radiation
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2017, Volume 18, Issue 10, pp. 1373 - 1385
Rindopepimut (also known as CDX-110), a vaccine targeting the deletion mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet...
GLIOMAS | ONCOLOGY | RECURSIVE PARTITIONING ANALYSIS | GROWTH-FACTOR | RADIOTHERAPY | CANCER | PEPTIDE | ADJUVANT TEMOZOLOMIDE | Dacarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Patient Selection | Dose-Response Relationship, Drug | Young Adult | Glioblastoma - genetics | Time Factors | Dacarbazine - analogs & derivatives | Adult | Female | Vaccines, Subunit - adverse effects | Brain Neoplasms - mortality | Dacarbazine - administration & dosage | Double-Blind Method | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Kaplan-Meier Estimate | Proportional Hazards Models | Brain Neoplasms - genetics | Cancer Vaccines - adverse effects | Treatment Outcome | Brain Neoplasms - drug therapy | Disease-Free Survival | Internationality | Vaccines, Subunit - administration & dosage | Glioblastoma - pathology | Survival Analysis | Aged | Temozolomide | Glioblastoma - drug therapy | Glioblastoma - mortality | Antimitotic agents | Clinical trials | Care and treatment | Product development | Antineoplastic agents | Glioblastoma multiforme | Analysis
GLIOMAS | ONCOLOGY | RECURSIVE PARTITIONING ANALYSIS | GROWTH-FACTOR | RADIOTHERAPY | CANCER | PEPTIDE | ADJUVANT TEMOZOLOMIDE | Dacarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Patient Selection | Dose-Response Relationship, Drug | Young Adult | Glioblastoma - genetics | Time Factors | Dacarbazine - analogs & derivatives | Adult | Female | Vaccines, Subunit - adverse effects | Brain Neoplasms - mortality | Dacarbazine - administration & dosage | Double-Blind Method | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Kaplan-Meier Estimate | Proportional Hazards Models | Brain Neoplasms - genetics | Cancer Vaccines - adverse effects | Treatment Outcome | Brain Neoplasms - drug therapy | Disease-Free Survival | Internationality | Vaccines, Subunit - administration & dosage | Glioblastoma - pathology | Survival Analysis | Aged | Temozolomide | Glioblastoma - drug therapy | Glioblastoma - mortality | Antimitotic agents | Clinical trials | Care and treatment | Product development | Antineoplastic agents | Glioblastoma multiforme | Analysis
Journal Article
Neurosurgery, ISSN 0148-396X, 11/2015, Volume 77, Issue 5, pp. 663 - 673
The current neurosurgical goal for patients with malignant gliomas is maximal safe resection of the contrast-enhancing tumor. However, a complete resection of...
fluorescence-guided surgery | glioma | GBM | 5-aminolevulinic acid
fluorescence-guided surgery | glioma | GBM | 5-aminolevulinic acid
Journal Article
Frontiers in Chemistry, ISSN 2296-2646, 2014, Volume 2, p. 109
Journal Article
Expert Review of Clinical Pharmacology, ISSN 1751-2433, 03/2012, Volume 5, Issue 2, pp. 173 - 186
Magnetic nanoparticles (MNPs) represent a promising nanomaterial for the targeted therapy and imaging of malignant brain tumors. Conjugation of peptides or...
convection-enhanced delivery | GBM | glioblastoma | iron oxide nanoparticles | MRI | malignant brain tumors | thermotherapy | magnetic nanoparticles | EGFR | PHARMACOLOGY & PHARMACY | Glioblastoma - diagnosis | Brain Neoplasms - diagnosis | Humans | Magnetic Resonance Imaging - methods | Magnetite Nanoparticles - therapeutic use | Clinical Trials as Topic | Magnetics | Glioblastoma - therapy | Animals | Brain Neoplasms - therapy | Blood-Brain Barrier - physiology | Contrast Media - therapeutic use | Hyperthermia, Induced - methods | Nanoparticles | Care and treatment | Peptides | Brain tumors | Gene therapy | Cancer | Tumors | Neuroimaging | Signal transduction | Translation | nanoparticles | Blood-brain barrier | Tumor cells | Antibodies | Clinical trials | Cell surface
convection-enhanced delivery | GBM | glioblastoma | iron oxide nanoparticles | MRI | malignant brain tumors | thermotherapy | magnetic nanoparticles | EGFR | PHARMACOLOGY & PHARMACY | Glioblastoma - diagnosis | Brain Neoplasms - diagnosis | Humans | Magnetic Resonance Imaging - methods | Magnetite Nanoparticles - therapeutic use | Clinical Trials as Topic | Magnetics | Glioblastoma - therapy | Animals | Brain Neoplasms - therapy | Blood-Brain Barrier - physiology | Contrast Media - therapeutic use | Hyperthermia, Induced - methods | Nanoparticles | Care and treatment | Peptides | Brain tumors | Gene therapy | Cancer | Tumors | Neuroimaging | Signal transduction | Translation | nanoparticles | Blood-brain barrier | Tumor cells | Antibodies | Clinical trials | Cell surface
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 4/2009, Volume 87, Issue 4, pp. 363 - 374
A rare subpopulation of cells within malignant gliomas, which shares canonical properties with neural stem cells (NSCs), may be integral to glial tumor...
Human Genetics | Biomedicine | Brain cancer | Central nervous system | Glioblastoma | Internal Medicine | Molecular Medicine | Cancer stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | SIDE POPULATION | GLIOBLASTOMA-MULTIFORME | MAGNETIC NANOPARTICLES | CANCER STEM-CELLS | ANAPLASTIC ASTROCYTOMA | GENETICS & HEREDITY | ADULT HUMAN BRAIN | CENTRAL-NERVOUS-SYSTEM | NEURAL PROGENITOR CELLS | GROWTH-FACTOR | HIGH-GRADE GLIOMA | Cell Lineage | Neurons - pathology | Animals | Cell Transformation, Neoplastic | Models, Biological | Glioma - pathology | Humans | Glioma - therapy | Brain - pathology | Neoplastic Stem Cells - pathology | Stem Cells - pathology | Physiological aspects | Development and progression | Care and treatment | Research | Gliomas | Stem cells
Human Genetics | Biomedicine | Brain cancer | Central nervous system | Glioblastoma | Internal Medicine | Molecular Medicine | Cancer stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | SIDE POPULATION | GLIOBLASTOMA-MULTIFORME | MAGNETIC NANOPARTICLES | CANCER STEM-CELLS | ANAPLASTIC ASTROCYTOMA | GENETICS & HEREDITY | ADULT HUMAN BRAIN | CENTRAL-NERVOUS-SYSTEM | NEURAL PROGENITOR CELLS | GROWTH-FACTOR | HIGH-GRADE GLIOMA | Cell Lineage | Neurons - pathology | Animals | Cell Transformation, Neoplastic | Models, Biological | Glioma - pathology | Humans | Glioma - therapy | Brain - pathology | Neoplastic Stem Cells - pathology | Stem Cells - pathology | Physiological aspects | Development and progression | Care and treatment | Research | Gliomas | Stem cells
Journal Article
Cancer Research, ISSN 0008-5472, 08/2010, Volume 70, Issue 15, pp. 6303 - 6312
The magnetic nanoparticle has emerged as a potential multifunctional clinical tool that can provide cancer cell detection by magnetic resonance imaging (MRI)...
GROWTH-FACTOR RECEPTOR | CELLS | CETUXIMAB | HYPERTHERMIA | ONCOLOGY | GLIOMA | RADIORESISTANCE | IN-VIVO | MALIGNANT BRAIN-TUMORS | MRI DETECTION | CANCER | Antibody Specificity | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Ferric Compounds - administration & dosage | Ferric Compounds - chemistry | Transplantation, Heterologous | Immunoconjugates - administration & dosage | Immunoconjugates - immunology | Receptor, Epidermal Growth Factor - metabolism | Brain Neoplasms - immunology | Astrocytes - drug effects | Receptor, Epidermal Growth Factor - immunology | Glioblastoma - diagnosis | Signal Transduction | Brain Neoplasms - diagnosis | Immunoconjugates - chemistry | Glioblastoma - therapy | Magnetic Resonance Imaging | Animals | Glioblastoma - immunology | Mice, Nude | Glioblastoma - pathology | Brain Neoplasms - therapy | Cell Line, Tumor | Mice | Nanoparticles - administration & dosage | Index Medicus
GROWTH-FACTOR RECEPTOR | CELLS | CETUXIMAB | HYPERTHERMIA | ONCOLOGY | GLIOMA | RADIORESISTANCE | IN-VIVO | MALIGNANT BRAIN-TUMORS | MRI DETECTION | CANCER | Antibody Specificity | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Ferric Compounds - administration & dosage | Ferric Compounds - chemistry | Transplantation, Heterologous | Immunoconjugates - administration & dosage | Immunoconjugates - immunology | Receptor, Epidermal Growth Factor - metabolism | Brain Neoplasms - immunology | Astrocytes - drug effects | Receptor, Epidermal Growth Factor - immunology | Glioblastoma - diagnosis | Signal Transduction | Brain Neoplasms - diagnosis | Immunoconjugates - chemistry | Glioblastoma - therapy | Magnetic Resonance Imaging | Animals | Glioblastoma - immunology | Mice, Nude | Glioblastoma - pathology | Brain Neoplasms - therapy | Cell Line, Tumor | Mice | Nanoparticles - administration & dosage | Index Medicus
Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 11/2015, Volume 45, pp. 97 - 102
Small extracellular organelles such as exosomes and microvesicles are currently being studied as a novel way to track tumor progression, pseudoprogression, and...
Biomarker | Exosome | Microvesicle | Glioblastoma | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | MICROVESICLES PROMOTE | PSEUDOPROGRESSION | BIOLOGICAL SIGNIFICANCE | PLASMA | MICROENVIRONMENT | EXOSOMES | Exosomes - metabolism | Glioblastoma - diagnosis | Glioblastoma - genetics | Extracellular Vesicles - genetics | Brain Neoplasms - diagnosis | Humans | Brain Neoplasms - genetics | Cell Communication | Exosomes - genetics | Biomarkers, Tumor - genetics | Extracellular Vesicles - metabolism | Development and progression | Glioblastoma multiforme | Tumors
Biomarker | Exosome | Microvesicle | Glioblastoma | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | MICROVESICLES PROMOTE | PSEUDOPROGRESSION | BIOLOGICAL SIGNIFICANCE | PLASMA | MICROENVIRONMENT | EXOSOMES | Exosomes - metabolism | Glioblastoma - diagnosis | Glioblastoma - genetics | Extracellular Vesicles - genetics | Brain Neoplasms - diagnosis | Humans | Brain Neoplasms - genetics | Cell Communication | Exosomes - genetics | Biomarkers, Tumor - genetics | Extracellular Vesicles - metabolism | Development and progression | Glioblastoma multiforme | Tumors
Journal Article